Apoptosis
Apoptosis inhibitors are compounds that prevent or delay the process of programmed cell death, known as apoptosis. These inhibitors are vital in studying cell survival mechanisms and are used to investigate diseases where apoptosis is dysregulated, such as cancer, neurodegenerative disorders, and autoimmune diseases. By modulating apoptosis, these inhibitors can help in the development of therapies aimed at controlling cell death. At CymitQuimica, we provide a comprehensive selection of high-quality apoptosis inhibitors to support your research in cell biology, oncology, and related fields.
Subcategories of "Apoptosis"
- ASK(6 products)
- BCL(11 products)
- Caspase(125 products)
- FOXO1(3 products)
- IAP(66 products)
- Mdm2(12 products)
- PD-1/PD-L1(125 products)
- PDK(9 products)
- PERK(25 products)
- Serine/threonin kinase(15 products)
- Survivin(13 products)
- TNF(92 products)
- c-RET(51 products)
- p53(62 products)
Show 6 more subcategories
Found 5599 products of "Apoptosis"
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c-Met-IN-10
CAS:<p>c-Met-IN-10: potent kinase inhibitor (IC50=16 nM), halts cancer cell activity/movement, induces apoptosis, for anticancer research.</p>Formula:C26H21FN6O5Color and Shape:SolidMolecular weight:516.48CUR61414
CAS:<p>CUR61414 is a cell-permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM) and selectively binds to smoothened (Ki = 44 nM).</p>Formula:C31H42N4O5Purity:97.34% - 98%Color and Shape:SolidMolecular weight:550.69Anticancer agent 128
CAS:<p>Anticancer agent 128 (compound 1) is an IAP inhibitor that covalently binds to the BIR3 domains of XIAP, cIAP1, and cIAP2, exhibiting IC50 values of 24.9 nM, 19</p>Formula:C26H38N4O4Purity:98%Color and Shape:SolidMolecular weight:470.6NSC 48160
CAS:<p>NSC 48160 is an anti-pancreatic cancersmall molecule that inhibits growth and enhance apoptosis of pancreatic cancer cells through the mitochondrial pathway.</p>Formula:C18H29NOPurity:98.10%Color and Shape:SolidMolecular weight:275.43JNJ-1013
CAS:<p>JNJ-1013 is a selective IRAK1 PROTAC degrader with an IC50 of 72 nM ,antiproliferative and proapoptotic, increases cleaved-PARP expression.</p>Formula:C46H55N9O7SPurity:99.596%Color and Shape:SolidMolecular weight:878.05MS-177
CAS:<p>MS-177 is a PROTAC EZH2 degrader that promotes cholangiocarcinoma growth through the EZH2-mediated WNT7B/β-catenin pathway.</p>Formula:C48H55N11O8Color and Shape:SolidMolecular weight:914.02Anticancer agent 105
CAS:<p>Anticancer agent 105, a thienopyrimidine scaffold-based compound, exhibits selective toxicity towards melanoma and induces apoptosis.</p>Formula:C25H24KN3O6SPurity:98%Color and Shape:SolidMolecular weight:533.64Anticancer agent 127
CAS:<p>Anticancer agent 127 (142D6), an IAP inhibitor, covalently binds to the BIR3 domains of XIAP, cIAP1, and cIAP2, with IC50 values of 12 nM, 14 nM, and 9 nM,</p>Formula:C26H37FN4O6SPurity:98%Color and Shape:SolidMolecular weight:552.66Ferroptocide
CAS:<p>Ferroptocide is a thioredoxin inhibitor that induces iron death in cancer cells and can be used in breast cancer research.</p>Formula:C30H36ClN3O7Color and Shape:SolidMolecular weight:586.08IM156
