Apoptosis
Apoptosis inhibitors are compounds that prevent or delay the process of programmed cell death, known as apoptosis. These inhibitors are vital in studying cell survival mechanisms and are used to investigate diseases where apoptosis is dysregulated, such as cancer, neurodegenerative disorders, and autoimmune diseases. By modulating apoptosis, these inhibitors can help in the development of therapies aimed at controlling cell death. At CymitQuimica, we provide a comprehensive selection of high-quality apoptosis inhibitors to support your research in cell biology, oncology, and related fields.
Subcategories of "Apoptosis"
- ASK(9 products)
- BCL(1 products)
- Caspase(154 products)
- FOXO1(2 products)
- IAP(67 products)
- Mdm2(12 products)
- PD-1/PD-L1(126 products)
- PDK(9 products)
- PERK(23 products)
- Serine/threonin kinase(17 products)
- Survivin(14 products)
- TNF(90 products)
- c-RET(61 products)
- p53(63 products)
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Found 6170 products of "Apoptosis"
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XmAb-2513
XmAb-2513 is a humanized monoclonal antibody inhibitor targeting CD30. It demonstrates significant anti-proliferative activity along with excellent antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP). XmAb-2513 is applicable in research on hematological malignancies such as Hodgkin lymphoma (HL) and anaplastic large cell lymphoma (ALCL).Color and Shape:Odour LiquidCAY10678
CAS:CAY10678 is an mPGES-1 inhibitor that inhibits PD-1.CAY10678 reduces collagen deposition and T-cell depletion, and may be used to study melanoma.CASHIPSFormula:C23H34N4OPurity:99.66%Color and Shape:SolidMolecular weight:382.54UM4118
CAS:UM4118 (N-quinolin-8-ylpyridine-2-carboxamide) is a copper ion carrier used in the study of acute myeloid leukemia.Formula:C15H11N3OPurity:99.76%Color and Shape:SolidMolecular weight:249.27Macrophage-activating lipopeptide 2 TFA
Macrophage-activating lipopeptide 2 TFA (MALP-2 TFA) is a diacylglycerol lipopeptide and TLR-2/TLR-6 agonist activates immune cell responses macrophages,Formula:C99H167N19O30S·xC2HF3O2Purity:97.56%Color and Shape:SolidMolecular weight:2135.56 (free base)Acetyl coenzyme A
CAS:Acetyl coenzyme A (Acetyl-CoA) is a pivotal molecule connecting multiple cellular metabolic pathways in the tricarboxylic acid cycle, fatty acid synthesisFormula:C23H38N7O17P3SPurity:91.68%Color and Shape:SolidMolecular weight:809.57Etanercept
CAS:Etanercept is a fusion protein consisting of the soluble portion of the p75-tumor necrosis factor receptor (TNFR) and the Fc fragment of human IgG1 and is commonly used to treat patients with rheumatoid arthritis.Cost-effective and quality-assured.
Purity:98%Color and Shape:LiquidGolimumab
CAS:Golimumab (CNTO-148), an anti-TNFα IgG1κ monoclonal antibody with anti-inflammatory and anti-cancer activity, can be used to prevent inflammation and cartilage.Color and Shape:LiquidMolecular weight:146.93 kDaGliotoxin
CAS:Gliotoxin, a mycotoxin, inhibits Wnt pathway, causing apoptosis in mutated colorectal cancer cells and blocks NF-κB by preserving IκB.Formula:C13H14N2O4S2Purity:98%Color and Shape:SolidMolecular weight:326.39MG-277
MG-277 is a molecular glue compound transformed from PROTAC degradation agent, MG-277 potently inhibits tumor cell growth in a p53-independent manner.Formula:C41H42Cl2FN5O5Purity:98%Color and Shape:SolidMolecular weight:774.71CPD-10
CAS:CPD-10 is a potent bifunctional PROTAC degrader targeting CCND1 and CDK4 and exhibits antiproliferative effects. It induces apoptosis and reduces the protein expression of Cyclin D1, Cyclin D3, CDK4, and P-Rb(5807/811) in a dose-dependent manner.Formula:C46H61N15O4Color and Shape:SolidMolecular weight:888.08CQ-Mito
CQ-Mito, a derivative of CQ, demonstrates excellent phototherapeutic efficacy with a PI value of 167. This compound induces cell death through mechanisms such as apoptosis and ferroptosis. It mediates mitochondrial dysfunction, characterized by alterations in mitochondrial morphology and loss of MMP. Additionally, CQ-Mito effectively inhibits tumor growth in 3D multicellular tumor spheroid models.Formula:C45H42BrN6O4PColor and Shape:SolidMolecular weight:841.73PROTAC TRIB2 degrader-1
PROTAC TRIB2 degrader-1 (Compound 5k) is a potent TRIB2 degrader that selectively induces TRIB2 degradation via the CRBN-dependent ubiquitin-proteasome pathway. It effectively inhibits cell proliferation and induces cell apoptosis (apoptosis), making it useful in cancer research.Formula:C45H45FN8O6Color and Shape:SolidMolecular weight:812.89EJMC-1
CAS:EJMC-1 is an inhibitor of TNF-α with an IC50 value of 42 μM and can be used in studies about auto-inflammatory diseases.Formula:C17H11ClN2O4SPurity:98.38%Color and Shape:SolidMolecular weight:374.8BIM-46174 HCl
BIM-46174 HCl is a G-protein inhibitor with anticancer activity that induces cysteine 3-dependent apoptosis.
