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CAS 113507-06-5

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Moxidectin

Description:
Moxidectin is a semi-synthetic macrocyclic lactone belonging to the class of compounds known as avermectins, which are derived from the fermentation of the bacterium Streptomyces avermitilis. It is primarily used as an antiparasitic agent, particularly in veterinary medicine, for the treatment of various parasitic infections in animals, including nematodes and ectoparasites. Moxidectin exhibits a broad spectrum of activity and is known for its prolonged duration of action, which allows for less frequent dosing compared to some other antiparasitic agents. The compound works by binding to glutamate-gated chloride channels in the nervous system of parasites, leading to paralysis and death of the organism. Moxidectin is typically administered orally or via injection, and its pharmacokinetics are characterized by good absorption and distribution in tissues. It is important to note that while Moxidectin is effective against many parasites, it is not effective against all, and its use should be guided by veterinary recommendations to ensure safety and efficacy.
Formula:C37H53NO8
InChI:InChI=1/C37H53NO8/c1-21(2)14-25(6)33-26(7)31(38-42-8)19-36(46-33)18-29-17-28(45-36)13-12-23(4)15-22(3)10-9-11-27-20-43-34-32(39)24(5)16-30(35(40)44-29)37(27,34)41/h9-12,14,16,21-22,26,28-30,32-34,39,41H,13,15,17-20H2,1-8H3/b10-9+,23-12+,25-14+,27-11+,38-31-/t22-,26-,28+,29-,30-,32+,33+,34+,36-,37+/m0/s1
InChI key:InChIKey=YZBLFMPOMVTDJY-LSGXYNIPSA-N
SMILES:C(=C\C(C)C)(\C)/[C@H]1O[C@@]2(C[C@@]3(C[C@](O2)(C/C=C(\C)/C[C@@H](C)/C=C/C=C\4/[C@@]5(O)[C@](C(=O)O3)(C=C(C)[C@@H](O)[C@]5(OC4)[H])[H])[H])[H])C/C(=N\OC)/[C@@H]1C
Synonyms:
  • (2aE,4E,4'E,5'S,6R,8E,11R,13R,15S,17aR,20R,20aR,20bS)-20,20b-dihydroxy-4'-(methoxyimino)-5',6,8,19-tetramethyl-6'-[(2E)-4-methylpent-2-en-2-yl]-3',4',5',6,6',7,10,11,14,15,17a,20,20a,20b-tetradecahydro-2H,17H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacyclooctadecine-13,2'-pyran]-17-one
  • (6R,23E,25S)-5-O-Demethyl-28-deoxy-25-[(1E)-1,3-dimethyl-1-buten-1-yl]-6,28-epoxy-23-(methoxyimino)milbemycin B
  • 23-Methoxime-LL-F 28249α
  • 5-O-demethyl-28-deoxy-25-(1E)-1,3-dimethyl-1-butenyl-6,28-epoxy-23-(methoxyimino)-, (6R,23E,25S)-
  • Cl 301423
  • Cydectin
  • Equest
  • Milbemycin B, 5-O-demethyl-28-deoxy-25-(1,3-dimethyl-1-butenyl)-6,28-epoxy-23-(methoxyimino)-, [6R,23E,25S(E)]-
  • Milbemycin B, 5-O-demethyl-28-deoxy-25-[(1E)-1,3-dimethyl-1-buten-1-yl]-6,28-epoxy-23-(methoxyimino)-, (6R,23E,25S)-
  • Milbemycin B, 5-O-demethyl-28-deoxy-25-[(1E)-1,3-dimethyl-1-butenyl]-6,28-epoxy-23-(methoxyimino)-, (6R,23E,25S)-
  • See more synonyms
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