Apoptosis
Apoptosis inhibitors are compounds that prevent or delay the process of programmed cell death, known as apoptosis. These inhibitors are vital in studying cell survival mechanisms and are used to investigate diseases where apoptosis is dysregulated, such as cancer, neurodegenerative disorders, and autoimmune diseases. By modulating apoptosis, these inhibitors can help in the development of therapies aimed at controlling cell death. At CymitQuimica, we provide a comprehensive selection of high-quality apoptosis inhibitors to support your research in cell biology, oncology, and related fields.
Subcategories of "Apoptosis"
- ASK(9 products)
- BCL(1 products)
- Caspase(154 products)
- FOXO1(2 products)
- IAP(67 products)
- Mdm2(12 products)
- PD-1/PD-L1(126 products)
- PDK(9 products)
- PERK(23 products)
- Serine/threonin kinase(17 products)
- Survivin(14 products)
- TNF(90 products)
- c-RET(61 products)
- p53(63 products)
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Found 6170 products of "Apoptosis"
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VEGFR-2-IN-11
VEGFR-2-IN-11 is a potent inhibitor of VEGFR-2 (IC50: 60.27 nM) with an IC50 value of 60.27 nM, which induces apoptosis and has anticancer activity.Formula:C29H22BrN5SColor and Shape:SolidMolecular weight:552.49β-Carotene-13C10
CAS:β-Carotene-13C10 (Provitamin A-13C10) is a form of β-Carotene labeled with 13C. It is a carotenoid compound and serves as a natural precursor to vitamin A. This compound acts as a regulator of reactive oxygen species (ROS), exhibiting both antioxidant and anti-inflammatory properties. Depending on its intrinsic characteristics and the redox potential of the biological environment, β-Carotene can function either as an antioxidant or a pro-oxidant. It also possesses anticancer activity, inducing apoptosis in breast cancer cells.Formula:C40H56Color and Shape:SolidMolecular weight:546.799Ferrostatin-1 diyne
CAS:Ferrostatin-1 diyne (Fer-1 diyne) (compound 2) serves as an inhibitor of ferroptosis, accumulating in cellular lysosomes, mitochondria, and the endoplasmic reticulum. It notably inhibits ferroptosis independently of lysosomal and mitochondrial activity.Formula:C18H22N2O2Color and Shape:SolidMolecular weight:298.38VDR agonist 1
CAS:Compound 28 is a nonsteroidal VDR agonist with 690 nM potency, inducing cell cycle arrest and apoptosis in MCF-7 cells.Formula:C32H51N3O2Purity:98%Color and Shape:SolidMolecular weight:509.77Antiangiogenic agent 7
CAS:Antiangiogenic agent 7 (Compound 1) induces apoptosis, elevates Reactive Oxygen Species (Reactive Oxygen Species), and inhibits the intracellular enzyme thioredoxin reductase. It exhibits anticancer activity with IC50 values ranging from 0.08 to 3.5 μM against cervical cancer cells (HeLa), prostate cancer cells (PC-3), and non-small cell lung cancer cells (A549). Additionally, Antiangiogenic agent 7 suppresses tumor growth in a mouse xenograft model.Formula:C24H26AuN3P2SColor and Shape:SolidMolecular weight:647.46CRI9
CRI9 effectively inhibits the c-MET/PI3K/Akt/mTOR axis, suppressing the proliferation of hepatocellular carcinoma (HCC) cells. This compound exhibits potent cytotoxicity against HCC cells and induces apoptosis.Formula:C26H18N6O4Color and Shape:SolidMolecular weight:478.463′-Hydroxyflavanone
CAS:3′-Hydroxyflavanone is a cyclized flavonoid with anti-tumor properties that induces apoptosis in HeLa cells.Formula:C15H12O3Color and Shape:SolidMolecular weight:240.25EGFR-IN-134
EGFR-IN-134 (compound 3f) is a triazolo[3,4-a]quinoline derivative and functions as a potent EGFR inhibitor with an IC50 of 0.023 µM. It induces apoptosis and necrosis in cells, and causes cell cycle arrest in the G2/M and pre-G1 phases. EGFR-IN-134 modulates the expression of apoptosis-regulating proteins by downregulating anti-apoptotic protein Bcl2 and upregulating pro-apoptotic proteins p53, Bax, and caspases 3, 8, and 9, demonstrating significant antiproliferative and anticancer activities.Formula:C36H30N6O5Color and Shape:SolidMolecular weight:626.66Isoforretin A
CAS:Isoforretin A is a potent inhibitor of thioredoxin-1 (Trx1) with significant biological activity, inducing anti-tumor effects mediated by reactive oxygen species (ROS). The compound inhibits Trx1 activity by covalently binding to the activation site residues Cys32/Cys35, which triggers ROS accumulation, leading to DNA damage and apoptosis (Apoptosis) in cancer cells. Additionally, Isoforretin A has demonstrated the ability to suppress the growth of HepG2 tumors in a mouse hepatic cell carcinoma xenograft model.Formula:C28H38O10Color and Shape:SolidMolecular weight:534.6MLKL-IN-6
MLKL-IN-6 (compound P28) is a mixed lineage kinase inhibitor that specifically targets the Mixed Lineage Kinase domain-like (MLKL) protein.