Formula:C22H31ClN4OSPurity:99.77% - 99.77%Color and Shape:SolidMolecular weight:435.03CDK8-IN-13
CAS:CDK8-IN-13 is a CDK8 inhibitor (IC50: 51.9 nM) with potent, selective and oral activity.Formula:C14H11N3OPurity:99.28%Color and Shape:SoildMolecular weight:237.26BM 957
CAS:BM 957 is an effective Bcl-2 and Bcl-xL inhibitor (Kis: 1.2 and <1 nM; IC50s: 5.4 and 6.0 nM).Formula:C52H56ClF3N6O7S3Purity:98%Color and Shape:SolidMolecular weight:1065.68Voreloxin
CAS:Voreloxin (SNS-595) is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity. Phase 2.Formula:C18H19N5O4SPurity:98%Color and Shape:SolidMolecular weight:401.44PERK-IN-4
CAS:PERK-IN-4 is a potent and selective PERK inhibitor with an IC50 value of 0.3 nM.PERK-IN-4 can be used in the study of cancer and neurological disorders.Formula:C24H19F4N5OPurity:99.44% - 99.49%Color and Shape:SolidMolecular weight:469.43BCL-XL-IN-3
CAS:BCL-XL-IN-3 (Compound 11) is an inhibitor of BCL-XL, with a Ki of less than 0.01 nM. It suppresses cell viability in both normal Molt-4 cells and digitonin-permeabilized Molt-4 cells, with EC50 values of 77.8 nM and 0.07 nM, respectively. BCL-XL-IN-3 can be utilized as an ADC toxin for synthesizing Clezutoclax.Formula:C46H55N7O6SColor and Shape:SolidMolecular weight:834.04N-Stearoyltyrosine
CAS:N-Stearoyltyrosine (N-(1-Oxooctadecyl)-L-tyrosine) is an analog of Anandamide. It exhibits neuroprotective effects by safeguarding the CA1 region of the hippocampus in a gerbil ischemia-reperfusion model. Additionally, N-Stearoyltyrosine inhibits free radical generation, enhances antioxidant capacity, and reduces IR-induced apoptosis (cell apoptosis).Formula:C27H45NO4Color and Shape:SolidMolecular weight:447.65FA4-Cu
FA4-Cu is a compound formed from the effective pancreatic cancer inhibitor FA4 and Cu(II), which can induce apoptosis by triggering ER and mitochondrial stress.Formula:C27H33Cl2CuN5O2SColor and Shape:SolidMolecular weight:626.1BK60106
BK60106 is a selective and direct inhibitor of the transmembrane protein CD99, which causes cell death in Ewing Sarcoma cells.Formula:C15H15FN6O3Purity:99.30% - >99.99%Color and Shape:SolidMolecular weight:346.32Caerin 1.1 TFA
Caerin 1.1 TFA, a host defense peptide derived from the Australian tree frog Litoria's glandular secretions, exhibits anti-proliferative effects on HeLa cellsPurity:98%Color and Shape:Odour SolidFerroptosis-IN-3
Ferroptosis-IN-3 (Compound 25), a ferroptosis inhibitor, demonstrates potent activity by inhibiting RSL3-induced ferroptosis in HT-1080 cells (EC50: 8.6 nM).Purity:98%Color and Shape:Odour SolidAra-SH
Ara-SH, a derivative of Cytarabine with a mercaptopropionic acid substitution, serves as the initiator for the self-assembly of a smart, co-loaded CytarabineFormula:C12H17N3O6SPurity:98%Color and Shape:SolidMolecular weight:331.342'-epi-2'-O-Acetylthevetin B
CAS:2'-Epi-2'-O-Acetylthevetin B (GHSC-74), a cardiac glycoside extractable from Cerbera manghas L.Formula:C44H68O19Purity:98%Color and Shape:SolidMolecular weight:901Apoptosis inducer 11
Apoptosis Inducer 11 (compound 3u) promotes apoptosis via the mitochondrial pathway and elicits a G2/M block alongside a marked reduction in the S phase withinFormula:C27H28N2O5Purity:98%Color and Shape:SolidMolecular weight:460.52Pyridinium bisretinoid A2E TFA
