Tirosina Quinase/Adaptador
Os inibidores de tirosina quinase e adaptadores são compostos que têm como alvo as tirosina quinases e suas proteínas adaptadoras associadas, que desempenham papéis fundamentais na sinalização celular, crescimento e diferenciação. Esses inibidores são ferramentas essenciais na pesquisa sobre o câncer, pois muitas tirosina quinases estão envolvidas nas vias de sinalização que impulsionam o crescimento e a metástase dos tumores. Ao inibir as tirosina quinases, esses compostos podem bloquear cascatas de sinalização críticas, oferecendo potenciais estratégias terapêuticas para vários tipos de câncer e outras doenças que envolvem sinalização celular anormal. Na CymitQuimica, oferecemos uma ampla gama de inibidores de tirosina quinase e adaptadores de alta qualidade para apoiar sua pesquisa em oncologia, biologia molecular e desenvolvimento de terapias direcionadas.
Subcategorias de "Tirosina Quinase/Adaptador"
- ALK(116 produtos)
- CSF-1R(42 produtos)
- EGFR(572 produtos)
- Receptor de Efrina(23 produtos)
- FLT(91 produtos)
- Receptor do Factor de Crescimento Fibroblasto (FGFR)(169 produtos)
- HER(5 produtos)
- Hck(3 produtos)
- IGF-1R(92 produtos)
- PDGFR(126 produtos)
- PYK2(7 produtos)
- Src(80 produtos)
- Receptor TAM(32 produtos)
- Tie-2(21 produtos)
- Receptor TrK(59 produtos)
- Tirosina Quinases(26 produtos)
- VEGFR(262 produtos)
- c-Fms(108 produtos)
- c-Kit(102 produtos)
- c-Met/HGFR(129 produtos)
- c-RET(51 produtos)
Exibir 13 mais subcategorias
Foram encontrados 1342 produtos de "Tirosina Quinase/Adaptador"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
BMS 777607
CAS:<p>BMS 777607 (BMS 817378) is a Met-related inhibitor for c-Met/Axl/Ron/Tyro3. BMS-777607 has been investigated for the basic science of Malignant Solid Tumour.</p>Fórmula:C25H19ClF2N4O4Pureza:98.30% - >99.99%Cor e Forma:SolidPeso molecular:512.89Butein
CAS:Butein is a cAMP-specific PDE inhibitor, protein tyrosine kinase inhibitor, and SIRT1 activator.Cost-effective and quality-assured.Fórmula:C15H12O5Pureza:98.76% - >99.99%Cor e Forma:SolidPeso molecular:272.25TL-895
CAS:<p>TL-895 is a potent, selective ATP-competitive BTK inhibitor (IC50 = 1.5 nM, Ki = 11.9 nM).</p>Fórmula:C25H26FN5O2Pureza:99.96%Cor e Forma:SolidPeso molecular:447.5SU 5402
CAS:<p>SU 5402 is a potent multi-targeted receptor tyrosine kinase inhibitor with IC50 of 20 nM, 30 nM, and 510 nM for VEGFR2, FGFR1, and PDGF-Rβ, respectively.</p>Fórmula:C17H16N2O3Pureza:98.91% - 99.64%Cor e Forma:Yellow-Green SolidPeso molecular:296.32SKLB 610
CAS:<p>SKLB610, a novel multi-targeted inhibitor, inhibits angiogenesis-related tyrosine kinase VEGFR2, FGFR2, and PDGFR at a rate of 97%, 65%, and 55%, respectively,</p>Fórmula:C21H16F3N3O3Pureza:99.33% - 99.83%Cor e Forma:SolidPeso molecular:415.37MK-8033
CAS:<p>MK-8033 is a new and selective dual ATP competitive c-Met/Ron inhibitor (IC50: 1 nM Wt c-Met).</p>Fórmula:C25H21N5O3SPureza:97.16%Cor e Forma:SolidPeso molecular:471.53CEP-28122
