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Apoptosis

Apoptosis

Apoptosis inhibitors are compounds that prevent or delay the process of programmed cell death, known as apoptosis. These inhibitors are vital in studying cell survival mechanisms and are used to investigate diseases where apoptosis is dysregulated, such as cancer, neurodegenerative disorders, and autoimmune diseases. By modulating apoptosis, these inhibitors can help in the development of therapies aimed at controlling cell death. At CymitQuimica, we provide a comprehensive selection of high-quality apoptosis inhibitors to support your research in cell biology, oncology, and related fields.

Subcategories of "Apoptosis"

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Found 5592 products of "Apoptosis"

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  • Mepacrine
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    Mepacrine

    CAS:
    <p>Mepacrine (Erion) is an acridine derivative formerly widely used as an antimalarial.</p>
    Formula:C23H30ClN3O
    Purity:98.78%
    Color and Shape:Bright Yellow Crystals
    Molecular weight:399.96

    Ref: TM-T24449

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    Apoptosis inducer 30

    <p>Apoptosisinducer 30 (Compound 15a) acts as an anticancer agent. It induces apoptosis in MCF-7 cells through the mitochondrial pathway. This compound elevates intracellular levels of reactive oxygen species (ROS), decreases mitochondrial membrane potential, and arrests the cell cycle at the G0/G1 phase. Apoptosisinducer 30 inhibits cell growth, with an IC50 value of 0.32 μM against MCF-7 cells, and suppresses tumor growth in a mouse breast cancer model.</p>
    Formula:C52H69BrNO4P
    Color and Shape:Solid
    Molecular weight:882.99

    Ref: TM-T201277

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    HSP70-IN-6

    <p>HSP70-IN-6 (Compound JL-15) acts as an inhibitor of the Hsp70-Bim protein-protein interactions (PPI) with an IC50 value of 70 nM. It induces apoptosis in chronic myeloid leukemia (CML) cells with EC50 values of 0.43 μM (BV173), 0.88 μM (K562), and 0.19 μM (K562-R3).</p>
    Color and Shape:Odour Solid

    Ref: TM-T89363

  • Emavusertib hydrochloride
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    Emavusertib hydrochloride

    CAS:
    <p>Emavusertib (CA-4948) hydrochloride, a selective and potent IRAK4/FLT3 inhibitor, is designed for oral administration. It achieves an IC 50 of 57 nM against IRAK4 in a FRET kinase assay and demonstrates anti-tumor activity [1] [2] [3].</p>
    Formula:C24H26ClN7O5
    Color and Shape:Solid
    Molecular weight:527.96

    Ref: TM-T86366

  • BMSpep-57
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    BMSpep-57

    CAS:
    <p>BMSpep-57: Macrocyclic peptide, inhibits PD-1/PD-L1, IC50=7.68 nM, binds PD-L1 (Kd=19 nM/MST, 19.88 nM/SPR), boosts T cell IL-2 in PBMCs.</p>
    Formula:C89H126N24O19S
    Color and Shape:Solid
    Molecular weight:1868.2

    Ref: TM-T39106

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    CDC20-IN-2

    <p>CDC20-IN-2 (14c) is an inhibitor of Cdc20 with a KD of 7.65 μM, inducing G2/M phase arrest, promoting DNA damage accumulation, and stabilizing key substrates such as Cyclin B1 and Bim. This leads to enhanced apoptosis, as well as inhibition of tumor cell proliferation and migration.</p>
    Color and Shape:Odour Solid

    Ref: TM-T207018

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    FOXO4-DRI

    CAS:
    <p>FOXO4-DRI: a peptide blocking FOXO4/p53 interaction; induces senescent cells' apoptosis.</p>
    Formula:C228H388N86O64
    Color and Shape:Solid
    Molecular weight:5358.06

    Ref: TM-T76563

  • SPOP-IN-6lc
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    SPOP-IN-6lc

    CAS:
    <p>SPOP-IN-6lc is a SPOP inhibitor with oncogenic effects in renal cancer cells.SPOP-IN-6lc can be used to study apoptosis.</p>
    Formula:C26H31N7O2S
    Purity:99.19%
    Color and Shape:Solid
    Molecular weight:505.64

    Ref: TM-T69877

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    Emfizatamab

    CAS:
    <p>Emfizatamab (GNC-038) is a tetravalent antibody that activates CD3 and 4-1BB on T cells while targeting CD19 or PD-L1 on tumor cells, resulting in T-cell-mediated cytotoxicity against human leukemia and lymphoma cells.</p>
    Color and Shape:Liquid