CAS:Pyridinium bisretinoid A2E (A2E) TFA, a fluorophore derived from retinal pigment epithelium (RPE) lipofuscin, initiates blue-light-induced apoptosis, mediatesFormula:C44H58F3NO3Purity:98%Color and Shape:SolidMolecular weight:705.93Antitumor agent-112
Antitumor agent-112 (compound 3a) is a potent antitumor agent that induces apoptosis and exhibits cytotoxic activity on A549 cells, with an IC50 value of 91.35Formula:C18H17ClN4O2SPurity:98%Color and Shape:SolidMolecular weight:388.87Anticancer agent 106
Compound 106 (compound 10ic) induces apoptosis in B16-F10 melanoma cells and potently inhibits metastatic nodules in mouse models of lung metastatic melanoma,Formula:C26H25N3O4SPurity:98%Color and Shape:SolidMolecular weight:475.56FD2157
FD2157, a photosensitive PI3K inhibitor, exhibits inhibitory IC50 values of 43 nM for PI3Kα, 83 nM for PI3Kβ, 84 nM for PI3Kγ, and 14 nM for PI3Kδ.Formula:C27H21ClN6O8SPurity:98%Color and Shape:SolidMolecular weight:625.01cpm-1285
CAS:CPM-1285 induces apoptosis by effectively inhibiting the function of intracellular Bcl-2 and associated death antagonists.Formula:C153H240N44O42SPurity:98%Color and Shape:SolidMolecular weight:3399.88Anticancer agent 132
Compound Rh1 (Anticancer agent 132) acts as an inducer of apoptosis and autophagy, exhibiting both antitumor and antimetastatic activities.Formula:C24H16Cl3F3N5ORhPurity:98%Color and Shape:SolidMolecular weight:656.68Antitumor agent-103
Antitumor Agent-103 (compound 24l) induces apoptosis and possesses antiproliferative and anti-colony formation properties.Formula:C36H36N8O9S2Purity:98%Color and Shape:SolidMolecular weight:788.85Anticancer agent 153
Anticancer Agent 153 (Compound 3) promotes apoptosis through the generation of Reactive Oxygen Species (ROS) and elevates the loss of Mitochondrial MembraneFormula:C16H11Cl2N3O3Purity:98%Color and Shape:SolidMolecular weight:364.18Cholesteryl Hemisuccinate Tris Salt
CAS:Cholesteryl Hemisuccinate Tris Salt is a cholesteryl ester with anticancer activity.Cholesteryl hemisuccinate has antitumor activity and inhibits tumor growth.Formula:C35H61NO7Purity:≥98%Color and Shape:SolidMolecular weight:607.864-hydroperoxy cyclophosphamide
CAS:4-hydroperoxy cyclophosphamide (4-OOH-CY) induces hepatotoxicity. It increases ghrelin levels and enhances inflammatory factors and oxidative markers.Formula:C7H15Cl2N2O4PPurity:98%Color and Shape:SolidMolecular weight:293.09Thrombospondin-1 (1016-1023) (human, bovine, mouse)
CAS:Thrombospondin-1 (1016-1023) (human, bovine, mouse) is part of Thrombospondin-1 (TSP-1), a peptide with CD47 agonism.Formula:C56H81N13O10SPurity:99.23%Color and Shape:SolidMolecular weight:1128.39Ref: TM-T75720
1mg49.00€5mg105.00€10mg172.00€25mg268.00€50mg416.00€100mg600.00€1mL*10mM (DMSO)200.00€MY-943
MY-943, a potent inhibitor of tubulin polymerization and LSD1, exhibits anticancer properties by inducing G2/M phase arrest, promoting apoptosis, andFormula:C30H36N4O6S2Color and Shape:SolidMolecular weight:612.763-Hydroxyterphenyllin
CAS:3-Hydroxyterphenyllin from A. candidus is a fungal compound with antioxidant, anticancer, antibacterial, and antiviral effects.Formula:C20H18O6Color and Shape:SolidMolecular weight:354.35Stem bromelain