CAS:<p>IM156, a Metformin derivative, activates AMPK, enhances cognition in aging animals, and inhibits OXPHOS in solid tumor research.</p>Formula:C13H16F3N5OPurity:99.67%Color and Shape:SolidMolecular weight:315.29TM5441 sodium
CAS:<p>TM5441, an orally bioavailable plasminogen activator inhibitor-1 (PAI-1) inhibitor with IC50 values ranging from 13.9 to 51.1 μM, effectively induces intrinsic apoptosis across multiple human cancer cell lines. Additionally, it mitigates Nω-nitro-l-arginine methyl ester-induced cardiac hypertension and vascular senescence [1] [2].</p>Formula:C21H16ClN2NaO6Color and Shape:SolidMolecular weight:450.8HDAC-IN-50
CAS:<p>HDAC-IN-50, a potent FGFR/HDAC inhibitor (IC50: 0.18-13 nM), induces apoptosis, cell cycle arrest, and shows anti-tumor activity.</p>Formula:C31H41N7O4Color and Shape:SolidMolecular weight:575.7Anticancer agent 81
CAS:<p>Compound 37b3, an anticancer, halts tumor growth, triggers cell death, and pairs with Trastuzumab to form T-PBA, an ADC with targeted delivery.</p>Formula:C46H46N6O5Purity:98%Color and Shape:SolidMolecular weight:762.89Ezatiostat hydrochloride
CAS:<p>Ezatiostat HCl (TLK199) inhibits glutathione S-transferase, GSTP1-1 specifically, and may treat cytopenias.</p>Formula:C27H36ClN3O6SPurity:98%Color and Shape:SolidMolecular weight:566.11RIPK-IN-4
CAS:<p>RIPK-IN-4 is an effective and selective inhibitor of RIPK2. It also has excellent oral bioavailability (IC50: 3 nM).</p>Formula:C18H21FN4O3SPurity:98%Color and Shape:SolidMolecular weight:392.45hGGPPS-IN-3
CAS:<p>13h (hGGPPS-IN-3), a strong C2-ThP-BPs hGGPPS blocker, triggers MM cell apoptosis and shows in vivo anti-myeloma effects.</p>Formula:C21H19BrN4O7P2SPurity:98%Color and Shape:SolidMolecular weight:613.31BQZ-485
CAS:<p>BQZ-485, a potent GDI2 inhibitor, interacts with Tyr245 to disrupt the native GDI2-Rab1A interaction.</p>Formula:C32H39NO3Purity:98%Color and Shape:SolidMolecular weight:485.66SD 1008
CAS:<p>SD 1008 is a JAK2/STAT3 signaling pathway inhibitor. SD 1008 inhibits activation of STAT3, JAK2, and Src.</p>Formula:C18H19NO5Purity:98%Color and Shape:SolidMolecular weight:329.35AAPK-25
CAS:<p>AAPK-25, a dual Aurora/PLK inhibitor, disrupts mitosis, induces apoptosis, and has antitumor properties.</p>Formula:C21H13Cl2N3O2SPurity:97.05%Color and Shape:SolidMolecular weight:442.32SM-433
CAS:<p>SM-433: Smac mimetic, blocks IAPs, strong XIAP BIR3 affinity (IC50 <1 μM). See patent WO2008128171A2.</p>Formula:C32H43N5O4Color and Shape:SolidMolecular weight:561.71Met-F-AEA
CAS:<p>Met-F-AEA is a metabolically stable analogue of anandamine that exhibits antitumor activity by inhibiting cell growth through the activation of apoptosis [1].</p>Formula:C23H38FNOColor and Shape:SolidMolecular weight:363.561AMRI-59
CAS:<p>AMRI-59 is a potent inhibitor of PrxI with anti-tumor activity.</p>Formula:C25H27N3O2Purity:99.79%Color and Shape:SolidMolecular weight:401.5BET-IN-20
