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Apoptosis

Apoptosis

Apoptosis inhibitors are compounds that prevent or delay the process of programmed cell death, known as apoptosis. These inhibitors are vital in studying cell survival mechanisms and are used to investigate diseases where apoptosis is dysregulated, such as cancer, neurodegenerative disorders, and autoimmune diseases. By modulating apoptosis, these inhibitors can help in the development of therapies aimed at controlling cell death. At CymitQuimica, we provide a comprehensive selection of high-quality apoptosis inhibitors to support your research in cell biology, oncology, and related fields.

Subcategories of "Apoptosis"

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Found 6039 products of "Apoptosis"

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  • AKT-IN-3
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    AKT-IN-3

    CAS:
    AKT-IN-3: potent oral Akt inhibitor with low hERG blockage. IC50: 1.4-1.7 nM for Akt1-3. Inhibits AGC kinases like PKA, PKC.
    Formula:C23H23Cl2F2N5O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:526.36

    Ref: TM-T10275

  • ISR modulator-1
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    ISR modulator-1

    CAS:
    ISR Modulator-1 (Compound 212) acts as a regulator for the integrated stress response pathway (ISR).
    Formula:C20H21ClF4N4O4
    Color and Shape:Solid
    Molecular weight:492.85

    Ref: TM-T88550

  • LRRK2-IN-17
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    LRRK2-IN-17

    CAS:
    LRRK2-IN-17 is an orally active LRRK2 inhibitor with IC50 values of 3.5 nM for WT and 3.3 nM for G2019S, and it also inhibits RET kinase with an IC50 of 59 nM. LRRK2-IN-17 is utilized in research related to cancer and Parkinson's disease (PD).
    Formula:C18H18N8
    Color and Shape:Solid
    Molecular weight:346.39

    Ref: TM-T207158

  • Rafutrombopag
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    Rafutrombopag

    CAS:
    Rafutrombopag is a thrombopoietin (TPO) agonist.
    Formula:C25H22N4O5
    Color and Shape:Solid
    Molecular weight:458.47

    Ref: TM-T62865

  • ASK1 ligand 1
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    ASK1 ligand 1

    CAS:
    ASK1ligand 1 is a binding ligand for ASK1 and can be utilized to synthesize PROTACs such as dASK1-VHL.
    Formula:C17H16F2N6O
    Color and Shape:Solid
    Molecular weight:358.35

    Ref: TM-T210696

  • FLT3-IN-32
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    FLT3-IN-32

    CAS:
    FLT3-IN-32 is a potent FLT3 inhibitor with high selectivity, effectively suppressing FLT3 activating mutations and inducing apoptosis. It demonstrates good tolerance in non-tumor-bearing mice. In NOD/SCID mice loaded with MV4-11 cells, FLT3-IN-32 exhibits outstanding antitumor efficacy, significantly extending mouse survival. FLT3-IN-32 is applicable for acute myeloid leukemia research.
    Formula:C28H29N5O5
    Color and Shape:Solid
    Molecular weight:515.56

    Ref: TM-T210598

  • eIF4A-IN-1
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    eIF4A-IN-1

    CAS:
    eIF4A-IN-1 is an eIF4A inhibitor used in tumor research.
    Formula:C31H33N3O5
    Color and Shape:Solid
    Molecular weight:527.61

    Ref: TM-T212212

  • MAO-B-IN-45
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    MAO-B-IN-45

    CAS:
    MAO-B-IN-45 is a dual inhibitor of ferroptosis and MAO-B. It selectively inhibits MAO-B with an IC50 of 87.47 nM, demonstrating a selectivity over MAO-A by more than 229 times. In vitro, MAO-B-IN-45 exhibits significant anti-ferroptosis activity by modulating iron metabolism pathways and the GSH-GPX4 axis. Additionally, it improves cognitive and behavioral deficits in 3×Tg (APP/Tau/Ps1) Alzheimer's disease mice and significantly reduces levels of ferritin heavy chain 1 (FTH1), β-amyloid protein (APP), and Tau protein phosphorylation (p-Tau) in their brains.
    Formula:C17H14ClNO3
    Color and Shape:Solid
    Molecular weight:315.75

    Ref: TM-T211128

  • sEH-IN-21
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    sEH-IN-21

    CAS:
    sEH-IN-21 is an orally active inhibitor of sEH, exhibiting IC50 values of 0.1 nM for both hsEH and msEH. It significantly suppresses the NF-κB signaling pathway. sEH-IN-21 demonstrates potent anti-inflammatory activity by reducing IL-6 and TNF-α release and maintaining intestinal barrier integrity. It is applicable in research on inflammatory bowel disease (IBD).
    Formula:C30H40N4O5S
    Color and Shape:Solid
    Molecular weight:568.73