CAS:Stem bromelain: cysteine protease from pineapple stem with fibrinolytic, anti-inflammatory, antitumoral properties.Color and Shape:SolidMas7
CAS:Amphiphilic peptide Mas7, a structural analogue of mastoparan is a known activator of heterotrimeric Gi-proteins and its downstream effectors.Formula:C67H124N18O15Purity:98%Color and Shape:SolidMolecular weight:1421.81Ac-FEID-CMK TFA
Ac-FEID-CMK TFA is a zebrafish GSDMEb-derived peptide inhibitor that acts by inhibiting the caspy2-mediated atypical inflammatory vesicle pathway.Formula:C29H38ClF3N4O11Purity:95%Color and Shape:SolidMolecular weight:711.08IMMH 010 maleate
CAS:IMMH 010 maleate (YPD-30 maleate) is a programmed cell death ligand 1 inhibitor used in the study of neurological disorders and advanced malignant solid tumors.Formula:C36H36BrClN2O9Color and Shape:SoildMolecular weight:756.04LL-K9-3
CAS:LL-K9-3, a selective hydrophobic tagging technology (HyT)-based degrader, specifically targets the CDK9-cyclin T1 complex, displaying DC50 values of 589 nM forFormula:C31H49N5O6S3Color and Shape:SolidMolecular weight:683.94BODIPY FL thalidomide
CAS:BODIPY FL thalidomide is a fluorescent probe that binds human cereblon protein with high affinity, exhibiting a dissociation constant (Kd) of 3.6 nM [1].Formula:C37H43BF2N6O7Color and Shape:SolidMolecular weight:732.58fac-[Re(CO)3(L3)(H2O)][NO3]
Fac-[Re(CO)3(L3)(H2O)][NO3] (Compound 3), a rhenium(I) tricarbonyl aqua complex, acts as an anticancer agent through the induction of mitochondrial dysfunction.Formula:C25H17N6O8ReColor and Shape:SolidMolecular weight:715.64Thalidomide-Piperazine 5-fluoride hydrochloride
CAS:Thalidomide-Piperazine 5-fluoride hydrochloride, a derivative of the cereblon (CRBN) inhibitor Thalidomide, serves as a ligand for E3 ubiquitin ligase (Ligands for E3 Ligase), facilitating the synthesis of PROTACs [1].Formula:C17H18ClFN4O4Color and Shape:SolidMolecular weight:396.8Lon-TK
Lon-TK is a glycolysis inhibitor of LTB, linked with a linker conjugate. LTB is an intelligent responsive prodrug, comprised of Lonidamine (Lon) and a PD-L1 inhibitor (BMS-1), which are connected through a thioketal linkage. It effectively inhibits glycolytic metabolism in tumor cells and blocks the PD-1/PD-L1 immune escape pathway. Lon-TK holds potential for use in photodynamic-enhanced immunotherapy research.Formula:C24H28Cl2N2O3S2Color and Shape:SolidMolecular weight:527.532-Methylbiphenyl-oxadiazole-NH-Ph-CHO
CAS:2-Methylbiphenyl-oxadiazole-NH-Ph-CHO functions as a PD-L1 ligand for AUTACPD-L1degrader-3. It is also applicable in the synthesis of AUTAC.Formula:C22H17N3O2Color and Shape:SolidMolecular weight:355.39PD-L1 ligand 1
PD-L1 ligand 1 is classified as a PROTAC-targeted protein ligand, primarily utilized as a degradation agent for PD-L1.Color and Shape:Odour SolidD5B
D5B is an effective and selective PD-L1 inhibitor that has been modified with DBCO. It degrades PD-L1 in 4T1 and B16-F10 tumor cells with EC50 values of 5.4 μM and 6.2 μM, respectively. D5B can block the PD-L1/PD-1 interaction and exhibits antitumor activity.Formula:C58H66N2O12Color and Shape:SolidMolecular weight:983.15Compound TPX-0046
CAS:Compound TPX-0046 is an inhibitor of RET. Compound TPX-0046 can inhibit the RET autophosphorylation. Compound TPX-0046 can be used for the research of cancer.Formula:C21H21FN6O3Purity:99.94%Color and Shape:SoildMolecular weight:424.43SLF-amido-C2-COOH