Formula:C20H18N4O5Purity:98%Color and Shape:SolidMolecular weight:394.38QTX125 TFA
QTX125 TFA: Potent, selective HDAC6 inhibitor with antitumor effects.Formula:C25H20F3N3O7Color and Shape:SolidMolecular weight:531.44Bayer-18
CAS:Bayer-18 is an inhibitor of TYK2. It inhibits the viability of anaplastic large cell lymphoma cells, including K299, SR786, Mac1, and Mac2a, with an IC50 ranging from 2-3 µM. Additionally, Bayer-18 induces apoptosis in K299 and SR786 cells.Formula:C19H27FN6O2Color and Shape:SolidMolecular weight:390.46HP590
CAS:HP590: potent oral STAT3 inhibitor, IC50=27.8 nM, blocks ATP, IC50=24.7 nM, hinders gastric cancer growth, triggers cell death.Formula:C29H24F6N4O3Color and Shape:SolidMolecular weight:590.52Cetzole
CAS:Cetzole (Compound 1) acts as an inducer of ferroptosis (iron-dependent cell death) through the accumulation of ROS, leading to cell death. The compound exhibits varying half-maximal cytotoxic concentrations (CC50) against several cell lines: 2.56 μM in NCI-H522, 10.31 μM in NCI-H522 GFP-SCL7A11 #8, 2.71 μM in NCI-H522 RV-GFP, 3.07 μM in HT-1080, 14.9 μM in NARF2, and 6.28 μM in MDA-MB-231. This highlights Cetzole's potential for research in cancer therapeutics.Formula:C11H11NOSColor and Shape:SolidMolecular weight:205.28VEGFR-IN-3
CAS:VEGFR-IN-3 inhibits cancer cell growth (OVCAR-4, MDA-MB-468) with IC50s: 0.29, 0.35μM. Used in cancer research.Formula:C27H28N2O6Color and Shape:SolidMolecular weight:476.52SL-176
CAS:SL-176, a WIP1 inhibitor, when combined with GSK-J4, can induce cell cycle arrest and apoptosis (apoptosis), thereby inhibiting tumor growth both in vitro and in vivo.Formula:C24H48O4Si2Color and Shape:SolidMolecular weight:456.806VEGFR-2-IN-15
VEGFR-2-IN-15 (Compound 14b) is a potent inhibitor of VEGFR-2. VEGFR-2-IN-15 inhibits the growth of HepG2 cells in the Pre-G1 phase and induces apoptosis.Formula:C23H18ClN3O4SColor and Shape:SolidMolecular weight:467.92Caspase-3-IN-2
CAS:Caspase-3-IN-2 (Compound 4d) acts as an inhibitor of α-Chymotrypsin. It also exhibits inhibitory activity against HIV protease and caspase 3, with inhibition rates of 57% and 51% respectively at a concentration of 100 μM.Formula:C10H6ClNO5Color and Shape:SolidMolecular weight:255.611SM-433 hydrochloride
SM-433 hydrochloride, a Smac mimetic & IAP inhibitor, binds XIAP BIR3; potent IC50 <1 μM. (Patent WO2008128171A2)Formula:C32H44ClN5O4Color and Shape:SolidMolecular weight:598.18Flonoltinib sulfate
CAS:Flonoltinib maleate is an orally active dual inhibitor of JAK2/FLT3, with IC50 values of 0.7 nM for JAK2, 4 nM for FLT3, 26 nM for JAK1, and 39 nM for JAK3. It exhibits anticancer properties.Formula:C25H36FN7O5SColor and Shape:SolidMolecular weight:565.661AQX-435
CAS:AQX-435 activates SHIP1, inhibits PI3K in BCR signaling, induces apoptosis in B cells, and slows lymphoma growth.Formula:C27H34N2O4Color and Shape:SolidMolecular weight:450.57CK156
CAS:CK156 inhibits DAPK with high selectivity; IC50: 182 nM (DRAK1), 34 μM (CK2a1), 39 μM (CK2a2); key in autoimmune/inflammation research.Formula:C21H25N5O3Color and Shape:SolidMolecular weight:395.45c-Met/HDAC-IN-2
CAS:Potent dual c-Met/HDAC inhibitor, IC50: HDAC1 5.4 nM, c-Met 18.49 nM; anti-cancer, induces apoptosis, G2/M arrest in HCT-116.Formula:C34H33N5O7Color and Shape:SolidMolecular weight:623.66Rafutrombopag
CAS:Rafutrombopag is a thrombopoietin (TPO) agonist.Formula:C25H22N4O5Color and Shape:SolidMolecular weight:458.472-Deoxy-L-ribose
CAS:2-Deoxy-L-ribose is the stereoisomer of 2-Deoxy-D-ribose and can inhibit the anti-apoptotic effects of 2-Deoxy-D-ribose. Additionally, 2-Deoxy-L-ribose is capable of suppressing tumor cell metastasis by downregulating thymidine phosphorylase overexpression.Formula:C5H10O4Color and Shape:SolidMolecular weight:134.13(R)-SL18
