Apoptosis
Apoptosis inhibitors are compounds that prevent or delay the process of programmed cell death, known as apoptosis. These inhibitors are vital in studying cell survival mechanisms and are used to investigate diseases where apoptosis is dysregulated, such as cancer, neurodegenerative disorders, and autoimmune diseases. By modulating apoptosis, these inhibitors can help in the development of therapies aimed at controlling cell death. At CymitQuimica, we provide a comprehensive selection of high-quality apoptosis inhibitors to support your research in cell biology, oncology, and related fields.
Subcategories of "Apoptosis"
- ASK(6 products)
- BCL(11 products)
- Caspase(125 products)
- FOXO1(3 products)
- IAP(66 products)
- Mdm2(12 products)
- PD-1/PD-L1(125 products)
- PDK(9 products)
- PERK(25 products)
- Serine/threonin kinase(15 products)
- Survivin(13 products)
- TNF(92 products)
- c-RET(51 products)
- p53(62 products)
Show 6 more subcategories
Found 5592 products of "Apoptosis"
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CPT-Se3
CAS:<p>CPT-Se3, a camptothecin derivative, boosts anticancer activity, triggers apoptosis in Hep G2, and is cytotoxic to various cells with IC50 of 2.19-4.7 μM.</p>Formula:C24H20N2O6Se2Purity:98%Color and Shape:SolidMolecular weight:590.35HDAC-IN-46
CAS:<p>HDAC-IN-46 inhibits HDAC1 & HDAC6, affects p-p38, Bcl-xL & cyclin D1, blocks G2 phase & induces apoptosis in TNBC research.</p>Formula:C22H30N8O2Color and Shape:SolidMolecular weight:438.53AAPK-25
CAS:<p>AAPK-25, a dual Aurora/PLK inhibitor, disrupts mitosis, induces apoptosis, and has antitumor properties.</p>Formula:C21H13Cl2N3O2SPurity:97.05%Color and Shape:SolidMolecular weight:442.32Bcl-2-IN-13
CAS:<p>Bcl-2-IN-13 is a potent inhibitor of Bcl-2, exhibiting an IC50 of 17 nM, and holds potential for use in cancer research [1].</p>Formula:C42H44ClN7O6S3Color and Shape:SolidMolecular weight:874.49EAD1 TFA(1644388-26-0 Free base)
CAS:<p>EAD1 HCL is a potent autophagy inhibitor with antiproliferative activity in lung and pancreatic cancer cells. EAD1 HCL also induces apoptosis</p>Formula:C26H28Cl2F3N7O2Purity:97.41%Color and Shape:SolidMolecular weight:598.451-Stearoyl-2-Adrenoyl-sn-glycero-3-PC
CAS:<p>1-Stearoyl-2-Adrenoyl-sn-glycero-3-PC (PC(18:0/22:4)) acts as a cyclin-dependent kinase (CDK) inhibitor, promoting apoptosis and restricting the proliferation of various cancer cell lines [1].</p>Formula:C48H88NO8PColor and Shape:SolidMolecular weight:838.19APE1-IN-2
CAS:<p>APE1-IN-2 (AP1), a Pt(IV) proagent, targets APE1 protein, induces DNA damage, and triggers apoptosis with anticancer effects.</p>Formula:C9H12Cl2N4O5PtPurity:98%Color and Shape:SolidMolecular weight:522.21C 87
CAS:<p>C 87: Small-molecule TNF-α inhibitor, binds TNFα, inhibits cytotoxicity with IC50 of 8.73 μM, blocks signaling.</p>Formula:C24H15ClN6O3SPurity:≥98%Color and Shape:SolidMolecular weight:502.93BTM-3566
CAS:<p>BTM-3566 triggers ISR via OMA1, induces apoptosis in cancer cells, and is used to research DLBCL.</p>Formula:C24H23F4N3O2S2Purity:99.95%Color and Shape:SolidMolecular weight:525.58Z-YVAD-CMK
