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Apoptosis

Apoptosis

Apoptosis inhibitors are compounds that prevent or delay the process of programmed cell death, known as apoptosis. These inhibitors are vital in studying cell survival mechanisms and are used to investigate diseases where apoptosis is dysregulated, such as cancer, neurodegenerative disorders, and autoimmune diseases. By modulating apoptosis, these inhibitors can help in the development of therapies aimed at controlling cell death. At CymitQuimica, we provide a comprehensive selection of high-quality apoptosis inhibitors to support your research in cell biology, oncology, and related fields.

Subcategories of "Apoptosis"

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Found 5592 products of "Apoptosis"

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  • CymitQuimica logo
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    YTHDF2-IN-1

    <p>YTHDF2-IN-1 (Compound CK-75) is an inhibitor of YT521-B homology domain family 2 (YTHDF2) with a dissociation constant (Kd) of 26.2 μM, and it effectively blocks the interaction between YTHDF2 and m6A RNA. It suppresses colony formation in JAR cells and exhibits antiproliferative activity in various cancer cell lines, with an IC50 in the micromolar range. Additionally, YTHDF2-IN-1 induces apoptosis in K562 cells and causes cell cycle arrest at the G0/G1 phase.</p>
    Formula:C21H14N2O4
    Color and Shape:Solid
    Molecular weight:358.35

    Ref: TM-T205078

  • VEGFR-2-IN-61
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    VEGFR-2-IN-61

    <p>VEGFR-2-IN-61 (Compound 7b) is an inhibitor of VEGFR-2 with an IC50 of 2.83 µM. It effectively inhibits the proliferation of various cancer cells, including MCF-7 cells, with an IC50 of 2.12 µM. Additionally, VEGFR-2-IN-61 suppresses cell migration and induces oxidative stress and apoptosis in MCF-7 cells.</p>
    Formula:C27H25N5O
    Color and Shape:Solid
    Molecular weight:435.52

    Ref: TM-T204905

  • BC13
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    BC13

    <p>BC13 is a CDK6/BRD4 inhibitor with IC50 values of 234 nM for CDK6 and 36 nM for BRD4. It exhibits antiproliferative properties, induces apoptosis (cell death) and DNA damage, and elevates ROS levels.</p>
    Formula:C37H39N7O5
    Color and Shape:Solid
    Molecular weight:661.75

    Ref: TM-T204938

  • Estradiol (cypionate)
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    Estradiol (cypionate)

    CAS:
    <p>Estradiol cypionate (Depofemin), the 17 β-cyclopentylpropinate ester of estradiol, inhibits ET-1 synthesis via estrogen receptor.</p>
    Formula:C26H36O3
    Purity:99.53% - >99.99%
    Color and Shape:White Or Off-White Crystalline Powder
    Molecular weight:396.56

    Ref: TM-T0168

  • (Iso)-Z-VAD(OMe)-FMK
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    (Iso)-Z-VAD(OMe)-FMK

    CAS:
    <p>(Iso)-Z-VAD(OMe)-FMK is an isomer of Z-VAD(OMe)-FMK, which is a pan-caspase inhibitor with irreversible properties. Z-VAD(OMe)-FMK is also an inhibitor UCHL1.</p>
    Formula:C22H30FN3O7
    Purity:97.10%
    Color and Shape:Soild
    Molecular weight:467.49

    Ref: TM-T88862

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    Caspase-3 activator 3

    <p>Caspase-3 activator 3 (compound 2h) effectively induces apoptosis in HL-60 and K562 cells by substantially activating caspase-3, demonstrating antileukemic</p>
    Purity:98%
    Color and Shape:Odour Solid

    Ref: TM-T82774

  • Terrein
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    Terrein

    CAS:
    <p>Terrain (NSC 291308), a fungal metabolite, reduces age-related inflammation via Nrf2/ERK1/2/HO-1 and inhibits IL-6 in human fibroblasts.</p>
    Formula:C8H10O3
    Color and Shape:Solid
    Molecular weight:154.16

    Ref: TM-T34811

  • XZ739
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    XZ739

    CAS:
    <p>XZ739: Cereblon-based PROTAC, degrades BCL-XL (DC50 2.5 nM in MOLT-4, 16hr), induces caspase apoptosis.</p>
    Formula:C65H76ClF3N8O12S3
    Color and Shape:Solid
    Molecular weight:1349.99

    Ref: TM-T39909

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    TNF-α-IN-11

    <p>TNF-α-IN-11 (Compound 10) is a TNF-α inhibitor exhibiting a dissociation constant (K D) of 12.06 μM.</p>
    Formula:C24H26N2O5
    Color and Shape:Solid
    Molecular weight:422.47

