Apoptosis
Apoptosis inhibitors are compounds that prevent or delay the process of programmed cell death, known as apoptosis. These inhibitors are vital in studying cell survival mechanisms and are used to investigate diseases where apoptosis is dysregulated, such as cancer, neurodegenerative disorders, and autoimmune diseases. By modulating apoptosis, these inhibitors can help in the development of therapies aimed at controlling cell death. At CymitQuimica, we provide a comprehensive selection of high-quality apoptosis inhibitors to support your research in cell biology, oncology, and related fields.
Subcategories of "Apoptosis"
- ASK(6 products)
- BCL(11 products)
- Caspase(125 products)
- FOXO1(3 products)
- IAP(66 products)
- Mdm2(12 products)
- PD-1/PD-L1(125 products)
- PDK(9 products)
- PERK(25 products)
- Serine/threonin kinase(15 products)
- Survivin(13 products)
- TNF(92 products)
- c-RET(51 products)
- p53(62 products)
Show 6 more subcategories
Found 5592 products of "Apoptosis"
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Thalidomide-NH-PEG4-COOH
CAS:<p>Thalidomide-NH-PEG4-COOH is a E3 ligase ligand-linker for synthesizing the selective degrader dCBP-1 targeting p300/CBP.</p>Formula:C24H31N3O10Color and Shape:SolidMolecular weight:521.523Asparanin A
CAS:<p>Asparanin A, an apoptosis inducer with anticancer properties, arrests the cell cycle in the G0/G1 phase via the mitochondria and PI3K/AKT signaling pathways.</p>Formula:C39H64O13Purity:98%Color and Shape:SolidMolecular weight:740.92Anticancer agent 130
<p>Anticancer agent 130 (compound 8d) significantly induces apoptosis in A549 cells [1].</p>Formula:C38H46FN5O5Purity:98%Color and Shape:SolidMolecular weight:671.8PROTAC EGFR degrader 5
CAS:<p>PROTAC EGFR degrader 5 effectively breaks down EGFR Del19 in HCC827 cells at 34.8 nM, inducing apoptosis and G1 arrest.</p>Formula:C57H72FN13O5SColor and Shape:SolidMolecular weight:1070.33Ro 48-8071
CAS:<p>Oxidosqualene cyclase inhibitor</p>Formula:C23H27BrFNO2Purity:98%Color and Shape:SolidMolecular weight:448.37Vallesiachotamine
CAS:<p>Vallesiachotamine, a recognized monoterpene indole alkaloid, exhibits anti-tumor activity [1].</p>Formula:C21H22N2O3Color and Shape:SolidMolecular weight:350.41Tomuzotuximab
CAS:<p>Tomuzotuximab: fully human, glycoengineered IgG1 anti-EGFR monoclonal antibody with anticancer properties.</p>Color and Shape:LiquidMBC-11 triethylamine
<p>MBC-11 triethylamine, a first-in-class etidronate-araC conjugate, may treat TIBD.</p>Formula:C17H35N4O14P3Purity:98%Color and Shape:SolidMolecular weight:612.4WF 10129
CAS:<p>WF 10129 is a new angiotensin converting enzyme inhibitor generated by a fungus, Doratomyces putredinis.</p>Formula:C20H28N2O8Purity:98%Color and Shape:SolidMolecular weight:424.45Anti-Mouse PD-L1 Antibody (10F.9G2)
<p>Anti-Mouse PD-L1 Antibody (10F.9G2) is an IgG-class antibody against mouse PD-L1.</p>Purity:98.92% - >95% Determined by SDS-PAGEColor and Shape:Odour LiquidPoly (I:C):Kanamycin (1:1)
<p>Poly (I:C):Kanamycin (1:1) is an equimolar mixture of Poly(I:C) and kanamycin. TLR3 agonist commonly used as a vaccine adjuvant; enhanced Poly(I:C) stability.</p>Color and Shape:SolidPROTAC Bcl-xL degrader-1
<p>PROTAC Bcl-xL degrader-1 targets Bcl-xL & IAP E3 ligases, degrades Bcl-xL, toxic to human platelets & MyLa 1929 (IC50: 62 nM, 8.5 μM).</p>Formula:C76H96ClF3N10O11S3Color and Shape:SolidMolecular weight:1514.28VB-85247
<p>VB-85247 is a STING agonist that, by activating the STING pathway, induces the upregulation of inflammatory cytokines IFNα/β, TNFα, IL6, and CXCL10, as well as the maturation and activation of dendritic cells. It can lead to the regression of tumors within the bladder and is applicable in bladder cancer research.</p>Color and Shape:Odour SolidPacmilimab
CAS:<p>Pacmilimab (CX-072) is a Probody immune checkpoint inhibitor targeting programmed death ligand 1 (PD-L1) with anti-tumor activity for the study of solid tumors.</p>Purity:98.8% (SDS-PAGE); 96.3% (SEC-HPLC) - 98.8% (SDS-PAGE); 96.3% (SEC-HPLC)Color and Shape:Liquid5-LOX-IN-2
CAS:<p>5-LOX-in-2: a 5-lipoxygenase inhibitor with IC50 of 0.33 μM, reduces kidney cancer cell activity, induces apoptosis.</p>Formula:C17H16O4Purity:98.74%Color and Shape:SoildMolecular weight:284.31Rosomidnar
CAS:<p>PNT100: 24-base DNA oligo targeting BCL-2 regulatory region; halts tumor cell growth, induces death.</p>Formula:C227H291O141P23Color and Shape:SolidMolecular weight:7220.63Latikafusp
CAS:<p>Latikafusp (AMG 256) is a fusion protein that is a PD-1 blocker and IL-21R agonist with antitumor activity.</p>Purity:97.1% (SDS-PAGE); 97.4% (SEC-HPLC) - 97.1% (SDS-PAGE); 97.4% (SEC-HPLC)Color and Shape:LiquidP-gp inhibitor 16
<p>P-gp inhibitor 16 (compound 14) is an inhibitor of p-glycoprotein. It significantly enhances apoptosis induced by doxorubicin and displays anticancer properties.</p>Formula:C35H35N5O4Molecular weight:589.2689Cu(I) chelator 1
<p>Cu(I) chelator 1 (Compound LH2) is a chelating agent specifically targeting the Cu(I) redox state. It inhibits the production of ROS.</p>Formula:C16H27NO4S3Molecular weight:393.11022RIPK2-IN-4
<p>RIPK2-IN-4 is a potent and specific inhibitor of RIPK2 with an IC50 value of 5 nM.</p>Formula:C16H10N6S2Molecular weight:350.04084MDM2/4-p53-IN-3
<p>MDM2/4-p53-IN-3 inhibits MDM2/4-p53 PPIs (IC50: 18.5nM MDM2, 14.8nM MDM4), used in cancer research.</p>Formula:C25H24Cl2FN3O3Color and Shape:SolidMolecular weight:504.38Dimethachlor
CAS:<p>Dimethachlor is a pesticide and herbicide used in wetland areas.</p>Formula:C13H18ClNO2Color and Shape:SolidMolecular weight:255.74Thalidomide-N-C3-O-C4-O-C3-OH
<p>Thalidomide-N-C3-O-C4-O-C3-OH is a conjugate of an E3 ligase ligand and a linker, used in the synthesis of the Aster-APROTAC degrader.</p>Formula:C23H31N3O7Molecular weight:461.2162EGFR-PK/JNK-2-IN-1
<p>EGFR-PK/JNK-2-IN-1 (Compound 6c) is a dual inhibitor of EGFR-PK and JNK-2, with IC50 values of 2.7 and 3.0 μM, respectively. It can induce apoptosis and cause cell cycle arrest at various stages. This compound is applicable in cancer research.</p>Formula:C22H17ClN4O3SMolecular weight:452.07099Anticancer agent 204
<p>Anticanceragent 204 (Compound 6) is a fluorinated derivative of cinnamamides with anticancer activity. It can arrest the cell cycle of HepG2 cells in the G1 phase and induces apoptosis by reducing mitochondrial membrane polarization (MMP) levels.</p>Formula:C26H18FN5O3SMolecular weight:499.11144PROTAC PD-L1 degrader-1
<p>PROTACPD-L1 degrader-1 is a CRBN-based PD-L1-PROTAC degrader with significant PD-L1 protein degradation capacity. It demonstrates strong PD-L1 degradation activity in 4T1 cells, with a DC50 of 0.609 μM. This compound is applicable to breast cancer research.</p>RIP1 kinase inhibitor 9
