Apoptosis
Apoptosis inhibitors are compounds that prevent or delay the process of programmed cell death, known as apoptosis. These inhibitors are vital in studying cell survival mechanisms and are used to investigate diseases where apoptosis is dysregulated, such as cancer, neurodegenerative disorders, and autoimmune diseases. By modulating apoptosis, these inhibitors can help in the development of therapies aimed at controlling cell death. At CymitQuimica, we provide a comprehensive selection of high-quality apoptosis inhibitors to support your research in cell biology, oncology, and related fields.
Subcategories of "Apoptosis"
- ASK(9 products)
- BCL(1 products)
- Caspase(154 products)
- FOXO1(2 products)
- IAP(67 products)
- Mdm2(12 products)
- PD-1/PD-L1(126 products)
- PDK(9 products)
- PERK(23 products)
- Serine/threonin kinase(17 products)
- Survivin(14 products)
- TNF(90 products)
- c-RET(61 products)
- p53(63 products)
Show 6 more subcategories
Found 6170 products of "Apoptosis"
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Thalidomide-O-amide-C5-NH2
CAS:Thalidomide-O-amide-C5-NH2 is a synthetic E3 ligase linker combining cereblon ligand and PROTAC linker.Formula:C20H24N4O6Color and Shape:SolidMolecular weight:416.43Bcl-2-IN-4
CAS:Bcl-2-IN-4: potent, selective, oral Bcl-2 inhibitor with 1.5 nM IC50, >200x selectivity over Bcl-xL.Formula:C46H50ClN9O7SColor and Shape:SolidMolecular weight:908.46cis-Clovamide
CAS:cis-Clovamide is a naturally occurring phenolic compound with noteworthy antioxidant, anti-inflammatory, and antiapoptotic properties.Formula:C18H17NO7Color and Shape:SolidMolecular weight:359.334Bim BH3, Peptide IV
CAS:This Bim peptide belongs to the pro-apoptotic group of the Bcl-2 family of proteins.Formula:C145H222N44O41SPurity:98%Color and Shape:SolidMolecular weight:3269.65Kinamycin C
CAS:Kinamycin C is a bacterial metabolite used as an anticancer agent.Formula:C24H20N2O10Color and Shape:SolidMolecular weight:496.428MRIA9
CAS:MRIA9 inhibits SIK1/2/3 & PAK2/3 with IC50: SIK1 (516 nM), SIK2 (180 nM), SIK3 (127 nM); ATP-competitive.Formula:C24H22ClFN6O3Color and Shape:SolidMolecular weight:496.92Thalidomide-O-C4-COOH
CAS:Thalidomide-O-C4-COOH is a synthetic E3 ligase linker derived from Thalidomide for PROTAC tech.Formula:C18H18N2O7Color and Shape:SolidMolecular weight:374.3447Odoroside A
CAS:Odoroside A, from Nerium oleander leaves, induces cancer cell death via ROS/p53, causing apoptosis and cell cycle arrest.Formula:C30H46O7Color and Shape:SolidMolecular weight:518.68(Rac)-BIO8898
CAS:(Rac)-BIO8898 is a chemical compound that serves as an inhibitor of the co-stimulatory interaction between CD40 and CD154.Formula:C53H64N8O6Color and Shape:SolidMolecular weight:909.13PARP1-IN-16
PARP1-IN-16 (compound 12a) serves as a potent PARP1 inhibitor, exhibiting an IC50 value of 1.89 nM.Purity:98%Color and Shape:Odour SolidThalidomide-NH-PEG2-COOH
CAS:Thalidomide-NH-PEG2-COOH: a synthesized E3 ligase ligand-linker with cereblon ligand and PROTAC linker.Formula:C20H23N3O8Color and Shape:SolidMolecular weight:433.417EGFR/COX-2-IN-1
EGFR/COX-2-IN-1 is an EGFR/COX-2 inhibitor that effectively targets EGFRWT, EGFRT790M, COX-1, and COX-2 with IC50 values of 0.12, 0.076, 20.1, and 1.52 μM, respectively. It inhibits MCF-7, HT-29, and A-549 cells with IC50 values of 1.20, 5.14, and 14.81 μM, respectively. The compound induces apoptosis by upregulating Bax protein and downregulating Bcl-2 protein levels. Additionally, EGFR/COX-2-IN-1 significantly increases the proportion of cells in the G2/M phase in MCF-7 cells, demonstrating a broad-spectrum antitumor effect.Formula:C20H17FN6O2S2Color and Shape:SolidMolecular weight:456.52Thalidomide-NH-C6-NH-Boc
