Apoptosis
Apoptosis inhibitors are compounds that prevent or delay the process of programmed cell death, known as apoptosis. These inhibitors are vital in studying cell survival mechanisms and are used to investigate diseases where apoptosis is dysregulated, such as cancer, neurodegenerative disorders, and autoimmune diseases. By modulating apoptosis, these inhibitors can help in the development of therapies aimed at controlling cell death. At CymitQuimica, we provide a comprehensive selection of high-quality apoptosis inhibitors to support your research in cell biology, oncology, and related fields.
Subcategories of "Apoptosis"
- ASK(9 products)
- BCL(1 products)
- Caspase(154 products)
- FOXO1(2 products)
- IAP(67 products)
- Mdm2(12 products)
- PD-1/PD-L1(126 products)
- PDK(9 products)
- PERK(23 products)
- Serine/threonin kinase(17 products)
- Survivin(14 products)
- TNF(90 products)
- c-RET(61 products)
- p53(63 products)
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Found 6170 products of "Apoptosis"
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MS1943
CAS:MS1943 is a orally bioavailable EZH2 selective degrader(IC50 of 120 nM).Formula:C42H54N8O3Purity:95.41% - 95.82%Color and Shape:SolidMolecular weight:718.93Ref: TM-T13780
1mg39.00€2mg52.00€5mg84.00€10mg130.00€25mg250.00€50mg439.00€100mg802.00€200mg1,324.00€1mL*10mM (DMSO)120.00€Ganoderic acid T1
Ganoderic acid T1, a derivative of Ganoderic acid T, triggers cancer cell apoptosis by boosting ROS and activating caspases.Formula:C34H50O7Color and Shape:SolidMolecular weight:570.76Camrelizumab
CAS:Camrelizumab (SHR-1210) is a human IgG4-κ monoclonal antibody with high affinity and directed against PD-1.Camrelizumab binds PD-1 with a binding affinity of up
Purity:95% - 98.6%Color and Shape:LiquidMolecular weight:143.7 kDaSPOP-IN-6lc
CAS:SPOP-IN-6lc is a SPOP inhibitor with oncogenic effects in renal cancer cells.SPOP-IN-6lc can be used to study apoptosis.
Formula:C26H31N7O2SPurity:99.19%Color and Shape:SolidMolecular weight:505.64Thalidomide-NH-amido-C6-NH2 hydrochloride
Thalidomide-NH-amido-C6-NH2 hydrochloride is a synthetic E3 ligase ligand-linker conjugate that includes a thalidomide-based cereblon ligand and a linker, designed for the synthesis of PROTAC.Formula:C21H28ClN5O5Molecular weight:465.1779(-)-Mcl-1 inhibitor 21
CAS:(-)-Mcl-1 inhibitor 21 (Example 1-38) is an Mcl-1 inhibitor with an IC50 of 7.51 μM. It exhibits pro-apoptotic and anti-proliferative activity against SUDHL5 and SUDHL10 cell lines, making it useful for cancer research.
Formula:C32H33N3O4Color and Shape:SolidMolecular weight:523.622P-gp inhibitor 16
P-gp inhibitor 16 (compound 14) is an inhibitor of p-glycoprotein. It significantly enhances apoptosis induced by doxorubicin and displays anticancer properties.Formula:C35H35N5O4Molecular weight:589.2689Cu(I) chelator 1
Cu(I) chelator 1 (Compound LH2) is a chelating agent specifically targeting the Cu(I) redox state. It inhibits the production of ROS.Formula:C16H27NO4S3Molecular weight:393.11022PROTAC FLT3/CDK9 degrader-1
Potent PROTAC degrader for FLT3/CDK9, induces apoptosis, and shows promise for FLT3-ITD mutated AML research.Formula:C48H62N12O7Color and Shape:SolidMolecular weight:919.08EGFR-IN-107
EGFR-IN-107 (compound 3r) is an orally active EGFR inhibitor with IC50 values of 0.4333 μM for EGFRWT and 0.0438 μM for EGFRL858R/T790M. It exhibits antiproliferative activity, effectively inhibiting the proliferation of H1975 cells and inducing apoptosis (apoptosis). EGFR-IN-107 is applicable in cancer research.Formula:C34H36FN7O2Molecular weight:593.29145NCA029
NCA029 is a potent activator of human caseinolytic protease P (HsClpP) with an EC50 of 0.15 μM. It targets HsClpPP and triggers an ATF3-dependent integrated stress response, resulting in the death of colon cancer cells.Formula:C22H20F3N3OMolecular weight:399.1558512-HETE
