Apoptosis
Apoptosis inhibitors are compounds that prevent or delay the process of programmed cell death, known as apoptosis. These inhibitors are vital in studying cell survival mechanisms and are used to investigate diseases where apoptosis is dysregulated, such as cancer, neurodegenerative disorders, and autoimmune diseases. By modulating apoptosis, these inhibitors can help in the development of therapies aimed at controlling cell death. At CymitQuimica, we provide a comprehensive selection of high-quality apoptosis inhibitors to support your research in cell biology, oncology, and related fields.
Subcategories of "Apoptosis"
- ASK(9 products)
- BCL(1 products)
- Caspase(154 products)
- FOXO1(2 products)
- IAP(67 products)
- Mdm2(12 products)
- PD-1/PD-L1(126 products)
- PDK(9 products)
- PERK(23 products)
- Serine/threonin kinase(17 products)
- Survivin(14 products)
- TNF(91 products)
- c-RET(61 products)
- p53(63 products)
Show 6 more subcategories
Found 6170 products of "Apoptosis"
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Fludarabine triphosphate trisodium
Fludarabine triphosphate (F-ara-ATP) trisodium inhibits DNA synthesis; IC50 2.3 μM, Ki 6.1 μM, blocks DNA primase, prompts apoptosis.Formula:C10H12FN5Na3O13P3Color and Shape:SolidMolecular weight:591.12Ac-FEID-CMK
Ac-FEID-CMK: Potent inhibitor for zebrafish GSDMEb, reduces pyroptosis, and lessens septic AKI.Formula:C27H37ClN4O9Color and Shape:SolidMolecular weight:597.06Boc-Asp(OBzl)-CMK
CAS:Boc-Asp(OBzl)-CMK, an inhibitor of IL-1 converting enzyme (ICE, caspase1), prevents the death of CHP100 neuroblastoma cells and inhibits IL-1β release induced by the viral coat protein [1].Formula:C17H22ClNO5Color and Shape:SolidMolecular weight:355.81PROTAC EGFR degrader 5
CAS:PROTAC EGFR degrader 5 effectively breaks down EGFR Del19 in HCC827 cells at 34.8 nM, inducing apoptosis and G1 arrest.Formula:C57H72FN13O5SColor and Shape:SolidMolecular weight:1070.33Pep19-2.5
CAS:Pep19-2.5: Synthetic antitoxin peptide inhibits LP/LPS signals via PRRs, preventing inflammation and pyroptosis.Formula:C135H187N37O22SColor and Shape:SolidMolecular weight:2712.23Vallesiachotamine
CAS:Vallesiachotamine, a recognized monoterpene indole alkaloid, exhibits anti-tumor activity [1].Formula:C21H22N2O3Color and Shape:SolidMolecular weight:350.41BM-1197
CAS:BM-1197, a highly potent and specific dual inhibitor of Bcl-2 and Bcl-xL, effectively targets these proteins with IC50 values of 3.5 nM and 5.2 nM for Bcl-2 andFormula:C53H59ClF4N6O7S4Color and Shape:SolidMolecular weight:1131.77ReACp53
ReACp53 inhibits amyloid formation, restores p53 in cancer cells and HGSOC-derived organoids.Formula:C108H206N52O24Purity:98%Color and Shape:SolidMolecular weight:2617.13Thalidomide-4-C3-NH2 hydrochloride
CAS:Thalidomide-4-C3-NH2 HCl is a cereblon ligand for CRBN recruitment, used to make PROTACs with a linker.Formula:C16H18ClN3O4Color and Shape:SolidMolecular weight:351.785Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2
Thalidomide-PEG conjugate for E3 ligase in PROTACs; has cereblon ligand and 3-unit PEG linker.Formula:C27H35F3N4O11Purity:98%Color and Shape:SolidMolecular weight:648.58(D)-PPA 1 TFA
(D)-PPA 1 TFA is a hydrolysis-resistant D-peptide antagonist and a potent PD-1/PD-L1 inhibitor, exhibiting an affinity for PD-1 of 0.51 μM and demonstratingFormula:C72H99F3N20O23Purity:98%Color and Shape:SolidMolecular weight:1669.678-hydroxy Efavirenz