    Ref: TM-T78730

  • Ganoderic acid Mf
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    Ganoderic acid Mf

    CAS:
    <p>Ganoderic acid Mf: antitumor triterpenoid, arrests G1 cell cycle, selective for cancer cells, triggers apoptosis via mitochondria.</p>
    Formula:C32H48O5
    Color and Shape:Solid
    Molecular weight:512.72

    Ref: TM-T75630

  • PZ703b
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    PZ703b

    CAS:
    <p>PZ703b is a novel BCL-XL PROTAC degrader with enhanced BCL-2 inhibition.</p>
    Formula:C80H102ClF3N10O11S4
    Color and Shape:Solid
    Molecular weight:1600.44

    Ref: TM-T40135

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    BTK-IN-37

    <p>BTK-IN-37 (compound 8d), a BTK inhibitor, demonstrates potent apoptotic effects on cancer cells by targeting BTK with K_i and IC_50 values of 5.07 nM and 3.6 nM, respectively. Additionally, this compound selectively promotes the enrichment of genes associated with necroptosis and pyroptosis.</p>
    Formula:C29H29N9O4S
    Color and Shape:Solid
    Molecular weight:599.66

    Ref: TM-T200249

  • Barakol
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    Barakol

    CAS:
    <p>Barakol, a primary compound found in Cassia siamea, inhibits MMP-3 activity and enhances the anti-metastatic effects of doxorubicin. Additionally, Barakol induces apoptosis (Apoptosis), generates reactive oxygen species, increases the Bax/Bcl-2 expression ratio, and activates caspase-9. This compound also exhibits laxative, anti-anxiety, central nervous system depressant, antioxidant, and anticancer properties.</p>
    Formula:C13H12O4
    Color and Shape:Solid
    Molecular weight:232.23

    Ref: TM-TN8213

  • Malformin A
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    Malformin A

    CAS:
    <p>Malformin A, from A. niger, is a plant growth regulator and has anti-TMV and cancer cell cytotoxic properties. Intraperitoneal LD50 in mice is 3.1 mg/kg.</p>
    Formula:C23H39N5O5S2
    Color and Shape:Solid
    Molecular weight:529.72

    Ref: TM-T36489

  • (±)-Indoxacarb
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    (±)-Indoxacarb

    CAS:
    <p>(±)-Indoxacarb is a pyrazoline insecticide with insecticidal activity and cytotoxicity, blocks sodium channels in insect neurons, and can induce apoptosis.</p>
    Formula:C22H17ClF3N3O7
    Color and Shape:Solid
    Molecular weight:527.83

    Ref: TM-T84330

  • AM-8553
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    AM-8553

    CAS:
    <p>AM-8553 is potent and selective piperidine the MDM2-p53 interaction inhibitor.</p>
    Formula:C25H29Cl2NO4
    Color and Shape:Solid
    Molecular weight:478.41

    Ref: TM-T23713

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    HSP90-IN-33

    <p>HSP90-IN-33 (compound 24e) is an effective Hsp90 inhibitor, demonstrating dissociation constants (Kd) of ≥200 µM for Hsp90α and 7.3 µM for Hsp90β. This compound induces cellular apoptosis (apoptosis) and arrests the cell cycle at the G0/G1 phase. Additionally, HSP90-IN-33 reduces the protein expression of ERα, CDK4, and Akt.</p>
    Formula:C21H25Cl2N5O2
    Color and Shape:Solid
    Molecular weight:450.36

    Ref: TM-T201275

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    Ac-YVAD-CHO acetate

    <p>Ac-YVAD-CHO acetate, potent reversible ICE and caspase-1 inhibitor; K_i: 3.0 nM (mouse), 0.76 nM (human); blocks IL-lβ production.</p>
    Formula:C25H36N4O10
    Color and Shape:Solid
    Molecular weight:552.57

    Ref: TM-T73852

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    Placulumab

    CAS:
    <p>Placulumab (ART621), an anti-TNF α monoclonal antibody, targets inflammation, potentially aiding arthritis treatment.</p>
    Color and Shape:Liquid

    Ref: TM-T77114

  • Prodigiosin
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    Prodigiosin

    CAS:
    <p>Prodigiosin is a secondary metabolite of Symbiotic bacteria. It also has anti-fungal and anti-cancer activity.</p>
    Formula:C20H25N3O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:323.44

    Ref: TM-T16580