Tirosina Quinase/Adaptador
Os inibidores de tirosina quinase e adaptadores são compostos que têm como alvo as tirosina quinases e suas proteínas adaptadoras associadas, que desempenham papéis fundamentais na sinalização celular, crescimento e diferenciação. Esses inibidores são ferramentas essenciais na pesquisa sobre o câncer, pois muitas tirosina quinases estão envolvidas nas vias de sinalização que impulsionam o crescimento e a metástase dos tumores. Ao inibir as tirosina quinases, esses compostos podem bloquear cascatas de sinalização críticas, oferecendo potenciais estratégias terapêuticas para vários tipos de câncer e outras doenças que envolvem sinalização celular anormal. Na CymitQuimica, oferecemos uma ampla gama de inibidores de tirosina quinase e adaptadores de alta qualidade para apoiar sua pesquisa em oncologia, biologia molecular e desenvolvimento de terapias direcionadas.
Subcategorias de "Tirosina Quinase/Adaptador"
- ALK(112 produtos)
- CSF-1R(42 produtos)
- EGFR(572 produtos)
- Receptor de Efrina(23 produtos)
- FLT(92 produtos)
- Receptor do Factor de Crescimento Fibroblasto (FGFR)(169 produtos)
- HER(5 produtos)
- Hck(3 produtos)
- IGF-1R(87 produtos)
- PDGFR(126 produtos)
- PYK2(7 produtos)
- Src(79 produtos)
- Receptor TAM(32 produtos)
- Tie-2(20 produtos)
- Receptor TrK(59 produtos)
- Tirosina Quinases(26 produtos)
- VEGFR(268 produtos)
- c-Fms(108 produtos)
- c-Kit(101 produtos)
- c-Met/HGFR(128 produtos)
- c-RET(51 produtos)
Exibir 13 mais subcategorias
Foram encontrados 1372 produtos de "Tirosina Quinase/Adaptador"
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Epertinib
CAS:<p>Epertinib is a reversible and selective tyrosine kinase inhibitor of EGFR, HER2, and HER4 (IC50s: 1.48 nM, 7.15 nM, and 2.49 nM).</p>Fórmula:C30H27ClFN5O3Pureza:98%Cor e Forma:SolidPeso molecular:560.02Bezuclastinib
CAS:<p>Bezuclastinib (CGT9486) is a novel, potent and highly selective tyrosine kinase and c-kit D816V inhibitor for the study of advanced mastocytosis.</p>Fórmula:C19H17N5OPureza:99.55%Cor e Forma:SolidPeso molecular:331.37DBPR112
CAS:<p>DBPR112: oral furanopyrimidine EGFR inhibitor; IC50: 15 nM (EGFRWT), 48 nM (L858R/T790M); blocks ATP site, strong antitumor effects.</p>Fórmula:C32H31N5O3Pureza:99.25%Cor e Forma:SolidPeso molecular:533.62AC710 Mesylate
CAS:<p>AC710 Mesylate is a potent PDGFR inhibitor (Kds: 0.6, 1.57, 1, 1.3, 1.0 nM for FLT3, CSF1R, KIT, PDGFRα and PDGFRβ).</p>Fórmula:C32H46N6O7SPureza:98%Cor e Forma:SolidPeso molecular:658.81EGFR-IN-28
CAS:<p>EGFR-IN-28 is a potent EGFR inhibitor. EGFR-IN-28 has antitumor activity .</p>Fórmula:C31H39BrN10O3SCor e Forma:SolidPeso molecular:711.68AC710
CAS:<p>AC710 is a potent PDGFR inhibitor (Kds: 0.6, 1, 1.57, 1.3, 1 nM for FLT3, KIT, CSF1R, PDGFRα and PDGFRβ).</p>Fórmula:C31H42N6O4Pureza:99.67%Cor e Forma:SolidPeso molecular:562.7EGFR-IN-73
CAS:<p>EGFR-IN-73 (Compound 3f) effectively inhibits the prevalent EGFR mutation, EGFR Del19, exhibiting an IC50 value of 119 nM [1].</p>Fórmula:C19H17ClFN3O4Pureza:98%Cor e Forma:SolidPeso molecular:405.81Limertinib