CAS:(R)-SL18 is a degrader of ANXA3 that facilitates its breakdown via ubiquitination. This compound can inhibit the proliferation, migration, invasion, and colony formation of breast cancer cells, while also inducing apoptosis. (R)-SL18 is applicable for research in triple-negative breast cancer.Formula:C26H21ClN6O5S2Color and Shape:SolidMolecular weight:597.065Antiproliferative agent-8
Compound 5a, an anticancer agent, enhances P53 and has antiproliferative effects.Formula:C22H16ClN3O3Color and Shape:SolidMolecular weight:405.83SSB-2548
CAS:SSB-2548 is a CXCR-4 inhibitor that suppresses the proliferation and migration of acute myeloid leukemia cells and induces apoptosis (apoptosis). It is well absorbed in the gastrointestinal tract and can be used for leukemia research.Formula:C18H17N5O2Color and Shape:SolidMolecular weight:335.36TZEP7
CAS:TZEP7 functions as an EGFR kinase inhibitor in cancer cells. It exhibits cytotoxicity and induces apoptosis within these cells. TZEP7 downregulates the anti-apoptotic protein Bcl-2, upregulates the pro-apoptotic protein Bax, and increases caspase levels. This compound holds potential for research in anticancer drug development.Formula:C27H19ClFNSColor and Shape:SolidMolecular weight:443.963TrxR/EGFR-IN-1
CAS:TrxR/EGFR-IN-1 (Compound L1Au2) is a TrxR/EGFR inhibitor with activity against both gefitinib-sensitive and -resistant lung cancer, effectively suppressing tumor proliferation and promoting apoptosis. It enhances GPX4 degradation through autophagosome-lysosome and proteasome pathways, leading to ferroptosis. Additionally, it induces endoplasmic reticulum stress and triggers immunogenic cell death, making it applicable for studies on gefitinib-resistant lung cancer.Formula:C24H24AuClFN6O2PColor and Shape:SolidMolecular weight:710.878p38 MAPK-IN-3
Compound 2c is a potent p38α MAPK inhibitor with antitumor effects, enhancing apoptosis and ROS.Formula:C22H17BrO2Color and Shape:SolidMolecular weight:393.27PARP1/BRD4-IN-2
PARP1/BRD4-IN-2, a potent inhibitor of PARP1 and BRD4, halts cell cycle, triggers apoptosis, and has antitumor effects on TNBC.Formula:C25H20N4O4Color and Shape:SolidMolecular weight:440.45MJC13
CAS:MJC13 is an FKBP52-targeting agent with antitumor activity, suitable for prostate cancer research.Formula:C13H15Cl2NOColor and Shape:SolidMolecular weight:272.17Enpp-1-IN-25
CAS:Enpp-1-IN-25 (Compound 30) is an ENPP1 inhibitor with an IC50 of 8.05 nM and exhibits low oral bioavailability. By inhibiting cGAMP degradation, it effectively activates the intracellular STING pathway. Enpp-1-IN-25 can enhance immune cell infiltration and type I interferon response in the tumor microenvironment, thereby increasing the antitumor efficacy of anti-PD-L1 antibodies. It is applicable for research in cancer immunotherapy.Formula:C15H21N5O4SColor and Shape:SolidMolecular weight:367.423Aplysin
CAS:Aplysin suppresses breast cancer cells and protects liver cells by blocking PI3K/AKT/FOXO3a and preventing oxidative damage.Formula:C15H19BrOColor and Shape:SolidMolecular weight:295.21HER2-IN-11
HER2-IN-11 is a psoralen derivative that induces apoptosis. HER2-IN-11 shows light-activated cytotoxicity and also exhibits anti-breast cancer activity [1].Formula:C17H11NO6Color and Shape:SolidMolecular weight:325.27Mcl-1 inhibitor 9
CAS:Mcl-1 Inhibitor 9 (Example 2) is a potent inhibitor of myeloid cell leukemia 1 (Mcl-1), demonstrating anti-tumor activity with an IC50 value of 0.21889 nM.Formula:C32H39ClN2O5SColor and Shape:SolidMolecular weight:599.18eIF4E-IN-4
CAS:eIF4E-IN-4 (Compound 33) is a selective inhibitor of the eukaryotic initiation factor 4E (eIF4E) with a biochemical activity value of 95 nM. It inhibits cap-dependent mRNA translation with an IC50 of 2.5 μM and is applicable in research on breast cancer, colon cancer, and head and neck cancer.Formula:C20H19ClN5O5PColor and Shape:SolidMolecular weight:475.822WEHI-9625
