Apoptosis
Apoptosis inhibitors are compounds that prevent or delay the process of programmed cell death, known as apoptosis. These inhibitors are vital in studying cell survival mechanisms and are used to investigate diseases where apoptosis is dysregulated, such as cancer, neurodegenerative disorders, and autoimmune diseases. By modulating apoptosis, these inhibitors can help in the development of therapies aimed at controlling cell death. At CymitQuimica, we provide a comprehensive selection of high-quality apoptosis inhibitors to support your research in cell biology, oncology, and related fields.
Subcategories of "Apoptosis"
- ASK(9 products)
- BCL(1 products)
- Caspase(154 products)
- FOXO1(2 products)
- IAP(67 products)
- Mdm2(12 products)
- PD-1/PD-L1(126 products)
- PDK(9 products)
- PERK(23 products)
- Serine/threonin kinase(17 products)
- Survivin(14 products)
- TNF(91 products)
- c-RET(61 products)
- p53(63 products)
Show 6 more subcategories
Found 6170 products of "Apoptosis"
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NDI-Lyso
CAS:NDI-Lyso is an anticancer agent targeting lysosomes, functioning through an enzyme-induced self-assembly (EISA) mechanism catalyzed by Cathepsin B. In cancer cell lysosomes, it forms rigid long fibers, promoting lysosomal swelling, lysosomal membrane permeabilization (LMP), and membrane disruption. This leads to non-classical caspase-independent apoptosis (Apoptosis). NDI-Lyso demonstrates significant selective anticancer activity across various cancer cell lines and drug-resistant cancer cells (IC50 approximately 10 μM), while exhibiting low toxicity to normal cells (IC50 > 60 μM).Formula:C71H100N22O13Color and Shape:SolidMolecular weight:1469.69Daporinad hydrochloride
CAS:Daporinad hydrochloride (FK 866 hydrochloride) is a NAMPT inhibitor with antitumor and antiangiogenic activity that induces apoptosis in tumor cells.Formula:C24H30ClN3O2Purity:98.99%Color and Shape:SolidMolecular weight:427.97Canfosfamide
CAS:Canfosfamide, a prodrug activated by GSTP1-1, induces apoptosis and inhibits DNA-PK, producing an alkylating agent for cancer research.Formula:C26H40Cl4N5O10PSColor and Shape:SolidMolecular weight:787.47Etanercept
CAS:Etanercept is a fusion protein consisting of the soluble portion of the p75-tumor necrosis factor receptor (TNFR) and the Fc fragment of human IgG1 and is commonly used to treat patients with rheumatoid arthritis.Cost-effective and quality-assured.
Purity:98%Color and Shape:LiquidAnagrelide hydrochloride monohydrate
CAS:Anagrelide HCl monohydrate is a platelet-reducing imidazoquinazoline for ET and PV research.Formula:C10H10Cl3N3O2Color and Shape:SolidMolecular weight:310.56Ganglioside GD3 disodium salt
CAS:Ganglioside GD3 disodium salt is a melanoma-associated antigen often targeted in immune therapy for melanomas.Formula:C70H123N3Na2O29Color and Shape:SolidMolecular weight:1516.71Dynorphin A
CAS:Dynorphin A is a endogenous opioid peptide and a κ-opioid receptor (KOR) agonist,a neurotransmitter and regulator in the central and peripheral nervous systemsFormula:C99H155N31O23Purity:95.93%Color and Shape:SolidMolecular weight:2147.48R1-ICR-5
CAS:R1-ICR-5 is a selective PROTAC degrader targeting serine/threonine-protein kinase 1 (RIPK1). Mediated by VHL, R1-ICR-5 promotes the degradation of RIPK1, disrupting the TNFR1 and TLR3/4 signaling hubs, enhancing NF-κB, MAPK, and IFN signal output, and facilitating RIPK3 activation and necroptosis induction. R1-ICR-5 holds potential for research in cancer and inflammatory diseases.Formula:C54H70N8O7S2Color and Shape:SolidMolecular weight:1007.31Liensinine Perchlorate
CAS:Liensinine is the active constituent of plumula nelambinis with anti-hypertension.