CAS:<p>Z-YVAD-CMK is an inhibitor of both caspase-1 and caspase-3, as referenced in [1].</p>Formula:C30H37ClN4O9Purity:98%Color and Shape:SolidMolecular weight:633.09SCH79797 dihydrochloride
CAS:<p>SCH79797 dihydrochloride is a PAR1 antagonist with IC50 70 nM, Ki 35 nM, antiproliferative, and pro-apoptotic properties.</p>Formula:C23H27Cl2N5Purity:99.5%Color and Shape:SolidMolecular weight:444.4INU-152
CAS:<p>INU-152: pan-RAF inhibitor with potent anti-tumor effects on BRAFV600E cancers, inhibits MAPK in mutant cells, minimal side effects on RAS-mutant melanoma.</p>Formula:C20H13F2N7O3SPurity:98%Color and Shape:SolidMolecular weight:469.42Siremadlin (R Enantiomer)
CAS:<p>Siremadlin R Enantiomer is the R enantiomer of Siremadlin. Siremadlin is a potent and highly specific inhibitor of MDM-2/p53.</p>Formula:C26H24Cl2N6O4Purity:98%Color and Shape:SolidMolecular weight:555.41USP7-IN-3
CAS:<p>USP7-IN-3 is a potent and selective allosteric inhibitor of ubiquitin-specific protease 7 (USP7).</p>Formula:C29H31F3N6O3Purity:98%Color and Shape:SolidMolecular weight:568.59SC 67655
CAS:<p>SC 67655 is a peptidomimetic that specifically suppresses human leukocyte antigen DRB10401-restricted T cell proliferation.</p>Formula:C37H62N6O9Purity:98%Color and Shape:SolidMolecular weight:734.92Merodantoin
CAS:<p>Merodantoin induces apoptosis in KRAS-mutant cancer cells via ROS-autophagy and Akt pathway.</p>Formula:C11H18N2O2SPurity:99.8%Color and Shape:SolidMolecular weight:242.34PF-07284892
CAS:<p>PF-07284892 (ARRY-558) is an orally active allosteric SHP2 inhibitor (IC50 = 21 nM) that reduces pERK expression and may be employed in solid tumour research.</p>Formula:C21H22ClN7SPurity:97.77%Color and Shape:SolidMolecular weight:439.96HM90822
CAS:<p>HM90822 is an IAP antagonist that inhibits XIAP and cIAP1/2 protein expression, induces IAP ubiquitination and promotes proteasome-dependent IAP degradation.</p>Formula:C30H36ClF2N7O4Purity:99.66%Color and Shape:SolidMolecular weight:632.1LY303511 hydrochloride
CAS:<p>LY303511, a structural analog of LY294002, selectively inhibits mTOR-dependent phosphorylation of S6K, unlike its counterpart, which acts as a phosphatidylinositol 3-kinase (PI3K) inhibitor. It effectively reduces cell proliferation in human lung epithelial adenocarcinoma cells by hindering G2/M phase progression and suppressing casein kinase 2 activity. Additionally, LY303511 enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) sensitivity in HeLa cells resistant to TRAIL-induced apoptosis and blocks voltage-gated potassium (Kv) channels.</p>Formula:C19H20Cl2N2O2Color and Shape:SolidMolecular weight:379.28Bcl-2-IN-12
CAS:<p>Bcl-2-IN-12 (Compound 1) is a potent Bcl-2 inhibitor with an IC50 value of 6 nM, utilized in cancer research [1].</p>Formula:C47H41ClN4O6SColor and Shape:SolidMolecular weight:825.37Mcl-1 inhibitor 17