CAS:WEHI-9625 is a tricyclic sulfone small molecule apoptosis inhibitor (EC50: 69 nM).Formula:C34H27NO5S2Purity:98%Color and Shape:SolidMolecular weight:593.71Antitumor agent-184
CAS:Antitumor Agent-184 (compound 12aa) triggers apoptosis in various cell lines, exhibiting IC50 values of 2.35 μM in B16-F10 cells, 7.32 μM in 4T1 cells, and 10.31 μM in CT26 cells.Formula:C22H16N4O2SColor and Shape:SolidMolecular weight:400.45YCW-E11
CAS:YCW-E11 is an antiapoptotic Bcl-2 family proteins inhibitor.Formula:C25H21Cl2N3O6S2Purity:98%Color and Shape:SolidMolecular weight:594.49XSJ05
CAS:XSJ05, a derivative of camptothecin (CPT), exhibits anti-cancer activity by inhibiting topoisomerase I (Topo I). This compound induces DNA double-strand breaks, leading to DNA damage. Furthermore, XSJ05 stifles the growth of colorectal cancer (CRC), halts the cell cycle in the G2/M phase, and induces apoptosis.Formula:C29H25N5O4SColor and Shape:SolidMolecular weight:539.60Neral
CAS:Neral, a monoterpenoid compound, exhibits anti-inflammatory and anticancer activities. It inhibits TNF-α and IL-6, along with inflammatory mediators such as pro-IL-1β, iNOS, COX-2, and NLRP-3.Formula:C10H16OColor and Shape:SolidMolecular weight:152.23Lepidozin G
Lepidozin G blocks cancer growth (IC50=4.2-5.7μM) and triggers apoptosis in PC-3 cells via mitochondria.Formula:C30H48O4Color and Shape:SolidMolecular weight:472.7INNO-220
CAS:INNO-220 is an orally active, CRBN-dependent molecular glue degrader that targets CK1α. By degrading CK1α, INNO-220 induces cell cycle arrest at the G0/G1 phase and triggers apoptosis (Apoptosis). It disrupts the assembly and function of the CARD11/BCL10/MALT1 complex, inhibiting the NF-κB signaling pathway in T cells and lymphoma cells with activating mutations in CARD11. INNO-220 offers a novel direction for lymphoma research.Formula:C23H20N4O3Color and Shape:SolidMolecular weight:400.43KIM-161
CAS:KIM-161 is a PIK3CA inhibitor. It demonstrates significant antiproliferative activity, with IC50 values of 1.428 and 1.562 µM against PI3KCA-mutant breast cancer cell lines MCF7 and T47D, respectively. KIM-161 induces apoptosis and cell cycle arrest by inhibiting the PI3K/AKT/mTOR signaling pathway, leading to ROS production. It is applicable for research on breast cancer and its PI3KCA-mutant subtypes.Formula:C27H25N3O3Color and Shape:SolidMolecular weight:439.51NPB-1575
CAS:NPB-1575 is a potent, orally active anti-inflammatory agent capable of crossing the blood-brain barrier. It mitigates neuroinflammation and resists ferroptosis by activating IRS2/Nrf2/NF-κB. NPB-1575 protects against cerebral ischemic injury and improves neurological function outcomes, making it suitable for research in focal ischemic stroke.Formula:C19H22O4Color and Shape:SolidMolecular weight:314.38HC-5404-Fu
CAS:HC-5404-Fu is an inhibitor of PERK with anti-tumor activity. This compound inhibits the signaling pathway of the endoplasmic reticulum stress response. Additionally, HC-5404-Fu increases the sensitivity of renal cell carcinoma cells to vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitors (TKIs). It holds potential for research into renal cell carcinoma, stomach cancer, metastatic breast cancer, small cell lung cancer, and other solid tumors.Formula:C28H28F2N4O7Color and Shape:SolidMolecular weight:570.54Thalidomide-O-PEG4-amine TFA
CAS:Thalidomide-O-PEG4-amine TFA is a synthetic E3 ligase ligand-linker conjugate, composed of a cereblon ligand derived from Thalidomide and a single linker.Formula:C25H32F3N3O11Molecular weight:607.53TOPOI/PARP-1-IN-1