Formula:C37H43ClN2O10Purity:99.80%Color and Shape:SolidMolecular weight:711.2Dapirolizumab
Dapirolizumab is an anti-CD40 monoclonal antibody used in research on systemic lupus erythematosus (SLE) and other autoimmune diseases.Purity:>95%Color and Shape:LiquidMolecular weight:150 kDaAntitumor agent-64
CAS:Antitumor Agent-64 (Compound 8d), a diosgenin derivative, exhibits potent cytotoxic activity against the A549 cell line and induces apoptosis in A549 cellsFormula:C35H47N3O3SColor and Shape:SolidMolecular weight:589.83(-)-Mcl-1 inhibitor 21
CAS:(-)-Mcl-1 inhibitor 21 (Example 1-38) is an Mcl-1 inhibitor with an IC50 of 7.51 μM. It exhibits pro-apoptotic and anti-proliferative activity against SUDHL5 and SUDHL10 cell lines, making it useful for cancer research.
Formula:C32H33N3O4Color and Shape:SolidMolecular weight:523.622KH16
KH16 is an HDAC inhibitor.KH16 stimulates apoptosis and is able to inhibit gene expression patterns in a variety of tumor cells.Formula:C18H20N6O2Purity:98.15%Color and Shape:SolidMolecular weight:352.39Xylopine
CAS:Xylopine: an aporphine alkaloid, cytotoxic to cancer cells, induces oxidative stress, G2/M arrest, and apoptosis.Formula:C18H17NO3Color and Shape:SolidMolecular weight:295.33ARB-272572 hydrochloride
CAS:ARB-272572 hydrochloride is a PD-L1 inhibitor that inhibits PD-1/PD-L1 cell signaling by inducing PD-L1 protein homology interactions.Formula:C32H36N6O4·xClHPurity:99.38%Color and Shape:SoildMolecular weight:568.68(Free base）Tripchlorolide
Tripchlorolide is a useful organic compound for research related to life sciences and the catalog number is T126047.Formula:C20H25ClO6Color and Shape:SolidMolecular weight:396.86BCMA72-80
CAS:BCMA72-80: HLA-A2-specific peptide with high affinity; used in multiple myeloma and other BCMA+ tumor research.Formula:C59H97N13O11SPurity:98%Color and Shape:SolidMolecular weight:1196.55XmAb-2513
XmAb-2513 is a humanized monoclonal antibody inhibitor targeting CD30. It demonstrates significant anti-proliferative activity along with excellent antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP). XmAb-2513 is applicable in research on hematological malignancies such as Hodgkin lymphoma (HL) and anaplastic large cell lymphoma (ALCL).Color and Shape:Odour LiquidPIYLGGVFQ
PIYLGGVFQ is a TNF-α peptide inhibitor. It can suppress TNF-α-mediated apoptosis, nuclear translocation, and activation of NF-κB. In a CIA mouse model, PIYLGGVFQ has demonstrated anti-arthritic activity.Formula:C49H72N10O12Color and Shape:SolidMolecular weight:993.16MK-1248
MK-1248 is a human IgG4 monoclonal antibody (mAb) targeting TNFSF18. It enhances the proliferative response of tumor-infiltrating lymphocytes to anti-CD3 stimulation and promotes the production of anti-tumor associated regulatory cytokines. MK-1248 is utilized in research on solid tumors.Color and Shape:Odour LiquidTRP-601