<p>RIP1 kinase inhibitor 9 (compound SY-1) is a selective inhibitor of RIP kinase. It effectively reduces central inflammatory responses caused by seizures. RIP1 kinase inhibitor 9 also obstructs Z-VAD-FMK-induced necroptosis in HT-29 cells, with an EC50 of 7.04 nM.</p>Formula:C25H21N3O3Molecular weight:411.15829Thalidomide-PEG2-C2-NH2
CAS:<p>Thalidomide-O-amido-PEG3-C2-NH2 is a cereblon ligand-linked E3 ligase used in PROTAC with a 2-unit PEG.</p>Formula:C19H24N4O6Purity:98%Color and Shape:SolidMolecular weight:404.42OPBP-1
<p>OPBP-1 is a D-peptide developed through phage display screening, molecular docking, and molecular dynamics simulations. It exhibits high stability, strong antitumor activity, and oral bioavailability. OPBP-1 selectively binds to the PD-L1 protein, significantly blocking the interaction between PD-1 and PD-L1, which helps restore and enhance T lymphocyte function while reducing the proportion of myeloid-derived suppressor cells (MDSCs), counteracting tumor-induced immune evasion. OPBP-1 is applicable for research in cancer immunotherapy.</p>Formula:C64H92N20O19SMolecular weight:1476.65683Sudubrilimab
<p>Sudubrilimab (HS636) is an IgG1-κ monoclonal antibody targeting PDL1, fused with TGFBR2-ECD to block PD-1/PDL1 and TGF-β in tumors.</p>Color and Shape:Odour LiquidS2/IAPinh
<p>S2/IAPinh is a conjugate composed of an inhibitor of apoptosis proteins inhibitor (IAPinh) and a ligand of sigma 2 SW43. It demonstrates anti-proliferative and apoptosis-inducing activity by degrading inhibitor of apoptosis proteins (clAP-1).</p>Formula:C52H75Cl2FN6O6SMolecular weight:1000.48299Holothurin A
CAS:<p>Holothurin A is a triterpene glycoside.</p>Formula:C54H86NaO27SColor and Shape:SolidMolecular weight:1222.35-LOX-IN-8
<p>5-LOX-IN-8 is a 5-LOX inhibitor with anti-inflammatory properties. It suppresses IL-6, IL-1β, TNF-α, and IFN-γ in macrophages and reduces IL-8 secretion in SW480 cells. Additionally, 5-LOX-IN-8 decreases the disease activity index in DSS colitis models. This compound is applicable for research in inflammatory bowel disease (IBD).</p>Color and Shape:Odour SolidPD-L1-IN-5
<p>PD-L1-IN-5 (X22) is an orally active PD-L1 inhibitor with an IC50 of 785.6 nM, demonstrating antitumor activity in vivo.</p>Pantoprazole Sodium Hydrate
CAS:<p>Pantoprazole Sodium Hydrate (BY1023 (sodium hydrate)) is a proton pump inhibitor drug, used for short-term treatment of erosion and ulceration of the esophagus</p>Formula:C16H14F2N3NaO4SH2OPurity:98.32%Color and Shape:SolidMolecular weight:432.37PROTAC GPX4 degrader-4
CAS:<p>PROTACGPX4 degrader-4 is a GPX4 PROTAC degrader with a DC50 of 5.32 nM. It inhibits the activity of cancer cell lines RT4, T24, and J82 with IC50 values of 0.09, 2.97, and 7.58 μM, respectively. This compound elevates lipid ROS levels and induces ferroptosis in T24 and RT4 cells. In T24 tumor-bearing BALB/c nude mouse models, PROTACGPX4 degrader-4 demonstrates antitumor activity. It is applicable to bladder cancer research.</p>Formula:C43H58N2O13Color and Shape:SolidMolecular weight:810.93FR900359
CAS:<p>FR900359 is a macrocyclic Gq protein inhibitor that inhibits melanoma cell proliferation and can be used to study asthma, inflammation and cancer.</p>Formula:C49H75N7O15Purity:98%Color and Shape:SolidMolecular weight:1002.16Thymidine 3',5'-diphosphate tetrasodium
CAS:<p>Thymidine 3',5'-diphosphate tetrasodium inhibits staphylococcal nuclease, SND1 & tyrosyl nuclease; has anti-tumor properties & catalyzes biochemical reactions.</p>Formula:C10H12N2Na4O11P2Color and Shape:SolidMolecular weight:490.12Human PD-L1 inhibitor IV
CAS:<p>PD-L1 inhibitor IV, a polypeptide, competitively blocks hPD-1 with a Kd of 1.38 μM, preventing hPD-1/hPD-L1 interaction.</p>Formula:C80H113N25O27Color and Shape:SolidMolecular weight:1856.932BIIB023
<p>BIIB023 is a human monoclonal antibody (mAb) that targets TNFRSF12A/TWEAKR/CD266. It is applicable for research in lupus nephritis and rheumatoid arthritis.</p>Color and Shape:Odour LiquidUNC10245380
<p>UNC10245380 is a CIB1 inhibitor with an IC50 of 8 μM. It also inhibits the phosphorylation of AKT and ERK while upregulating the expression of TRAIL-R1/D5. UNC10245380 specifically kills cancer cells that are dependent on CIB1, demonstrating its potential value in the development of CIB1 probes and cancer research.</p>Color and Shape:Odour SolidPBE-AMF
<p>PBE-AMF is a prodrug that activates H2O2 and exhibits anticancer activity. It impedes tumor proliferation by inhibiting DNA synthesis, reducing ATP levels, inducing cell death (apoptosis), and blocking the cell cycle. PBE-AMF effectively and selectively inhibits the proliferation of MDA-MB-231 cells (IC50=6.4 μM) while sparing non-cancerous MCF-10A cells.</p>Color and Shape:Odour SolidTNF-α Antagonist
CAS:<p>TNF-α antagonist is an exocyclic peptide that mimics the critical TNF-α recognition loop on TNF receptor I complex and, thus, prevents ligand interaction with</p>Formula:C58H71N11O15S2Color and Shape:SolidMolecular weight:1226.39Pomstafib-2
CAS:<p>Pomstafib-2, a potent and selective inhibitor of STAT5b, reduces pSTAT5b expression and effectively induces apoptosis [1] [2].</p>Formula:C52H66N2O20P2Color and Shape:SolidMolecular weight:1101.03Vonlerizumab
<p>Vonlerizumab (Anti-TNFRSF4/OX40/CD134 Antibody) is a humanized monoclonal antibody targeting OX40, used in tumor research.</p>Purity:>95%Color and Shape:LiquidMolecular weight:145.5 kDaRA-XII
CAS:<p>RA-XII is a useful organic compound for research related to life sciences. The catalog number is T125868 and the CAS number is 143343-98-0.</p>Formula:C46H58N6O14Color and Shape:SolidMolecular weight:918.998Desmethyl-WEHI-345 analog
CAS:<p>Desmethyl-WEHI-345 analog, a protein kinase inhibitor, holds potential for colon cancer research.</p>Formula:C22H23N7OColor and Shape:SolidMolecular weight:401.474FAK-IN-25
<p>FAK-IN-25 (4c) is an inhibitor of FAK with an IC50 value of 50.98 nM. It induces apoptosis and causes cell cycle arrest in the G1 phase, making it relevant for cancer research.</p>Formula:C22H13ClN4OS2Color and Shape:SolidMolecular weight:448.95RO5353
CAS:<p>RO5353 is a potent and orally active inhibitor of p53-MDM2.</p>Formula:C29H29Cl2FN4O4SPurity:98%Color and Shape:SolidMolecular weight:619.53CDK2-IN-45
<p>CDK2-IN-45 is a CDK2 inhibitor with an IC50 value of 0.64 μM. It effectively inhibits the proliferation of DU-145 and PC-3 cell lines, with IC50 values of 2.20 μM and 4.17 μM, respectively. Additionally, CDK2-IN-45 induces G0/G1 phase cell cycle arrest and apoptosis. It is utilized in prostate cancer research.</p>Formula:C25H16ClN5SColor and Shape:SolidMolecular weight:453.95Os30
<p>Os30 is a potent fourth-generation EGFR inhibitor, specifically targeting the EGFRC797S-TK mutation with IC50 values of 18 nM for EGFRDel19/T790M/C797S TK and</p>Purity:98%Color and Shape:Odour SolidEriosematin
CAS:<p>Eriosematin has anti-proliferative and apoptosis-inducing properties and is a compound extracted from the root of Flemingia philippinensis in the Philippines.</p>Formula:C19H20O4Purity:98%Color and Shape:SolidMolecular weight:312.36PROTAC Bcl-xL ligand-1