CAS:<p>Limertinib (ASK120067) is a EGFR tyrosine kinase inhibitor targeting EGFR T790M, applicable for the study of non-small cell lung cancer.</p>Fórmula:C29H32ClN7O2Pureza:97.44%Cor e Forma:SolidPeso molecular:546.06ALK-IN-5
CAS:<p>ALK-IN-5 is a potent, selective, and brain-penetrant inhibitor of anaplastic lymphoma kinase (ALK, IC50: 2.9 nM).</p>Fórmula:C24H25FN6O3Pureza:98%Cor e Forma:SolidPeso molecular:464.49(E/Z)-CP-724714
CAS:<p>(E/Z)-CP-724714, comprising racemic mixtures of (E)-CP-724714 and (Z)-CP-724714 isomers, is a potent, selective, and orally active inhibitor of ErbB2 (HER2)[1].</p>Fórmula:C27H27N5O3Pureza:98%Cor e Forma:SolidPeso molecular:469.54SSR128129E free acid
CAS:<p>SSR128129E free acid is an orally available and allosteric inhibitor of FGFR(IC50 of 1.9 μM for FGFR1).</p>Fórmula:C18H16N2O4Pureza:98%Cor e Forma:SolidPeso molecular:324.33BAY 2476568
CAS:<p>BAY 2476568 is a selective and potent EGFR inhibitor that acts on both wild-type EGFR (IC50 <0.2 nM) and mutant EGFR (IC50 <0.2 nM).</p>Fórmula:C24H27FN4O4Cor e Forma:SolidPeso molecular:454.49ALK2-IN-2
CAS:<p>ALK2-IN-2 is a potent and selective inhibitor of activin receptor-like kinase 2 (ALK2) (IC50: 9 nM), inhibiting ALK2 700-fold more than ALK3.</p>Fórmula:C28H27N5O2SPureza:99.55%Cor e Forma:SolidPeso molecular:497.61Mutated EGFR-IN-2
CAS:<p>Mutated EGFR-IN-2 is an inhibitor of mutant-selective EGFR.</p>Fórmula:C29H35FN8O3Pureza:98%Cor e Forma:SolidPeso molecular:562.64LDC0496
CAS:<p>LDC0496: Potent EGFR/Her2 exon 20 inhibitor; selective for wild-type EGFR, kinase-specific.</p>Fórmula:C32H35N5O3Cor e Forma:SolidPeso molecular:537.65GW 583340 dihydrochloride
CAS:<p>GW 583340 dihydrochloride is a potent and orally available dual EGFR/ErbB2 inhibitor and inhibits 80% of tumor growth in a mouse xenograft mode.</p>Fórmula:C28H27Cl3FN5O3S2Pureza:98.80%Cor e Forma:SolidPeso molecular:671.03NSC81111
CAS:<p>NSC81111 shows anticaner effects which is a potent and orally active inhibitor of EGFR-TK (IC50 = 0.15 nM) [1].</p>Fórmula:C19H16O4Cor e Forma:SolidPeso molecular:308.33c-Fms-IN-8
CAS:<p>c-Fms-IN-8 is a colony-stimulating factor-1 receptor (CSF-1R, c-FMS) Type II inhibitor (IC50: 9.1 nM). It is compound 4a in the reference.</p>Fórmula:C27H30N2O5Pureza:98%Cor e Forma:SolidPeso molecular:462.54EGFR-IN-67
CAS:<p>EGFR-IN-67 (Compound 7d) is a potent inhibitor of EGFR with anticancer activity (IC 50 = 0.34 μM) [1].</p>Fórmula:C18H17N3SCor e Forma:SolidPeso molecular:307.41MS 154N
CAS:<p>MS 154N is a negative control for MS 154, binds WT/L858R EGFR tightly (Kd 3-4.3nM), doesn't trigger mutant EGFR degradation.</p>Fórmula:C47H56ClFN8O8Cor e Forma:SolidPeso molecular:915.45Tyrphostin 51
CAS:<p>Tyrphostin 51 is an effective inhibitor of EGFR kinase.</p>Fórmula:C13H8N4O3Pureza:98%Cor e Forma:SolidPeso molecular:268.23EGFR/HER2-IN-9