CAS:12-HETE ((±)12-HETE) is a regulator of PGE2, having both antithrombotic and prothrombotic effects.Formula:C20H32O3Color and Shape:SolidMolecular weight:320.47Canfosfamide
CAS:Canfosfamide, a prodrug activated by GSTP1-1, induces apoptosis and inhibits DNA-PK, producing an alkylating agent for cancer research.Formula:C26H40Cl4N5O10PSColor and Shape:SolidMolecular weight:787.47OICR12694 TFA
CAS:OICR12694 (JNJ-65234637) TFA, an orally active B cell lymphoma 6 (BCL6) inhibitor [1], demonstrates effectiveness in targeting BCL6 pathways.Formula:C29H28ClF3N8O4·xC2HF3O2Color and Shape:SolidNSC90616
NSC90616 is a mutant p53 rescue compound [1] .Formula:C23H30FNa2O9PColor and Shape:SolidMolecular weight:546.43sEH inhibitor-19
sEH inhibitor-19 (Compound (R)-14i) is an orally active soluble epoxide hydrolase (sEH) inhibitor with an IC50 of 1.2 nM. This compound suppresses the expression of TNF-α and IL-6 and exhibits anti-inflammatory effects in mouse models of acute pancreatitis and Carrageenan-induced edema.Formula:C28H28F3N3O4Color and Shape:SolidMolecular weight:527.535Anticancer agent 178
Anticanceragent 178 (compound C2) is a potent anticancer compound. It effectively inhibits the proliferation and metabolic activity of MDA-MB 231 cells, with IC50 values of 1.1 and 4.2 μM, respectively. Additionally, Anticanceragent 178 induces ferroptosis and necroptosis in cells.Formula:C32H30ClFeN2O6Molecular weight:629.11418Milademetan tosylate hydrate
CAS:Milademetan tosylate hydrate, an oral MDM2 inhibitor targeting AML and solid tumors, induces G1 arrest and apoptosis.Formula:C37H44Cl2FN5O8SColor and Shape:SolidMolecular weight:808.74Chloranthalactone B
CAS:Chloranthalactone B, a sesquiterpenoid from Sarcandra glabra, inhibits inflammation via AP-1 & p38 MAPK.Formula:C15H16O3Color and Shape:SolidMolecular weight:244.29Tubulin polymerization-IN-43
CAS:Tubulin polymerization-IN-43 disrupts microtubules, arrests cell cycle, and induces apoptosis in leukemia by targeting colchicine sites.Formula:C17H13F4N3OPurity:99.98%Color and Shape:SoildMolecular weight:351.3RET-IN-4
CAS:RET-IN-4: Oral RET inhibitor, IC50 ~1 nM for variants. Selective over JAK2/FLT3. Potent anticancer use.Formula:C27H31FN10O2Color and Shape:SolidMolecular weight:546.611PRDX1-IN-2
PRDX1-IN-2 (compound 15) is a selective inhibitor of the antioxidant enzyme Peroxiredoxin 1 (PRDX1) with an IC50 of 0.35 μM. It reduces mitochondrial membrane potential in SW620 cells, potentially due to increased ROS resulting from PRDX1 inhibition, leading to apoptosis. PRDX1-IN-2 is applicable in colorectal cancer research.DMUP
CAS:DMUP inhibits CD47-SIRPα, induces apoptosis, boosts macrophage activity in A549 cells, and has antitumor properties.Formula:C24H24Cl2N2O10PtColor and Shape:SolidMolecular weight:766.45Necrosis inhibitor 2 (hydrocholide)
Necrosis inhibitor 2 hydrochloride (Compound B19) is an agent that inhibits cellular necrosis. It is useful for researching diseases associated with necrotic pathways, including inflammation, cancer, metabolic disorders, and neurodegenerative diseases.Formula:C24H26ClN5O5Molecular weight:499.16225DA5-HTL
DA5-HTL is a compound that combines dasatinib with the HaloTag system, effectively inhibiting the growth of tumor cells, with a GI50 of 1.923 nM.Formula:C39H58Cl2N8O8SMolecular weight:868.34754Thalidomide-NH-C6-NH-Boc
CAS:Thalidomide-based E3 ligase ligand for PROTAC degrader MI-389 synthesis, linked to cereblon and Boc.Formula:C24H32N4O6Color and Shape:SolidMolecular weight:472.542Anticancer agent 204
Anticanceragent 204 (Compound 6) is a fluorinated derivative of cinnamamides with anticancer activity. It can arrest the cell cycle of HepG2 cells in the G1 phase and induces apoptosis by reducing mitochondrial membrane polarization (MMP) levels.Formula:C26H18FN5O3SMolecular weight:499.11144ECDD-S16