<p>PROTAC Bcl-xL ligand-1 serves as a ligand targeting Bcl-xL, essential in synthesizing PROTACs [1].</p>Formula:C32H29IN4O4S2Color and Shape:SolidMolecular weight:724.63IRF1-IN-2
CAS:<p>IRF1-IN-2 is a small molecule IRF1 inhibitor that suppresses pyroptosis, protecting against radiation-induced skin damage.</p>Formula:C18H20N2O4SPurity:99.85%Color and Shape:SolidMolecular weight:360.43Zapalog
CAS:<p>Zapalog: photocleavable dimerizer controlling instant protein interactions.</p>Formula:C58H73N7O15Purity:98%Color and Shape:SolidMolecular weight:1108.24Ac-Trp-Glu-His-Asp-Aldehyde
CAS:<p>Ac-Trp-Glu-His-Asp-Aldehyde is a powerful and selective inhibitor of caspase-1, demonstrating a K_i value of 56 pM [1] [2].</p>Formula:C28H33N7O9Color and Shape:SolidMolecular weight:611.6PROTAC MNK1 degrader-1
<p>ROTACMNK1degrader-1 is a selective MNK1 PROTAC degrader with a DC50 of 11.92 nM and a Dmax greater than 96% in MV4-11 cells. It significantly reduces p-eIF4E levels with an IC50 of 22.07 nM, induces apoptosis, and causes cell cycle arrest at the G1 phase. This compound exhibits potent antitumor activity, demonstrating strong anti-leukemic effects in MV4-11 xenograft mouse models with acceptable drug safety.</p>Formula:C35H38N6O6SColor and Shape:SolidMolecular weight:670.78Gliotoxin
CAS:<p>Gliotoxin, a mycotoxin, inhibits Wnt pathway, causing apoptosis in mutated colorectal cancer cells and blocks NF-κB by preserving IκB.</p>Formula:C13H14N2O4S2Purity:98%Color and Shape:SolidMolecular weight:326.39Atibuclimab
CAS:<p>Atibuclimab is a chimeric monoclonal antibody targeting CD14, consisting of a mouse variable region and a human IgG4 Fc region.</p>Purity:> 95% - > 95%Color and Shape:LiquidMolecular weight:145.28 kDaXIAP BIR2/BIR2-3 inhibitor-3
CAS:<p>XIAP BIR2/BIR2-3 Inhibitor-3 functions as a dual inhibitor targeting both BIR2 and BIR2-3 domains, exhibiting potent activity with IC50 values below 1 nM. This compound is utilized in cancer research [1].</p>Formula:C86H106N18O16S2Color and Shape:SolidMolecular weight:1712Emfizatamab
CAS:<p>Emfizatamab (GNC-038) is a tetravalent antibody that activates CD3 and 4-1BB on T cells while targeting CD19 or PD-L1 on tumor cells, resulting in T-cell-mediated cytotoxicity against human leukemia and lymphoma cells.</p>Color and Shape:LiquidZamzetoclax
CAS:<p>Zamzetoclax (compound 1) acts as a potential inhibitor of Mcl-1.</p>Formula:C38H46ClN5O6SColor and Shape:SolidMolecular weight:736.32Oenothein B
CAS:<p>Oenothein B inhibits PAR-glycohydrolase with antioxidant, anti-inflammatory, antifungal, anti-HCV, and antitumor effects.</p>Formula:C68H48O44Purity:99.30%Color and Shape:SolidMolecular weight:1569.08CDC20-IN-2
<p>CDC20-IN-2 (14c) is an inhibitor of Cdc20 with a KD of 7.65 μM, inducing G2/M phase arrest, promoting DNA damage accumulation, and stabilizing key substrates such as Cyclin B1 and Bim. This leads to enhanced apoptosis, as well as inhibition of tumor cell proliferation and migration.</p>Color and Shape:Odour Solid5-Fluorouracil-13C,15N2
CAS:<p>5-Fluorouracil-13C,15N2 is a standard for quantifying 5-fluorouracil via GC/LC-MS and blocks DNA synthesis, causing cell apoptosis.</p>Formula:C4H3FN2O2Color and Shape:SolidMolecular weight:133.057Necroptosis-IN-4
<p>Necroptosis-IN-4 is an effective inhibitor of necroptosis, specifically targeting RIP kinase 1 (RIPK1) without inhibitory activity against RIPK3. It exhibits weak inhibitory effects on VEGFR1/2 and PDGFR-α.</p>Color and Shape:Odour SolidPD-1/PD-L1-IN-48
<p>PD-1/PD-L1-IN-48 (compound HD10) is an effective inhibitor of the PD-1/PD-L1 interaction, exhibiting an IC50 of 3.1 nM. It plays a vital role in cancer research.</p>Color and Shape:Odour SolidBorrelidin
CAS:<p>Borrelidin (Treponemycin) is an inhibitor of trehalose-6-phosphate synthase, a nitrogen-containing macrolide antibiotic isolated from Streptomyces rochei.</p>Formula:C28H43NO6Purity:98%Color and Shape:White To Off-White PowderMolecular weight:489.64Mcl-1 inhibitor 15
<p>Mcl-1 Inhibitor 15 (Compound (Ra)-15), with a K i of 0.02 nM, is utilized in cancer research [1].</p>Formula:C40H42ClFN6O4SColor and Shape:SolidMolecular weight:757.32Apoptosis inducer 13
<p>Apoptosis Inducer 13 (Compound Ru4) promotes apoptosis in cancer cells while also suppressing their migration and invasion.</p>Formula:C59H54ClF6N8O4PRuPurity:98%Color and Shape:SolidMolecular weight:1220.6Terrein
CAS:<p>Terrain (NSC 291308), a fungal metabolite, reduces age-related inflammation via Nrf2/ERK1/2/HO-1 and inhibits IL-6 in human fibroblasts.</p>Formula:C8H10O3Color and Shape:SolidMolecular weight:154.16SACLAC
CAS:<p>SACLAC is a cysteine asparaginase activation inhibitor with antitumor activity used in the study of acute myeloid leukemia and cancer.</p>Formula:C20H40ClNO3Purity:97.03%Color and Shape:SoildMolecular weight:377.99Diprovocim-1
CAS:<p>Diprovocim-1: TLR1/2 agonist; triggers TNF-α in THP-1 cells; boosts ovalbumin IgG1 & CTLs against tumors with anti-PD-L1 in mice.</p>Formula:C56H56N6O6Color and Shape:SolidMolecular weight:909.1Δ8-Tetrahydrocannabinoquinone
CAS:<p>Δ8-Tetrahydrocannabinoquinone (HU-336) is a potent anti-angiogenic agent that inhibits angiogenesis by directly inducing apoptosis in vascular endothelial cells. It achieves this without altering the expression of pro-angiogenic and anti-angiogenic cytokines and receptors. Δ8-Tetrahydrocannabinoquinone also shows significant effectiveness against tumor xenografts in nude mice.</p>Formula:C21H28O3Color and Shape:SolidMolecular weight:328.45Petromurin C
CAS:<p>Petromurin C, a bis-indolyl benzenoid from P. muricatus, is cytotoxic to NS-1 cells (IC50=33μg/ml) and active against T. foetus (IC50=100μg/ml).</p>Formula:C26H24N2O5Color and Shape:SolidMolecular weight:444.4873-Hydroxyterphenyllin
CAS:<p>3-Hydroxyterphenyllin from A. candidus is a fungal compound with antioxidant, anticancer, antibacterial, and antiviral effects.</p>Formula:C20H18O6Color and Shape:SolidMolecular weight:354.35MY-943
<p>MY-943, a potent inhibitor of tubulin polymerization and LSD1, exhibits anticancer properties by inducing G2/M phase arrest, promoting apoptosis, and</p>Formula:C30H36N4O6S2Color and Shape:SolidMolecular weight:612.76Angiogenesis inhibitor 3
CAS:<p>Angiogenesis Inhibitor 3 (compound 8) is a potent anti-cancer agent, blocking HUVEC/HCT-15 cell growth and inducing apoptosis.</p>Formula:C44H42BrN3O9Color and Shape:SolidMolecular weight:836.72Fludarabine triphosphate
CAS:<p>Fludarabine triphosphate inhibits key enzymes, causing cell death.</p>Formula:C10H15FN5O13P3Color and Shape:SolidMolecular weight:525.17Lactoferrin (17-41)
CAS:<p>Amino acids 17-41 of lactoferrin, lactoferricin B, enhance anti-fungal effects, targeting Candida Albicans.</p>Formula:C141H224N46O29S3Purity:98%Color and Shape:SolidMolecular weight:3123.77BCL-XL-IN-3
