Apoptosis
Apoptosis inhibitors are compounds that prevent or delay the process of programmed cell death, known as apoptosis. These inhibitors are vital in studying cell survival mechanisms and are used to investigate diseases where apoptosis is dysregulated, such as cancer, neurodegenerative disorders, and autoimmune diseases. By modulating apoptosis, these inhibitors can help in the development of therapies aimed at controlling cell death. At CymitQuimica, we provide a comprehensive selection of high-quality apoptosis inhibitors to support your research in cell biology, oncology, and related fields.
Subcategories of "Apoptosis"
- ASK(6 products)
- BCL(11 products)
- Caspase(125 products)
- FOXO1(3 products)
- IAP(66 products)
- Mdm2(12 products)
- PD-1/PD-L1(125 products)
- PDK(9 products)
- PERK(25 products)
- Serine/threonin kinase(15 products)
- Survivin(13 products)
- TNF(92 products)
- c-RET(51 products)
- p53(62 products)
Show 6 more subcategories
Found 5592 products of "Apoptosis"
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TQB-2858
<p>TQB-2858 is a bifunctional fusion protein composed of an anti-PD-L1 monoclonal antibody fused with the extracellular domain of the TGF-β receptor. It exhibits high affinity for PD-L1, TGF-β1, and TGF-β3, and demonstrates a high target occupancy rate for PD-L1. TQB-2858 can be used in research on osteosarcoma and alveolar soft part sarcoma (ASPS).</p>Color and Shape:Odour LiquidPCC0208017
CAS:<p>PCC0208017 is an inhibitor of MARK3 and MARK4 with IC50s of 1.8 and 2.01 nM. PCC0208017 disrupts microtubule dynamics and displays potent antitumor activity.</p>Formula:C19H20F3N7Purity:99.48%Color and Shape:SolidMolecular weight:403.4Thalidomide-O-PEG4-azide
CAS:<p>Thalidomide-O-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].</p>Formula:C23H29N5O9Purity:98%Color and Shape:SolidMolecular weight:519.5Ac-LEHD-AMC
CAS:<p>Ac-LEHD-AMC, a fluorogenic caspase-9 substrate, releases fluorescent AMC upon cleavage, aiding caspase-9 activity measurement.</p>Formula:C33H41N7O11Color and Shape:SolidMolecular weight:711.729Calphostin C
CAS:<p>Calphostin C is a protein kinase C inhibitor.</p>Formula:C44H38O14Purity:98%Color and Shape:Red To Brown PowderMolecular weight:790.76Apoptosis inducer 32
<p>Apoptosisinducer 32 (Compound 7g) is an apoptosis inducer with a KD of 42 μM, demonstrating antitumor activity by causing significant morphological changes, such as membrane blebbing, nuclear fragmentation, and apoptotic body formation, in MDA-MB-231 cells. The IC50 values for Apoptosisinducer 32 are 4.77 μM in MCF-7 cells, 6.56 μM in MDA-MB-231 cells, and 337.8 μM in HEK cells.</p>Formula:C29H27Cl2N3O8Color and Shape:SolidMolecular weight:616.45A-1208746
CAS:<p>A-1208746 is an inhibitor of MCL-1 with a Ki value of 0.454 nM. This compound effectively activates caspase-3/-7, induces apoptosis in H929 cells, and reduces mitochondrial membrane potential. Additionally, A-1208746 synergizes with Navitoclax, making it applicable in cancer research.</p>Formula:C45H52N6O7SColor and Shape:SolidMolecular weight:821CGP 3466B maleate
CAS:<p>CGP 3466B (Omigapil) is an oral drug inhibiting GAPDH nitrosylation and apoptosis, potentially treating Alzheimer's and CMD.</p>Formula:C23H21NO5Purity:98.58%Color and Shape:SolidMolecular weight:391.42TPP-resveratrol