ECDD-S16 is a potent inhibitor of pyroptosis. It effectively suppresses pyroptosis in Raw264.7 cells activated by surface and endosomal TLR ligands.Formula:C35H31FO12Molecular weight:662.179953-Methoxy-9H-Carbazole
CAS:3-methoxy-9H-carbazole: photosensitizer, anti-breast cancer, from Klauseneria spp., induces apoptosis.Formula:C13H11NOPurity:99.24%Color and Shape:SolidMolecular weight:197.23R1-ICR-5
CAS:R1-ICR-5 is a selective PROTAC degrader targeting serine/threonine-protein kinase 1 (RIPK1). Mediated by VHL, R1-ICR-5 promotes the degradation of RIPK1, disrupting the TNFR1 and TLR3/4 signaling hubs, enhancing NF-κB, MAPK, and IFN signal output, and facilitating RIPK3 activation and necroptosis induction. R1-ICR-5 holds potential for research in cancer and inflammatory diseases.Formula:C54H70N8O7S2Color and Shape:SolidMolecular weight:1007.31MX106-4C
MX106-4C is a survivin inhibitor that selectively targets ABCB1-positive colorectal cancer cells. It can work synergistically with Doxorubicin for enhanced anticancer effects or restore Doxorubicin sensitivity in drug-resistant ABCB1 cells.Formula:C23H25BrN2O2Molecular weight:440.10994PROTAC GPX4 degrader-2
PROTACGPX4 degrader-2 (compound 18a) is a proteolysis-targeting chimera (PROTAC) that targets the degradation of glutathione peroxidase 4 (GPX4), with a DC50, 48h value of 1.68 μM. It induces the accumulation of lipid peroxides and mitochondrial depolarization, subsequently triggering ferroptosis. Additionally, PROTACGPX4 degrader-2 exhibits antiproliferative activity.Formula:C50H61ClN8O9Molecular weight:952.425Thalidomide-5-propargyne-NH2 hydrochloride
CAS:Thalidomide derivative for CRBN protein recruitment, used in PROTACs production for protein degradation.Formula:C16H14ClN3O4Color and Shape:SolidMolecular weight:347.753WEE1-IN-7
WEE1-IN-7 (compound 12h) is a potent, orally active WEE1 inhibitor with an IC50 value of 2.1 nM. This compound induces apoptosis and causes cell cycle arrest in the S phase, demonstrating antitumor activity.Anticancer agent 104
Anticancer agent 104 has anticancer activity, and induces cancer cell apoptosis [1] .Formula:C34H47F3N2O2S2Color and Shape:SolidMolecular weight:636.87TAS-117
CAS:TAS-117, a PKB/Akt inhibitor, is used potentially for the treatment of solid tumors.Formula:C26H24N4O2Color and Shape:SolidMolecular weight:424.49Topoisomerase II inhibitor 17
TopoisomeraseII inhibitor 17 (compound 4c) is a thiazolopyrimidine-based inhibitor of Topoisomerase II with an IC50 of 0.23 μM. This compound significantly disrupts the cell cycle and induces apoptosis.Formula:C25H22Cl3N3O5SMolecular weight:581.03458S2/IAPinh
S2/IAPinh is a conjugate composed of an inhibitor of apoptosis proteins inhibitor (IAPinh) and a ligand of sigma 2 SW43. It demonstrates anti-proliferative and apoptosis-inducing activity by degrading inhibitor of apoptosis proteins (clAP-1).Formula:C52H75Cl2FN6O6SMolecular weight:1000.48299Odoroside A
CAS:Odoroside A, from Nerium oleander leaves, induces cancer cell death via ROS/p53, causing apoptosis and cell cycle arrest.Formula:C30H46O7Color and Shape:SolidMolecular weight:518.68Ru-Poma
Ru-Poma is an Ru(II)-based photosensitizer designed to enhance the efficacy of photodynamic therapy (PDT) against tumors resistant to Cisplatin. It targets Pomalidomide to partially degrade CRBN, inducing ferroptosis by increasing lipid peroxides and downregulating GPX4 and GAPDH expression. In A549 cells, Ru-Poma exhibits cytotoxicity with IC50 values of 18.46 μM in the dark and 0.37 μM under illumination.Formula:C89H75Cl2N11O11Ru·7H2OAntimycobacterial agent-5