CAS:<p>Mcl-1 Inhibitor 17 is a compound that functions as an inhibitor of the Mcl-1 protein, specifically designed for use in cancer and other disease research [1].</p>Formula:C27H25FN4O2Color and Shape:SolidMolecular weight:456.51Lepadin E
CAS:<p>Lepadin E, a notably cytotoxic compound, effectively stimulates ferroptosis via the canonical p53-SLC7A11-GPX4 pathway.</p>Formula:C26H47NO3Purity:98%Color and Shape:SolidMolecular weight:421.66Calicheamicin
CAS:<p>Calicheamicin (Calicheamicin γ1) is an antitumor antibiotic and is a DNA synthesis inhibitor. It also is a cytotoxic agent that causes double-strand DNA breaks.</p>Formula:C55H74IN3O21S4Purity:98.22% - 98.78%Color and Shape:SolidMolecular weight:1368.35PD-1/PD-L1-IN-22
CAS:<p>PD-1/PD-L1-IN-22 is a small molecule inhibitor of PD-1/PD-L1 protein-protein interactions that blocks PD-1/PD-L1 interactions (IC50: 0.732 μM).</p>Formula:C25H26BrClN2O3Color and Shape:SolidMolecular weight:517.84rac-CCT-250863
CAS:<p>Rac-CCT-250863, a potent Nek2 inhibitor, exhibits selectivity for Nek2 over PLK1, MPS1, Cdk2 and Aurora A.</p>Formula:C24H25F3N4O2SColor and Shape:SolidMolecular weight:490.54YM458
CAS:<p>YM458 inhibits EZH2 (490 nM) and BRD4 (34 nM), curbing tumor cell growth and inducing apoptosis.</p>Formula:C53H61ClN8O5SPurity:98%Color and Shape:SolidMolecular weight:957.62WYE-132
CAS:<p>WYE-125132: potent mTOR inhibitor, IC50 0.19 nM, selective over PI3Ks/hSMG1/ATR.</p>Formula:C27H33N7O4Purity:99.16%Color and Shape:SolidMolecular weight:519.6CA-170
CAS:<p>PD-1-IN-1 is a programmed cell dealth-1inhibitor. PD-1-IN-1 can be used as an immune modulator.</p>Formula:C12H20N6O7Purity:98%Color and Shape:SolidMolecular weight:360.32RIPK-IN-4
CAS:<p>RIPK-IN-4 is an effective and selective inhibitor of RIPK2. It also has excellent oral bioavailability (IC50: 3 nM).</p>Formula:C18H21FN4O3SPurity:98%Color and Shape:SolidMolecular weight:392.45CPT-Se4
CAS:<p>CPT-Se4, a seleno-derivative of CPT, effectively kills cancer cells, triggers apoptosis, and is cytotoxic against various cell lines.</p>Formula:C25H24N2O7Se2Purity:98%Color and Shape:SolidMolecular weight:622.39c-Met/MEK1/Flt-3-IN-1
<p>Antiproliferative Against-3 (comp 33) demonstrates significant activity against Hela (IC 50 = 0.21 µM), A549 (IC 50 = 0.39 µM), and MCF-7 (IC 50 = 0.33 µM) cell</p>Formula:C39H37FN6O5Color and Shape:SolidMolecular weight:688.75PIM447
CAS:<p>PIM447 (LGH447) is a pan-PIM kinase inhibitor with anti-tumor and bone protective effects. PIM447 reduces the viability, and motility of HuH6 cell.</p>Formula:C24H23F3N4OPurity:98.97%Color and Shape:SolidMolecular weight:440.46HSP90/mTOR-IN-1
<p>"HSP90/mTOR-IN-1 is a dual Hsp90/mTOR inhibitor (IC50: 69/29 nM), halting SW780 cell growth and inducing apoptosis/autophagy in cancer research."</p>Formula:C36H34ClFN6O5SColor and Shape:SolidMolecular weight:717.21MI-219
CAS:<p>MI-219 is a human double minute 2 (HDM2) inhibitor.</p>Formula:C27H32Cl2FN3O4Color and Shape:SolidMolecular weight:552.47Boserolimab
CAS:<p>Boserolimab (MK-5890) is a chimeric, humanized IgG1κ antibody that targets the signaling regulatory protein CD27 in mice.</p>Color and Shape:LiquidHDAC-IN-53