CAS:<p>BET-IN-20 (compound 10), a BRD4 BD1 inhibitor (IC 50 =1.9 nM), exhibits significant anticancer properties. It promotes apoptosis in acute myeloid leukemia (AML) cells and arrests the cell cycle in the G0/G1 phase. Additionally, BET-IN-20 inhibits both c-Myc and CDK6, and enhances PARP cleavage [1].</p>Formula:C25H24N4O2Color and Shape:SolidMolecular weight:412.48CA-170
CAS:<p>PD-1-IN-1 is a programmed cell dealth-1inhibitor. PD-1-IN-1 can be used as an immune modulator.</p>Formula:C12H20N6O7Purity:98%Color and Shape:SolidMolecular weight:360.32Tylvalosin
CAS:<p>Tylvalosin (Acetylisovaleryltylosin) is a broad-spectrum macrolide antibiotic with antibacterial and antiviral properties, effective against PRRSV infection.</p>Formula:C53H87NO19Purity:98%Color and Shape:SolidMolecular weight:1042.25TMX-2164
CAS:<p>TMX-2164: strong, irreversible BCL6 inhibitor, IC50=152 nM, long-lasting action, inhibits cell proliferation.</p>Formula:C25H24ClFN6O6SColor and Shape:SolidMolecular weight:591.01ERα antagonist 1
CAS:<p>ERα antagonist 1 is a selective, potent, covalent estrogen receptor alpha (ERα) antagonist that blocks the cell cycle of MCF-7 cells in G0/G1 phase and induces</p>Formula:C33H32N2O5SColor and Shape:SolidMolecular weight:568.68SC 67655
CAS:<p>SC 67655 is a peptidomimetic that specifically suppresses human leukocyte antigen DRB10401-restricted T cell proliferation.</p>Formula:C37H62N6O9Purity:98%Color and Shape:SolidMolecular weight:734.92Merodantoin
CAS:<p>Merodantoin induces apoptosis in KRAS-mutant cancer cells via ROS-autophagy and Akt pathway.</p>Formula:C11H18N2O2SPurity:99.8%Color and Shape:SolidMolecular weight:242.34PRMT6-IN-3
CAS:<p>PRMT6-IN-3 is a selective PRMT6 inhibitor with an IC50 value of 192 nM.PRMT6-IN-3 has anticancer activity and induces apoptosis in cancer cells.</p>Formula:C19H26N4O2SPurity:98.12%Color and Shape:SolidMolecular weight:374.5NBI-961
CAS:<p>NBI-961, a potent NEK2 inhibitor, suppresses proteasomal degradation and effectively induces G2/mitosis arrest and apoptosis within diffuse large B cell</p>Formula:C28H27F3N6O2SColor and Shape:SolidMolecular weight:568.61Antitumor agent-92
CAS:<p>Antitumor Agent-92, a derivative of Icaritin, halts cell cycle, triggers cell death, and is promising for liver cancer study.</p>Formula:C33H41NO10Purity:98%Color and Shape:SolidMolecular weight:611.68GSK2245035
CAS:<p>GSK2245035: selective nasal TLR7 agonist, boosts Type-1 IFN (pEC50: 9.3 IFNα, 6.5 TFNα), curbs Th2 cytokines in blood cultures.</p>Formula:C20H34N6O2Color and Shape:SolidMolecular weight:390.52Topoisomerase II inhibitor 15
CAS:<p>Topoisomerase II inhibitor 15 (compound 2g) serves as a potent apoptotic inducer, exhibiting heightened selectivity for head and neck tumors [1].</p>Formula:C15H11Cl2N5Purity:98%Color and Shape:SolidMolecular weight:332.19FGFR-IN-8
CAS:<p>FGFR-IN-8, potent oral FGFR inhibitor for wild-type/mutant types, induces apoptosis with anti-cancer properties.</p>Formula:C27H31Cl2N9O2Color and Shape:SolidMolecular weight:584.5(+)-Apogossypol
CAS:<p>(+)-Apogossypol is an antagonist of pan-BCL-2. (+)-Apogossypol binds to Mcl-1(Bcl-2 and Bcl-xL with EC50s of 2.6, 2.8 and 3.69 μM, respectively).</p>Formula:C28H30O6Purity:98%Color and Shape:SolidMolecular weight:462.53Thaspine acetate