CAS:<p>BCL-XL-IN-3 (Compound 11) is an inhibitor of BCL-XL, with a Ki of less than 0.01 nM. It suppresses cell viability in both normal Molt-4 cells and digitonin-permeabilized Molt-4 cells, with EC50 values of 77.8 nM and 0.07 nM, respectively. BCL-XL-IN-3 can be utilized as an ADC toxin for synthesizing Clezutoclax.</p>Formula:C46H55N7O6SColor and Shape:SolidMolecular weight:834.04NSC90616
<p>NSC90616 is a mutant p53 rescue compound [1] .</p>Formula:C23H30FNa2O9PColor and Shape:SolidMolecular weight:546.43sEH inhibitor-19
<p>sEH inhibitor-19 (Compound (R)-14i) is an orally active soluble epoxide hydrolase (sEH) inhibitor with an IC50 of 1.2 nM. This compound suppresses the expression of TNF-α and IL-6 and exhibits anti-inflammatory effects in mouse models of acute pancreatitis and Carrageenan-induced edema.</p>Formula:C28H28F3N3O4Color and Shape:SolidMolecular weight:527.535PDE4D inhibitor 1
<p>PDE4-IN-1 is a PDE4 inhibitor characterized by high potency (IC50: 8.6 nM) and superior selectivity over other PDE subtypes. This compound inhibits the release of inflammatory cytokines and chemokines. Additionally, PDE4-IN-1 significantly restores the damaged cAMP-CREB signaling pathway, inhibits proliferation, and promotes differentiation to reverse psoriasis formation.</p>Color and Shape:Odour SolidBcl-2-IN-4
CAS:<p>Bcl-2-IN-4: potent, selective, oral Bcl-2 inhibitor with 1.5 nM IC50, >200x selectivity over Bcl-xL.</p>Formula:C46H50ClN9O7SColor and Shape:SolidMolecular weight:908.46TV 3279
CAS:<p>TV 3279 is a ChE-MAI inhibitor with neuroprotection via anti-apoptotic protein induction and blocks pro-apoptotic enzymes in cells.</p>Formula:C16H20N2O2Purity:97%Color and Shape:SoildMolecular weight:272.34SFI003
CAS:<p>SFI003 is a novel SRSF3 inhibitor that exerts anticancer activity against colorectal cancer by modulating the SRSF3 / DHCR24 / ROS axis and driving apoptosis in</p>Formula:C19H17N5OSPurity:98.92%Color and Shape:SoildMolecular weight:363.44eIF4A3-IN-7
CAS:<p>eIF4A3-IN-7: Potent eIF4A3 inhibitor, potential cancer/dysproliferation research (WO2019161345A1, Compound 8).</p>Formula:C26H25NO7Color and Shape:SolidMolecular weight:463.48684-B10
CAS:<p>84-B10 provides protection in cisplatin-induced acute kidney injury, reversing lipid peroxidation accumulation and downregulation of key ferroptosis inhibitors.</p>Formula:C25H22F3NO5Purity:99.76%Color and Shape:SolidMolecular weight:473.44Lesigercept
<p>Lesigercept is a humanized antibody that targets IGHE.</p>Color and Shape:Odour LiquidKP1019
CAS:<p>KP1019 is now discontinued.</p>Formula:C21H19Cl4N6RuColor and Shape:SolidMolecular weight:598.30Bromoiodoacetamide
CAS:<p>Bromoiodoacetamide (I-HAcAm): cytotoxic, induces ROS & apoptosis in HepG-2 cells.</p>Formula:C2H3BrINOColor and Shape:SolidMolecular weight:263.86Thalidomide-O-C4-COOH
CAS:<p>Thalidomide-O-C4-COOH is a synthetic E3 ligase linker derived from Thalidomide for PROTAC tech.</p>Formula:C18H18N2O7Color and Shape:SolidMolecular weight:374.3447Thalidomide-NH-C6-NH-Boc
CAS:<p>Thalidomide-based E3 ligase ligand for PROTAC degrader MI-389 synthesis, linked to cereblon and Boc.</p>Formula:C24H32N4O6Color and Shape:SolidMolecular weight:472.542Antitumor agent-64
CAS:<p>Antitumor Agent-64 (Compound 8d), a diosgenin derivative, exhibits potent cytotoxic activity against the A549 cell line and induces apoptosis in A549 cells</p>Formula:C35H47N3O3SColor and Shape:SolidMolecular weight:589.83Golimumab
CAS:<p>Golimumab (CNTO-148), an anti-TNFα IgG1κ monoclonal antibody with anti-inflammatory and anti-cancer activity, can be used to prevent inflammation and cartilage.</p>Color and Shape:LiquidMolecular weight:146.93 kDaEtanercept
CAS:<p>Etanercept is a fusion protein consisting of the soluble portion of the p75-tumor necrosis factor receptor (TNFR) and the Fc fragment of human IgG1 and is commonly used to treat patients with rheumatoid arthritis.Cost-effective and quality-assured.</p>Purity:98%Color and Shape:LiquidFC-116
CAS:<p>FC-116 is a potent Tubulin inhibitor with antitumour activity and inhibits tumour growth in mice.FC-116 induces apoptosis and promotes protein degradation.</p>Formula:C21H20FNO4Purity:98.18%Color and Shape:SoildMolecular weight:369.39CAY10678
CAS:<p>CAY10678 is an mPGES-1 inhibitor that inhibits PD-1.CAY10678 reduces collagen deposition and T-cell depletion, and may be used to study melanoma.CASHIPS</p>Formula:C23H34N4OPurity:99.66%Color and Shape:SolidMolecular weight:382.54Antitumor agent-116
<p>Antitumor Agent-116 (Compound 6C) is an anti-tumor agent that exhibits anti-proliferative properties and induces apoptosis.</p>Formula:C31H23BrN4O4SPurity:98%Color and Shape:SolidMolecular weight:627.51AFMK
CAS:<p>AFMK (Formyl-N-acetyl-5-methoxykynurenamine) is an active metabolite of Melatonin with antioxidant and free radical scavenging activity.</p>Formula:C13H16N2O4Purity:98.34% - 99.81%Color and Shape:SolidMolecular weight:264.28Pralnacasan
CAS:<p>Pralnacasan blocks IL-18, IL-1β, IFN-γ. It’s a potent oral enzyme inhibitor with use in arthritis therapy (Ki: 1.4 nM).</p>Formula:C26H29N5O7Purity:98%Color and Shape:SolidMolecular weight:523.54PERK-IN-4
CAS:<p>PERK-IN-4 is a potent and selective PERK inhibitor with an IC50 value of 0.3 nM.PERK-IN-4 can be used in the study of cancer and neurological disorders.</p>Formula:C24H19F4N5OPurity:98.07% - 98.95%Color and Shape:SolidMolecular weight:469.43WK499
<p>BCL6-IN-10 (Compound WK499) is an inhibitor of BCL6, disrupting its interaction with the SMRT protein and promoting apoptosis, cell cycle arrest, and DNA damage</p>Formula:C21H20BrN7O3Color and Shape:SolidMolecular weight:498.33CDK-TCIP1
CAS:<p>CDK-TCIP1 is a bivalent molecule that links the CDK9 inhibitor SNS-032 with the BCL6 ligand BI3812. It effectively and specifically kills cells overexpressing BCL6, with an EC50 of 7.7 nM for SUDHL5 cells.</p>Formula:C48H62ClN11O8S2Color and Shape:SolidMolecular weight:1020.66PD1-PDL1-IN 1 TFA
<p>PD1-PDL1-IN 1 TFA (compound 16) is a potent inhibitor of programmed cell death 1 (PD-1), functioning as an immune modulator [1].</p>Formula:C16H24F3N7O8Color and Shape:SolidMolecular weight:499.4VEGFR-2-IN-36
<p>VEGFR-2-IN-36 (compound 15) serves as a potent VEGFR-2 inhibitor, exhibiting an IC50 value of 0.067 μM, and acts as an apoptosis inducer with demonstrated</p>Formula:C24H23N7O5Purity:98%Color and Shape:SolidMolecular weight:489.48Cannflavin A
CAS:<p>Cannflavin A, isolated from Cannabis sativa L., exhibits anti-cancer, neuroprotective, and anti-inflammatory activities by inhibiting Aβ1-42 aggregation and</p>Formula:C26H28O6Color and Shape:SolidMolecular weight:436.5DH-18