CAS:<p>HDAC-IN-53 inhibits HDAC1-3 with IC50s: 47, 125, 450 nM. Inactive on class II HDACs; triggers apoptosis; reduces tumor growth in mice.</p>Formula:C23H20ClN7O2Purity:98%Color and Shape:SolidMolecular weight:461.9CUR61414
CAS:<p>CUR61414 is a cell-permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM) and selectively binds to smoothened (Ki = 44 nM).</p>Formula:C31H42N4O5Purity:97.34% - 98%Color and Shape:SolidMolecular weight:550.69eIF4A3-IN-9
CAS:<p>eIF4A3-IN-9, a silvestrol analogue, disrupts eIF4F complex assembly; EC50s: 29/450/80 nM (myc/tub-LUC, MB-231 cells); for cancer research.</p>Formula:C28H27NO8Color and Shape:SolidMolecular weight:505.52HDAC-IN-59
CAS:<p>HDAC-IN-59 (compound 13a), a potent histone deacetylase (HDAC) inhibitor, enhances intracellular reactive oxygen species (ROS) production, induces DNA damage,</p>Formula:C20H25NO7Purity:98%Color and Shape:SolidMolecular weight:391.42eIF4A3-IN-18
CAS:<p>eIF4A3-IN-18, a silvestrol analogue with EC50s: 0.8/35/2 nM, inhibits eIF4F complex and is cytotoxic (LC50: 0.06 nM) for cancer research.</p>Formula:C29H28N2O6Color and Shape:SolidMolecular weight:500.54BPR1J-340
CAS:<p>BPR1J-340, a novel potent FLT3 inhibitor, shows anticancer promise, with IC50 ~25 nM and GC50 ~5 nM, causing apoptosis in AML cells.</p>Formula:C29H34N8O3Color and Shape:SolidMolecular weight:542.63YS-363
CAS:<p>YS-363 is a potent, selective, and orally active inhibitor of the epidermal growth factor receptor (EGFR), exhibiting half-maximal inhibitory concentrations (</p>Formula:C30H30N4O3Purity:98%Color and Shape:SolidMolecular weight:494.58FLT3-IN-14
CAS:<p>FLT3-IN-14: FLT3 inhibitor; FLT3-WT IC50=5.6nM, FLT3-ITD IC50=1.4nM; blocks Y591 phosphorylation; G1 arrest; pro-apoptotic.</p>Formula:C25H24N6O2SColor and Shape:SolidMolecular weight:472.56Immunosuppressant-1
CAS:<p>Immunosuppressant-1 (Compound 31) suppresses T-cell proliferation triggered by anti-CD3/anti-CD28 co-stimulation and demonstrates immunosuppressive effects,</p>Formula:C14H12BrNO3Purity:98%Color and Shape:SolidMolecular weight:322.15RUNX-IN-2
CAS:<p>RUNX-IN-2 (Compound Conjugate 3) covalently attaches to RUNX-binding sequences, preventing RUNX proteins from associating with their targets, thereby inhibiting</p>Formula:C71H88Cl2N24O11Purity:98%Color and Shape:SolidMolecular weight:1524.52Thaspine acetate
CAS:<p>Thaspine: inhibits topoisomerase IB, reduces VEGF, stops endothelial cell growth via PI3K/MAPK pathways.</p>Formula:C22H23NO8Color and Shape:SolidMolecular weight:429.425ST1074
CAS:<p>ST1074, a dual inhibitor of CerS2 and CerS4, promotes apoptosis and is applicable in cancer research [1].</p>Formula:C20H36ClNO3Purity:98%Color and Shape:SolidMolecular weight:373.96BQZ-485
CAS:<p>BQZ-485, a potent GDI2 inhibitor, interacts with Tyr245 to disrupt the native GDI2-Rab1A interaction.</p>Formula:C32H39NO3Purity:98%Color and Shape:SolidMolecular weight:485.66IK-862
CAS:<p>IK-862 is a selective TACE inhibitor with potential anti-inflammatory and anticancer activity for the study of neuritis.</p>Formula:C25H27N3O4Purity:97.75% - 98.29%Color and Shape:SolidMolecular weight:433.5Tubulin polymerization-IN-56