CAS:<p>EGFR/HER2-IN-9, a compound inhibiting both EGFR and HER2, demonstrates potency with IC50 values of 3.2 nM for EGFR, 14 nM for HER2, and 8.3 nM against the EGFR</p>Fórmula:C25H25ClFN5O4Cor e Forma:SolidPeso molecular:513.95JNJ28871063 hydrochloride
CAS:<p>ErbB receptor family inhibitor</p>Fórmula:C24H28Cl2N6O3Pureza:98%Cor e Forma:SolidPeso molecular:519.42PDGFRα kinase inhibitor 1
CAS:<p>PDGFRα kinase inhibitor 1 is a type II PDGFRα kinase inhibitor that inhibits both PDGFRα and PDGFRβ.</p>Fórmula:C34H34N8O2Pureza:99.78%Cor e Forma:SolidPeso molecular:586.69TrkA-IN-1
CAS:<p>TrkA-IN-1 is a potent and selective inhibitor of Tropomyosin-related kinase A (TrkA) (IC50: 99 nM in a cell-based assay) with analgesic activity.</p>Fórmula:C25H20N4OPureza:98%Cor e Forma:SolidPeso molecular:392.45c-Fms-IN-2
CAS:<p>c-Fms-IN-2 is an inhibitor of c-FMS kinase (IC50 = 24 nM).</p>Fórmula:C19H21N3O3Pureza:99.56%Cor e Forma:SolidPeso molecular:339.39EGFR/C797S-IN-1
CAS:<p>EGFR/C797S-IN-1: Potent EGFR-C797S inhibitor, IC50 of 0.128 µM, dose-dependent p-EGFR suppression, anti-tumor properties.</p>Fórmula:C28H30N4O3Cor e Forma:SolidPeso molecular:470.56BKI-1369
CAS:<p>BKI-1369 is a bumped kinase inhibitor. BKI-1369 increases hERG-inhibitory activity (IC50:1.52 μM).</p>Fórmula:C23H27N7OCor e Forma:SolidPeso molecular:417.51EGFR-IN-63
CAS:<p>EGFR- IN-63 is an EGFR inhibitor with an IC50 value of 0.096 μM. EGFR- IN-63 exhibited anticancer effects on MCF-7 cells (IC50: 2.49 μM).</p>Fórmula:C20H12BrN5SCor e Forma:SolidPeso molecular:434.31Tavilermide
CAS:<p>Tavilermide (MIM-D3) is a selective TrkA agonist, a cyclic mimetic, which can be used to study dry keratoconjunctivitis and dry eye syndrome.</p>Fórmula:C24H32N6O11Pureza:98.98%Cor e Forma:SolidPeso molecular:580.54DUN73423
CAS:<p>DUN73423 (RET-IN-21) is a potent tyrosine kinase (RET) inhibitor with antitumour activity for the study of cancer.</p>Fórmula:C19H16N6OPureza:98.09%Cor e Forma:SolidPeso molecular:344.37EGFR-IN-64
CAS:<p>EGFR-IN-64 inhibits EGFR with 0.33 μM IC50, showing promising anticancer properties.</p>Fórmula:C20H21N3O3Cor e Forma:SolidPeso molecular:351.4UNC-CA359
CAS:<p>UNC-CA359: potent EGFR inhibitor, IC50=18 nM, strong anti-tumor effect, promising for chordoma.</p>Fórmula:C18H14ClN3O2Cor e Forma:SolidPeso molecular:339.78BIBX 1382 Dihydrochloride
CAS:<p>BIBX 1382 Dihydrochloride blocks Lassa/Ebola entry, aids in studying virus-host interactions, and hints at kinase targets for therapy.</p>Fórmula:C18H21Cl3FN7Cor e Forma:SolidPeso molecular:460.76PDZ1i
CAS:<p>PDZ1i: potent MDA-9/Syntenin inhibitor; crosses blood-brain barrier; targets GBM, FAK, EGFRvIII; lowers MMP secretion.</p>Fórmula:C28H26N8O4Cor e Forma:SolidPeso molecular:538.56PF-4618433
CAS:<p>PF-4618433 is a selective PYK2 inhibitor with osteogenic activity.</p>Fórmula:C24H27N7O2Pureza:99.95%Cor e Forma:SolidPeso molecular:445.52MMPP
CAS:<p>MMPP is a VEGFR2 inhibitor with anti-inflammatory activity, inhibits STAT3 , inhibits angiogenesis, and can be used to alleviate myocardial injury.</p>Fórmula:C17H18O3Pureza:99.31% - 99.83%Cor e Forma:SolidPeso molecular:270.32Rp-cAMPS triethylammonium salt