CAS:Thalidomide-based E3 ligase ligand for PROTAC degrader MI-389 synthesis, linked to cereblon and Boc.Formula:C24H32N4O6Color and Shape:SolidMolecular weight:472.542DMUP
CAS:DMUP inhibits CD47-SIRPα, induces apoptosis, boosts macrophage activity in A549 cells, and has antitumor properties.Formula:C24H24Cl2N2O10PtColor and Shape:SolidMolecular weight:766.45PTP1B-IN-30
PTP1B-IN-30 (Compound 3j) is an inhibitor of PTP1B with an IC50 of 0.51 µM. It suppresses the proliferation of T47D cancer cells with an IC50 of 21.21 µM, induces cell cycle arrest at the S phase, and triggers apoptosis in T47D cells.Formula:C22H21N3O5SColor and Shape:SolidMolecular weight:439.48BRD6257
BRD6257 is an orally active inhibitor of protein phosphatase 1D (proteinphosphatase, Mg2+/Mn2+ dependent 1D, PPM1D) with an IC50 of 5 nM. It activates the p53 signaling pathway (EC50 of 51 nM), enhances p21 expression, and inhibits the proliferation of cancer cells MOLM13 (IC50 = 2.8 μM). BRD6257 demonstrates good metabolic stability in human and rat liver microsomes.Formula:C24H22F4N6O3SColor and Shape:SolidMolecular weight:550.53RET-IN-4
CAS:RET-IN-4: Oral RET inhibitor, IC50 ~1 nM for variants. Selective over JAK2/FLT3. Potent anticancer use.Formula:C27H31FN10O2Color and Shape:SolidMolecular weight:546.611CQ1373
CQ1373 is a potent RET inhibitor that demonstrates cellular activity against BaF3 cells expressing CCDC6-RET, CCDC6-RET-G810C, and CCDC6-RET-G810R, with IC50 values of 13.0, 25.7, and 28.4 nM, respectively. It shows excellent selectivity for wild-type RET and solvent front mutants G810C/R, with IC50 values of 4.2, 7.1, and 32.4 nM. CQ1373 inhibits RET phosphorylation and downstream signaling through SHC. Additionally, it induces apoptosis (Apoptosis) and cell cycle arrest in BaF3 cells. CQ1373 possesses antitumor efficacy, making it a candidate for cancer research.Formula:C25H22ClF3N6O3Color and Shape:SolidMolecular weight:546.93Nur77 modulator 4
Nur77 modulator 4 (Compound 15h) is a Nur77 inducer with a KD of 0.477 μM. It significantly promotes Nur77 expression and apoptosis, exhibiting excellent growth inhibitory effects on HepG2 and MCF-7 cells, with an IC50 of less than 5 μM. Nur77 modulator 4 activates Nur77-mediated ER stress through the PERK-ATF4 and IRE1 signaling pathways, leading to apoptosis. This compound is applicable in cancer research.Formula:C26H28ClN5O2Color and Shape:SolidMolecular weight:477.99Chloranthalactone B
CAS:Chloranthalactone B, a sesquiterpenoid from Sarcandra glabra, inhibits inflammation via AP-1 & p38 MAPK.Formula:C15H16O3Color and Shape:SolidMolecular weight:244.29Milademetan tosylate hydrate
CAS:Milademetan tosylate hydrate, an oral MDM2 inhibitor targeting AML and solid tumors, induces G1 arrest and apoptosis.Formula:C37H44Cl2FN5O8SColor and Shape:SolidMolecular weight:808.74NYY-6a
NYY-6a is a ferroptosis (Ferroptosis) inhibitor, demonstrating significant suppression of RSL3-induced ferroptosis in 786-O and HT-1080 cells, with EC50 values of 52 nM and 50 nM, respectively. As a radical-trapping antioxidant (RTA), NYY-6a effectively reduces lipid peroxidation, comparable to ferrostatin-1 and liproxstatin-1, making it useful for research into ferroptosis-related pathologies.Formula:C23H22N2O3Color and Shape:SolidMolecular weight:374.43FMP
FMP is a platinum (IV) complex. It significantly upregulates the expression of γ-H2AX and p53, enhances ROS production, and markedly increases the expression of apoptosis (Apoptosis) related proteins (DR5, Fas, caspase-8, Cyt-c, caspase-3, cleaved-PARP1, Bax). FMP exhibits antiproliferative activity against breast cancer.Formula:C18H18Cl2N2O7PtColor and Shape:SolidMolecular weight:640.33TS-IN-6