    Ref: TM-T211654

  • ST-899
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    ST-899

    CAS:
    ST-899 is an innovative platelet-activating factor (PAF) receptor antagonist. It significantly reduces the mortality rate in mice experiencing shock induced by endotoxins (LPS). The compound markedly inhibits the LPS-induced increase in serum tumor necrosis factor (TNF) levels while leaving interleukin-6 (IL-6) unaffected. The mechanism by which ST-899 operates involves disrupting the positive feedback loop between PAF and TNF, thereby mitigating inflammatory responses. ST-899 is applicable for studies related to inflammatory diseases such as septic shock.
    Formula:C22H29BrClNO6
    Color and Shape:Solid
    Molecular weight:518.83

    Ref: TM-T211047

  • Citric acid-13C2
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    Citric acid-13C2

    CAS:
    Citric acid-13C2 is a 13C-labeled form of citric acid. Citric acid serves as a preservative and food additive. It induces apoptosis in HaCaT cells and causes cell cycle arrest at the G2/M and S phases. Additionally, citric acid contributes to liver oxidative damage by reducing antioxidant enzyme activity. It also functions as an acidulant, emulsifier, chelating agent, and buffer, with extensive applications across multiple industries.
    Formula:C6H8O7
    Color and Shape:Solid
    Molecular weight:194.11

    Ref: TM-T211892

  • GlcNAc-MurNAc
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    GlcNAc-MurNAc

    CAS:
    GlcNAc-MurNAc is a disaccharide and mild TLR4 agonist with a Kd of 383 μM for mouse TLR4. It directly binds to TLR4, activating the downstream NF-κB and IRF pathways. Additionally, GlcNAc-MurNAc ameliorates dextran sulfate sodium salt (DSS)-induced colitis in mice through a TLR4-dependent mechanism, making it useful for inflammatory bowel disease research.
    Formula:C19H32N2O13
    Color and Shape:Solid
    Molecular weight:496.46

    Ref: TM-T211496

  • Z-VAD-AMC
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    Z-VAD-AMC

    CAS:
    Z-VAD-AMC acts as a substrate specifically for caspase-9.
    Formula:C30H34N4O9
    Molecular weight:594.61

    Ref: TM-TP3281

  • 6:2 Cl-PFAES
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    6:2 Cl-PFAES

    CAS:
    6:2 Cl-PFAES exhibits reproductive toxicity by elevating the levels of serum estradiol and vitellogenin in adult males, which can harm the embryonic development of offspring.
    Formula:C8ClF16KO4S
    Color and Shape:Solid
    Molecular weight:570.67

    Ref: TM-T201602

  • Anticancer agent 183
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    Anticancer agent 183

    CAS:
    Anticancer agent 183 (compound 4h) exhibits potent inhibition of matrix metalloproteinase-9 (MMP-9), reducing its viability by more than 75% at a concentration of 100 μg/mL. Additionally, it demonstrates significant anticancer activity, with an IC50 value of <0.14 μM against the A549 cell line and induces apoptotic [1] processes.
    Formula:C19H18N4O4S
    Color and Shape:Solid
    Molecular weight:398.44

    Ref: TM-T85672

  • CymitQuimica logo
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    T-1-PMPA

    CAS:
    T-1-PMPA, a potent EGFR inhibitor, demonstrates apoptotic properties and effectively inhibits EGFR WT and EGFR 790m, with IC50 values of 86 nM and 561.73 nM, respectively [1].
    Formula:C16H17N5O3
    Molecular weight:327.34

    Ref: TM-T87486

  • RIPK3-IN-6
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    RIPK3-IN-6

    CAS:
    RIPK3-IN-6 (compound 1) is a type I RIPK3 inhibitor with low selectivity within the RIPK family, particularly in relation to RIPK2 activity.
    Formula:C21H17N3O
    Color and Shape:Solid
    Molecular weight:327.38

    Ref: TM-T210739

  • MG-B-28
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    MG-B-28

    MG-B-28, a BTLA-HVEM inhibitor, demonstrates an IC50 value of 906 nM. It promotes T cell activation dose-dependently by inhibiting the interaction between BTLA and HVEM.
    Formula:C28H25N5O3
    Color and Shape:Solid
    Molecular weight:479.53

    Ref: TM-T201695

  • 06:0 PE
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    06:0 PE

    CAS:
    06:0 PE (PE(6:0/6:0)) is a water-soluble phospholipid characterized by its short acyl chains. It possesses notable antitumor activity and can inhibit tumor progression in the body. Additionally, it exhibits antiproliferative and pro-apoptotic properties, and serves as a precursor for phosphatidylcholine and phosphatidylethanolamine.
    Formula:C17H34NO8P
    Color and Shape:Solid
    Molecular weight:411.43

    Ref: TM-T200930

  • DOR agonist 2
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    DOR agonist 2

    CAS:
    Compound 3 (DOR agonist 2) acts as a Delta Opioid Receptor agonist. It inhibits the expression of TNF-α, obstructs NF-κB transportation to the nucleus, and activates the G protein-mediated ERK1/2 pathway. This compound is useful for research into neurodegenerative diseases.
    Formula:C29H26N2O3
    Color and Shape:Solid
    Molecular weight:450.53

    Ref: TM-T200382