CAS:SLF-amido-C2-COOH is a synthetic ligand for FKBP (SLF), and can be used in the synthesis of PROTACs.Formula:C34H44N2O9Purity:95.8%Color and Shape:SolidMolecular weight:624.72GGTI298 Trifluoroacetate
CAS:GGTI298 trifluoroacetate (GGTI298TFA salt) is a geranylgeranyltransferase I inhibitor that causes cell cycle arrest and induces apoptosis.Formula:C27H33N3O3S·C2HF3O2Purity:98.07% - >99.99%Color and Shape:SolidMolecular weight:593.66Barakol
CAS:Barakol, a primary compound found in Cassia siamea, inhibits MMP-3 activity and enhances the anti-metastatic effects of doxorubicin. Additionally, Barakol induces apoptosis (Apoptosis), generates reactive oxygen species, increases the Bax/Bcl-2 expression ratio, and activates caspase-9. This compound also exhibits laxative, anti-anxiety, central nervous system depressant, antioxidant, and anticancer properties.Formula:C13H12O4Color and Shape:SolidMolecular weight:232.23HSP90-IN-33
HSP90-IN-33 (compound 24e) is an effective Hsp90 inhibitor, demonstrating dissociation constants (Kd) of ≥200 µM for Hsp90α and 7.3 µM for Hsp90β. This compound induces cellular apoptosis (apoptosis) and arrests the cell cycle at the G0/G1 phase. Additionally, HSP90-IN-33 reduces the protein expression of ERα, CDK4, and Akt.Formula:C21H25Cl2N5O2Color and Shape:SolidMolecular weight:450.36TOPOI/PARP-1-IN-2
TOPOI/PARP-1-IN-2 (compound 6c) serves as a dual inhibitor targeting both PARP-1 and topoisomerase 1 (TOPO-1), with IC50 values of 32.2 nM and 46.2 nM, respectively. This compound exhibits greater selectivity for PARP-1 over PARP-2. Additionally, TOPOI/PARP-1-IN-2 disrupts the S phase of the cell cycle and induces apoptosis in the NCI-60 cancer cell lines.Formula:C16H11ClN4O2SColor and Shape:SolidMolecular weight:358.80CQ-ER
CQ-ER is a Coumarin-quinazolinone-based photosensitizer targeting the endoplasmic reticulum (ER). It induces ferroptosis, thereby enhancing photodynamic therapy (PDT).Formula:C33H33N7O6SColor and Shape:SolidMolecular weight:655.72STK17A/B-IN-1 hydrochloride
STK17A/B-IN-1 hydrochloride is a potent, selective, orally active inhibitor of STK17A/B, displaying an IC50 value of 23 nM against STK17A. It is utilized in the research of tumors.Formula:C26H28ClN7OColor and Shape:SolidMolecular weight:490.00SZU-B6
CAS:SZU-B6, a PROTAC degrader, targets and degrades SIRT6 with DC50 values of 45 nM in SK-HEP-1 cells and 154 nM in Huh-7 cells. It inhibits the proliferation of SK-HEP-1 cells with an IC50 of 1.51 μM and suppresses colony formation in both SK-HEP-1 and Huh-7 cell lines. Additionally, SZU-B6 induces apoptosis in SK-HEP-1 cells and causes cell cycle arrest at the G2/M phase. It demonstrates anti-tumor activity in murine models.Formula:C29H32FN7O6Color and Shape:SolidMolecular weight:593.61PAR4 antagonist 8
PAR4 antagonist8 (Compound 20f) is an effective oral and selective PAR4 antagonist with an IC50 of 15.32 nM, boasting favorable pharmacokinetic properties. It effectively inhibits human platelet aggregation induced by PAR4 agonists (IC50=6.39 nM) and also suppresses platelet aggregation in mice. PAR4 antagonist8 is utilized in anti-thrombotic research.Formula:C28H19F2N5O4SMolecular weight:559.54Anticancer agent 39
