Apoptosis
Apoptosis inhibitors are compounds that prevent or delay the process of programmed cell death, known as apoptosis. These inhibitors are vital in studying cell survival mechanisms and are used to investigate diseases where apoptosis is dysregulated, such as cancer, neurodegenerative disorders, and autoimmune diseases. By modulating apoptosis, these inhibitors can help in the development of therapies aimed at controlling cell death. At CymitQuimica, we provide a comprehensive selection of high-quality apoptosis inhibitors to support your research in cell biology, oncology, and related fields.
Subcategories of "Apoptosis"
- ASK(9 products)
- BCL(11 products)
- Caspase(144 products)
- FOXO1(3 products)
- IAP(67 products)
- Mdm2(12 products)
- PD-1/PD-L1(139 products)
- PDK(9 products)
- PERK(26 products)
- Serine/threonin kinase(18 products)
- Survivin(14 products)
- TNF(93 products)
- c-RET(62 products)
- p53(63 products)
Show 6 more subcategories
Found 6068 products of "Apoptosis"
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CSF1R-IN-26
CAS:CSF1R-IN-26 (Compound III-1) is an inhibitor of CSF-1R with an IC50 of 20.07 nM. It promotes the polarization of M2 macrophages to M1 macrophages, inducing apoptosis in MC-38 cancer cells. CSF1R-IN-26 inhibits the activation of the AKT/ERK/STAT3 signaling pathways, remodels the tumor immune microenvironment, and exhibits antitumor activity in mouse models. In SD rats, CSF1R-IN-26 demonstrates favorable pharmacokinetic properties, with a half-life of 1.86 hours and an oral bioavailability of 79.22%.Formula:C20H22ClN5O3Color and Shape:Odour SolidMolecular weight:415.871,2,3,4-Tetrahydronaphthalen-2-ol
CAS:1,2,3,4-Tetrahydronaphthalen-2-ol exhibits weak inhibitory activity against Bcl-xL and is widely used in biochemical experiments and drug synthesis research.Formula:C10H12OColor and Shape:SolidMolecular weight:148.2TNF-α-IN-9
CAS:TNF-α-IN-9 is an NDM-1 inhibitor-3 analog and is a TNF-α inhibitor.TNF-α-IN-9 shows low inhibitory activity.Formula:C17H14O4Purity:99.21%Color and Shape:SoildMolecular weight:282.29Thalidomide-O-amido-C8-NH2
CAS:Thalidomide-O-amido-C8-NH2 is a thalidomide-based ligand-linker for PROTAC synthesis.Formula:C23H30N4O6Purity:98%Color and Shape:SolidMolecular weight:458.51FAK-IN-24
CAS:FAK-IN-24 (Compound 9f) is a potent FAK inhibitor with an IC50 of 0.815 nM. It induces DNA damage and apoptosis, and exhibits activity against glioblastoma. FAK-IN-24 effectively inhibits proliferation of glioblastoma cell lines U87-MG (IC50= 15 nM) and U251 (IC50= 20 nM), and suppresses tumor growth in U87-MG xenograft models.Formula:C39H45Cl2F3N8O3Color and Shape:SolidMolecular weight:801.728CV-4-26
CV-4-26 (Compound 22) acts as a covalent inhibitor of TEAD. By inhibiting YAP/TEAD-driven transcription, it diminishes the expression of CTGF and CYR61. Furthermore, CV-4-26 impedes colony formation in Huh7 and HepG2 cells, inducing cell cycle arrest and apoptosis (apoptosis). This compound demonstrates anti-tumoral activity against hepatocellular carcinoma (HCC) and hepatoblastoma (HB).Color and Shape:Odour Solid(Rac)-BIO8898
CAS:(Rac)-BIO8898 is a chemical compound that serves as an inhibitor of the co-stimulatory interaction between CD40 and CD154.Formula:C53H64N8O6Color and Shape:SolidMolecular weight:909.13Valproic acid sodium salt
CAS:Sodium valproate is an anti-epileptic, boosting brain GABA levels and possibly affecting potassium channels for membrane stability.Formula:C8H15NaO2Purity:98% - 99.78%Color and Shape:White PowderMolecular weight:166.2HYS-072