CAS:Compound B6, also known as TOPOI/PARP-1-IN-1, is a dual inhibitor targeting TOPOI and PARP, exhibiting low cytotoxicity and oral activity with a PARP1 IC 50 of 0.09 μM. This compound effectively inhibits cancer cell proliferation and migration, induces cell cycle arrest at the G0/G1 phase, and triggers apoptosis. In murine models, TOPOI/PARP-1-IN-1 demonstrated a tumor growth inhibition rate (TGI) of 75.4% [1].Formula:C36H38Br2N4O2Color and Shape:SolidMolecular weight:718.52Tubulin inhibitor 17
Compound 3b inhibits tubulin polymerization, IC50 12.38 µM, with anticancer properties and promotes cell apoptosis.Formula:C17H16N2OColor and Shape:SolidMolecular weight:264.32Caspase-3 activator 4
CAS:Caspase-3 Activator 4 (compound 4o) is an effective caspase-3 activator that can cross the blood-brain barrier. This compound exhibits antiproliferative activity and can induce cell apoptosis (apoptosis). Additionally, Caspase-3 Activator 4 enhances the gene expression of TNF-α and reduces the expression of cleaved caspase-3/caspases 3.Formula:C31H27N5O3Color and Shape:SolidMolecular weight:517.58NLRP3-IN-26
CAS:NLRP3-IN-26 (compound 15Z), with an IC50 of 0.13 μM, functions as an inhibitor of NLRP3. It is applicable in studies involving the DSS-induced colitis model [1].Formula:C31H33ClN2O6SColor and Shape:SolidMolecular weight:597.12Anticancer agent 14
Anticancer agent 14: a potent breast cancer inhibitor; induces cell death, disrupts mito. membrane potential (IC50: 0.20-0.65 μM).Formula:C29H34N2O3Color and Shape:SolidMolecular weight:458.59ZSH-512
CAS:ZSH-512 is a potent inhibitor of RARγ with antiproliferative properties. It induces apoptosis and reduces the expression of CD133, NANOG, SOX2, and EPCAM proteins. ZSH-512 exhibits anticancer activity and shows potential for colorectal cancer research.
Formula:C20H21N3O3SColor and Shape:SolidMolecular weight:383.464WYJ-2
CAS:WYJ-2, a selective agonist for toll-like receptor 2/1 (TLR2/1), demonstrates an EC50 of 18.57 nM in HEK 293T cells transiently co-transfected with human TLR2 and TLR1. It induces pyroptosis and has shown anticancer activity against non-small cell lung cancer (NSCLC) [1].Formula:C17H9F2N3O4Color and Shape:SolidMolecular weight:357.27WK88-1
CAS:WK88-1, an inhibitor of Hsp90, effectively induces the degradation of various oncogenic signaling molecules, including EGFR, ErbB2, and ErbB3, in the gefitinib-resistant H1975 cell line. This leads to subsequent growth arrest and apoptosis.Formula:C28H42N2O6Color and Shape:SolidMolecular weight:502.64ZNU-IMB-Z15
CAS:Compound Z15 (ZNU-IMB-Z15) acts as an antagonist and degrader of the androgen receptor (AR). It inhibits the proliferation of castration-resistant prostate cancer (CRPC) cell lines that are AR-positive and induces apoptosis. Compound Z15 exhibits anticancer activity both in vivo and in vitro.Formula:C20H17N3O3S2Color and Shape:SolidMolecular weight:411.5p53 Stabilizer 2
CAS:p53 Stabilizer 2 (Compound 17a16) is a p53 stabilizing agent. It can induce S-phase arrest and apoptosis in both p53-functional and p53-deficient cancer cells. Additionally, p53 Stabilizer 2 triggers mitochondrial stress and activates two immune checkpoint pathways: NA-PKcs dependent p53 stabilization and the ATR-Chk1 axis activation. It also inhibits tumor growth in p53-deficient xenograft models.Formula:C30H37NO7SeColor and Shape:SolidMolecular weight:602.58DeFer-2
CAS:DeFer-2 is a ferritin PROTAC degrader (Kd= 17.1 μM). It triggers the degradation of ferritin leading to the accumulation of free iron ions and an increase in ROS, which subsequently initiates caspase 3-GSDME mediated pyroptosis in cancer cells. DeFer-2 significantly inhibits tumor growth and extends the survival of mice with subcutaneous B16F10 tumors, and it is useful for melanoma research.Formula:C44H69N5O5SColor and Shape:SolidMolecular weight:780.11Anticancer agent 69
Anticancer agent 69 targets PC3 cells (IC50=26 nM), raises ROS, lowers EGFR, and induces apoptosis.Formula:C19H26N8SColor and Shape:SolidMolecular weight:398.53Topo II/HDAC-IN-2