CAS:Compound B12, a JOA derivative, collapses MMP to induce apoptosis, inhibits cloning/migration, and has an IC50 of 0.39 μM against HGC-27 cells.Formula:C50H65N5O10Color and Shape:SolidMolecular weight:896.083MB-PP1
CAS:3MB-PP1 is a bulky purine analog and a Polo-like kinase 1 (Plk1) inhibitor.Formula:C17H21N5Purity:99.96%Color and Shape:White SolidMolecular weight:295.38Ref: TM-T21678
5mg50.00€10mg92.00€25mg166.00€50mg255.00€100mg374.00€500mgTo inquire1mL*10mM (DMSO)55.00€MK-4166
MK-4166 is a humanized IgG1 agonistic monoclonal antibody targeting GITR. It is capable of enhancing the proliferation of both naive T lymphocytes and tumor-infiltrating T lymphocytes.5-Methoxysterigmatocystin
CAS:5-Methoxysterigmatocystin is a mycotoxin characterized by its cytotoxic and genotoxic properties. It exhibits cytotoxic effects on cancer cell lines A549 and HepG2, with IC50 values of 5.5 μM and 0.7 μM, respectively. Additionally, it induces DNA damage. 5-Methoxysterigmatocystin acts as a photosensitizer, generating singlet oxygen (1O2) under visible light.Formula:C19H14O7Molecular weight:354.31Bcl-2-IN-21
Bcl-2-IN-21 (compound C1), an iridium-based anticancer agent, effectively targets and inhibits Bcl-2, thereby impeding cancer cell colony formation and promoting increased levels of Bax and caspase 3.Formula:C45H33F6IrN5PMolecular weight:980.96Human PD-L1 inhibitor I
CAS:Human PD-L1 inhibitor I, a peptide, blocks PD-L1/PD-1 interaction with 3.39 μM affinity.Formula:C110H152N26O32Color and Shape:SolidMolecular weight:2350.576Isorhamnetin 3-glucuronide
Isorhamnetin 3-glucuronide is a useful organic compound for research related to life sciences and the catalog number is T124938.Formula:C22H20O13Color and Shape:SolidMolecular weight:492.389Apoptosis inducer 29
Apoptosis Inducer 29 (compound Y9) demonstrates anticancer efficacy in non-small cell lung cancer by inducing lysosomal dysfunction and apoptosis, and exhibits superior performance to Gboixn both in vitro and in vivo.Formula:C33H46ClN3O3Color and Shape:SolidMolecular weight:568.19ACP-0052
CAS:ACP-0052(SL-052, ACP-SL-052) is a photosensitizer based on hypoclintin that may be used in the treatment of prostate cancer.Formula:C35H32N2O7Color and Shape:SolidMolecular weight:592.648CWI1-2 HCL
CAS:CWI1-2 HCL: Potent IGF2BP2 inhibitor, induces apoptosis/differentiation, targets leukemia therapy.Formula:C22H18Cl4N6O3Purity:98.09%Color and Shape:SolidMolecular weight:556.23Ref: TM-T67930L
1mg49.00€5mg92.00€10mg145.00€25mg281.00€50mg409.00€100mg580.00€200mg798.00€1mL*10mM (DMSO)116.00€Sodium propionate
CAS:Sodium propionate (Propionic acid sodium salt) has potential anti-inflammatory and anti-apoptotic activities, inhibiting certain signaling pathways.Formula:C3H5NaO2Color and Shape:SoildMolecular weight:96.06Silicon naphthalocyanine dichloride
CAS:Silicon naphthalocyanine dichloride is a photosensitizer with potential anti-tumor activity. This compound is employed in photodynamic therapy to inhibit cancer by effectively absorbing specific wavelengths of light, thereby generating oxygen radicals that aid in the destruction of cancer cells. The biocompatibility of Silicon naphthalocyanine dichloride demonstrates promising prospects for medical applications.Formula:C48H24Cl2N8SiColor and Shape:SolidMolecular weight:811.75PROTAC BRD4 Degrader-33