CAS:<p>Tubulin Polymerization-IN-56 (compound 8l), an indazole derivative, potently inhibits tubulin polymerization by targeting the colchicine site, which induces</p>Formula:C22H22ClN3O3Color and Shape:SolidMolecular weight:411.88D359-0396
CAS:<p>D359-0396 is an orally active NLRP3 inflammasome inhibitor that mitigates pyroptosis and reduces IL-1β release in macrophages by inhibiting the oligomerization</p>Formula:C24H24N4O2Purity:98%Color and Shape:SolidMolecular weight:400.472-Chlorophenoxazine
CAS:<p>2-Chlorophenoxazine is an Akt inhibitor that demonstrates an in vitro inhibitory concentration (IC50) of 2-5 μM and has the capacity to induce apoptosis.</p>Formula:C12H8ClNOPurity:98%Color and Shape:SolidMolecular weight:217.65(Rac)-Lisaftoclax
CAS:<p>(Rac)-Lisaftoclax ((Rac)-APG-2575), a Bcl-2 inhibitor, is utilized in hematologic malignancy research (CN112898295A) [1].</p>Formula:C45H48ClN7O8SColor and Shape:SolidMolecular weight:882.42NWP-0476
CAS:<p>NWP-0476 is a modified BCL-2/BCL-xL inhibitor with enhanced specificity for BCL-xL, suitable for research on relapsed T-acute lymphoblastic leukemia (T-ALL) [1</p>Formula:C47H53ClN8O8SColor and Shape:SolidMolecular weight:925.49FHND5071
CAS:<p>FHND5071, a potent and selective RET kinase inhibitor, exerts antitumor effects through the inhibition of RET autophosphorylation and may be utilized for tumor</p>Formula:C30H30D3N9OColor and Shape:SolidMolecular weight:538.66p-Tolylmaleimide
CAS:<p>p-Tolylmaleimide (p Tolylmaleimide) is an inhibitor of the water channel and binds to Aquaporin Z.</p>Formula:C11H9NO2Purity:99.94%Color and Shape:SolidMolecular weight:187.19MP7
CAS:<p>MP7 (PDK1 inhibitor) is a inhibitor of phosphoinositide-dependent kinase-1 (PDK1).</p>Formula:C28H22F2N4O4Purity:99.84% - 99.89%Color and Shape:SolidMolecular weight:516.5Eeyarestatin I
CAS:<p>Eeyarestatin I blocks ER protein degradation, hinders p97/atx3 processes, and induces anticancer proteins.</p>Formula:C27H25Cl2N7O7Purity:98% - 98.99%Color and Shape:SolidMolecular weight:630.44KSQ-4279
CAS:<p>KSQ-4279 (USP1-IN-1) is an inhibitor of USP1 and PARP.KSQ-4279 has anticancer activity and is used in the study of non-small cell lung cancer, osteosarcoma,</p>Formula:C27H25F3N8OPurity:99.76% - 99.79%Color and Shape:SoildMolecular weight:534.54PARP1/2/TNKS1/2-IN-1
CAS:<p>PARP1/2/TNKS1/2-IN-1 is a multi-target inhibitor of PARP-1, PARP-2, TNKS1 and TNKS2.PARP1/2/TNKS1/2-IN-1 has anti-tumor activity and induces apoptosis.</p>Formula:C35H31FN6O5Purity:99.63%Color and Shape:SolidMolecular weight:634.66Nanatinostat
CAS:<p>Nanatinostat (CHR-3996) is an HDAC inhibitor with selectivity and oral bioavailability, for HDAC1/2/3 .anti-proliferation apoptosis.</p>Formula:C20H19FN6O2Purity:99.03%Color and Shape:SolidMolecular weight:394.4CPI-360
CAS:<p>CPI-360 is a small molecule EZH2 inhibitor (IC50: 0.002 μM, EC50: 0.080 μM) that shows antitumor activity in an EZH200-dependent tumor xenograft model.</p>Formula:C25H31N3O4Purity:99.52%Color and Shape:SolidMolecular weight:437.53M3541