CAS:8-hydroxy Efavirenz, a main efavirenz metabolite by CYP2B6, causes apoptosis in rat neurons at 0.01 μM.Formula:C14H9ClF3NO3Color and Shape:SolidMolecular weight:331.68Chalcones A-N-5
CAS:Chalcones A-N-5, a non-cytotoxic trihydroxy chalcone, aids cell growth & neuroprotection, inhibits ferroptosis, and targets AD research.Formula:C21H20N4O4Color and Shape:SolidMolecular weight:392.41Ac-Trp-Glu-His-Asp-Aldehyde
CAS:Ac-Trp-Glu-His-Asp-Aldehyde is a powerful and selective inhibitor of caspase-1, demonstrating a K_i value of 56 pM [1] [2].Formula:C28H33N7O9Color and Shape:SolidMolecular weight:611.6Sanggenon G
CAS:Sanggenon G inhibits XIAP by binding its BIR3 domain; affinity is 34.26 μM, boosting caspase activation.Formula:C40H38O11Color and Shape:SolidMolecular weight:694.724-Nitrothalidomide
CAS:4-Nitrothalidomide is a modified form of thalidomide that inhibits the growth and proliferation of HUVEC cells and is commonly used in the synthesis of pomalidomide, which has anticancer potential.Formula:C13H9N3O6Purity:99.94%Color and Shape:SolidMolecular weight:303.23AMG-7209
CAS:AMG-7209 is an effective and selective MDM2-p53 interaction inhibitor.Formula:C37H41Cl2FN2O7SColor and Shape:SolidMolecular weight:747.7Pexelizumab
CAS:Pexelizumab is a humanized antibody targeting C5 to inhibit apoptosis and treat cerebral IR injury and myocardial infarction.Color and Shape:LiquidGSK-1070916
CAS:GSK-1070916 (GSK-1070916A) is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM.Formula:C30H33N7OPurity:99.73%Color and Shape:SolidMolecular weight:507.63ASK1-IN-4
CAS:ASK1-IN-4 is an ASK1 inhibitor, IC50 = 0.2 μM.Formula:C18H14BrNO4S2Purity:99.756%Color and Shape:SolidMolecular weight:452.34Haemanthamine hydrochloride
Haemanthamine hydrochloride, an alkaloid from Amaryllidaceae, has anticancer, antioxidant, antiviral, antimalarial, and anticonvulsant properties.Formula:C17H20ClNO4Color and Shape:SolidMolecular weight:337.8(E/Z)-Eltrombopag 13C4
CAS:(E/Z)-Eltrombopag 13C4 is a mix of E/Z isotopologues, both 13C-labeled TPO receptor agonists for thrombocytopenia.Formula:C25H22N4O4Color and Shape:SolidMolecular weight:446.444LSD1-IN-26
LSD1-IN-26 (12u) is a potent LSD1 inhibitor (IC50=25.3 nM), also inhibits MAO-A/B, induces apoptosis in MGC-803, for gastric cancer research.Formula:C27H25Cl2F2N3OColor and Shape:SolidMolecular weight:516.41Antagonist G TFA
Potent vasopressin blocker, Antagonist G TFA also mildly inhibits GRP & Bradykinin, triggers AP-1, enhances chemo response.Formula:C51H67F3N12O8SColor and Shape:SolidMolecular weight:1065.21TPP-1 TFA
TPP-1 TFA is a high-affinity PD-L1 inhibitor (KD=95nM) that boosts T-cell function to curb tumor growth.Formula:C109H151F3N34O34S2Color and Shape:SolidMolecular weight:2602.69CDC20-IN-2
CDC20-IN-2 (14c) is an inhibitor of Cdc20 with a KD of 7.65 μM, inducing G2/M phase arrest, promoting DNA damage accumulation, and stabilizing key substrates such as Cyclin B1 and Bim. This leads to enhanced apoptosis, as well as inhibition of tumor cell proliferation and migration.Color and Shape:Odour Solid5-LOX-IN-8
5-LOX-IN-8 is a 5-LOX inhibitor with anti-inflammatory properties. It suppresses IL-6, IL-1β, TNF-α, and IFN-γ in macrophages and reduces IL-8 secretion in SW480 cells. Additionally, 5-LOX-IN-8 decreases the disease activity index in DSS colitis models. This compound is applicable for research in inflammatory bowel disease (IBD).Color and Shape:Odour SolidNecroptosis-IN-5