TS-IN-6 (Compound 10) is a thymidylate synthase (TS) inhibitor with an IC50 value of 0.54 μM, showing significant antiproliferative activity. It can induce G1 phase cell cycle arrest and apoptosis (with notable increases in early and late apoptosis rates) and is useful for research in cancers such as colon, breast, and liver cancer.Formula:C29H22F2N6OSColor and Shape:SolidMolecular weight:540.59sEH inhibitor-19
sEH inhibitor-19 (Compound (R)-14i) is an orally active soluble epoxide hydrolase (sEH) inhibitor with an IC50 of 1.2 nM. This compound suppresses the expression of TNF-α and IL-6 and exhibits anti-inflammatory effects in mouse models of acute pancreatitis and Carrageenan-induced edema.Formula:C28H28F3N3O4Color and Shape:SolidMolecular weight:527.535Tubulin polymerization-IN-76
Tubulin polymerization-IN-76 (compound 20b) is a potent and orally active inhibitor of tubulin polymerization. It acts at the colchicine binding site to inhibit tubulin polymerization with an IC50 value of 2.505 μM, effectively disrupting the intracellular microtubule network and interfering with mitosis. Tubulin polymerization-IN-76 shows significant inhibitory effects on MGC-803 and HGC-27 cells, with IC50 values of 1.61 and 1.82 nM, respectively. It effectively suppresses colony formation and cell migration activities in these cell lines, inducing G2/M phase cell cycle arrest and apoptosis (Apoptosis). Furthermore, Tubulin polymerization-IN-76 exhibits broad-spectrum antiproliferative activity.Formula:C20H21N5SColor and Shape:SolidMolecular weight:363.48NSC90616
NSC90616 is a mutant p53 rescue compound [1] .Formula:C23H30FNa2O9PColor and Shape:SolidMolecular weight:546.43Hypoxia inducer-1
Hypoxia inducer-1 (Compound N6) is a NO donor compound that is orally active and activated under hypoxic conditions. It exhibits high selectivity in releasing NO, inhibiting apoptosis, necrosis, and elevated levels of reactive oxygen species (ROS) associated with hypoxia. It modulates vasodilation and shows protective effects in a mouse model of myocardial hypoxic injury, making it useful for coronary heart disease research.Formula:C14H12FN3O4Color and Shape:SolidMolecular weight:305.261Canfosfamide
CAS:Canfosfamide, a prodrug activated by GSTP1-1, induces apoptosis and inhibits DNA-PK, producing an alkylating agent for cancer research.Formula:C26H40Cl4N5O10PSColor and Shape:SolidMolecular weight:787.47PROTAC FLT3/CDK9 degrader-1
Potent PROTAC degrader for FLT3/CDK9, induces apoptosis, and shows promise for FLT3-ITD mutated AML research.Formula:C48H62N12O7Color and Shape:SolidMolecular weight:919.08PD-L1/VISTA-IN-2
PD-L1/VISTA-IN-2 (Compound S8) is an orally active dual inhibitor targeting PD-L1 and VISTA, with an IC50 of 1.4 μM for PD-L1 and a KD of 2.1 μM for VISTA. This compound can activate the tumor immune microenvironment, exerting anticancer effects.Formula:C22H22N2O3Color and Shape:SolidMolecular weight:362.42Ilicicolin A
CAS:Ilicicolin A is a useful organic compound for research related to life sciences. The catalog number is T125289 and the CAS number is 22581-06-2.Formula:C23H31ClO3Color and Shape:SolidMolecular weight:390.95Cuprichydroxide
CAS:Cuprichydroxide exhibits inhibitory activity against Ralstonia solanacearum and A549 cells and has acute pulmonary toxicity.Formula:CuH2O2Color and Shape:SolidMolecular weight:97.56FGA139
FGA139 is an inhibitor of cysteine proteases, specifically targeting cathepsin B and L with IC50 values of 4.98 μM and 3.14 μM, respectively. It reduces the production of NO in LPS-induced RAW264.7 cells and lowers TNFα levels in microglia, demonstrating antioxidant and anti-inflammatory properties. Additionally, FGA139 enhances the secretion of neuroprotective metabolites such as purines and linoleic acid in LPS-stimulated microglia. This compound is applicable in the study of neuroinflammatory diseases.