CAS:Topo II/HDAC-IN-2 (8d) demonstrates remarkable dual inhibitory effects on Topo II and HDAC, and also induces apoptosis [1].Formula:C17H20N4O3SColor and Shape:SolidMolecular weight:360.43PD-1/PD-L1-IN-53
CAS:PD-1/PD-L1-IN-53 (compound B3) serves as an inhibitor targeting both the PD-1/PD-L1 and VISTA signaling pathways. It is utilized in cancer research.Formula:C31H37N3O4Color and Shape:SolidMolecular weight:515.64RIPK1-IN-14
CAS:RIPK1-IN-14 inhibits RIPK1 with 92 nM IC50 and reduces necrotic apoptosis in U937 cells.Color and Shape:SoildLSD1-IN-35
CAS:LSD1-IN-35 (Compound Z-1) is a selective inhibitor of LSD1, exhibiting an IC50 of 108 nM. This compound inhibits the demethylation of H3K4me1/2 and acts as an immunomodulator. Additionally, LSD1-IN-35 enhances the responsiveness of gastric cancer cells to T-cell killing by reducing PD-L1 expression, thereby weakening the PD-1/PD-L1 interaction.Formula:C25H26N4O2SColor and Shape:SolidMolecular weight:446.57eIF4A-IN-1
CAS:eIF4A-IN-1 is an eIF4A inhibitor used in tumor research.Formula:C31H33N3O5Color and Shape:SolidMolecular weight:527.61Casuarinin
CAS:Casuarinin, an ellagitannin found in pomegranates and certain Casuarina/Stachyurus plants, is a carbonic anhydrase inhibitor and astringent.Formula:C41H28O26Color and Shape:SolidMolecular weight:936.65Tuspetinib dihydrochloride
CAS:Tuspetinib (HM43239) dihydrochloride is a selective FLT3 inhibitor with oral bioactivity, exhibiting IC50 values of 1.1 nM for FLT3 wild type, 1.8 nM for FLT3ITD mutant type, and 1.0 nM for FLT3D835Y mutant type. As a reversible type I inhibitor, it directly suppresses FLT3 kinase activity and modulates p-STAT5, p-ERK, SYK, JAK1/2, and TAK1. Tuspetinib dihydrochloride inhibits the proliferation of leukemia cells and induces apoptosis (apoptosis).Formula:C29H35Cl3N6Color and Shape:SolidMolecular weight:573.99CLM3
CAS:CLM3, a pyrazolopyrimidine derivative, functions as a multitargeted tyrosine kinase inhibitor. It exhibits antiproliferative and proapoptotic activities on endothelial and cancer cells, activities that are synergistically enhanced by SN38. The primary mechanism of action for CLM3 involves the inhibition of phosphorylation in tyrosine kinases such as VEGFR-2, EGFR, and RET, along with their associated signaling pathways.Formula:C21H21N5Color and Shape:SolidMolecular weight:343.43ZLHQ-5f
ZLHQ-5f inhibits CDK2/Topo I, with IC50 of 0.145μM for CDK2/CycA2, and promotes apoptosis by arresting HCT116 cells in S phase.Formula:C28H25N5O2Color and Shape:SolidMolecular weight:463.53HDAC6/HSP90-IN-2
HDAC6/HSP90-IN-2, a cancer research chemical, inhibits HDAC6 & Hsp90 with IC50s of 105.7 & 61 nM.Formula:C19H22N2O5Color and Shape:SolidMolecular weight:358.39Dicycloplatin
CAS:Dicycloplatin is an inducer of DNA damage. It activates doubly phosphorylated checkpoint kinase 2 (CHK2), breast cancer 1 (BRCA1), and triply phosphorylated p53 to induce DNA damage. Dicycloplatin can cause cell cycle arrest, inhibit proliferation, and trigger apoptosis in prostate cancer PC3 cells and lung cancer NCI/H446 cells. It is applicable for research in the field of cancer.Formula:C12H20N2O8PtMolecular weight:515.38FGFR4-IN-7
FGFR4-IN-7 is a covalent, reversible FGFR4 inhibitor (IC50: 0.42 μM) that blocks the FGFR4 signaling pathway, thereby inducing apoptosis.Formula:C26H25Cl2N5O3Color and Shape:SolidMolecular weight:526.41TBC-1
CAS:TBC-1 is a chlorophyll-a derivative that acts as a photosensitizer for photodynamic therapy (PDT). It efficiently generates type I ROS and targets the endoplasmic reticulum. TBC-1 demonstrates in vitro biocompatibility and PDT effectiveness under both normoxic and hypoxic conditions.Formula:C31H28BrN3O3Color and Shape:SolidMolecular weight:570.476BRD1991
CAS:BRD1991 is a chemical compound that specifically disrupts the interaction between Beclin 1 and Bcl-2, thereby inducing autophagy.Formula:C33H35Cl2N3O4Color and Shape:SolidMolecular weight:608.55hCAIX/XII-IN-1