Antimycobacterial agent-5 (compound 27) is an imidazopyridine amide compound that targets the Mycobacterium electron transport chain (ETC) respiratory CIII2CIV2 supercomplex. It acts on Mycobacterium smegmatis CIII2CIV2 with an IC50 of 441 nM.Formula:C25H34ClN3OMolecular weight:427.23904Thalidomide-O-C4-COOH
CAS:Thalidomide-O-C4-COOH is a synthetic E3 ligase linker derived from Thalidomide for PROTAC tech.Formula:C18H18N2O7Color and Shape:SolidMolecular weight:374.3447MRIA9
CAS:MRIA9 inhibits SIK1/2/3 & PAK2/3 with IC50: SIK1 (516 nM), SIK2 (180 nM), SIK3 (127 nM); ATP-competitive.Formula:C24H22ClFN6O3Color and Shape:SolidMolecular weight:496.92Bim BH3, Peptide IV
CAS:This Bim peptide belongs to the pro-apoptotic group of the Bcl-2 family of proteins.Formula:C145H222N44O41SPurity:98%Color and Shape:SolidMolecular weight:3269.65PROTAC EGFR degrader 9
CAS:PROTACEGFRdegrader 9 (Compound C6) is an orally active, CRBN-based PROTAC EGFR degrader. It has a DC50 of 10.2 nM and a Kd of 240.2 nM against EGFRL858R/T790M/C797S. PROTACEGFRdegrader 9 demonstrates effective degradation activity against various EGFR mutants while not affecting EGFRWT.
Formula:C45H48F3N9O6SMolecular weight:899.98PRMT5-IN-33
PRMT5-IN-33 (compound A8) is a selective inhibitor of PRMT5 that competes with SAM, exhibiting an IC50 of 10.9 nM. It induces apoptosis and inhibits the proliferation of Z-138 and MOLM-13 cells, demonstrating antitumor activity.Formula:C25H24BrN5O3SMolecular weight:553.07832Bcl-2-IN-4
CAS:Bcl-2-IN-4: potent, selective, oral Bcl-2 inhibitor with 1.5 nM IC50, >200x selectivity over Bcl-xL.Formula:C46H50ClN9O7SColor and Shape:SolidMolecular weight:908.46PDE4D inhibitor 1
PDE4-IN-1 is a PDE4 inhibitor characterized by high potency (IC50: 8.6 nM) and superior selectivity over other PDE subtypes. This compound inhibits the release of inflammatory cytokines and chemokines. Additionally, PDE4-IN-1 significantly restores the damaged cAMP-CREB signaling pathway, inhibits proliferation, and promotes differentiation to reverse psoriasis formation.Color and Shape:Odour SolidFludarabine triphosphate
CAS:Fludarabine triphosphate inhibits key enzymes, causing cell death.Formula:C10H15FN5O13P3Color and Shape:SolidMolecular weight:525.17tetrathiomolybdate
CAS:Tetrathiomolybdate (TM) promotes the dimerization of the metal-binding domain (WLN4) of the cellular copper efflux protein ATP7B through its characteristicFormula:MoS4Color and Shape:SolidMolecular weight:224.2MY-943
MY-943, a potent inhibitor of tubulin polymerization and LSD1, exhibits anticancer properties by inducing G2/M phase arrest, promoting apoptosis, andFormula:C30H36N4O6S2Color and Shape:SolidMolecular weight:612.763-Hydroxyterphenyllin
CAS:3-Hydroxyterphenyllin from A. candidus is a fungal compound with antioxidant, anticancer, antibacterial, and antiviral effects.Formula:C20H18O6Color and Shape:SolidMolecular weight:354.35PROTAC GPX4 degrader-4
CAS:PROTACGPX4 degrader-4 is a GPX4 PROTAC degrader with a DC50 of 5.32 nM. It inhibits the activity of cancer cell lines RT4, T24, and J82 with IC50 values of 0.09, 2.97, and 7.58 μM, respectively. This compound elevates lipid ROS levels and induces ferroptosis in T24 and RT4 cells. In T24 tumor-bearing BALB/c nude mouse models, PROTACGPX4 degrader-4 demonstrates antitumor activity. It is applicable to bladder cancer research.Formula:C43H58N2O13Color and Shape:SolidMolecular weight:810.93FR900359
CAS:FR900359 is a macrocyclic Gq protein inhibitor that inhibits melanoma cell proliferation and can be used to study asthma, inflammation and cancer.Formula:C49H75N7O15Purity:98%Color and Shape:SolidMolecular weight:1002.16Petromurin C
CAS:Petromurin C, a bis-indolyl benzenoid from P. muricatus, is cytotoxic to NS-1 cells (IC50=33μg/ml) and active against T. foetus (IC50=100μg/ml).Formula:C26H24N2O5Color and Shape:SolidMolecular weight:444.487MS105