<p>TPP-resveratrol is a conjugate of Resveratrol and triphenylphosphine (TPP), noted for its anticancer activity. This compound enhances the efficacy of Resveratrol by facilitating its targeted delivery to mitochondria, thus inducing mitochondrial-mediated cell apoptosis (apoptosis).</p>Formula:C36H32BrO4PColor and Shape:SolidMolecular weight:639.51CPTH2 (hydrochloride) (357649-93-5 free base)
CAS:<p>CPTH2 is an inhibitor of the HAT activity of Gcn5.</p>Formula:C14H15Cl2N3SPurity:98%Color and Shape:SolidMolecular weight:328.26AUNP-12
CAS:<p>AUNP-12, a new immune checkpoint modulator, is an inhibitor of the PD-1 pathway.</p>Formula:C142H226N40O48Purity:98%Color and Shape:SolidMolecular weight:3261.55TRAP-1
<p>TRAP-1 (XJZ-06-462) is a p53 transcription activator that effectively activates mutant p53 and triggers the transcription of p53 target genes. In the p53Y220C pancreatic cell line, TRAP-1 rapidly upregulates p21 and other p53 target genes. TRAP-1 also inhibits cell proliferation, exhibiting IC50 values of 3.94 μM and 0.531 μM in BxPC-3 and A549 cell lines, respectively. Additionally, TRAP-1 modulates autophagy in lung cancer cells and provides protection against oxidative stress and apoptosis.</p>Formula:C57H66ClF3N11O3PSColor and Shape:SolidMolecular weight:1108.69Anti-Mouse PD-1 Antibody (D265A) Antibody (RMP1-14)
<p>Anti-Mouse PD-1 Antibody (D265A) is an IgG2a, κ antibody inhibitor derived from mice, specifically targeting mouse PD-1.</p>Color and Shape:Odour LiquidPARP1-IN-27
<p>PARP1-IN-27 (Compound 9B) serves as an inhibitor of both PARP1 and PARP2, exhibiting IC 50 values of 2.53 nM and 6.45 nM, respectively, in SUM149PT cells. This compound effectively suppresses the proliferation of BRCA-mutated cancer cell lines such as SUM149PT, HCC1937, and Capan-1, with respective IC 50 values of 0.62, 1.91, and 4.26 μM. Additionally, PARP1-IN-27 exacerbates DNA double-strand breaks, enhances ROS production, causes G2/M phase cell cycle arrest, and triggers apoptosis in SUM149PT cells.</p>Formula:C17H12FNO4Color and Shape:SolidMolecular weight:313.28CNDAC hydrochloride
CAS:<p>CNDAC hydrochloride, a nucleoside analog, is a metabolite of the sapacitabine.</p>Formula:C10H13ClN4O4Purity:99.45%Color and Shape:SolidMolecular weight:288.69Daporinad hydrochloride
CAS:<p>Daporinad hydrochloride (FK 866 hydrochloride) is a NAMPT inhibitor with antitumor and antiangiogenic activity that induces apoptosis in tumor cells.</p>Formula:C24H30ClN3O2Purity:98.99%Color and Shape:SolidMolecular weight:427.97Apoptosis inducer 27
<p>Apoptosisinducer 27 (compound 1c) is a potent inhibitor of MDA-MB-231 breast cancer cells, demonstrating an IC50 of 12.8 μM and inducing early apoptosis in these cells. Additionally, it can bind to DNA molecules as well as Bax and Bcl-2 proteins, thereby inducing DNA damage.</p>Formula:C29H37BrN2Color and Shape:SolidMolecular weight:493.52BMH-7 HCl
<p>BMH-7 HCl is a p53 activator, showing anti-cancer activity by activating the p53 pathway.</p>Formula:C20H22ClN5OPurity:99.62%Color and Shape:SolidMolecular weight:383.88Pantoprazole Sodium Hydrate
CAS:<p>Pantoprazole Sodium Hydrate (BY1023 (sodium hydrate)) is a proton pump inhibitor drug, used for short-term treatment of erosion and ulceration of the esophagus</p>Formula:C16H14F2N3NaO4SH2OPurity:98.32%Color and Shape:SolidMolecular weight:432.372,2'-Dihydroxy chalcone
CAS:<p>2,2'-Dihydroxy chalcone inhibits β-glucuronidase (IC50=1.6 μM) and lysozyme (IC50=1.4 μM), and fights E. coli, S. fowleri, S. albicans, S. aureus.</p>Formula:C15H12O3Purity:99.7%Color and Shape:SolidMolecular weight:240.25