<p>DH-18 is an inhibitor of matrix metalloproteinase-2 (MMP-2), exhibiting IC50 values of 139.45 nM for MMP-2, 518.11 nM for MMP-9, and 833.34 nM for MMP-8. The compound promotes cell apoptosis and causes cell cycle arrest in the G0/G1 phase. DH-18 also inhibits cell growth, making it potential for research in chronic myeloid leukemia.</p>Formula:C26H23F6N3O5SColor and Shape:SolidMolecular weight:603.53BM 957
CAS:<p>BM 957 is an effective Bcl-2 and Bcl-xL inhibitor (Kis: 1.2 and <1 nM; IC50s: 5.4 and 6.0 nM).</p>Formula:C52H56ClF3N6O7S3Purity:98%Color and Shape:SolidMolecular weight:1065.68PROTAC EZH2 Degrader-3
<p>PROTAC EZH2 Degrader-3 (compound ZJ-20) is a potent EZH2 degrader that exhibits strong inhibitory effects not only on EZH2 protein expression but also on the levels of other PRC2 subunits and H3k27me3 protein. Additionally, PROTAC EZH2 Degrader-3 demonstrates antiproliferative activity by blocking the cell cycle at the G0-G1 phase and inducing apoptosis (cell death). At a concentration of 5 μM and over a period of 24 hours, it effectively suppresses the expression of these critical proteins involved in cell regulation and growth.</p>Formula:C56H68N8O8Color and Shape:SolidMolecular weight:981.19FGFR1/VEGFR2-IN-3
<p>FGFR1/VEGFR2-IN-3 (Compound 8m) acts as a dual inhibitor of FGFR1 and VEGFR2. This compound exhibits both anti-cancer cell proliferation and anti-migration activities, and it also has the capability to induce cell apoptosis (apoptosis).</p>Formula:C27H18N4O4Color and Shape:SolidMolecular weight:462.46p53 and MDM2 proteins-interaction-inhibitor (racemic)
CAS:<p>p53 and MDM2 proteins-interaction-inhibitor (racemic) is an inhibitor of the interaction between p53 and MDM2 proteins.</p>Formula:C40H49Cl2N5O4Purity:98%Color and Shape:SolidMolecular weight:734.75ROS inducer 5
<p>ROS inducer 5 (compound 6e) induces intracellular ROS accumulation and subsequent nuclear fragmentation. It can provoke apoptosis in MCF-7 cells with an IC50 of 3.85 μM. ROS inducer 5 is useful for cancer research applications.</p>Formula:C20H15ClN4O2S3Color and Shape:SolidMolecular weight:475.01PRMT5-IN-45
<p>PRMT5-IN-45 (compound 36) is a potent and selective inhibitor of PRMT5, exhibiting an IC50 value of 3 nM. This compound effectively reduces the levels of symmetrical dimethylarginine (sDMA) and inhibits the proliferation of the MOLM-13 cell line by inducing apoptosis and causing cell cycle arrest.</p>Formula:C26H31N7O2Color and Shape:SolidMolecular weight:473.57EGFR-IN-131
<p>EGFR-IN-131 (compound 3a) is an efficacious EGFR inhibitor capable of crossing the blood-brain barrier, with an IC50 value of 272.9 nM. This compound exhibits anti-proliferative activity, induces cellular apoptosis (apoptosis), and causes cell cycle arrest in the G0/G1 phase. Additionally, EGFR-IN-131 reduces the protein expression of p-EGFR.</p>Formula:C26H23FN4O2SColor and Shape:SolidMolecular weight:474.55Asaretoclax
CAS:<p>Asaretoclax is an effective inhibitor of B-cell lymphoma 2 (Bcl-2), demonstrating potential for use in cancer research.</p>Formula:C47H57F2N7O7SColor and Shape:SolidMolecular weight:902.06JAK05
<p>JAK05 exhibits inhibitory activity against Helicobacter pylori, effectively suppressing strains J63, J196, and J107, with a MIC of 3-5 µg/mL. It shows affinity for binding to H+/K+-ATPase, COX-1/2, TNF-α, and PGE2, and possesses antioxidant and anti-inflammatory properties. In a rat model of ethanol-induced gastric ulcers, JAK05 demonstrates anti-ulcer activity.</p>Formula:C27H27ClN4O9SColor and Shape:SolidMolecular weight:619.043PLD-IN-1
<p>PLD-IN-1 (Compound 3r) is an orally effective inhibitor of phospholipase D (phospholipaseD) with an IC50 of 1.97 μM. It reduces the expression of CD24, CD47, and PD-L1 while enhancing the expression of calreticulin, thereby modulating the immune evasion mechanisms of lung cancer cells by promoting the phagocytosis of cancer cells by macrophages. PLD-IN-1 inhibits the viability of lung cancer cell lines A549, HCC44, H460, and HCC15 with IC50 values of 18.44, 22.31, 24.85, and 21.45 μM, respectively. It induces apoptosis (apoptosis) in A549 cells and inhibits cell migration. Additionally, PLD-IN-1 increases pro-inflammatory M1 macrophage levels and decreases anti-inflammatory M2 macrophage levels, exhibiting anti-tumor activity in mouse models.</p>Formula:C19H14F6N2OColor and Shape:SolidMolecular weight:400.32Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA
CAS:<p>Arg-Gly-Asp-D-Phe-Val (TFA) has anti-tumor activity and is an inhibitor of integrin αvβ3.</p>Formula:C28H39F3N8O9Purity:98%Color and Shape:SolidMolecular weight:688.662Moflerafusp alfa
CAS:<p>Moflerafusp alfa is a fusion protein that targets the human signal-regulatory protein alpha (SIRPα) variant V2 D1 domain and human programmed death-ligand 1 (PD-L1). It shows potential for research in various cancer treatments.</p>Color and Shape:LiquidDistamycin A
CAS:<p>Distamycin A (NSC-82150), oligopeptide antibiotic, binds A/T rich DNA, affects cleavage sites, enhances apoptosis.</p>Formula:C22H27N9O4Color and Shape:SolidMolecular weight:481.51C-Reactive Protein (CRP) (174-185)
CAS:<p>CRP protein and its fragment (174-185, RS-83277) boost human monocyte and macrophage cancer-killing effects in vitro.</p>Formula:C62H93N13O16Purity:98%Color and Shape:SolidMolecular weight:1276.48RMC-7977
CAS:<p>RMC-7977 is a inhibitor of the active (GTP-bound) forms of KRAS, HRAS, and NRAS with anticancer activity for the study of solid tumors with KRAS G12C mutations.</p>Formula:C47H60N8O6SPurity:97.11% - 99.86%Color and Shape:SolidMolecular weight:865.09Sarglaroids F
<p>Sarglaroids F (compound 6), an anti-inflammatory agent extracted from the roots of Grass Coral, suppresses LPS/ATP-induced IL-1β secretion by modulating K+</p>Formula:C38H44O12Purity:98%Color and Shape:SolidMolecular weight:692.75Poly(I:C):Kanamycin (1:1) sodium
<p>Poly(I:C):Kanamycin (1:1) sodium is a complex.Poly(I:C) is a TLR3 and RIG-I/MDA5 agonist.Kanamycin is an antimicrobial,Gram-negative and positive bacteria.</p>Purity:99%Color and Shape:SolidDL-Sulforaphane N-acetyl-L-cysteine
CAS:<p>DL-Sulforaphane N-acetyl-L-cysteine (SFN-NAC), induces apoptosis through α-microtubulin and phosphorylation of ERK1/2-mediated Stathmin-1, and Hsp70 (NSCLC).</p>Formula:C11H20N2O4S3Color and Shape:SolidMolecular weight:340.48ARV-393 HCl
<p>ARV-393 HCl is an orally active and potent PROTAC targeting BCL6 with antitumor activity for the study of non-Hodgkin's lymphoma.</p>Formula:C46H54Cl2FN9O7Purity:99.79%Color and Shape:SolidMolecular weight:934.88Xerophilusin B
CAS:<p>Xerophilusin B from Isodon xerophilus halts ESCC cell growth, causes G2/M arrest, and induces apoptosis.</p>Formula:C20H26O5Color and Shape:SolidMolecular weight:346.42Stem bromelain
CAS:<p>Stem bromelain: cysteine protease from pineapple stem with fibrinolytic, anti-inflammatory, antitumoral properties.</p>Color and Shape:SolidCDK9-Cyclin T1 PPI-IN-1
<p>CDK9-Cyclin T1 PPI-IN-1 (Compound B19) is a selective inhibitor of the CDK9-Cyclin T1 protein-protein interaction (PPI), suppressing cell proliferation in TNBC</p>Purity:98%Color and Shape:Odour SolidPD-L1/LpxC-IN-1