CAS:<p>M3541: an oral ATM inhibitor with antitumor effects, hinders DNA repair and promotes cancer cell death.</p>Formula:C23H17FN6O2Purity:98.97%Color and Shape:SolidMolecular weight:428.42CDC801
CAS:<p>CDC801 is an inhibitor of PDE4 and TNF-α with IC50s of 1.1 μM and 2.5 μM, respectively.</p>Formula:C23H24N2O5Purity:99.61%Color and Shape:SolidMolecular weight:408.45CDDO-3P-Im
CAS:<p>CDDO-3P-Im is an orally active inhibitor of necroptosis with chemopreventive effects. CDDO-3P-Im can be used in studies about ischemia/reperfusion.</p>Formula:C39H46N4O3Purity:97.72%Color and Shape:SolidMolecular weight:618.81VU0661013
CAS:<p>VU0661013 is an effective and selective inhibitor of MCL-1.</p>Formula:C39H39Cl2N5O4Purity:99.04%Color and Shape:SolidMolecular weight:712.66NSC697923
CAS:<p>NSC-697923 inhibits UBE2N, triggers p53-dependent and JNK-mediated apoptosis, blocks DNA damage and NF-κB signaling in neuroblastoma cells.</p>Formula:C11H9NO5SPurity:97% - 99.71%Color and Shape:SolidMolecular weight:267.26GCN2-IN-7
CAS:<p>GCN2-IN-7 is an inhibitor of the environmental sensing protein GCN2 with antitumor activity for the study of melanoma.</p>Formula:C22H23BrN8OSPurity:99.12%Color and Shape:SolidMolecular weight:527.44CDDO-2P-Im
CAS:<p>CDDO-2P-Im shows chemopreventive effect and reduces the size and severity of the lung tumors in the mouse lung cancer model.</p>Formula:C39H46N4O3Purity:99.54%Color and Shape:SolidMolecular weight:618.81Elobixibat
CAS:<p>Elobixibat (A 3309) blocks IBAT in mice/humans/dogs (IC50: 0.13/0.53/5.8 nM); used for constipation research.</p>Formula:C36H45N3O7S2Purity:97.43% - 98.03%Color and Shape:SolidMolecular weight:695.89JHU395
CAS:<p>JHU395, an oral prodrug of glutamine antagonist DON, shows stable antitumor effects on MPNST in vitro and vivo.</p>Formula:C22H29N3O7Purity:99.15% - 99.26%Color and Shape:SolidMolecular weight:447.48AZA197
CAS:<p>AZA197 (AZA-197) is a selective Cdc42 inhibitor.</p>Formula:C24H36N6Purity:98.28%Color and Shape:SolidMolecular weight:408.58ZNL 02-096
CAS:<p>ZNL 02-096 (Pomalidomide-C3-adavosertib) is a rapid and selective degrader of Wee1 (IC50=3.58 nM).ZNL 02-096 selectively degrades Wee1 at submolar</p>Formula:C42H45N11O6Purity:99.02% - 99.84%Color and Shape:SolidMolecular weight:799.88RH01386
CAS:<p>RH01386, a small molecule, prevents ER stress in β cells, inhibits proapoptotic genes, and may treat type 2 diabetes by restoring insulin secretion.</p>Formula:C18H15F3N4O3SPurity:99.16% - 99.67%Color and Shape:SolidMolecular weight:424.4Tefinostat
CAS:<p>Tefinostat (CHR-2845) is a potent monocyte/macrophage-targeted histone deacetylase (HDAC) inhibitor.</p>Formula:C28H37N3O5Purity:99.83%Color and Shape:SolidMolecular weight:495.61GP 1a
CAS:<p>GP 1a: potent CB2 receptor agonist (EC50=7.1), 30x CB2 over CB1 preference, boosts P-ERK1/2, aids skin healing, anti-inflammatory.</p>Formula:C23H22Cl2N4OPurity:99.79%Color and Shape:SolidMolecular weight:441.35LB42708