CAS:MS105 is an orally active, selective protein tyrosine kinase 6 (PTK6) PROTAC degrader. It recruits the VHL E3 ligase through a VHL ligand fragment, facilitating ubiquitination and proteasomal degradation of PTK6, thereby inhibiting the proliferation and migration of breast cancer cells and inducing apoptosis (apoptosis). MS105 is a promising compound for breast cancer research.Formula:C56H70FN13O6SColor and Shape:SolidMolecular weight:1072.30Vinepidine sulfate
CAS:Vinepidine (LY-119863) sulfate, a derivative of vincristine, exhibits antitumor activity .Formula:C46H58N4O13SColor and Shape:SolidMolecular weight:907.04Diprovocim-1
CAS:Diprovocim-1: TLR1/2 agonist; triggers TNF-α in THP-1 cells; boosts ovalbumin IgG1 & CTLs against tumors with anti-PD-L1 in mice.Formula:C56H56N6O6Color and Shape:SolidMolecular weight:909.1Tubulin polymerization-IN-67
Tubulin polymerization-IN-67 (Compound 5h) serves as an inhibitor of microtubule protein polymerization at the colchicine binding site, exhibiting an IC50 value of 2.92 μM. It effectively inhibits the proliferation of various cancer cell lines including HT29, A549, U2OS, MG-63, and HeLa, with IC50 values ranging from 0.12 to 4.13 μM. Additionally, Tubulin polymerization-IN-67 induces cell cycle arrest at the G2/M phase and triggers apoptosis in U2OS cells. It also inhibits cell migration in A549 and reduces mitochondrial membrane potential (MMP) while increasing intracellular ROS levels, thereby suppressing angiogenesis in HUVEC cells. Furthermore, this compound demonstrates antitumor activity in mice.Color and Shape:Odour SolidPipermethystine
Pipermethystine is a useful organic compound for research related to life sciences and the catalog number is T124340.Formula:C16H17NO4Color and Shape:SolidMolecular weight:287.315Antiproliferative agent-42
Antiproliferative Agent-42 (Compound 7m), a dihydrodipyrrolo compound, exhibits antiproliferative activity against the Panc-1 cell line, with an IC 50 of 12.54Color and Shape:Odour SolidBeclin1-Bcl-2 interaction inhibitor 1
Beclin1-Bcl-2 Interaction Inhibitor 1 effectively disrupts the binding of Beclin 1 to Bcl-2, and is utilized in cancer and neurodegeneration research [1].Color and Shape:Odour SolidAc-FEID-CMK
Ac-FEID-CMK: Potent inhibitor for zebrafish GSDMEb, reduces pyroptosis, and lessens septic AKI.Formula:C27H37ClN4O9Color and Shape:SolidMolecular weight:597.06Azalamellarin N
CAS:Azalamellarin N is a pyroptosis inhibitor that exhibits varying inhibitory effects on different pyroptosis inducers. It functions by targeting molecules upstream of NLRP3 inflammasome activation, instead of directly affecting the components of the NLRP3 inflammasome. Its inhibitory potency against various inducers is ranked as follows: Nigericin > R837 [1].Formula:C28H22N2O7Color and Shape:SolidMolecular weight:498.48Trilexium
CAS:Trilexium (TRX-E-009-1), a third-generation benzopyran structurally related to TRX-E-002-1, increases p21 protein expression, induces apoptosis, depolymerizes microtubules, and demonstrates broad anti-cancer activity [1] [2].Formula:C24H23FO6Color and Shape:SolidMolecular weight:426.43Barasertib
CAS:AZD1152 is a pro-drug of Barasertib (AZD1152)-hQPA. Which is a highly selective Aurora B inhibitor with IC50 of 0.37 nM in a cell-free assay.Formula:C26H31FN7O6PPurity:99.92% - 99.97%Color and Shape:SolidMolecular weight:587.54XIAP BIR2/BIR2-3 inhibitor-1
CAS:XIAP BIR2/BIR2-3 inhibitor-1 (compound 3) serves as a potent dual inhibitor targeting BIR2 and BIR2-3 domains, with IC50 values of 1.9 nM and 0.8 nM, respectively. This compound is utilized in cancer research studies [1].Formula:C72H96N16O14Color and Shape:SolidMolecular weight:1409.63Azurin p28 peptide
CAS:Azurin p28 peptide, a tumor-penetrating antitumor agent, stabilizes p53 by reducing its proteasomal degradation via the formation of a p28:p53 complex.