CAS:<p>Thaspine: inhibits topoisomerase IB, reduces VEGF, stops endothelial cell growth via PI3K/MAPK pathways.</p>Formula:C22H23NO8Color and Shape:SolidMolecular weight:429.425Mezigdomide
CAS:<p>Mezigdomide (CC-92480) is a potent, novel cereblon E3 ubiquitin ligase modulator (CELMoD) that acts as a molecular glue.Cost-effective and quality-assured.</p>Formula:C32H30FN5O4Purity:97.21% - 99.68%Color and Shape:SolidMolecular weight:567.61WEHI-345 analog
CAS:<p>WEHI-345 analog is an Src inhibitor.</p>Formula:C23H25N7OPurity:98%Color and Shape:SolidMolecular weight:415.49HDAC-IN-53
CAS:<p>HDAC-IN-53 inhibits HDAC1-3 with IC50s: 47, 125, 450 nM. Inactive on class II HDACs; triggers apoptosis; reduces tumor growth in mice.</p>Formula:C23H20ClN7O2Purity:98%Color and Shape:SolidMolecular weight:461.9Prostaglandin A1
CAS:<p>Prostaglandin A1, a dehydration derivative of Prostaglandin E1, demonstrates inhibitory effects on tumor growth, inflammation, virus replication, platelet aggregation, and excitotoxin-induced neuron apoptosis [1].</p>Formula:C20H32O4Color and Shape:SolidMolecular weight:336.472HDAC-IN-63
CAS:<p>HDAC-IN-63 (Compound 63) is a dual FLT3/HDAC inhibitor with IC50 values of 0.844 nM for FLT3 and 30.0 nM for HDAC1.</p>Formula:C25H26Cl2N6O3Color and Shape:SolidMolecular weight:529.42RIP2 kinase inhibitor 2
CAS:<p>RIP2 kinase inhibitor 2 is a receptor-interacting protein-2 kinase inhibitor.</p>Formula:C21H28N4O4SPurity:98%Color and Shape:SolidMolecular weight:432.54RIPK1-IN-10
CAS:<p>RIPK1-IN-10 is a potent inhibitor of RIPK1.</p>Formula:C30H28F2N6O4Color and Shape:SolidMolecular weight:574.58PI3K/VEGFR2-IN-1
CAS:<p>PI3K/VEGFR2-IN-1 is a potent dual inhibitor targeting both PI3K and VEGFR2 with IC50 values of 2.21 μM for PI3K and 68 μM for VEGFR2, respectively.</p>Formula:C17H14ClN3OSPurity:98%Color and Shape:SolidMolecular weight:343.83PLK1/BRD4-IN-1
CAS:<p>PLK1/BRD4-IN-1 (9b) is an orally active dual inhibitor of PLK1 (IC50: 22 nM) and BRD4 (IC50: 109 nM).</p>Formula:C31H43N9O2Color and Shape:SolidMolecular weight:573.73Methyl 12-methyltridecanoate
CAS:<p>Methyl 12-methyltridecanoate ((R)-betaxolol hydrochloride), a biosurfactant derived from Brevibacterium casei LS14, enhances the biocompatibility of</p>Formula:C15H30O2Purity:98%Color and Shape:SolidMolecular weight:242.4WF-210
CAS:<p>WF-210 is an effective activator of procaspase-3 that acts by inducing apoptosis in cancer cells and reducing tumor growth.</p>Formula:C41H38FN7O7SPurity:98%Color and Shape:SolidMolecular weight:791.85Lepadin E
CAS:<p>Lepadin E, a notably cytotoxic compound, effectively stimulates ferroptosis via the canonical p53-SLC7A11-GPX4 pathway.</p>Formula:C26H47NO3Purity:98%Color and Shape:SolidMolecular weight:421.66PF-07284892
CAS:<p>PF-07284892 (ARRY-558) is an orally active allosteric SHP2 inhibitor (IC50 = 21 nM) that reduces pERK expression and may be employed in solid tumour research.</p>Formula:C21H22ClN7SPurity:97.77%Color and Shape:SolidMolecular weight:439.96