    Ref: TM-T9901A-100

  • Leucettamol A
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    Leucettamol A

    CAS:
    <p>Leucettamol A, from Leucetta microraphis, blocks LTB4 receptor and prevents Ubc13-Uev1A complex formation.</p>
    Formula:C30H52N2O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:472.758

    Ref: TM-T27815

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    BCL-XL-IN-1

    <p>BCL-XL-IN-1 (Compound 11) is a selective inhibitor of BCL-XL, exhibiting a Ki of less than 0.01 nM against BCL-XLTR-FERT. It is primarily used in cancer research.</p>
    Formula:C46H55N7O6S
    Color and Shape:Solid
    Molecular weight:834.04

    Ref: TM-T201020

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    LSD1-IN-36

    <p>LSD1-IN-36, an effective LSD1 inhibitor with an IC50 value of 0.8 nM, induces cell apoptosis and arrests the cell cycle. This compound also exhibits antitumor activity.</p>
    Formula:C22H25N3O6S
    Color and Shape:Solid
    Molecular weight:459.52

    Ref: TM-T201218

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    Antiproliferative agent-59

    <p>Antiproliferative agent-59 (Compound 14u) acts as an inhibitor of tubulin polymerization. Demonstrating anticancer activity in Huh7, SGC-7901, and MCF-7 cell lines, this compound achieves IC50 values of 0.03, 0.18, and 0.13 μM, respectively. Additionally, it arrests the cell cycle at the G2/M phase and induces apoptosis in Huh7 cells. In a xenograft mouse model utilizing Huh7 cells, Antiproliferative agent-59 exhibits antitumor effects against hepatocellular carcinoma without significant toxicity.</p>
    Formula:C26H22N2O3
    Color and Shape:Solid
    Molecular weight:410.46

    Ref: TM-T201186

  • ASK1-IN-4
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    ASK1-IN-4

    CAS:
    <p>ASK1-IN-4 is an ASK1 inhibitor, IC50 = 0.2 μM.</p>
    Formula:C18H14BrNO4S2
    Purity:99.756%
    Color and Shape:Solid
    Molecular weight:452.34

    Ref: TM-T67857

  • GSK-1070916
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    GSK-1070916

    CAS:
    <p>GSK-1070916 (GSK-1070916A) is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM.</p>
    Formula:C30H33N7O
    Purity:99.73%
    Color and Shape:Solid
    Molecular weight:507.63

    Ref: TM-T6129

  • RLX HCl
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    RLX HCl

    CAS:
    <p>RLX HCl is anticancer, inhibits tumour proliferation by suppressing the PI3K/Akt/FoxO3a in experimental colon cancer, antiproliferative.</p>
    Formula:C13H15ClN2O
    Purity:99.43%
    Color and Shape:Soild
    Molecular weight:250.72

    Ref: TM-T24715L

  • Ac-Trp-Glu-His-Asp-Aldehyde
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    Ac-Trp-Glu-His-Asp-Aldehyde

    CAS:
    <p>Ac-Trp-Glu-His-Asp-Aldehyde is a powerful and selective inhibitor of caspase-1, demonstrating a K_i value of 56 pM [1] [2].</p>
    Formula:C28H33N7O9
    Color and Shape:Solid
    Molecular weight:611.6

    Ref: TM-T76600

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    Sarglaroids F

    <p>Sarglaroids F (compound 6), an anti-inflammatory agent extracted from the roots of Grass Coral, suppresses LPS/ATP-induced IL-1β secretion by modulating K+</p>
    Formula:C38H44O12
    Purity:98%
    Color and Shape:Solid
    Molecular weight:692.75

    Ref: TM-T79992

  • IRF1-IN-2
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    IRF1-IN-2

    CAS:
    <p>IRF1-IN-2 is a small molecule IRF1 inhibitor that suppresses pyroptosis, protecting against radiation-induced skin damage.</p>
    Formula:C18H20N2O4S
    Purity:99.85%
    Color and Shape:Solid
    Molecular weight:360.43

    Ref: TM-T203076

  • Ac-IEPD-AFC
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    Ac-IEPD-AFC

    CAS:
    <p>Ac-IEPD-AFC (IEPD) is a fluorescent substrate for granzyme B and can be used to measure granzyme B activity.</p>
    Formula:C32H38F3N5O11
    Purity:99.16%
    Color and Shape:Solid
    Molecular weight:725.67

    Ref: TM-TP1128