Formula:C122H197N31O47S2Color and Shape:SolidMolecular weight:2914.18PD-1/PD-L1-IN-48
PD-1/PD-L1-IN-48 (compound HD10) is an effective inhibitor of the PD-1/PD-L1 interaction, exhibiting an IC50 of 3.1 nM. It plays a vital role in cancer research.Color and Shape:Odour SolidBcI-2/BcI-xI ligand 1
CAS:BcI-2/BcI-xI ligand 1, functioning as a BcI-2/BcI-xI ligand, is utilized in the synthesis of PROTAC BcI-2/BcI-xI Degrader-1 .Formula:C53H64ClF3N6O8S3Color and Shape:SolidMolecular weight:1101.75Necroptosis-IN-4
Necroptosis-IN-4 is an effective inhibitor of necroptosis, specifically targeting RIP kinase 1 (RIPK1) without inhibitory activity against RIPK3. It exhibits weak inhibitory effects on VEGFR1/2 and PDGFR-α.Color and Shape:Odour Solid5-Fluorouracil-13C,15N2
CAS:5-Fluorouracil-13C,15N2 is a standard for quantifying 5-fluorouracil via GC/LC-MS and blocks DNA synthesis, causing cell apoptosis.Formula:C4H3FN2O2Color and Shape:SolidMolecular weight:133.057RET Ligand-Linker Conjugate-1
RET Ligand-Linker Conjugate-1 consists of a complex formed by a RET ligand and a linker, which can be utilized in the synthesis of QZ2135.Formula:C40H44N10OColor and Shape:SolidMolecular weight:680.84Necroptosis-IN-5
Necroptosis-IN-5 (Compound 26) is an orally active inhibitor of necroptotic cell death (necroptosis). This compound also exhibits potent inhibitory activity against receptor-interacting protein kinase 1 (RIPK1). It can be utilized in research related to inflammatory diseases, neurodegenerative disorders, and cancer associated with necroptosis.Color and Shape:Odour SolidEGFR/DHFR-IN-2
EGFR/DHFR-IN-2 (9b) is a dual inhibitor of h-DHFR/EGFR TK, exhibiting IC50 values of 0.192 μM for h-DHFR and 0.109 μM for EGFR. It causes cell cycle arrest at the G1/S phase and induces apoptosis. Additionally, EGFR/DHFR-IN-2 (9b) is a potential inhibitor of CYP2C9 and CYP3A4. This compound can be utilized in cancer research.Formula:C24H16N4O5Color and Shape:SolidMolecular weight:440.11207PBE-AMF
PBE-AMF is a prodrug that activates H2O2 and exhibits anticancer activity. It impedes tumor proliferation by inhibiting DNA synthesis, reducing ATP levels, inducing cell death (apoptosis), and blocking the cell cycle. PBE-AMF effectively and selectively inhibits the proliferation of MDA-MB-231 cells (IC50=6.4 μM) while sparing non-cancerous MCF-10A cells.Color and Shape:Odour SolidFOXO4-DRI
CAS:FOXO4-DRI: a peptide blocking FOXO4/p53 interaction; induces senescent cells' apoptosis.Formula:C228H388N86O64Color and Shape:SolidMolecular weight:5358.06TNF-α Antagonist
CAS:TNF-α antagonist is an exocyclic peptide that mimics the critical TNF-α recognition loop on TNF receptor I complex and, thus, prevents ligand interaction withFormula:C58H71N11O15S2Color and Shape:SolidMolecular weight:1226.39Antagonist G TFA
Potent vasopressin blocker, Antagonist G TFA also mildly inhibits GRP & Bradykinin, triggers AP-1, enhances chemo response.Formula:C51H67F3N12O8SColor and Shape:SolidMolecular weight:1065.21(E/Z)-Eltrombopag 13C4