CAS:<p>CEP-28122 is a highly potent and selective orally active ALK inhibitor.</p>Fórmula:C28H35ClN6O3Pureza:99.87% - >99.99%Cor e Forma:SolidPeso molecular:539.07GLPG0634 analog
CAS:<p>GLPG0634 analog (GLPG0634 analogue) is a specific JAK1 inhibitor with IC50 of 10/28/810/116 nM for JAK1/2/3 and TYK2, respectively.</p>Fórmula:C23H18N6O2Pureza:99.52% - >99.99%Cor e Forma:SolidPeso molecular:410.43PD158780
CAS:<p>PD 158780 blocks all ErbB receptors: EGFR, ErbB2-4, with IC50s: 8μM, 49-52 nM.</p>Fórmula:C14H12BrN5Pureza:98.81%Cor e Forma:SolidPeso molecular:330.18Eph inhibitor 2
CAS:<p>Eph inhibitor 2 is an Eph family tyrosine kinase inhibitor targeting Eph receptors.</p>Fórmula:C18H15N5OPureza:99.01%Cor e Forma:SolidPeso molecular:317.34FGFR4-IN-1
CAS:<p>FGFR4-IN-1 is a potent FGFR4 inhibitor (IC50: 0.7 nM).</p>Fórmula:C24H27N7O5Pureza:98.96%Cor e Forma:SolidPeso molecular:493.52SU5204
CAS:SU5204 (3-[(2-Ethoxyphenyl)methylidene]-1H-indol-2-one), an analogue of SU5025, pharmacologically inhibits VEGFR2(IC50s of 4 and 51.5 μM for FLK-1 (VEGFR-2) andFórmula:C17H15NO2Pureza:99.46%Cor e Forma:SolidPeso molecular:265.31PP2
CAS:<p>PP2 (AG 1879,AGL 1879) is a effective inhibitor of Lck/Fyn (IC50:4/5 nM) , ~100-fold less potent to EGFR, inactive for ZAP-70, PKA and JAK2.</p>Fórmula:C15H16ClN5Pureza:98% - 98.21%Cor e Forma:White SolidPeso molecular:301.77Tyrphostin AG30
CAS:<p>Tyrphostin AG30 (AG30) (AG30) is a potent protein tyrosine kinases (PTK) inhibitor.</p>Fórmula:C10H7NO4Pureza:99.02%Cor e Forma:SolidPeso molecular:205.17PD-161570
CAS:PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM.Fórmula:C26H35Cl2N7OPureza:99.92%Cor e Forma:SolidPeso molecular:532.51Lazertinib
CAS:<p>Lazertinib (GNS-1480) is a potent, selective, irreversible EGFR-TKI; IC50: 1.7-76 nM for various EGFR mutations.</p>Fórmula:C30H34N8O3Pureza:98.7% - 99.90%Cor e Forma:SolidPeso molecular:554.64Tivozanib
CAS:<p>Tivozanib (KRN951) is an oral VEGFRs 1-3 inhibitor with potential antiangiogenic and cancer-fighting properties.</p>Fórmula:C22H19ClN4O5Pureza:98.08% - 99.67%Cor e Forma:SolidPeso molecular:454.86β-Hydroxyisovalerylshikonin
CAS:<p>Beta-Hydroxyisovalerylshikonin is an inhibitor of protein-tyrosine kinases such as v-Src and EGFR, and has been shown to induce apoptosis in several human tumor</p>Fórmula:C21H24O7Pureza:98.16%Cor e Forma:SolidPeso molecular:388.41PKG drug G1
CAS:<p>PKG drug G1 targets PKG Iα C42. PKG drug G1 can couple to vasodilation and blood pressure lowering by a C42 PKG Iα-independent mechanism.</p>Fórmula:C13H11N3OSPureza:97.57% - 97.67%Cor e Forma:SolidPeso molecular:257.31UNC2025 2HCl (1429881-91-3(free base))
<p>UNC2025 is a potent and orally bioavailable Mer/Flt3 dual inhibitor with IC50 of 0.8/0.74 nM for Mer/Flt3.</p>Fórmula:C28H42Cl2N6OPureza:99.71%Cor e Forma:SolidPeso molecular:549.62PRN1371
CAS:<p>PRN1371 is a specific and potent FGFR1-4 and CSF1R inhibitor (IC50s: 0.6/1.3/4.1/19.3/8.1 nM for FGFR1/2/3/4 and CSF1R).</p>Fórmula:C26H30Cl2N6O4Pureza:98.65%Cor e Forma:SolidPeso molecular:561.46MAZ51