Necroptosis-IN-5 (Compound 26) is an orally active inhibitor of necroptotic cell death (necroptosis). This compound also exhibits potent inhibitory activity against receptor-interacting protein kinase 1 (RIPK1). It can be utilized in research related to inflammatory diseases, neurodegenerative disorders, and cancer associated with necroptosis.Color and Shape:Odour SolidRET Ligand-Linker Conjugate-1
RET Ligand-Linker Conjugate-1 consists of a complex formed by a RET ligand and a linker, which can be utilized in the synthesis of QZ2135.Formula:C40H44N10OColor and Shape:SolidMolecular weight:680.84MitoEbselen-2 chloride
CAS:MitoEbselen-2 mitigates radiation, cuts lipid hydroperoxides, blocks cell death, and boosts survival in irradiated mice.Formula:C35H30ClN2O2PSeColor and Shape:SolidMolecular weight:656.01DS-5272
CAS:DS-5272 is a potent and orally active inhibitor of p53-MDM2 interaction.Formula:C34H38Cl2F2N6O2SColor and Shape:SolidMolecular weight:703.67BM-1074
CAS:BM-1074 is a potent and highly efficacious inhibitor of Bcl-2/Bcl-xL with Ki value of < 1nM [1].Formula:C50H57ClN8O7S3Color and Shape:SolidMolecular weight:1013.69BMSpep-57
CAS:BMSpep-57: Macrocyclic peptide, inhibits PD-1/PD-L1, IC50=7.68 nM, binds PD-L1 (Kd=19 nM/MST, 19.88 nM/SPR), boosts T cell IL-2 in PBMCs.Formula:C89H126N24O19SColor and Shape:SolidMolecular weight:1868.2CQ1373
CQ1373 is a potent RET inhibitor that demonstrates cellular activity against BaF3 cells expressing CCDC6-RET, CCDC6-RET-G810C, and CCDC6-RET-G810R, with IC50 values of 13.0, 25.7, and 28.4 nM, respectively. It shows excellent selectivity for wild-type RET and solvent front mutants G810C/R, with IC50 values of 4.2, 7.1, and 32.4 nM. CQ1373 inhibits RET phosphorylation and downstream signaling through SHC. Additionally, it induces apoptosis (Apoptosis) and cell cycle arrest in BaF3 cells. CQ1373 possesses antitumor efficacy, making it a candidate for cancer research.Formula:C25H22ClF3N6O3Color and Shape:SolidMolecular weight:546.93ZX782
ZX782 acts as a GPX4 protein degrader and an inducer of ferroptosis (Ferroptosis), targeting GPX4 for destruction via both the ubiquitin-proteasome system and the autophagy-lysosome pathway. Following the degradation of GPX4 induced by ZX782, there is a significant increase in the accumulation of lipid reactive oxygen species (ROS) in HT1080 cells.Formula:C39H48ClN5O8Color and Shape:SolidMolecular weight:750.281-Methyl-1H-pyrrolo[2,3-b]pyridine
CAS:1-Methyl-1H-pyrrolo[2,3-b]pyridine exhibits cytotoxicity against MCF-7 cells and can be used in related research in the field of life sciences.Formula:C8H8N2Purity:98.89%Color and Shape:SolidMolecular weight:132.16Thalidomide-NH-C4-NH2 TFA
CAS:Compound 29c, a Thalidomide-linker conjugate for potent PROTAC BRD2/BRD4 degrader-1, targets BET proteins.Formula:C19H21F3N4O6Purity:98%Color and Shape:SolidMolecular weight:458.39AZD5582 TFA
AZD5582 TFA is a potent IAP antagonist that binds to the BIR3 domain of cIAP1, cIAP2, and XIAP with IC50 values of 15, 21, and 15 nM, respectively.AZD5582 TFAFormula:C60H79F3N8O10Purity:99.89%Color and Shape:SoildMolecular weight:1129.31Ref: TM-T36201L
1mg55.00€5mg96.00€10mg149.00€25mg259.00€50mg442.00€100mg647.00€1mL*10mM (DMSO)144.00€Oligomycin B
CAS:Oligomycin B is an antibiotic isolated from marine Streptomyces, is an eukaryotic ATP synthase inhibitor, induces apoptosis.Formula:C45H72O12Purity:98%Color and Shape:SolidMolecular weight:805.05Thymidine 3',5'-disphosphate