<p>PD-L1/LpxC-IN-1 (Compound 12b) is an inhibitor of PD-L1 and LpxC, with IC50 values of 5.2 μM and 0.081 μM, respectively. This compound disrupts bacterial lipopolysaccharide biosynthesis, leading to bacterial cell lysis and death. It effectively inhibits Gram-negative bacteria, exhibiting a minimum inhibitory concentration (MIC) of 0.25-0.5 μg/mL against K. pneumoniae ATCC 13883, E. coli ATCC 8739, S. typhimurium ATCC 14028, and P. aeruginosa ATCC 9027. Additionally, PD-L1/LpxC-IN-1 modulates the immune response by downregulating the expression of inflammatory cytokines IL-2 and IFN-γ, and upregulating CD4+ and CD8+ cells, thus activating the immune system and mitigating excessive inflammatory responses. In a mouse model of K. pneumoniae ATCC 13883 infection, PD-L1/LpxC-IN-1 demonstrated antibacterial activity.</p>Color and Shape:Odour SolidJacaric Acid
CAS:<p>Conjugated 18-C ω-6 fatty acid from Jacaranda seeds, induces cancer cell apoptosis via oxidative stress; metabolizes to cytotoxic CLA.</p>Formula:C18H30O2Color and Shape:SolidMolecular weight:278.436D-Trimannuronic acid
CAS:<p>D-Trimannuronic acid from seaweed induces TNF-α in mouse macrophages; useful in pain, dementia studies.</p>Formula:C18H26O19Color and Shape:SolidMolecular weight:546.387MDM2 ligand 4
<p>MDM2ligand 4 is a ligand of MDM2 and can be used in the synthesis of the PROTAC degrader [KT-253].</p>Formula:C31H33Cl2FN2O4Color and Shape:SolidMolecular weight:587.509AB-3PRGD2
CAS:<p>AB-3PRGD2 is a radiolabeled agent that targets integrin αvβ3. It enhances tumor uptake and prolongs retention time in tumors, significantly improving the inhibition of tumor growth. AB-3PRGD2 also remodels the tumor immune microenvironment by upregulating PD-L1 expression and increasing tumor-infiltrating CD8+ T cells.</p>Formula:C137H215IN30O45SColor and Shape:SolidMolecular weight:3161.32EGFR-IN-143
<p>EGFR-IN-143 (Compound 5f) is a potent EGFR inhibitor with an IC50 value of 0.15 μM. It induces apoptosis by arresting the cell cycle at the G2/M phase and exhibits antitumor activity.</p>Formula:C20H21ClN6O3Color and Shape:SolidMolecular weight:428.872TrxR-IN-7
<p>TrxR-IN-7 (14f) is a potent inhibitor of thioredoxin reductase (TrxR), with an IC50 value of 3.5 µM. It exhibits antiproliferative activity and can induce apoptosis and the production of reactive oxygen species (ROS).</p>Formula:C22H21NO3Color and Shape:SolidMolecular weight:347.407ATPase-IN-3
CAS:<p>ATPase-IN-3 is an ATPase (ATPase) inhibitor that can be used in the study of metabolism-related diseases.</p>Formula:C10H6N2O3S2Purity:97.76%Color and Shape:SoildMolecular weight:266.3PCC0208017
CAS:<p>PCC0208017 is an inhibitor of MARK3 and MARK4 with IC50s of 1.8 and 2.01 nM. PCC0208017 disrupts microtubule dynamics and displays potent antitumor activity.</p>Formula:C19H20F3N7Purity:99.48%Color and Shape:SolidMolecular weight:403.4Lacto-N-fucopentaose I
CAS:<p>Lacto-N-fucopentaose I is a milk oligosaccharide.</p>Formula:C32H55NO25Color and Shape:SolidMolecular weight:853.774Mcl-1 inhibitor 3
CAS:<p>Mcl-1 inhibitor 3 shows good pharmacokinetic properties and excellent in vivo efficacy without toxicity.Mcl-1 inhibitor 3 is a highly potent and orally activate</p>Formula:C40H52ClF2N5O7SPurity:98%Color and Shape:SolidMolecular weight:820.39Thalidomide-O-C8-COOH
CAS:<p>Thalidomide-O-C8-COOH, also known as Cereblon ligand 3, is a Thalidomide-derived compound that serves as a Cereblon (CRBN) ligand for the targeted recruitment</p>Formula:C22H26N2O7Color and Shape:SolidMolecular weight:430.45ZLDI-8
CAS:<p>ZLDI-8 is an inhibitor of Notch activating/cleaving enzyme ADAM-17 and inhibits the cleavage of Notch protein.</p>Formula:C24H23N3O3SPurity:98.09%Color and Shape:SolidMolecular weight:433.52AP1867-2-(carboxymethoxy)
CAS:<p>AP1867-2-(carboxymethoxy), a moiety based on the synthetic FKBP12F36V-directed ligand AP1867, connects to the CRBN ligand through a linker to generate dTAG</p>Formula:C38H47NO11Color and Shape:SolidMolecular weight:693.78Nemorosone
CAS:<p>Nemorosone, a PPAP from C. rosea, inhibits neuroblastoma and pancreatic cancer cell growth, induces apoptosis, and reduces mouse xenograft tumors.</p>Formula:C33H42O4Color and Shape:SolidMolecular weight:502.695ADPM06
CAS:<p>ADPM06: nonporphyrin PDT agent; leads in apoptosis, strong IC50 in µM against human tumors.</p>Formula:C34H24BBr2F2N3O2Color and Shape:SolidMolecular weight:715.19Chetomin
CAS:<p>Chetomin (BRN0077366) is an inhibitor of HIF-1 by weaken transcription of HIF-1, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar</p>Formula:C31H30N6O6S4Purity:98%Color and Shape:Off-White To Fawn SolidMolecular weight:710.87ChoKα inhibitor-3
<p>ChoKα Inhibitor-3, a sulfur-containing choline kinase inhibitor, effectively inhibits HChoK α1 with an IC50 value of 0.66 μM and possesses the capability to</p>Formula:C50H54Br2Cl2N4S2Color and Shape:SolidMolecular weight:1005.83CDK4/6/HDAC-IN-1
<p>CDK4/6/HDAC-IN-1 (Compound N14) is a dual-target inhibitor of CDK4/6 and HDAC, with IC50 values of 7.23 nM for CDK4, 13.20 nM for CDK6, 55.66 nM for HDAC1, and 48.38 nM for HDAC6. It induces apoptosis and G0/G1 phase arrest through the HDAC-p21-CDK signaling pathway and can inhibit hepatocellular carcinoma.</p>Formula:C35H39N9O5Color and Shape:SolidMolecular weight:665.742Sterigmatocystine
CAS:<p>Sterigmatocystine, a G1 phase and DNA synthesis inhibitor, curbs p21 and is a mycotoxin precursor from Aspergillus versicolor.</p>Formula:C18H12O6Purity:98%Color and Shape:Pale-Yellow Crystals Pale Yellow SolidMolecular weight:324.28DefNEtTrp
<p>DefNEtTrp is an iron bis-chelating ligand composed of Def and Trp groups. It demonstrates potent broad-spectrum antiproliferative and cytotoxic effects in cancer cell lines. DefNEtTrp induces apoptosis and ferroptosis, exhibiting cytotoxicity with an IC50 value of 0.77 μM.</p>Formula:C30H27N9O3SColor and Shape:SolidMolecular weight:593.659PROTAC TRIB2 degrader-1
<p>PROTAC TRIB2 degrader-1 (Compound 5k) is a potent TRIB2 degrader that selectively induces TRIB2 degradation via the CRBN-dependent ubiquitin-proteasome pathway. It effectively inhibits cell proliferation and induces cell apoptosis (apoptosis), making it useful in cancer research.</p>Formula:C45H45FN8O6Color and Shape:SolidMolecular weight:812.89TTQ-SA
<p>TTQ-SA is a near-infrared spiraling aggregation-induced emitter capable of converting near-infrared light (NIR) into thermal energy, resulting in thermal damage and death of tumor cells. In cancer cells MF-7, TTQ-SA shows cell uptake and targeting capabilities. TTQ-SA binds with DNAzyme to inhibit the expression of the survivin gene, enhancing the sensitivity of tumor cells to photothermal therapy.</p>Formula:C78H53N7SColor and Shape:SolidMolecular weight:1120.37PROTAC XPO1 degrader-1