CAS:(E/Z)-Eltrombopag 13C4 is a mix of E/Z isotopologues, both 13C-labeled TPO receptor agonists for thrombocytopenia.Formula:C25H22N4O4Color and Shape:SolidMolecular weight:446.444Endoplasmic Reticulum Stress Compound Library
A unique collection of 193 endoplasmic reticulum stress (ER stress) related compounds used for high throughput screening (HTS) and high content screening (HCS);Color and Shape:Odour SolidRef: TM-L9700
1mgTo inquire30μL*10mM (DMSO)To inquire50μL*10mM (DMSO)To inquire100μL*10mM (DMSO)To inquire250μL*10mM (DMSO)To inquireVarlilumab
CAS:Varlilumab (CDX-1127) is a novel human IgG1 anti-CD27 monoclonal antibody. Varlilumab has antitumor activity and can be used to study advanced solid tumors.Purity:SDS-PAGE:95% SEC-HPLC:98.65%Color and Shape:LiquidMolecular weight:146 kDaXIAP BIR2/BIR2-3 inhibitor-3
CAS:XIAP BIR2/BIR2-3 Inhibitor-3 functions as a dual inhibitor targeting both BIR2 and BIR2-3 domains, exhibiting potent activity with IC50 values below 1 nM. This compound is utilized in cancer research [1].Formula:C86H106N18O16S2Color and Shape:SolidMolecular weight:1712Cot inhibitor-1 hydrochloride
Cot inhibitor-1 hydrochloride blocks TPL-2 kinase (IC50=28nM) and TNF-α synthesis (IC50=5.7nM) in human blood.Formula:C27H28Cl3FN8Purity:98.37%Color and Shape:SoildMolecular weight:589.92Ref: TM-T10865L
1mg118.00€5mg227.00€10mg359.00€25mg598.00€50mg852.00€100mg1,153.00€1mL*10mM (DMSO)268.00€4-Nitrothalidomide
CAS:4-Nitrothalidomide is a modified form of thalidomide that inhibits the growth and proliferation of HUVEC cells and is commonly used in the synthesis of pomalidomide, which has anticancer potential.Formula:C13H9N3O6Purity:99.94%Color and Shape:SolidMolecular weight:303.23p-MPPF
CAS:p-MPPF is a 5-HT antagonist that can be used to study neurological diseases.Formula:C25H27FN4O2Purity:99.92%Color and Shape:SolidMolecular weight:434.51CIGB-300
CAS:CIGB-300 (P15-Tat) is an anti-casein kinase 2 (CK2) peptide that exhibits anticancer properties by disrupting the phosphorylation activity of protein kinase CK2. The compound induces apoptosis in various tumor cell lines, making it valuable for research in cancer therapy.Formula:C127H215N53O30S3Color and Shape:SolidMolecular weight:3060.6MMRi62
CAS:MMRi62, a MDM2-MDM4 inhibitor, induces ferroptosis and autophagy in PDAC, degrades FTH1 and mutant p53, and inhibits KRAS/TP53 mutant PDAC in mice.Formula:C21H15Cl2N3OPurity:99.87%Color and Shape:SoildMolecular weight:396.27Ref: TM-T60202
1mg35.00€5mg70.00€10mg104.00€25mg202.00€50mg329.00€100mg525.00€500mg1,121.00€1mL*10mM (DMSO)78.00€Ac-Trp-Glu-His-Asp-Aldehyde
CAS:Ac-Trp-Glu-His-Asp-Aldehyde is a powerful and selective inhibitor of caspase-1, demonstrating a K_i value of 56 pM [1] [2].Formula:C28H33N7O9Color and Shape:SolidMolecular weight:611.6Reproxalap
CAS:Reproxalap (NS-2) is a dry eye treatment that neutralizes aldehydes like malondialdehyde.