hCAIX/XII-IN-1: potent CAIX inhibitor (KI=0.48μM), CAXII (KI=0.83μM), antiproliferative, induces apoptosis in MCF-7 cells.Formula:C19H11NO5S2Color and Shape:SolidMolecular weight:397.42NiCur
CAS:NiCur is an effective and selective inhibitor of CBP histone acetyltransferase (HAT), with an IC50 of 0.35 μM.Formula:C22H16N2OPurity:99.22%Color and Shape:SolidMolecular weight:324.38Antitumor agent-37
Antitumor agent-37: strong anti-growth, anti-spread, induces DNA damage, apoptosis via Bcl-2/Bax/caspase3, boosts immune response.Formula:C16H18Cl2N2O4PtColor and Shape:SolidMolecular weight:568.32Antitumor agent-42
Antitumor agent-42 inhibits microtubule multimerisation and NO release, exhibiting anti-angiogenic, colony-forming and apoptosis-inducing effects.Formula:C24H19BrN2O8SColor and Shape:SolidMolecular weight:575.39GIC-20
CAS:GIC-20, a dual inducer of apoptosis and ferroptosis, exhibits antitumor efficacy against fibrosarcoma [1].Formula:C38H37ClN4O5SColor and Shape:SolidMolecular weight:697.24BCL6-IN-9
CAS:BCL6-IN-9 (compound 1) is a potent inhibitor of B-cell lymphoma 6 protein (BCL6) (IC50: 3.9 nM) and can be used to study cancer.Formula:C22H18ClF2N5O2Color and Shape:SolidMolecular weight:457.86HDAC-IN-81
CAS:HDAC-IN-81 (Compound 11g) is an HDAC inhibitor capable of effectively inhibiting HDAC1 with an IC50 value of 4.5 nM. Additionally, it exhibits anticancer activity by inhibiting cell proliferation and can induce cell apoptosis (apoptosis).Formula:C20H27N3O3Color and Shape:SolidMolecular weight:357.45BRD-K20733377
CAS:BRD-K20733377 is a Bcl-2 inhibitor that exhibits selective cytotoxicity toward senescent cells, specifically inhibiting the activity of etoposide-induced senescent IMR-90 cells with an IC50 of 10.7 μM. Additionally, BRD-K20733377 reduces the mRNA expression of aging-related genes p16, p21, and KI67 in aged mouse models.Formula:C23H18N4O3SColor and Shape:SolidMolecular weight:430.48p53 Activator 14
CAS:p53 Activator 14 (Compound 7A) is a derivative of Neratinib that can induce DNA damage and activate p53, thereby inhibiting the proliferation of various cancer cells, with an IC50 of 7.21 μM for HCT116 cells. This compound hinders adhesion, migration, and invasion of HCT116 cells, disrupts the cell cycle, and triggers apoptosis. In addition, p53 Activator 14 exhibits anti-tumor properties and inhibits angiogenesis in the chick embryo chorioallantoic membrane (CAM) model.Formula:C28H29ClN4O3Color and Shape:SolidMolecular weight:505.008FAK-IN-2
FAK-IN-2: potent oral FAK inhibitor, IC50 35 nM, reduces tumor growth, migration, and induces cell death.Formula:C28H31ClN8O3Color and Shape:SolidMolecular weight:563.05ASK1-IN-7
CAS:ASK1-IN-7 (Compound 4c) is an ASK1 inhibitor and a derivative of the ASK1 inhibitor scaffold 5-(5-Phenyl-furan-2-ylmethylene)-2-thioxo-thiazolidin-4-one. This compound is potentially applicable in research involving ASK1 signaling pathways, including studies on cellular stress response, inflammatory response, neurodegenerative diseases, and cardiovascular diseases.Formula:C13H8N2O2S2Color and Shape:SolidMolecular weight:288.345BRD-K44839765
CAS:BRD-K44839765 selectively targets Bcl-2, exhibiting an IC50 of 5.6 μM in IMR-90 cells. This compound is also orally active.Formula:C23H19N3O2S2Color and Shape:SolidMolecular weight:433.55Samuraciclib
CAS:Samuraciclib (CT7001) is an oral CDK7 inhibitor with 41 nM IC50, notable for its high selectivity and potency against breast cancer cells.Formula:C22H30N6OColor and Shape:SolidMolecular weight:394.51GI-Y2