PROTACBRD4 Degrader-33 is an enzyme-activated, click-responsive BRD4 PROTAC degrader designed with effective tumor microenvironment responsiveness. This compound exhibits exceptional penetration into tumor tissues and effectively inhibits PD-L1 protein expression. In the 4T1 tumor mouse model, PROTACBRD4 Degrader-33 demonstrates potent antitumor immunomodulatory activity.Color and Shape:Odour SolidMG-C-30
CAS:MG-C-30 is an orally active CD27 agonist with an EC50 of 0.84 μM. It activates co-stimulatory signaling in NK cells and T cells, thereby enhancing the immune response. In the EG7-OVA mouse model, MG-C-30 demonstrates antitumor activity.Formula:C24H26N4O3SColor and Shape:SolidMolecular weight:450.55Δ8-Tetrahydrocannabinoquinone
CAS:Δ8-Tetrahydrocannabinoquinone (HU-336) is a potent anti-angiogenic agent that inhibits angiogenesis by directly inducing apoptosis in vascular endothelial cells. It achieves this without altering the expression of pro-angiogenic and anti-angiogenic cytokines and receptors. Δ8-Tetrahydrocannabinoquinone also shows significant effectiveness against tumor xenografts in nude mice.Formula:C21H28O3Color and Shape:SolidMolecular weight:328.45Albicanol
CAS:Albicanol is a biochemical.Formula:C15H26OColor and Shape:SolidMolecular weight:222.372BM-962
CAS:BM-962 (Compound 31) is a potent small-molecule inhibitor with an IC50 value of 4 nM (Ki=0.8 nM) for Bcl-2 and an IC50 of 3.9 nM (Ki<1 nM) for Bcl-xL. It inhibits H1417 and H146 cell lines with IC50 values of 9 and 13 nM, respectively, and shows potential for use in cancer research.Formula:C53H58ClF3N6O7S3Color and Shape:SolidMolecular weight:1079.71AS-99 free base
CAS:AS-99 is a first-in-class, potent and selective ASH1L histone methyltransferase inhibitor (IC50= 0.79 μM, Kd= 0.89 μM) with anti-leukemic activity.Formula:C27H30F3N5O3S2Color and Shape:SolidMolecular weight:593.68Ceftiofur hydrochloride
CAS:Ceftiofur hydrochloride (U-67279A) is a stable, broad-spectrum 3rd-gen cephalosporin with antibacterial properties.Formula:C19H17N5O7S3·HClPurity:99.51%Color and Shape:Off-White SolidMolecular weight:560.02RET-IN-28
CAS:RET-IN-28 (Compound 16) is an inhibitor of RET (a transmembrane receptor tyrosine kinase). It specifically inhibits the activity of a mutant RET enzyme (RET-V804M) and is utilized in cancer research.Formula:C26H29N9Color and Shape:SolidMolecular weight:467.577,3′,5′-Trihydroxyflavanone
CAS:7,3′,5′-Trihydroxyflavanone, a flavanoid derivative, promotes apoptotic cell death in MCF-7 cells by augmenting Bax expression.Formula:C15H12O5Color and Shape:SolidMolecular weight:272.25Azadirone
CAS:Azadirone, a limonoid, sensitizes cancer cells to TRAIL by modulating DR4/DR5, survival, and apoptotic proteins.
Formula:C9H15N3O5Color and Shape:SolidMolecular weight:245.23Resolvin D2 n-3 DPA
CAS:RvD2 n-3 DPA is an SPM made from docosapentaenoic acid in human leukocytes, inhibiting neutrophil chemotaxis and adhesion.
Formula:C22H34O5Color and Shape:SolidMolecular weight:378.509Rozanolixizumab
CAS:Rozanolixizumab (RYSTIGGO) is a humanized IgG4 monoclonal antibody that targets FcRn in newborns for autoimmune research.