CAS:<p>Rp-cAMPS triethylammonium salt is a competitive inhibitor of cAMP-dependent protein kinase I and II.</p>Fórmula:C16H27N6O5PSPureza:98%Cor e Forma:SolidPeso molecular:446.46Syk-IN-3
CAS:<p>Syk-IN-3 is a Syk inhibitor with potential anti-inflammatory and anticancer activity and can be used to study immune dysregulation.</p>Fórmula:C24H28N4O3SPureza:97.29% - >99.99%Cor e Forma:SolidPeso molecular:452.57GSK-2250665A
CAS:<p>GSK-2250665A is an (Itk) inhibitor (pKi 9.2) with selectivity over Aurora B and Btk, inhibiting IFNγ in PBMCs for T-cell signaling studies.</p>Fórmula:C26H29N5OSPureza:98%Cor e Forma:SolidPeso molecular:459.61EGFR-IN-21
CAS:<p>EGFR-IN-21, a potent EGFR inhibitor, exhibits an IC50 of 0.38 nM, demonstrating significant antitumor activity.</p>Fórmula:C36H44BrN10O2PCor e Forma:SolidPeso molecular:759.68c-Fms-IN-1
CAS:<p>c-Fms-IN-1 is an inhibitor of c-FMS kinase (IC50 = 0.8 nM).</p>Fórmula:C22H27N5O2Pureza:99.94%Cor e Forma:SolidPeso molecular:393.48Antiproliferative agent-34
CAS:<p>Antiproliferative Agent-34 (Compound A14), a multitarget kinase inhibitor, demonstrates IC50 values of 177 nM for EGFR L858R/T790M and 1567 nM for EGFR WT.</p>Fórmula:C27H27N7O5Pureza:98%Cor e Forma:SolidPeso molecular:529.55Mutated EGFR-IN-3
CAS:<p>Mutated EGFR-IN-3: ATP-competitive, selective dibenzodiazepinone inhibitor for EGFR mutations, IC50 12-13 nM.</p>Fórmula:C31H29FN4O2Pureza:98%Cor e Forma:SolidPeso molecular:508.59Tyrphostin AG 112
CAS:<p>Tyrphostin AG 112 is an inhibitor of EGFR phosphorylation.</p>Fórmula:C13H8N4OPureza:97.01%Cor e Forma:SolidPeso molecular:236.23Glesatinib hydrochloride
CAS:<p>Glesatinib hydrochloride is an orally active and potent dual inhibitor of MET/SMO.</p>Fórmula:C31H28ClF2N5O3S2Pureza:98%Cor e Forma:SolidPeso molecular:656.16Infigratinib phosphate
CAS:<p>Infigratinib phosphate (BGJ-398 phosphate) is an effective inhibitor of the FGFR family (IC50: 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1, FGFR2, FGFR3, and</p>Fórmula:C26H34Cl2N7O7PPureza:99.24% - 99.6%Cor e Forma:SolidPeso molecular:658.47EGFR mutant-IN-2
CAS:<p>EGFR mutant-IN-2 (Compound D51) is an inhibitor of EGFR mutants, specifically targeting EGFR L858R/T790M/C797S and EGFR del19/T790M/C797S mutants with IC50 values of 14 nM and 62 nM, respectively. This compound exhibits favorable pharmacokinetic (PK) parameters, safety properties, in vivo stability, and demonstrates antitumor activity [1].</p>Fórmula:C27H27F3N6O2SCor e Forma:SolidPeso molecular:556.6JNJ-64264681
CAS:<p>JNJ-64264681 is a potent, orally active, selective, and irreversible covalent inhibitor of Bruton's tyrosine kinase (BTK).</p>Fórmula:C27H30N6O3SPureza:98%Cor e Forma:SolidPeso molecular:518.63Sotuletinib dihydrochloride
CAS:<p>Sotuletinib (BLZ945) dihydrochloride is an orally administered, blood-brain barrier-permeable inhibitor specifically targeting CSF1-R with an IC50 of 1 nM.</p>Fórmula:C20H24Cl2N4O3SPureza:98%Cor e Forma:SolidPeso molecular:471.4