CAS:TRP-601 is a caspase inhibitor.Formula:C40H48F2N6O11Purity:98%Color and Shape:SolidMolecular weight:826.852TQB2916
TQB2916 is a humanized IgG2 monoclonal antibody agonist that targets CD40. It exhibits significant antitumor activity by occupying CD40 and activating immune function. TQB2916 is applicable for research in advanced solid tumors and lymphomas.Color and Shape:Odour LiquidLZ-07
LZ-07 is an IRAK4 PROTAC degrader (DC50 = 1.14 nM), that, upon degradation of IRAK4, significantly inhibits the expression of cytokines such as IL-6, IL-1β, TNF-α, and IL-10. It is applicable in research related to autoimmune diseases.Color and Shape:Odour SolidIBI356
IBI356 is a humanized monoclonal antibody inhibitor that targets OX40L/CD134L/CD252. It can be utilized in the study of chronic inflammatory skin diseases, such as atopic dermatitis.Color and Shape:Odour LiquidPlaculumab
CAS:Placulumab (ART621), an anti-TNF α monoclonal antibody, targets inflammation, potentially aiding arthritis treatment.Color and Shape:LiquidThalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2
CAS:Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthetic conjugate compound that combines a Thalidomide-based cereblon ligand and a linker, which is commonly
Formula:C25H34N4O9Purity:98%Color and Shape:SolidMolecular weight:534.566Thalidomide-O-C8-Boc
CAS:Thalidomide-O-C8-Boc: CRBN ligand for PROTAC creation, derived from Thalidomide.Formula:C26H34N2O7Color and Shape:SolidMolecular weight:486.565SSE1806
SSE1806, a podophyllotoxin derivative (a natural antimitotic agent), functions as a microtubule/tubulin inhibitor, exhibiting potent anticancer andFormula:C21H18N2O5Color and Shape:SolidMolecular weight:378.38Baminercept
CAS:Baminercept (BG 9924) is a lymphotoxin-β receptor-immunoglobulin fusion protein that blocks the lymphotoxin-letter/LIGHT axis.Purity:95% (SDS-PAGE); 98.3% (SEC-HPLC) - 95% (SDS-PAGE); 98.3% (SEC-HPLC)Color and Shape:LiquidMolecular weight:46.88 kDaDazodalibep
CAS:Dazodalibep (MEDI 4920; VIB 4920) is a monoclonal antibody that specifically targets CD40LG/TNFSF5 and is fused to human serum albumin (ALB/HSA) [1].Color and Shape:LiquidhCAIX-IN-13
CAS:hCAIX-IN-13 (Pt2) inhibits CAIX with 6.57 μM IC50, curbs cancer cell growth, and induces apoptosis for cancer research.Formula:C37H33F3N6O7PtS2Color and Shape:SolidMolecular weight:989.9AB-3PRGD2
CAS:AB-3PRGD2 is a radiolabeled agent that targets integrin αvβ3. It enhances tumor uptake and prolongs retention time in tumors, significantly improving the inhibition of tumor growth. AB-3PRGD2 also remodels the tumor immune microenvironment by upregulating PD-L1 expression and increasing tumor-infiltrating CD8+ T cells.