Formula:C48H58BF2N7O5Color and Shape:SolidMolecular weight:861.45605Antitumor agent-36
Antitumor agent-36: potent anti-cancer; causes DNA damage, triggers apoptosis, enhances immune response by upregulating T cells.Formula:C32H30Cl2N2O6PtColor and Shape:SolidMolecular weight:804.58Thalidomide-Piperazine-PEG3-NH2
CAS:Thalidomide-Piperazine-PEG3-NH2: a cereblon ligand-linker for PROTAC E3 ligase recruitment.Formula:C25H35N5O7Color and Shape:SolidMolecular weight:517.583INF 195
CAS:INF 195 is an inflammasome NLRP3 inhibitor that can be used to study myocardial ischemia and myocardial infarction.Formula:C17H22ClNO3Purity:99.78%Color and Shape:SoildMolecular weight:323.81Anticancer agent 52
CAS:Anticancer agent 52 exhibits potent cytotoxicity, induces apoptosis, and has potential in bladder cancer research.Formula:C50H43Br2N2PColor and Shape:SolidMolecular weight:862.67Thalidomide-NH-(CH2)2-NH2 TFA
CAS:Thalidomide-NH-(CH2)2-NH2 TFA is an alkyl-modified derivative of Thalidomide serving as a Cereblon ligand to recruit CRBN proteins and a pivotal intermediate inFormula:C17H17F3N4O6Color and Shape:SolidMolecular weight:430.34MS78
MS78, an acetylation targeting chimera (AceTAC), specifically acetylates the p53Y220C mutant by recruiting the histone acetyltransferase p300/CBP.Formula:C57H66FN9O6SColor and Shape:SolidMolecular weight:1024.25Fascaplysin chloride
CAS:Fascaplysin inhibits CDK4/D1 (IC50=0.35μM), triggers caspase-activated autophagy-apoptosis crosstalk, and blocks PI3K/AKT/mTOR in HL-60 cells.Formula:C18H11ClN2OColor and Shape:SolidMolecular weight:306.75Thalidomide-NH-PEG3-COOH
CAS:Thalidomide-NH-PEG3-COOH is a cereblon-based E3 ligase ligand-linker for PROTAC synthesis.Formula:C22H27N3O9Color and Shape:SolidMolecular weight:477.47Schisandronic acid
CAS:Schisandronic acid is a triterpenoid acid isolated from the stems of Schisandra propinqua.Formula:C30H46O3Color and Shape:SolidMolecular weight:454.68PROTAC Bcl-xL ligand-1
PROTAC Bcl-xL ligand-1 serves as a ligand targeting Bcl-xL, essential in synthesizing PROTACs [1].Formula:C32H29IN4O4S2Color and Shape:SolidMolecular weight:724.63Moracin N
CAS:Moracin N, a ferroptosis inhibitor derived from mulberry leaves, exhibits neuroprotective activity by mitigating oxidative stress [1].Formula:C19H18O4Purity:98%Color and Shape:SolidMolecular weight:310.34Thalidomide-O-PEG2-propargyl
CAS:Thalidomide-O-PEG2-propargyl is a cereblon-based E3 ligase ligand with a PEG linker for PROTAC-induced protein degradation.Formula:C20H20N2O7Purity:98%Color and Shape:SolidMolecular weight:400.38Thalidomide-O-C10-NH2
CAS:Thalidomide-O-C10-NH2: synthetic cereblon-based E3 ligase ligand-linker for PROTACs.Formula:C23H31N3O5Color and Shape:SolidMolecular weight:429.517Narasin (sodium salt)
CAS:Narasin (sodium salt) (HainanMycin) induces tumor necrosis factor-related apoptosis-induced ligand (TRAIL)-mediated apoptosis by ER stress in glioma cells andFormula:C43H71NaO11Purity:98%Color and Shape:SolidMolecular weight:787.0127-O-(tert-Butyldimethylsilyl)withaferin A