<p>PROTAC XPO1 degrader-1 (Compound 2c) is an XPO1 degrader. It exhibits anti-proliferative effects, induces apoptosis, inhibits NF-κB activity, and causes cell cycle arrest at the G1 phase. PROTAC XPO1 degrader-1 is applicable to research on hematological malignancies.</p>Formula:C33H35ClF3N7O7Color and Shape:SolidMolecular weight:734.122STEP-IN-1
<p>STEP-IN-1 (Compound 14b) is a potent and selective inhibitor of STEP, with an IC50 of 5.27 μM. It offers neuroprotective effects by safeguarding neuronal cells from glutamate-induced toxicity, reducing intracellular reactive oxygen species (ROS) accumulation, and inhibiting apoptosis. STEP-IN-1 is applicable in research related to neurodegenerative diseases.</p>Formula:C21H10ClNO7Color and Shape:SolidMolecular weight:423.76JAK-IN-40
<p>JAK-IN-40 (Compound 46) is an inhibitor of JAK, effectively targeting JAK1, JAK2, and JAK3 with IC50 values of 0.022, 0.759, and 1.601 μM, respectively. It reduces the phosphorylation of STAT3 and inhibits the proliferation of cancer cells Ba/F3 and JAK1-TEL Ba/F3 with GI50 values of 0.614 μM and 0.193 μM. JAK-IN-40 arrests cell cycle progression at the G2/M phase in H1975 and H2087 cells, leading to apoptosis. Additionally, JAK-IN-40 exhibits a synergistic anti-tumor effect when used in combination with Osimertinib.</p>Formula:C26H32N8O3SColor and Shape:SolidMolecular weight:536.65TrxR1-IN-2
<p>TrxR1-IN-2 (Compound 6a) acts as a TrxR1 inhibitor that covalently bonds with the Cys475 and Sec498 sites of TrxR1. This interaction hampers TrxR1 activity, resulting in a redox homeostasis disruption and inducing apoptosis and ferroptosis.</p>Formula:C19H23NO6Color and Shape:SolidMolecular weight:361.389F1324 acetate
<p>F1324 acetate is an efficient, high-affinity b-cell lymphoma inhibitor with IC50 of 1 nM.</p>Formula:C85H125N21O22SPurity:98%Color and Shape:SolidMolecular weight:1825.09Episilvestrol
CAS:<p>Episilvestrol is a derivative of silvestrol with eIF4A-targeted antitumor properties, found in Aglaia silvestris fruits and twigs.</p>Formula:C34H38O13Purity:98%Color and Shape:SolidMolecular weight:654.66mTOR inhibitor-27
<p>mTORinhibitor-27 (Compound 7e) is an inhibitor of mammalian target of rapamycin (mTOR) with an IC50 value of 5.47 μM. It can induce apoptosis in tumor cells and arrest the cell cycle in the S phase, thereby inhibiting cancer cell growth. mTORinhibitor-27 presents potential for research in cancer, including skin cancer.</p>Color and Shape:Odour SolidDeoxynyboquinone
CAS:<p>Deoxynyboquinone is a potent inducer of cancer cell death with IC(50) values between 16 and 210 nM.</p>Formula:C15H12N2O4Purity:98%Color and Shape:SolidMolecular weight:284.27EMB-02
<p>EMB-02 is a bispecific antibody targeting both PD-1 and LAG-3. It inhibits the downregulation of T cell activation and proliferation mediated by PD-1 and LAG-3, showing potent anti-cancer properties.</p>Color and Shape:Odour LiquidDiazepinomicin
CAS:<p>Diazepinomicin, from Micromonospora, blocks EGF-Ras-ERK pathway and induces apoptosis; an anti-tumor agent for K-Ras mutants.</p>Formula:C28H34N2O4Purity:98%Color and Shape:SolidMolecular weight:462.58anti-TNBC agent-9
<p>Anti-TNBC agent-9 (Compound 3as) is an anticancer agent used for treating triple-negative breast cancer (TNBC). It exhibits significant inhibitory activity against MDA-MB-453 cells, with an IC50 value of 8.5 μM. Anti-TNBC agent-9 impedes tumor cell migration by upregulating E-cadherin and downregulating N-cadherin, matrix metalloproteinase 2 (MMP2), and MMP9. Additionally, it inhibits tumor cell proliferation by inducing apoptosis, achieved through the increased expression of pro-apoptotic protein BAX and decreased expression of anti-apoptotic protein BCL-2.</p>Color and Shape:Odour SolidMcl1-IN-12
CAS:<p>Mcl1-IN-12 has anti-tumor activity.It is a selective Mcl-1 inhibitor, less potent at Bcl-2, with Kis of 0.29 and 3.1 μM, respectively.</p>Formula:C45H46N4O6S2Purity:98%Color and Shape:SolidMolecular weight:803TopoII/tubulin-IN-1
<p>TopoII/tubulin-IN-1 (Compound 1B8) is an inhibitor of TopoII/tubulin. It effectively suppresses the proliferation of tumor cells and reduces ROS levels, while inducing apoptosis and cell cycle arrest, without showing significant cytotoxicity to normal cells. TopoII/tubulin-IN-1 exhibits antitumor activity.</p>Formula:C21H18ClN5O3Color and Shape:SolidMolecular weight:423.85HX009
<p>HX009 is a bispecific antibody that targets PD1 and CD47, though its binding to CD47 is attenuated. HX009 functions by blocking PD1/CD47 and can be utilized in research related to non-Hodgkin lymphoma (NHL).</p>Color and Shape:Odour LiquidH-20
CAS:<p>H-20 is a PD-1 agonist that reduces the required dosage of morphine for analgesia. It can be used in studies related to chronic pain.</p>Formula:C44H64N10O15Color and Shape:SolidMolecular weight:973.037(Iso)-Z-VAD(OMe)-FMK
CAS:<p>(Iso)-Z-VAD(OMe)-FMK is an isomer of Z-VAD(OMe)-FMK, which is a pan-caspase inhibitor with irreversible properties. Z-VAD(OMe)-FMK is also an inhibitor UCHL1.</p>Formula:C22H30FN3O7Purity:97.10%Color and Shape:SoildMolecular weight:467.49Human membrane-bound PD-L1 polypeptide
CAS:<p>Human membrane-bound PD-L1 polypeptide serves as an antigen for inducing the production of PD-L1 antibodies [1].</p>Formula:C85H140N26O36SPurity:98%Color and Shape:SolidMolecular weight:2134.24YF135
CAS:<p>YF135 is a reversible-covalent KRAS G12C PROTAC that degrades its target via the VHL-proteasome pathway.</p>Formula:C63H75ClN12O7SColor and Shape:SolidMolecular weight:1179.86Opamtistomig
CAS:<p>Opamtistomig is a humanized monoclonal antibody immunoglobulin (H-γ1-scFv-L-κ) dimer targeting human programmed death-ligand 1 (PD-L1), CD274, and tumor necrosis factor receptor superfamily member 9 (TNFRSF9). It is anticipated for use in research on various solid tumors and hematologic malignancies.</p>Color and Shape:LiquidINF200
<p>INF200 (compound 5), a sulfonylurea-based inhibitor of NLRP3 and associated pyroptosis, exhibits cardiometabolic benefits in a rat model of high-fat diet (HFD)-</p>Formula:C13H13ClN2O4Purity:98%Color and Shape:SolidMolecular weight:296.71Z-LEHD-fmk
CAS:<p>Z-LEHD-FMK is a selective and potent caspase-9 inhibitor that protects against reperfusion injury and slows apoptosis.Z-LEHD-FMK exhibits antitumor and</p>Formula:C32H43FN6O10Purity:96.13%Color and Shape:SolidMolecular weight:690.72(R)-MIK665
CAS:<p>(R)-MIK665 is the less active enantiomer of MIK665. MIK665 is a special inhibitor of Mcl-1(IC50 of 1.81 nM).</p>Formula:C47H44ClFN6O6SPurity:98%Color and Shape:SolidMolecular weight:875.41MG-277
<p>MG-277 is a molecular glue compound transformed from PROTAC degradation agent, MG-277 potently inhibits tumor cell growth in a p53-independent manner.</p>Formula:C41H42Cl2FN5O5Purity:98%Color and Shape:SolidMolecular weight:774.71Pim-1 kinase inhibitor 4