Formula:C137H215IN30O45SColor and Shape:SolidMolecular weight:3161.32Petromurin C
CAS:Petromurin C, a bis-indolyl benzenoid from P. muricatus, is cytotoxic to NS-1 cells (IC50=33μg/ml) and active against T. foetus (IC50=100μg/ml).Formula:C26H24N2O5Color and Shape:SolidMolecular weight:444.487Asunercept
CAS:Asunercept (APG101/CAN008) is a CD95-Fc protein targeting CD95L, used in GBM, MDS, and GvHD research.Color and Shape:Liquidδ-secretase inhibitor 11
CAS:δ-secretase inhibitor 11 is an inhibitor of δ-secretase and can be used as a lead compound for translational development of AD treatment.Formula:C10H12N4O2Purity:99.84%Color and Shape:SolidMolecular weight:220.23eIF4E-IN-5
eIF4E-IN-5 (Compound 6n) is a cell-permeable eIF4E inhibitor that binds to capped mRNA, thereby inhibiting cap-dependent translation [1].Formula:C30H39Cl2N6O8PColor and Shape:SolidMolecular weight:713.55Diprovocim-1
CAS:Diprovocim-1: TLR1/2 agonist; triggers TNF-α in THP-1 cells; boosts ovalbumin IgG1 & CTLs against tumors with anti-PD-L1 in mice.Formula:C56H56N6O6Color and Shape:SolidMolecular weight:909.1Diethanolamine hydrochloride
CAS:Diethanolamine hydrochloride is HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4) and pregnane X receptor (PXR), p53 Estrogen receptor.Formula:C4H12ClNO2Purity:99.69%Color and Shape:SolidMolecular weight:141.6Anti-Mouse PD-1 Antibody (RMP1-14)
Anti-Mouse PD-1 Antibody (RMP1-14) is an IgG2a antibody inhibitor against mouse PD-1 and can block PD-1/PD-L1 signaling. High-Quality, Low-Cost!Purity:14.68mg/ml - >95%Color and Shape:LiquidMolecular weight:147.57 kDaBeclin1-Bcl-2 interaction inhibitor 1
Beclin1-Bcl-2 Interaction Inhibitor 1 effectively disrupts the binding of Beclin 1 to Bcl-2, and is utilized in cancer and neurodegeneration research [1].Color and Shape:Odour SolidAtibuclimab
CAS:Atibuclimab is a chimeric monoclonal antibody targeting CD14, consisting of a mouse variable region and a human IgG4 Fc region.Purity:> 95% - > 95%Color and Shape:LiquidMolecular weight:145.28 kDaEfaprinermin alfa
CAS:Efaprimermin alfa (OMP-336B11) is a human monoclonal antibody that targets TNFRSF18, and functions as a GITR ligand-Fc fusion protein [1].Color and Shape:LiquidLatikafusp
CAS:Latikafusp (AMG 256) is a fusion protein that is a PD-1 blocker and IL-21R agonist with antitumor activity.Purity:97.1% (SDS-PAGE); 97.4% (SEC-HPLC) - 97.1% (SDS-PAGE); 97.4% (SEC-HPLC)Color and Shape:LiquidMolecular weight:159.55 kDaLenercept
CAS:Lenercept (Ro 45-2081) is a recombinant fusion protein combining the soluble TNF-receptor (p55) with the Fc portion of human IgG1 [1].Color and Shape:LiquidManelimab
CAS:Manelimab is a monoclonal antibody that inhibits programmed death-ligand 1 ( PD-L1 ) [1] .Color and Shape:LiquidPegsunercept
CAS:Pegsunercept (PEG sTNF-RI), a pegylated monoclonal antibody, selectively binds to TNFA, incorporating a polyethylene glycol (pegol) moiety [1].Color and Shape:LiquidXIAP BIR2/BIR2-3 inhibitor-1
CAS:XIAP BIR2/BIR2-3 inhibitor-1 (compound 3) serves as a potent dual inhibitor targeting BIR2 and BIR2-3 domains, with IC50 values of 1.9 nM and 0.8 nM, respectively. This compound is utilized in cancer research studies [1].Formula:C72H96N16O14Color and Shape:SolidMolecular weight:1409.63Azurin p28 peptide
CAS:Azurin p28 peptide, a tumor-penetrating antitumor agent, stabilizes p53 by reducing its proteasomal degradation via the formation of a p28:p53 complex.
Formula:C122H197N31O47S2Color and Shape:SolidMolecular weight:2914.18BMSpep-57
CAS:BMSpep-57: Macrocyclic peptide, inhibits PD-1/PD-L1, IC50=7.68 nM, binds PD-L1 (Kd=19 nM/MST, 19.88 nM/SPR), boosts T cell IL-2 in PBMCs.Formula:C89H126N24O19SColor and Shape:SolidMolecular weight:1868.2RET Ligand-Linker Conjugate-1
RET Ligand-Linker Conjugate-1 consists of a complex formed by a RET ligand and a linker, which can be utilized in the synthesis of QZ2135.Formula:C40H44N10OColor and Shape:SolidMolecular weight:680.84