Purity:SDS-PAGE:97.2%;SEC-HPLC:95.9%Color and Shape:LiquidMolecular weight:145.19 kDaInuviscolide
CAS:Inuviscolide induces apoptosis, G2/M arrest in melanoma, and has anti-cancer, anti-inflammatory effects.Formula:C15H20O3Color and Shape:SolidMolecular weight:248.32S9-CMC1 TFA
S9-CMC1 TFA is a covalent peptide lysine-specific demethylase 1 (LSD1) inhibitor with an IC50 value of 2.53 μM. It selectively targets the active site Cys360 of the enzyme. By inhibiting LSD1 activity, S9-CMC1 TFA elevates H3K4me1 and H3K4me2 levels, inducing G1 cell cycle arrest and apoptosis, thereby suppressing cell proliferation. In addition, S9-CMC1 TFA markedly inhibits tumor growth in A549 xenograft animal models.Formula:C97H151F3N32O17S2Color and Shape:SolidMolecular weight:2158.57Taltirelin acetate
CAS:Taltirelin acetate (TA-0910 acetate) is a superagonist at thyrotropin-releasing hormone receptor (TRH-R)(IC50 of 910 nM and EC50 of 36 nM for stimulating anFormula:C19H27N7O7Purity:99.21%Color and Shape:SolidMolecular weight:465.46Ref: TM-T13072
2mg34.00€5mg49.00€10mg80.00€25mg141.00€50mg230.00€100mg358.00€200mg530.00€1mL*10mM (DMSO)54.00€Ferroptosis-IN-14
Ferroptosis-IN-14 (compund 36) exhibits the most potent anti-ferroptotic activity with an EC50 value of 0.58 ± 0.02 μM, demonstrating excellent anti-ferroptotic efficacy, as well as stability in microsomes and plasma.Color and Shape:Odour SolidAM0001
AM0001 is a human monoclonal antibody (mAb) that targets PDCD1/PD-1/CD279. It is applicable in cancer research.Color and Shape:Odour LiquidAc-IEPD-AFC
CAS:Ac-IEPD-AFC (IEPD) is a fluorescent substrate for granzyme B and can be used to measure granzyme B activity.Formula:C32H38F3N5O11Purity:99.16%Color and Shape:SolidMolecular weight:725.6784-B10
CAS:84-B10 provides protection in cisplatin-induced acute kidney injury, reversing lipid peroxidation accumulation and downregulation of key ferroptosis inhibitors.Formula:C25H22F3NO5Purity:99.76%Color and Shape:SolidMolecular weight:473.44Ref: TM-T75268
1mg47.00€5mg92.00€10mg152.00€25mg289.00€50mg447.00€100mg670.00€200mg888.00€1mL*10mM (DMSO)92.00€VEGFR-2-IN-50
VEGFR-2-IN-50 (Compound 10f) is a VEGFR-2 inhibitor and apoptosis inducer with an IC50 of 0.33 μM. It exhibits growth inhibitory activity against the MCF-7 and MDA-MB-231 breast cancer cell lines, with IC50 values of 19.86 μM and 10.88 μM, respectively, making it a promising agent for breast cancer research.Color and Shape:Odour SolidKC01
CAS:KC01 selectively inhibits ABHD16A (IC50: 0.2-0.5 μM), much more potent than KC02 (>10 μM); human ABHD16A IC50: 90±20 nM.Formula:C22H39NO3Purity:98%Color and Shape:SolidMolecular weight:365.558GPX4-AUTAC
GPX4-AUTAC is an autophagy-mediated degrader (AUTAC) targeting GPX4. It consists of the inhibitor ML162-yne, a degradation tag FBnG, and a glycol linker. GPX4-AUTAC facilitates the ubiquitination of GPX4 by the E3 ligase TRAF6 and enhances its interaction with GPX4 and p62, leading to selective autophagy-dependent degradation of GPX4. This compound significantly induces ferroptosis and demonstrates potent anticancer activity in breast cancer cells, patient-derived organoids (PDOs), and MDA-MB-231 tumor xenograft mouse models. It shows strong synergy when used in combination with Sulfasalazine (SAS) or chemotherapy drugs (Paclitaxel or Cisplatin).Color and Shape:Odour SolidTralokinumab
CAS:Tralokinumab: human IgG4 monoclonal antibody, blocks IL-13, may treat atopic dermatitis.Purity:SDS-PAGE:95% SEC-HPLC:99.99%Color and Shape:LiquidMolecular weight:144.14 kDaRecQ helicase-IN-1
Frangulin B (Compd 11g) exhibits anticancer properties and acts as an effective RecQ helicase inhibitor. It induces apoptosis in both HCT-116 and MDA-MB-231 cells and can arrest HCT-116 cells in the G2/M phase.Formula:C25H21N3O3Molecular weight:411.15829TD1092
TD1092, a pan-IAP degrader, activates caspase 3/7, induces apoptosis in cancer cells, inhibits NF-κB, and is used in cancer research.Formula:C55H70N8O9Color and Shape:SolidMolecular weight:987.195α-dihydro Levonorgestrel
CAS:5α-dihydro Levonorgestrel is a metabolite of the synthetic progestin levonorgestrel .Formula:C21H30O2Color and Shape:SolidMolecular weight:314.469