CAS:Compound 9a, a withanolide, induces apoptosis and has anti-cancer properties.Formula:C34H52O6SiColor and Shape:SolidMolecular weight:584.86TNF-α-IN-6
CAS:TNF-α-IN-6 is an orally efficacious allosteric inhibitor of TNFα ( K D = 6.8 nM).
Formula:C26H25N9O2Color and Shape:SolidMolecular weight:495.547Calcimycin hemicalcium salt
CAS:Calcimycin (A-23187) is an antibiotic calcium ionophore that raises intracellular Ca2+ to induce cell death.Formula:C58H72CaN6O12Purity:98%Color and Shape:SolidMolecular weight:1085.322(Rac)-AMXT-1501 4HCl
CAS:AMXT-1501 tetrahydrochloride is an inhibitor of polyamine transport.Formula:C32H72Cl4N6O2Purity:98.31%Color and Shape:SolidMolecular weight:714.77RA-XII
CAS:RA-XII is a useful organic compound for research related to life sciences. The catalog number is T125868 and the CAS number is 143343-98-0.Formula:C46H58N6O14Color and Shape:SolidMolecular weight:918.998M24
CAS:M24 inhibits Mcl-1 (Ki = 0.33μM), blocks HepG2 cell growth, and triggers apoptosis.Formula:C44H40Cl3N5O11SColor and Shape:SolidMolecular weight:953.24SM-164 Hydrochloride
SM-164 Hydrochloride: Smac mimetic, cell-permeable, binds XIAP BIR2 and BIR3, IC50 of 1.39 nM, potent XIAP antagonist.Formula:C62H85ClN14O6Color and Shape:SolidMolecular weight:1157.88BM-1074
CAS:BM-1074 is a potent and highly efficacious inhibitor of Bcl-2/Bcl-xL with Ki value of < 1nM [1].Formula:C50H57ClN8O7S3Color and Shape:SolidMolecular weight:1013.69DS-5272
CAS:DS-5272 is a potent and orally active inhibitor of p53-MDM2 interaction.Formula:C34H38Cl2F2N6O2SColor and Shape:SolidMolecular weight:703.67MitoEbselen-2 chloride
CAS:MitoEbselen-2 mitigates radiation, cuts lipid hydroperoxides, blocks cell death, and boosts survival in irradiated mice.Formula:C35H30ClN2O2PSeColor and Shape:SolidMolecular weight:656.015-LOX-IN-8
5-LOX-IN-8 is a 5-LOX inhibitor with anti-inflammatory properties. It suppresses IL-6, IL-1β, TNF-α, and IFN-γ in macrophages and reduces IL-8 secretion in SW480 cells. Additionally, 5-LOX-IN-8 decreases the disease activity index in DSS colitis models. This compound is applicable for research in inflammatory bowel disease (IBD).Color and Shape:Odour SolidAnti-inflammatory agent 95
Anti-inflammatory agent 95 (Compound 2e) is a compound with potent anti-inflammatory properties, showing significant inhibition of NO production in LPS-induced RAW 264.7 mouse macrophages, with an IC50 of 8.8 μM. It also effectively suppresses the secretion of TNF-α and IL-1β, achieving inhibition rates of 60% and greater than 90% at 100 μM, respectively. Anti-inflammatory agent 95 holds promise for research into inflammatory diseases.Formula:C16H21NO4Color and Shape:SolidMolecular weight:291.34HTH-01-091 TFA
HTH-01-091 TFA: Potent, selective MELK inhibitor (IC50=10.5 nM); also targets PIM1/2/3, RIPK2, DYRK3, smMLCK, CLK2; used in breast cancer research.Formula:C28H29Cl2F3N4O4Color and Shape:SolidMolecular weight:613.46LSD1-IN-26
