Apoptosis
Apoptosis inhibitors are compounds that prevent or delay the process of programmed cell death, known as apoptosis. These inhibitors are vital in studying cell survival mechanisms and are used to investigate diseases where apoptosis is dysregulated, such as cancer, neurodegenerative disorders, and autoimmune diseases. By modulating apoptosis, these inhibitors can help in the development of therapies aimed at controlling cell death. At CymitQuimica, we provide a comprehensive selection of high-quality apoptosis inhibitors to support your research in cell biology, oncology, and related fields.
Subcategories of "Apoptosis"
- ASK(9 products)
- BCL(1 products)
- Caspase(154 products)
- FOXO1(2 products)
- IAP(67 products)
- Mdm2(12 products)
- PD-1/PD-L1(127 products)
- PDK(9 products)
- PERK(23 products)
- Serine/threonin kinase(17 products)
- Survivin(14 products)
- TNF(90 products)
- c-RET(61 products)
- p53(63 products)
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Found 6170 products of "Apoptosis"
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PG-11047 2HCl
PG-11047 2HCl treats genitourinary, immune, genetic, ocular, blood/lymphatic disorders, and aids lymphoma/prostate cancer research.Formula:C14H34Cl2N4Purity:99.51%Color and Shape:SolidMolecular weight:329.35Topoisomerase IIα-IN-10
TopoisomeraseIIα-IN-10 (Compound 13r) is a topoisomerase IIα inhibitor that binds to the active site of DNA when complexed with topoisomerase IIα. This binding is stabilized through interactions with DNA base pairs and amino acid residues. By intercalating into DNA, TopoisomeraseIIα-IN-10 induces apoptosis and disrupts the mitochondrial membrane potential in HCT116 cells, effectively inhibiting their growth with an IC50 of 4.37 μM. It is applicable for cancer research studies.Formula:C32H27N3O3Color and Shape:SolidMolecular weight:501.575IC 86621
CAS:IC 86621: DNA-PK ATP-competitive inhibitor, IC50 120 nM, enhances DSB antitumor effects, EC50 68 µM for repair.Formula:C12H15NO3Purity:99.68%Color and Shape:SolidMolecular weight:221.25AKT-IN-24
AKT-IN-24 (Compound M17) is an allosteric inhibitor of AKT exhibiting antitumor activity. In combination with Trametinib, it targets the AKT/mTOR and MEK/ERK signaling pathways while inhibiting epithelial-mesenchymal transition, resulting in a synergistic suppression effect on TNBC. This combination promotes apoptosis and inhibits cell proliferation and migration.Formula:C32H28N2O10Color and Shape:SolidMolecular weight:600.572NLRP3-IN-60
NLRP3-IN-60 (Compound 39) is an orally bioavailable inhibitor of NLRP3. It effectively suppresses pyroptosis in THP-1 cells with an IC50 of 13 nM and inhibits IL-1β release in human whole blood, exhibiting an IC50 of 225 nM.
Formula:C23H24F2N4O4SColor and Shape:SolidMolecular weight:490.523APG-1387
CAS:APG-1387 inhibits IAPs, degrades cIAP1/2, XIAP, boosts chemosensitivity, and induces apoptosis in NPC.Formula:C60H72N10O10S2Color and Shape:SolidMolecular weight:1157.41E3 ligase Ligand 36
CAS:E3 ligase Ligand 36 is an E3 ligase ligand that can be utilized for synthesizing PROTACs, such as PROTAC BRM/BRG1 degrader-1.Formula:C25H30N4O5SColor and Shape:SolidMolecular weight:498.6PROTAC LZK-IN-1
CAS:PROTAC LZK-IN-1 (Compound 21A) is a PROTAC molecule that targets the degradation of LZK (leucine zipper kinase, encoded by MAP3K13). At a concentration of 10 μM, PROTAC LZK-IN-1 facilitates the degradation of LZK and inhibits the expression of p53 and c-MYC, leading to reduced viability of global head and neck squamous cell carcinoma (HNSCC) cell lines. This compound is applicable in anticancer research.
Formula:C51H64F2N10O5SColor and Shape:SolidMolecular weight:967.18PEAQX tetrasodium hydrate
PEAQX tetrasodium hydrate: potent/selective oral NMDA antagonist, IC50 270 nM (1A/2A), 29600 nM (1A/2B).Formula:C17H15BrN3Na4O6PPurity:99%Color and Shape:SolidMolecular weight:560.15CSN5-IN-1
CSN5-IN-1 (compound Ac-11) serves as an inhibitor of CSN5, exhibiting IC50 values of 12.56 μM in FP assay and 19 μM in fluorescence assay. Additionally, it influences cellular protein expression by downregulating PD-L1 and upregulating NEDD8-Cul1.Formula:C17H22N2O2SColor and Shape:SolidMolecular weight:318.43PD-1-IN-20
PD-1-IN-20 is the less active enantiomer of PD-1-IN-1.Formula:C12H20N6O7Purity:98%Color and Shape:SolidMolecular weight:360.32L 683519
CAS:L 683519 is one of the Tacrolimus impurities with immunosuppressant and could restrain the activity of FK-506 binding protein.Formula:C43H67NO12Color and Shape:SolidMolecular weight:789.99Tyroserleutide hydrochloride
CAS:Tyroserleutide HCl, a tripeptide from pig spleen, inhibits tumor growth in vivo/vitro.Formula:C18H28ClN3O6Purity:98%Color and Shape:SolidMolecular weight:417.887,3′,5′-Trihydroxyflavanone
CAS:7,3′,5′-Trihydroxyflavanone, a flavanoid derivative, promotes apoptotic cell death in MCF-7 cells by augmenting Bax expression.Formula:C15H12O5Color and Shape:SolidMolecular weight:272.25Inuviscolide
CAS:Inuviscolide induces apoptosis, G2/M arrest in melanoma, and has anti-cancer, anti-inflammatory effects.Formula:C15H20O3Color and Shape:SolidMolecular weight:248.32OICR12694 TFA
CAS:OICR12694 (JNJ-65234637) TFA, an orally active B cell lymphoma 6 (BCL6) inhibitor [1], demonstrates effectiveness in targeting BCL6 pathways.Formula:C29H28ClF3N8O4·xC2HF3O2Color and Shape:SolidBAT-1306
BAT-1306 is a human monoclonal antibody (mAb) targeting PDCD1/PD-1/CD279. It is applicable for research in colorectal cancer and solid tumors.Color and Shape:Odour LiquidRTX-002
RTX-002 is a human monoclonal antibody (mAb) targeting PDCD1/PD-1/CD279. This compound is applicable in the research of autoimmune diseases such as systemic lupus erythematosus and multiple sclerosis.Color and Shape:Odour LiquidBRD4/FKBP12 degrader-1
BRD4/FKBP12 degrader-1 (a1d) is an anticancer agent that functions as a BRD4/FKBP12 degrader.Color and Shape:Odour SolidBim BH3
CAS:Bim BH3 is a bioactive peptide that belongs to the pro-apoptotic Bcl-2 family of proteins.Formula:C108H170N32O31SColor and Shape:SolidMolecular weight:2444.77