CAS:pdTp is a highly selective, small-molecule miRNA regulatory complex RISC subunit SND1 inhibitor.Formula:C10H16N2O11P2Color and Shape:SolidMolecular weight:402.19VPC-70063
CAS:VPC-70063 (Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)-) is an inhibitor of c-Myc-MAX.Formula:C16H12F6N2SPurity:99.98%Color and Shape:SolidMolecular weight:378.34Ref: TM-T60019
1mg49.00€5mg101.00€10mg152.00€25mg268.00€50mg385.00€100mg560.00€200mg790.00€1mL*10mM (DMSO)130.00€Varlilumab
CAS:Varlilumab (CDX-1127) is a novel human IgG1 anti-CD27 monoclonal antibody. Varlilumab has antitumor activity and can be used to study advanced solid tumors.Purity:SDS-PAGE:95% SEC-HPLC:98.65%Color and Shape:LiquidMolecular weight:146 kDaAnti-inflammatory agent 35
CAS:Anti-inflammatory agent 35 is a potent anti-inflammatory agent.Formula:C27H29NO8Purity:99.98%Color and Shape:SoildMolecular weight:495.52PI3K-AKT-mTOR Compound Library
A unique collection of 420 compounds targeting PI3K/Akt/mTOR signaling for research in PI3K/Akt/mTOR signaling, and drug discovery in diseases involved withColor and Shape:Odour SolidRef: TM-L1300
1mgTo inquire30μL*10mM (DMSO)To inquire50μL*10mM (DMSO)To inquire100μL*10mM (DMSO)To inquire250μL*10mM (DMSO)To inquireNecroptosis-IN-3
CAS:Necroptosis-IN-3 (Cyclohexanecarboxamide, N-(2-thienylmethyl)-) (Compound 69) is a Necroptosis inhibitor that inhibits TNF-α induced necroptosis.Formula:C12H17NOSPurity:99.85%Color and Shape:SoildMolecular weight:223.33CLEFMA
CAS:CLEFMA has anti-proliferative activity. CLEFMA inhibits tumor growth associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects.Formula:C23H17Cl2NO4Purity:99.00%Color and Shape:SolidMolecular weight:442.29Ref: TM-T9582
1mg64.00€5mg131.00€10mg188.00€25mg299.00€50mg427.00€100mg575.00€200mg750.00€1mL*10mM (DMSO)149.00€PROTAC 20S proteasome subunit β5 degrader 1
PROTAC 20S proteasome subunit β5 degrader 1 (compound 12f) serves as a targeted degrader of the 20S proteasome subunit β5, exhibiting a DC50 value of 0.11 μM in FaDu cells. This compound disrupts the cell cycle and promotes apoptosis (apoptosis), while inhibiting cell proliferation and migration in both FaDu and KM3/BTZ cells. It is applicable for research into resistance to Bortezomib in pharyngeal carcinoma and multiple myeloma.Color and Shape:Odour SolidFLT3/HDAC-IN-1
FLT3/HDAC-IN-1 is a dual inhibitor targeting FLT3 and HDAC, with IC50 values of 30.4 nM for FLT3 and 52.4, 14.7 nM for HDAC1/3, respectively. It induces apoptosis in MV-4-11 cells and exhibits antiproliferative effects against BaF3 cells transformed by FLT3 mutations. FLT3/HDAC-IN-1 is useful for research on refractory solid tumors and hematological malignancies.Color and Shape:Odour SolidFerroptosis inducer-6
CAS:Ferroptosisinducer 6 (6d) is an inducer of ferroptosis (ferroptosis) that exhibits potent potential for Type I/II photodynamic therapy by inducing ROS production, oxidative stress, and mitochondrial damage. Additionally, it demonstrates antitumor activity.Formula:C69H78F12N12P2RuColor and Shape:SolidMolecular weight:1466.44Uvarigrin
CAS:Uvarigrin induces tumor multidrug resistance cell apoptosis and triggers Caspase-9 activation. Uvarigrin is isolated from the roots of Uvaria calamistrata.Formula:C37H68O6Purity:98%Color and Shape:SolidMolecular weight:608.93
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