Formula:C12H13ClN2OPurity:99.4% - 99.97%Color and Shape:SolidMolecular weight:236.7YX0798
YX0798 is a selective, orally active CDK9 inhibitor (Kd: 0.28 nM). It downregulates the oncogenic protein c-MYC and the pro-survival protein MCL-1. YX0798 disrupts the cell cycle and causes transcriptome reprogramming, ultimately leading to apoptosis. The compound exhibits antitumor activity.Formula:C21H19ClF3N5O2Color and Shape:SolidMolecular weight:465.86Anti-inflammatory agent 35
CAS:Anti-inflammatory agent 35 is a potent anti-inflammatory agent.Formula:C27H29NO8Purity:99.98%Color and Shape:SoildMolecular weight:495.52Apoptosis inducer 32
Apoptosisinducer 32 (Compound 7g) is an apoptosis inducer with a KD of 42 μM, demonstrating antitumor activity by causing significant morphological changes, such as membrane blebbing, nuclear fragmentation, and apoptotic body formation, in MDA-MB-231 cells. The IC50 values for Apoptosisinducer 32 are 4.77 μM in MCF-7 cells, 6.56 μM in MDA-MB-231 cells, and 337.8 μM in HEK cells.Formula:C29H27Cl2N3O8Color and Shape:SolidMolecular weight:616.45PD-L1 inhibitory peptide
CAS:PD-L1inhibitory peptide is an inhibitor peptide that targets the programmed cell death ligand 1 (PD-L1). By binding to PD-L1, it lifts immune suppression and restores the anti-tumor activity of T cells. PD-L1inhibitory peptide holds promise for use in tumor research.Formula:C96H135N21O23SColor and Shape:SolidMolecular weight:1983.29FL118
CAS:FL118 is a novel survivin inhibitor that inhibits cancer stem cell-like properties.FL118 is a novel camptothecin analog with anticancer activity that inhibitsFormula:C21H16N2O6Purity:97.14%Color and Shape:SoildMolecular weight:392.36RIPK1-IN-25
RIPK1-IN-25 (WL8) is a RIPK1 inhibitor with blood-brain barrier permeability, displaying an EC50 of 19.9 nM and a Kd of 25 nM. It is utilized in the research of neurodegenerative diseases.Color and Shape:Odour SolidCarbonic anhydrase inhibitor 33
Carbonic anhydrase inhibitor33 (11D) is a dual inhibitor that targets both CA (carbonic anhydrase) IX/XII and CDK6. It exhibits Ki values of 19.7 nM for hCA IX and 26.1 nM for hCA XII. Additionally, Carbonic anhydrase inhibitor33 (11D) can induce G1 phase cell cycle arrest and apoptosis, making it relevant for research in non-small cell lung cancer (NSCLC).Formula:C19H15FN6O2SColor and Shape:SolidMolecular weight:410.09612CDK2-IN-45
CDK2-IN-45 is a CDK2 inhibitor with an IC50 value of 0.64 μM. It effectively inhibits the proliferation of DU-145 and PC-3 cell lines, with IC50 values of 2.20 μM and 4.17 μM, respectively. Additionally, CDK2-IN-45 induces G0/G1 phase cell cycle arrest and apoptosis. It is utilized in prostate cancer research.Formula:C25H16ClN5SColor and Shape:SolidMolecular weight:453.95PI3K-AKT-mTOR Compound Library
A unique collection of 420 compounds targeting PI3K/Akt/mTOR signaling for research in PI3K/Akt/mTOR signaling, and drug discovery in diseases involved withColor and Shape:Odour SolidRef: TM-L1300
1mgTo inquire30μL*10mM (DMSO)To inquire50μL*10mM (DMSO)To inquire100μL*10mM (DMSO)To inquire250μL*10mM (DMSO)To inquireNecroptosis-IN-3
CAS:Necroptosis-IN-3 (Cyclohexanecarboxamide, N-(2-thienylmethyl)-) (Compound 69) is a Necroptosis inhibitor that inhibits TNF-α induced necroptosis.Formula:C12H17NOSPurity:99.85%Color and Shape:SoildMolecular weight:223.33