LSD1-IN-26 (12u) is a potent LSD1 inhibitor (IC50=25.3 nM), also inhibits MAO-A/B, induces apoptosis in MGC-803, for gastric cancer research.Formula:C27H25Cl2F2N3OColor and Shape:SolidMolecular weight:516.41Thalidomide-O-amido-PEG2-C2-NH2
CAS:Thalidomide-O-amido-PEG2-C2-NH2, which combines an E3 ligase ligand with a linker, serves as an immunomodulator for cancer treatment.Formula:C21H26N4O8Color and Shape:SolidMolecular weight:462.459Pexelizumab
CAS:Pexelizumab is a humanized antibody targeting C5 to inhibit apoptosis and treat cerebral IR injury and myocardial infarction.Color and Shape:LiquidAMG-7209
CAS:AMG-7209 is an effective and selective MDM2-p53 interaction inhibitor.Formula:C37H41Cl2FN2O7SColor and Shape:SolidMolecular weight:747.7Dimethachlor
CAS:Dimethachlor is a pesticide and herbicide used in wetland areas.Formula:C13H18ClNO2Color and Shape:SolidMolecular weight:255.74Sanggenon G
CAS:Sanggenon G inhibits XIAP by binding its BIR3 domain; affinity is 34.26 μM, boosting caspase activation.Formula:C40H38O11Color and Shape:SolidMolecular weight:694.72Bleomycin A5
CAS:Bleomycin A5, or Pingyangmycin, is an oral glycopeptide antibiotic and acts as an antineoplastic and apoptosis inducer.Formula:C57H89N19O21S2Color and Shape:SolidMolecular weight:1440.56Chalcones A-N-5
CAS:Chalcones A-N-5, a non-cytotoxic trihydroxy chalcone, aids cell growth & neuroprotection, inhibits ferroptosis, and targets AD research.Formula:C21H20N4O4Color and Shape:SolidMolecular weight:392.41Tubulin polymerization-IN-45
Tubulin polymerization-IN-45, a tubulin-targeting agent, acts as a tubulin polymerization inhibitor by binding to the tubulin's colchicine site.Formula:C20H18N4O3Color and Shape:SolidMolecular weight:362.38QN523
CAS:QN523 has drug-like traits, kills cancer cells in vitro, effective in vivo against pancreatic cancer, works via autophagy.Formula:C14H10N4OPurity:99.83%Color and Shape:SolidMolecular weight:250.26Rosomidnar
CAS:PNT100: 24-base DNA oligo targeting BCL-2 regulatory region; halts tumor cell growth, induces death.Formula:C227H291O141P23Color and Shape:SolidMolecular weight:7220.63Destruxin B
CAS:Destruxin B: cyclic peptide from Metarhizium fungus, induces apoptosis in lung cancer via mitochondrial pathway.Formula:C30H51N5O7Purity:98%Color and Shape:SolidMolecular weight:593.766HDAC6 degrader-5
HDAC6degrader-5 (Compound 6) exhibits inhibitory and degradative activity against HDAC6, with an IC50 of 4.95 nM and a DC50 of 0.96 nM. It suppresses the release of TNF-α, IL-1β, and IL-6, and prevents apoptosis in liver cells. Additionally, HDAC6degrader-5 demonstrates anti-inflammatory properties in a mouse model of APAP-induced liver injury.Formula:C21H22N4O3Color and Shape:SolidMolecular weight:378.424Apoptosis inducer 3
CAS:Apoptosis Inducer 3 (Compound 3), a selective apoptosis triggering agent, induces both apoptosis and late-apoptosis phases, demonstrating cytotoxic effectsFormula:C49H55ClN2O7Color and Shape:SolidMolecular weight:819.42FHD-286