CAS:<p>LB42708 is an orally active farnesyltransferase (FTase) inhibitor (IC50: 0.8/1.2/2.0 nM toward H/N/K-ras).</p>Formula:C30H27BrN4O2Purity:99.36%Color and Shape:SolidMolecular weight:555.47Alrizomadlin
CAS:<p>Alrizomadlin is an orally active MDM2 inhibitor. APG-115 shows significant dose-dependent inhibitory effects on TP53wt AML cell lines.Cost-effective and quality-assured.</p>Formula:C34H38Cl2FN3O4Purity:98.41% - 99.47%Color and Shape:SolidMolecular weight:642.59DuP-697
CAS:<p>DuP-697 is an irreversible, specific COX-2 inhibitor with IC50 values of 10 nM and 800 nM for human COX-2 and COX-1.Cost-effective and quality-assured.</p>Formula:C17H12BrFO2S2Purity:99.92%Color and Shape:SolidMolecular weight:411.31PP5-IN-1
CAS:<p>PP5-IN-1 is a serine/threonine protein phosphatase-5 (PP5) inhibitor with potential anticancer activity that induces apoptosis in cancer cells.</p>Formula:C18H18N2O3SPurity:99.13%Color and Shape:SolidMolecular weight:342.41MC4033
CAS:<p>MC4033 exhibits inhibitory concentration 50 (IC50) values of 39.4 µM in HCT116, 52.1 µM in H1299, 41 µM in A549, and 30.1 µM in U937 [1].</p>Formula:C16H13N3O3Purity:98.16%Color and Shape:SolidMolecular weight:295.29Ac-DEVD-CHO
CAS:<p>Ac-DEVD-CHO is a specific Caspase-3 inhibitor (Ki: 230 pM).Ac-DEVD-CHO has an inhibitory effect in SLNT-induced apoptosis.</p>Formula:C20H30N4O11Purity:98.69%Color and Shape:SolidMolecular weight:502.47HM43239
CAS:<p>HM43239: oral FLT3 inhibitor; IC50: FLT3 WT 1.1nM, ITD 1.8nM, D835Y 1.0nM; blocks p-STAT5/p-ERK; affects SYK, JAK1/2, TAK1; halts leukemia cell growth.</p>Formula:C29H33ClN6Purity:99.7%Color and Shape:SolidMolecular weight:501.07mTOR/HDAC6-IN-1
<p>mTOR/HDAC6-IN-1 inhibits HDAC6 (IC50: 56 nM) & mTOR (IC50: 133.7 nM), may treat TNBC by inducing autophagy and apoptosis.</p>Formula:C20H20ClN5O2Color and Shape:SolidMolecular weight:397.86Ganoderic acid R
CAS:<p>Ganoderic acid R: potent anticancer, induces apoptosis, cytotoxic to MDR and sensitive tumor cells.</p>Formula:C34H50O6Color and Shape:SolidMolecular weight:554.76TNF-α-IN-2
CAS:<p>TNF-α-IN-2 is orally active TNFα inhibitor that distorts the TNFα trimer, causing abnormal signal transduction when it binds to TNFR1, rheumatoid arthritis.</p>Formula:C25H21ClF2N6OPurity:99.92%Color and Shape:SolidMolecular weight:494.92RWJ-56110
CAS:<p>protease-activated receptor-1 (PAR1) antagonist</p>Formula:C41H43Cl2F2N7O3Purity:98%Color and Shape:SolidMolecular weight:790.73MJC13
CAS:<p>MJC13 is an FKBP52-targeting agent with antitumor activity, suitable for prostate cancer research.</p>Formula:C13H15Cl2NOColor and Shape:SolidMolecular weight:272.17SSB-2548
CAS:<p>SSB-2548 is a CXCR-4 inhibitor that suppresses the proliferation and migration of acute myeloid leukemia cells and induces apoptosis (apoptosis). It is well absorbed in the gastrointestinal tract and can be used for leukemia research.</p>Formula:C18H17N5O2Color and Shape:SolidMolecular weight:335.36MG28