<p>Pim-1 kinase inhibitor 4 is a potent Pim-1 kinase inhibitor with an IC50 value of 17.01 nM.Pim-1 kinase inhibitor 4 also possesses antioxidant activity and</p>Formula:C19H12ClN3OPurity:97.72%Color and Shape:SolidMolecular weight:333.77PROTAC RIPK degrader-2
CAS:<p>PROTAC RIPK degrader-2 is a nonpeptidic PROTAC ,and potently targets serine-threonine kinase RIPK2 and has highly selective for RIPK2 degradation.</p>Formula:C52H65N7O11S3Purity:98%Color and Shape:SolidMolecular weight:1060.31Anticancer agent 137
<p>Anticancer agent 137 (8q), a potent PI3k inhibitor, exhibits broad-spectrum anticancer activity by inducing G2/M cell cycle arrest and apoptosis.</p>Formula:C26H27NO6Purity:98%Color and Shape:SolidMolecular weight:449.5Ecdysone
CAS:<p>Ecdysone is a major steroid hormone in insects and herbs.</p>Formula:C27H44O6Purity:99.22%Color and Shape:PowderMolecular weight:464.63Psalmotoxin 1
CAS:<p>Psalmotoxin 1 is a potent and selective acid-sensing ion channel 1a (ASIC1a) blocker.</p>Formula:C200H312N62O57S6Purity:98%Color and Shape:SolidMolecular weight:4689.41SP3N hydrochloride
<p>SP3N hydrochloride is a specific degrader of the prolyl isomerase (FKBP12). Its alkylamine moiety is metabolized into an active aldehyde (SP3CHO), which recruits the SCFFBXO22 ligase for the degradation of FKBP12. SP3N hydrochloride is applicable in cancer research.</p>Color and Shape:Odour SolidSuramin
CAS:<p>Suramin is an RdRp and PTPase inhibitor with anti-parasitic, anti-tumor, and anti-angiogenic activities, inhibiting sirtuins and DNA topoisomerase II.</p>Formula:C51H40N6O23S6Purity:99.80%Color and Shape:SolidMolecular weight:1297.28AlbA-DCA
<p>AlbA-DCA, a compound of Albiziabioside A and dichloroacetate, boosts ROS and reduces lactic acid in tumors, killing cancer cells and triggering apoptosis.</p>Formula:C43H67Cl2NO12Purity:98%Color and Shape:SolidMolecular weight:860.9PZ703b hydrochloride
<p>PZ703b hydrochloride, a Bcl-xl PROTAC, triggers apoptosis and halts cancer growth; used in bladder cancer studies.</p>Formula:C80H103Cl2F3N10O11S4Color and Shape:SolidMolecular weight:1636.9c-Met/HDAC-IN-4
<p>c-Met/HDAC-IN-4, a dual inhibitor of c-Met/HDAC, exhibits an IC 50 value of 28.92 nM for c-Met. This compound effectively induces G 0 /G 1 phase cell cycle arrest and apoptosis in MDA-MB-231 breast cancer cells. Additionally, c-Met/HDAC-IN-4 suppresses both the proliferation and invasion of breast cancer cell lines.</p>Formula:C37H36N8OColor and Shape:SolidMolecular weight:608.73LS-106
<p>LS-106 is an orally active, effective epidermal growth factor receptor (EGFR) inhibitor displaying antitumor activity both in vitro and in vivo. It inhibits the kinase activities of EGFR19del/T790M/C797S and EGFRL858R/T790M/C797S, with IC50 values of 2.4 nmol/L and 3.1 nmol/L, respectively, demonstrating stronger inhibition than Osimertinib. LS-106 induces cell apoptosis (Apoptosis), suppresses the proliferation of tumor cells carrying EGFR19del/T790M/C797S, and results in significant tumor reduction in a C797S mutant xenograft model.</p>Formula:C24H28BrClN5OPColor and Shape:SolidMolecular weight:548.84Sandalore
CAS:<p>Sandalore boosts hair growth, reduces cell death, and raises IGF-1, acting on olfactory receptor OR2AT4.</p>Formula:C14H26OPurity:97.96%Color and Shape:Light Yellow Viscous LiquidMolecular weight:210.36N-Deshydroxyethyl Dasatinib
CAS:<p>N-Deshydroxyethyl Dasatinib (N-Deshydroxyethyl BMS-354825) is a metabolite of Dasatinib, a dasatinib-based molecule that degrades ABL by binding to the IAP</p>Formula:C20H22ClN7OSPurity:95.96%Color and Shape:SolidMolecular weight:443.95CNDAC hydrochloride
CAS:<p>CNDAC hydrochloride, a nucleoside analog, is a metabolite of the sapacitabine.</p>Formula:C10H13ClN4O4Purity:99.45%Color and Shape:SolidMolecular weight:288.69Thalidomide 4'-oxyacetamide-alkyl-C2-amine HCl
CAS:<p>Thalidomide 4'-oxyacetamide-alkyl-C2-amine HCl is an E3 ligase ligand-linker conjugate containing the E3 ubiquitin ligase cereblon (CRBN) and linker.</p>Formula:C17H19ClN4O6Purity:99.78%Color and Shape:SolidMolecular weight:410.81Anticancer agent 267
<p>Anticanceragent 267 (Compound 5q) serves as an activator of RIPK3 and MLKL. It effectively inhibits the proliferation of several cancer cell lines, with IC50 values of 9.79, 10.77, and 5.94 μM for MDA-MB-231, MDA-MB-486, and MCF-7, respectively. The compound induces cell cycle arrest at the subG1 phase and triggers necroptosis in MDA-MB-231 cells. Additionally, Anticanceragent 267 demonstrates antitumor activity in mouse xenograft models.</p>Formula:C13H11N5O4SColor and Shape:SolidMolecular weight:333.32C-Peptide 1 (rat)
CAS:<p>C-Peptide 1 (rat) is a polypeptide isolated from proinsulin. C-Peptide acts as a β-catenin/GSK-3β activator, influences Na/K-ATPase, regulates apoptosis.</p>Formula:C140H228N38O51Purity:99.788%Color and Shape:SolidMolecular weight:3259.58AUNP-12
CAS:<p>AUNP-12, a new immune checkpoint modulator, is an inhibitor of the PD-1 pathway.</p>Formula:C142H226N40O48Purity:98%Color and Shape:SolidMolecular weight:3261.55Apoptosis inducer 24
CAS:<p>Apoptosisinducer 24 (Compound 4) inhibits the proliferation of gastric cancer cells with an IC50 range of 1.2-4.8 μM. It arrests the cell cycle at the G2/M phase, induces apoptosis in BGC-823 cells, and causes mitochondrial dysfunction. In mice, Apoptosisinducer 24 exhibits antitumor activity without significant toxicity, having an LD50 of 91.2 mg/kg.</p>Formula:C55H70BNO9Color and Shape:SolidMolecular weight:899.96PROTAC FGFR2 degrader 1
<p>PROTAC FGFR2 degrader 1 (compound N5) is a potent PROTAC that efficiently targets FGFR2, boasting a DC 50 value of 6.46 nM and an FGFR2 IC 50 of 0.08 nM. This compound exhibits significant anti-proliferative effects and high selectivity. It induces G0/G1 arrest in the cell cycles of KATOIII and SNU16 and inhibits apoptosis by diminishing the activation of p-ERK and p-PLCγ, the downstream proteins of FGFR2. Additionally, PROTAC FGFR2 degrader 1 maintains over 50% inhibition of gastric cancer cells at a concentration of 0.17 nM and effectively suppresses the growth of SNU16 xenograft tumors in a mouse model.</p>Color and Shape:Odour SolidIsoharringtonine
CAS:<p>Isoharringtonine, an alkaloid from Cephalotaxus koreana, inhibits and induces apoptosis in cancer cells.</p>Formula:C28H37NO9Color and Shape:SolidMolecular weight:531.59Ub4ix
CAS:<p>Ub4ix, a DUB/26S proteasome inhibitor, safeguards K48-linked Ub chains against cleavage by deubiquitinating enzymes (DUBs) and inhibits the proteasomal degradation of Ub-tagged proteins. Additionally, it diminishes the viability of Hela cells and triggers apoptosis, exhibiting an IC 50 value of 1.6 μM.</p>Formula:C84H106N18O23SColor and Shape:SolidMolecular weight:1767.91FKBP12 ligand-1
CAS:<p>FKBP12 ligand-1 is the target protein ligand for MC-25B, which is a PROTAC targeting FKBP12.</p>Formula:C32H41NO9Color and Shape:SolidMolecular weight:583.669