CAS:GI-Y2 is a GSDMD inhibitor that suppresses macrophage pyroptosis induced by oxidized low-density lipoprotein (ox-LDL). In vivo, GI-Y2 dose-dependently reduces atherosclerotic plaques and decreases lesion size and fibrosis in the aortic root of ApoE-/- mice. GI-Y2 holds potential for research in pyroptosis and cardiovascular diseases, such as atherosclerosis.Formula:C18H14N2O6SColor and Shape:SolidMolecular weight:386.379FTO-IN-13
CAS:FTO-IN-13 (compound 8t) is a potent FTO inhibitor with antiproliferative properties. It induces apoptosis (cell apoptosis) and reduces the expression of Bcl-2 and Caspase 3 active proteins. Additionally, FTO-IN-13 lowers the expression of MYC and CEBPA genes and demonstrates anticancer activity.Formula:C18H12Br2N2O4Color and Shape:SolidMolecular weight:480.107SC428
CAS:SC428 acts as an inhibitor of the androgen receptor (AR), specifically targeting the N-terminal domain of AR. This compound effectively diminishes the transactivation of various AR forms, including AR-V7, ARv567es, full-length AR (AR-FL), and its LBD mutants. Additionally, SC428 significantly inhibits AR-FL nuclear translocation, chromatin binding, and AR-regulated gene transcription under androgen stimulation. In vitro, SC428 suppresses the proliferation of tumor cells. In vivo, it inhibits tumor growth in mice transplanted with 22Rv1 cells by inducing apoptosis.Formula:C15H10F3N3OSColor and Shape:SolidMolecular weight:337.32CDK4/6-IN-10
CDK4/6-IN-10: Oral CDK4 (IC50: 22 nM) & CDK6 (IC50: 10 nM) inhibitor with anti-cancer potential for MM research.Color and Shape:SolidVEGFR-2-IN-13
VEGFR-2-IN-13 (Compound 19a) is a potent VEGFR-2 inhibitor (IC50: 3.4 nM). vEGFR-2-IN-13 arrests the HepG2 cell cycle in G2/M phase and induces apoptosis.Formula:C24H18N6O2SColor and Shape:SolidMolecular weight:454.5Lysosomal P-gp targeted agent 1
CAS:Lysosomal P-gp targeted agent 1 (Compound 14) is an antitumor drug that targets lysosomal P-glycoprotein (Pgp). It is selectively transported to lysosomes via overexpressed Pgp, releasing nitric oxide that generates reactive oxygen species (ROS), causing lysosomal membrane permeabilization (LMP) and inducing apoptosis. This compound can overcome resistance mediated by P-glycoprotein, leading to cell cycle arrest while maintaining relatively low toxicity to normal cells. It exhibits antitumor activity by significantly inhibiting tumor growth.Formula:C39H34N2O9SColor and Shape:SolidMolecular weight:706.76MD102
CAS:MD102, with an IC50 value of 0.35 μM, is a potent TG2 inhibitor that stabilizes p53 by inhibiting TG2. This results in a decrease in p-AKT and p-mTOR downstream signaling, ultimately inducing tumor cell apoptosis [1].Formula:C13H4BrCl2FN2O2Color and Shape:SolidMolecular weight:389.99Etalocib sodium
CAS:Etalocib (LY293111) sodium is an orally active leukotriene B4 (LTB4) receptor antagonist with a Ki value of 25 nM for inhibiting [3H]LTB4 binding. It exhibits an IC50 of 20 nM against LTB4-induced calcium mobilization. Additionally, Etalocib sodium can induce apoptosis.Formula:C33H32FNaO6Color and Shape:SolidMolecular weight:566.59Fluvastatin sodium monohydrate
CAS:Fluvastatin (XU 62-320) sodium monohydrate, a fully synthetic competitive HMG-CoA reductase inhibitor, features an IC 50 of 8 nM. This compound also safeguards vascular smooth muscle cells from oxidative stress via the Nrf2-dependent antioxidant pathway [1] [2].Formula:C24H27FNNaO5Color and Shape:SolidMolecular weight:451.46Top/HDAC-IN-1
Top/HDAC-IN-1: Dual Top/HDAC inhibitor, potent against HDAC1-3,6,8 and HCT116 cells; blocks G2 phase, induces apoptosis.Formula:C29H27N5O4Color and Shape:SolidMolecular weight:509.56GGTI298
CAS:GGTI298 is a potent GGTase I inhibitor; IC50 3μM for Rap1A, >20μM for Ha-Ras.Formula:C27H33N3O3SPurity:98%Color and Shape:SolidMolecular weight:479.63EGFR-IN-45
EGFR-IN-45: Strong EGFR/CDK2 inhibitor (IC50s: 0.4 & 1.6 μM), halts cancer cell cycle pre-G1, prompts apoptosis, also targets Topo I/II.Formula:C28H23N7OColor and Shape:SolidMolecular weight:473.53