CAS:FHD-286 is an inhibitor of BRM/BRG1 ATPase and can be used for studies on the treatment of BAF-related disorders such as acute myeloid leukemia.Formula:C24H30N6O6S2Purity:99.73%Color and Shape:SolidMolecular weight:562.66Ref: TM-T9749
1mg144.00€5mg283.00€10mg454.00€25mg615.00€50mg777.00€100mg1,064.00€1mL*10mM (DMSO)359.00€Antitumor agent-61
CAS:Antitumor agent-61, a potent Irinotecan derivative, exhibits IC50s of 0.92-3.23 μM in 6 cancer cells, inducing apoptosis via mitochondrial pathways.Formula:C54H63FN5O10PColor and Shape:SolidMolecular weight:992.08VB-85247
VB-85247 is a STING agonist that, by activating the STING pathway, induces the upregulation of inflammatory cytokines IFNα/β, TNFα, IL6, and CXCL10, as well as the maturation and activation of dendritic cells. It can lead to the regression of tumors within the bladder and is applicable in bladder cancer research.Color and Shape:Odour SolidPROTAC Bcl-xL degrader-1
PROTAC Bcl-xL degrader-1 targets Bcl-xL & IAP E3 ligases, degrades Bcl-xL, toxic to human platelets & MyLa 1929 (IC50: 62 nM, 8.5 μM).Formula:C76H96ClF3N10O11S3Color and Shape:SolidMolecular weight:1514.28CPTH2 (hydrochloride) (357649-93-5 free base)
CAS:CPTH2 is an inhibitor of the HAT activity of Gcn5.Formula:C14H15Cl2N3SPurity:98%Color and Shape:SolidMolecular weight:328.26Didocosahexaenoin
CAS:Didocosahexaenoin, omega-3 diglyceride, disrupts mitochondria, induces ROS, apoptosis, and is cytotoxic to prostate cancer cells.Formula:C25H40O5Color and Shape:SolidMolecular weight:420.58STM3006
CAS:STM3006 is an orally active, selective and and potent METTL3 inhibitor with antitumor activity for the study of acute myeloid leukemia (AML).Formula:C25H27BrN8Purity:97.16%Color and Shape:SoildMolecular weight:519.44Monactin
CAS:Monactin is a Marcrotetrolide antibiotic produced by cycloheximide producing species of Streptomyces. It is a homolog of nonactin from the same species.Formula:C41H66O12Purity:98%Color and Shape:SolidMolecular weight:750.96ReACp53
ReACp53 inhibits amyloid formation, restores p53 in cancer cells and HGSOC-derived organoids.Formula:C108H206N52O24Purity:98%Color and Shape:SolidMolecular weight:2617.137-Methoxy-1-tetralone
CAS:7-Methoxy-1-tetralone may have insecticidal activity.Formula:C11H12O2Purity:99.85% - 99.89%Color and Shape:White CrystalMolecular weight:176.21Cefatrizine
CAS:Cefatrizine inhibits eEF-2 kinase, affecting apoptosis, autophagy, and ER stress in cancers.Formula:C18H18N6O5S2Purity:98%Color and Shape:SolidMolecular weight:462.5PROTAC FLT-3 degrader 1
CAS:PROTAC FLT-3 degrader 1 is a PROTAC FLT-3 degrader of internal tandem duplication (ITD)(IC50 0.6 nM),with anti-proliferative activity.Formula:C52H61N9O9S2Purity:98%Color and Shape:SolidMolecular weight:1020.23BM-1197
CAS:BM-1197, a highly potent and specific dual inhibitor of Bcl-2 and Bcl-xL, effectively targets these proteins with IC50 values of 3.5 nM and 5.2 nM for Bcl-2 andFormula:C53H59ClF4N6O7S4Color and Shape:SolidMolecular weight:1131.77Bcl-2-IN-2