CAS:<p>MG28 exhibits significant cytotoxic effects, likely stemming from its direct and potent DNA-damaging activity. The compound is utilized in cancer research.</p>Formula:C27H25NO3SColor and Shape:SolidMolecular weight:443.56PD-1/PD-L1-IN-55
CAS:<p>PD-1/PD-L1-IN-55 (compound D6) is a potent PD-1/PD-L1 inhibitor with an IC50 of 4.8 nM. It enhances IFN-γ secretion and decreases the proportion of late apoptosis due to PD-L1.</p>Formula:C25H23ClN2O3Color and Shape:SolidMolecular weight:434.92Flizasertib
CAS:<p>Flizasertib is a serine/threonine kinase inhibitor that acts by inhibiting RIPK1, which has anti-inflammatory and therapeutic effects on immune disorders.</p>Formula:C15H14FN3OPurity:99.39% - 99.57%Color and Shape:SolidMolecular weight:271.29PD-L1/HDAC6-IN-1
CAS:<p>PD-L1/HDAC6-IN-1 (Compound HP29) is an inhibitor targeting both PD-L1 and HDAC6, effectively disrupting the PD-L1/PD-1 interaction and inhibiting HDAC6 activity, with IC50 values of 26.8 nM and 69 nM, respectively. This compound enhances the cytotoxicity of Jurkat T cells against HepG2 cells, exhibiting an IC50 of 3.4 μM. In rats, PD-L1/HDAC6-IN-1 demonstrates favorable pharmacokinetics, showing a drug exposure level of 871.62 ng·h/mL, and displays antitumor activity in a B16-F10 xenograft mouse model.</p>Formula:C27H33N3O3Color and Shape:SolidMolecular weight:447.569Anticancer agent 53
CAS:<p>Anticancer agent 53 exhibits potent in vitro cytotoxicity, triggers apoptosis, halts S/G2/M cycle, and has antitumor effects without toxicity.</p>Formula:C31H25FN4O6SColor and Shape:SolidMolecular weight:600.62D-Cl-amidine hydrochloride
<p>D-Cl-amidine hydrochloride is a potent and highly selective inhibitor of PAD1. It exhibits excellent tolerance and does not induce significant toxicity [1].</p>Formula:C14H20Cl2N4O2Color and Shape:SolidMolecular weight:347.24PIM1-IN-3
<p>PIM1-IN-3 (HL8) selectively blocks PIM1, induces Colo320 cell apoptosis, and may be researched for cancer.</p>Formula:C27H25BrN6OColor and Shape:SolidMolecular weight:529.43ZLHQ-5f
<p>ZLHQ-5f inhibits CDK2/Topo I, with IC50 of 0.145μM for CDK2/CycA2, and promotes apoptosis by arresting HCT116 cells in S phase.</p>Formula:C28H25N5O2Color and Shape:SolidMolecular weight:463.53HDAC-IN-9
<p>HDAC-IN-9, a dual tubulin/HDAC inhibitor, impedes A549 cell invasion/migration and shows strong anti-tumor/angiogenic effects.</p>Formula:C33H38N2O4Color and Shape:SolidMolecular weight:526.67Enpp-1-IN-25
CAS:<p>Enpp-1-IN-25 (Compound 30) is an ENPP1 inhibitor with an IC50 of 8.05 nM and exhibits low oral bioavailability. By inhibiting cGAMP degradation, it effectively activates the intracellular STING pathway. Enpp-1-IN-25 can enhance immune cell infiltration and type I interferon response in the tumor microenvironment, thereby increasing the antitumor efficacy of anti-PD-L1 antibodies. It is applicable for research in cancer immunotherapy.</p>Formula:C15H21N5O4SColor and Shape:SolidMolecular weight:367.423Microtubule inhibitor 2
<p>Microtubule inhibitor 2: potent, selective, oral, induces ferroptosis, strong antitumor effect.</p>Formula:C20H23NO7Color and Shape:SolidMolecular weight:389.4