<p>HYS-072 is an orally active derivative of chrysin with antitumor properties. It induces apoptosis (Apoptosis) and autophagy (Autophagy) by inhibiting the PI3K/AKT/mTOR signaling pathway, and suppresses tumor growth in xenograft models in vivo by modulating autophagy-related pathways. HYS-072 is applicable for research in treating triple-negative breast cancer.</p>Formula:C27H26N2O5Color and Shape:SolidMolecular weight:458.51RIP2 Kinase Inhibitor 4
CAS:RIP2 Kinase Inhibitor 4, a selective RIPK2 PROTAC, degrades RIPK2 (pIC50=8), inhibits TNF-α release.Formula:C50H66F2N14O7SColor and Shape:SolidMolecular weight:1045.23Betamethasone
CAS:Betamethasone (NSC-39470), a glucocorticoid steroid, has immunosuppressive and anti-inflammatory properties.Formula:C22H29FO5Purity:98% - 99.71%Color and Shape:White Or Almost White Powder Solid CrystallineMolecular weight:392.46Maceneolignan A
CAS:Maceneolignan A, a natural product isolated from the aril of Myristica fragrans (Myristicaceae), inhibits β-hexosaminidase release in RBL-2H3 cells, exhibitingFormula:C21H24O5Color and Shape:SolidMolecular weight:356.41Fisetin quarterhydrate
Fisetin quarterhydrate, a natural flavonol present in numerous fruits and vegetables, exhibits benefits including antioxidant, anticancer, and neuroprotectiveFormula:C15H10O6H2OColor and Shape:SolidMolecular weight:304.0583KRASG12C IN-16
KRASG12C IN-16 (Compound SK-17) is a selective, covalent, and orally active KRASG12C inhibitor. It can induce apoptosis and effectively prevent the activation of the MAPK and PI3K/mTOR signaling pathways. Additionally, KRASG12C IN-16 exhibits antitumor activity against pancreatic cancer.Formula:C28H35ClN8O2Color and Shape:SolidMolecular weight:551.08Thalidomide-NH-PEG2-COOH
CAS:Thalidomide-NH-PEG2-COOH: a synthesized E3 ligase ligand-linker with cereblon ligand and PROTAC linker.Formula:C20H23N3O8Color and Shape:SolidMolecular weight:433.417Siomycin A
CAS:<p>Siomycin A: thiopeptide antibiotic, selectively inhibits FOXM1, anti-tumor, induces apoptosis.</p>Formula:C71H81N19O18S5Purity:98%Color and Shape:SolidMolecular weight:1648.84AB-3PRGD2
CAS:<p>AB-3PRGD2 is a radiolabeled agent that targets integrin αvβ3. It enhances tumor uptake and prolongs retention time in tumors, significantly improving the inhibition of tumor growth. AB-3PRGD2 also remodels the tumor immune microenvironment by upregulating PD-L1 expression and increasing tumor-infiltrating CD8+ T cells.</p>Formula:C137H215IN30O45SColor and Shape:SolidMolecular weight:3161.32BAG3/HSP70-IN-1
USP1-IN-11 (compound 38-P2) is a selective, reversible, and non-competitive inhibitor of USP1 (Ubiquitin-specific protease 1). It activates the DDR (DNA damage repair) pathway, leading to cell cycle arrest and apoptosis, thereby inhibiting cell survival. USP1-IN-11 increases sensitivity to Olaparib in drug-resistant cells and works synergistically with Andrographolide in cancer cells with functional BRCA. In the MDA-MB-436 xenograft model, USP1-IN-11 demonstrates significant dose-dependent antitumor activity.Formula:C28H39N7O4Color and Shape:SolidMolecular weight:537.65Thalidomide-PEG2-C2-NH2 hydrochloride
CAS:Thalidomide-based cereblon ligand with 2-unit PEG linker for PROTAC, in hydrochloride form.Formula:C19H25ClN4O6Purity:98%Color and Shape:SolidMolecular weight:440.88Moracin N
CAS:Moracin N, a ferroptosis inhibitor derived from mulberry leaves, exhibits neuroprotective activity by mitigating oxidative stress [1].Formula:C19H18O4Purity:98%Color and Shape:SolidMolecular weight:310.34