CAS:Bcl-2-IN-2 is a highly potent and selective inhibitor targeting Bcl-2 and Bcl-xL.Formula:C48H57N7O7SColor and Shape:SolidMolecular weight:876.09Antagonist G
CAS:Antagonist G is an anticancer peptide and is also a broad spectrum neuropeptide growth factor antagonist.Formula:C49H66N12O6SPurity:98%Color and Shape:SolidMolecular weight:951.19Antitumor agent-113
Antitumor Agent-113 exhibits cytotoxicity in A549 cells, with an IC50 of 46.60 μM, and induces apoptosis, making it applicable for research in non-small cellFormula:C21H22ClN5O2SPurity:98%Color and Shape:SolidMolecular weight:443.95Thalidomide-Piperazine-PEG2-NH2
CAS:Thalidomide-Piperazine-PEG2-NH2 is a synthetic E3 ligase ligand-linker for PROTAC, combining cereblon ligand with a PEG2 linker.Formula:C23H31N5O6Color and Shape:SolidMolecular weight:473.53PROTAC EGFR degrader 5
CAS:PROTAC EGFR degrader 5 effectively breaks down EGFR Del19 in HCC827 cells at 34.8 nM, inducing apoptosis and G1 arrest.Formula:C57H72FN13O5SColor and Shape:SolidMolecular weight:1070.33KB02-SLF
KB02-SLF, a molecular glue, degrades nuclear FKBP12 by modifying E3 ligase DCAF16 and extends protein degradation.Formula:C50H65ClN4O12Purity:98%Color and Shape:SolidMolecular weight:949.52Fosbretabulin [free base]
CAS:Fosbretabulin is a natural cis-stilbene that interferes with cellular tubulin dynamics and selectively destroys tumor blood vessels.
Formula:C18H21O8PColor and Shape:SolidMolecular weight:396.33QZ2135
QZ2135 (compound 20) is a PROTAC degrader that specifically targets RET and exhibits antitumor activity in vivo within a Ba/F3-KIF5B-RET-G810C xenograft mouse model. The compound demonstrates degradation activity with DC50 values of 4.7 nM (WT), 17.2 nM (V804M), and 73.8 nM (G810C) when targeting KIF5B-RET. QZ2135 is composed of the target protein ligand (red part) RETligand-3, the E3 ligase ligand (blue part) Lenalidomide-F, and the PROTAC Linker (black part) 7-Iodohept-1-yne, wherein the target protein ligand combined with the linker forms the conjugate RETLigand-Linker Conjugate-1.Formula:C53H54N12O4Color and Shape:SolidMolecular weight:923.07Fludarabine triphosphate trisodium
Fludarabine triphosphate (F-ara-ATP) trisodium inhibits DNA synthesis; IC50 2.3 μM, Ki 6.1 μM, blocks DNA primase, prompts apoptosis.Formula:C10H12FN5Na3O13P3Color and Shape:SolidMolecular weight:591.12Osajin
CAS:Osajin is the major bioactive iso avone present in the fruit of Maclura pomifera. It has antitumor, antioxidant, and anti-inflammatory activities.Formula:C25H24O5Purity:98%Color and Shape:SolidMolecular weight:404.46Targaprimir-96
CAS:Targaprimir-96 is a potent microRNA-96 (miR-96) processing inhibitor.Formula:C77H102N18O7Purity:98%Color and Shape:SolidMolecular weight:1391.75CYP51/PD-L1-IN-1
CYP51/PD-L1-IN-1 (compound L11), a quinazoline with antifungal properties, simultaneously inhibits CYP51 (IC50: 0.884 μM) and PD-L1 (IC50: 0.083 μM).Formula:C20H15N5O2Color and Shape:SolidMolecular weight:357.37
![Fosbretabulin [free base]](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTM%2Fthumb-webp%2FT31857.webp&w=3840&q=75)