CAS:MAZ51 is a VEGFR-3 (Flt-4) tyrosine kinase inhibitor.Fórmula:C21H18N2OPureza:98.53%Cor e Forma:SolidPeso molecular:314.38Vactosertib
CAS:<p>Vactosertib (EW-7197) is an oral TGFBR1/ALK5 inhibitor with potential cancer-fighting properties.</p>Fórmula:C22H18FN7Pureza:98.85% - 99.81%Cor e Forma:SolidPeso molecular:399.422-D08
CAS:2-D08 is a synthetic flavone that inhibits sumoylation, also inhibits Axl with an IC50 of 0.49 nM.2-D08 showed anti-aggregatory and neuroprotective effect.Fórmula:C15H10O5Pureza:98.58% - 98.95%Cor e Forma:SolidPeso molecular:270.24Dacomitinib hydrate
CAS:<p>Dacomitinib hydrate (PF 299804) is a highly selective and second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor family of</p>Fórmula:C24H27ClFN5O3Pureza:99.52%Cor e Forma:SolidPeso molecular:487.96AZD2932
CAS:<p>AZD2932 is a potent and multi-targeted kinase inhibitor VEGFR2, PDGFβ, Flt-3, and c-Kit.</p>Fórmula:C24H25N5O4Pureza:97.71% - 98.37%Cor e Forma:SolidPeso molecular:447.49CH7057288
CAS:<p>CH7057288 is an effective and selective TRK inhibitor with an IC50 value of 1.1 nM, 7.8 nM and 5.1 nM for TRKA, TRKB and TRKC, respectively.</p>Fórmula:C32H31N3O5SPureza:99.92%Cor e Forma:SolidPeso molecular:569.67TAS6417
CAS:<p>Zipalertinib (TAS6417, CLN-081) is a novel, highly potent, orally active covalent EGFR tyrosine kinase inhibitor.Cost-effective and quality-assured.</p>Fórmula:C23H20N6OPureza:99.71%Cor e Forma:SolidPeso molecular:396.44Pyridostatin TFA
CAS:<p>Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay, which targets a series of proto-oncogenes including c-</p>Fórmula:C37H35F9N8O11Pureza:97.09% - 99.84%Cor e Forma:SolidPeso molecular:938.71SCR-1481B1
CAS:<p>SCR-1481B1 (c-Met inhibitor 2) has activity against cancers dependent on Met activation and also has activity against cancers as a VEGFR inhibitor</p>Fórmula:C32H40ClF2N6O13PPureza:98.07%Cor e Forma:SolidPeso molecular:821.12Pralsetinib
CAS:<p>Pralsetinib (Blu667) (BLU-667) is a highly potent, selective RET inhibitor (IC50s: 0.4, 0.3, 0.4, 0.4, and 0.4 nM for WT RET, RET mutants V804L, V804M, M918T</p>Fórmula:C27H32FN9O2Pureza:97.88% - 99.8%Cor e Forma:SolidPeso molecular:533.6LDN-214117
CAS:<p>LDN-214117 is a potent and selective ALK2 inhibitor.</p>Fórmula:C25H29N3O3Pureza:98% - 99.82%Cor e Forma:SolidPeso molecular:419.52RG14620
CAS:<p>RG14620 (Tyrphostin RG14620) is an epidermal growth factor receptor (EGFR) inhibitor.</p>Fórmula:C14H8Cl2N2Pureza:99.82% - 99.87%Cor e Forma:SolidPeso molecular:275.13Dovitinib lactate
CAS:<p>Dovitinib lactate (TKI-258 lactate)(TKI258) lactate is a potent inhibitor of fibroblast growth factor receptor 3 (FGFR3) (IC50 :5 nM).</p>Fórmula:C24H27FN6O4Pureza:99.54% - 99.77%Cor e Forma:SolidPeso molecular:482.51LDN193189
CAS:LDN193189 blocks BMP signaling by inhibiting ALK2/3; IC50: ALK1/2/3/6 = 0.8/0.8/5.3/16.7 nM.Fórmula:C25H22N6Pureza:98% - 99.86%Cor e Forma:SolidPeso molecular:406.48AAL-993
CAS:<p>AAL-993: VEGFR inhibitor; IC50: 130 nM (1), 23 nM (2), 18 nM (3); weak on other tyrosine kinases; antiangiogenic & antitumor.</p>Fórmula:C20H16F3N3OPureza:99.65%Cor e Forma:SolidPeso molecular:371.36Protein kinase inhibitors 1
CAS:Protein kinase inhibitors 1 is a novel inhibitor of HIPK2 with an IC50 of 74 nM and Kd of 9.5 nM.Fórmula:C18H17N5O3SPureza:98%Cor e Forma:SolidPeso molecular:383.42(Rac)-IBT6A
CAS:<p>(Rac)-IBT6A is a racemate of IBT6A. IBT6A is an impurity of Ibrutinib and can be used in the synthesis of IBT6A Ibrutinib dimer and IBT6A adduct.</p>Fórmula:C22H22N6OPureza:99.24%Cor e Forma:SolidPeso molecular:386.45squarunkinA
CAS:<p>squarunkinA is a novel modulator of the UNC119-Cargo Interaction, potently and selectively inhibiting the binding of a myristoylated peptide representing the N-</p>Fórmula:C25H32F3N5O4Pureza:99.29%Cor e Forma:SolidPeso molecular:523.55Malantide acetate(86555-35-3 free base)
<p>Malantide acetate is a dodecapeptide phosphorylated by cyclic AMP-dependent protein kinase (PKA), and increases PKA activity.Malantide is a synthetic peptide</p>Fórmula:C74H128N22O23Pureza:>99.99%Cor e Forma:SolidPeso molecular:1693.97R-268712
CAS:<p>R-268712 is a potent ALK5 inhibitor with a 2.5 nM IC50, also targeting TGF-β type I receptor orally.</p>Fórmula:C20H18FN5OPureza:99.61%Cor e Forma:SolidPeso molecular:363.39MSDC 0160
CAS:<p>MSDC 0160 (CAY10415) is a prototype mTOT-modulating insulin sensitizer being used in trials studying the treatment of Type 2 Diabetes and Alzheimer's Disease.</p>Fórmula:C19H18N2O4SPureza:98.11% - 99.53%Cor e Forma:SolidPeso molecular:370.42UNC2541
CAS:<p>UNC2541 is a potent and Mer tyrosine kinase (MerTK)-specific inhibitor.</p>Fórmula:C24H34FN7O2Pureza:98.33%Cor e Forma:SolidPeso molecular:471.57PKI 14-22 amide, myristoylated Acetate
<p>PKI 14-22 amide, myristoylated Acetate inhibit cAMP-dependent protein kinase (PKA) and blocks hyperalgesia produced by spinal administration of 8-bromo-cAMP. </p>Fórmula:C55H104N20O14Pureza:96.34%Cor e Forma:SolidPeso molecular:1269.54SU5205
CAS:<p>SU5205 is a VEGFR2 inhibitor.</p>Fórmula:C15H10FNOPureza:99.62% - 99.67%Cor e Forma:SolidPeso molecular:239.24Allitinib tosylate
CAS:<p>Allitinib tosylate (AST-1306) is a novel irreversible inhibitor of EGFR and ErbB2 with IC50 of 0.5 nM and 3 nM, respectively.</p>Fórmula:C31H26ClFN4O5SPureza:98.46% - 98.68%Cor e Forma:SolidPeso molecular:621.08Cerdulatinib
CAS:<p>Cerdulatinib (PRT2070) is an novel oral dual Syk/JAK inhibitor.</p>Fórmula:C20H27N7O3SPureza:98.74% - 99.49%Cor e Forma:SolidPeso molecular:445.54PKG inhibitor peptide TFA (82801-73-8 free base)
PKG inhibitor peptide TFA (82801-73-8 free base) is an inhibitor of ATP-competitive cGMP-dependent protein kinase (PKG).Fórmula:C40H75F3N18O12Pureza:98%Cor e Forma:SolidPeso molecular:1057.13Foretinib
CAS:<p>Foretinib (GSK1363089) is a broad-spectrum tyrosine kinase inhibitor with IC50s of 0.4 nM and 0.9 nM for Met and KDR.</p>Fórmula:C34H34F2N4O6Pureza:98.07% - 99.68%Cor e Forma:SolidPeso molecular:632.65Bemcentinib
CAS:<p>Bemcentinib (R428) is a selective inhibitor of Axl (IC50: 14 nM) and has been investigated for the treatment of NSCLC.</p>Fórmula:C30H34N8Pureza:97% - 99.8%Cor e Forma:SolidPeso molecular:506.64
