Apoptosis
Apoptosis inhibitors are compounds that prevent or delay the process of programmed cell death, known as apoptosis. These inhibitors are vital in studying cell survival mechanisms and are used to investigate diseases where apoptosis is dysregulated, such as cancer, neurodegenerative disorders, and autoimmune diseases. By modulating apoptosis, these inhibitors can help in the development of therapies aimed at controlling cell death. At CymitQuimica, we provide a comprehensive selection of high-quality apoptosis inhibitors to support your research in cell biology, oncology, and related fields.
Subcategories of "Apoptosis"
- ASK(6 products)
- BCL(11 products)
- Caspase(125 products)
- FOXO1(3 products)
- IAP(66 products)
- Mdm2(12 products)
- PD-1/PD-L1(125 products)
- PDK(9 products)
- PERK(25 products)
- Serine/threonin kinase(15 products)
- Survivin(13 products)
- TNF(92 products)
- c-RET(51 products)
- p53(62 products)
Show 6 more subcategories
Found 5592 products of "Apoptosis"
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Anticancer agent 154
<p>Anticancer agent 154 (Compound 8h) enhances reactive oxygen species production, causing mitochondrial damage, and promotes cell apoptosis and DNA damage.</p>Formula:C22H23N5O2Purity:98%Color and Shape:SolidMolecular weight:389.45Topoisomerase I/II inhibitor 6
<p>TopoisomeraseI/II inhibitor 6 (compound 3i) acts as an effective inhibitor of topoisomerase I and II, with IC50 values of 4.77 µM and 15 µM, respectively. Additionally, it exhibits antiproliferative activity against the human melanoma cell line LOX IMVI, demonstrating IC50 values of 26.7 µM and 25.4 µM.</p>Formula:C31H28F2N4O6SColor and Shape:SolidMolecular weight:622.64Azurin p28 peptide
CAS:<p>Azurin p28 peptide, a tumor-penetrating antitumor agent, stabilizes p53 by reducing its proteasomal degradation via the formation of a p28:p53 complex.</p>Formula:C122H197N31O47S2Color and Shape:SolidMolecular weight:2914.18EGFR-IN-144
<p>EGFR-IN-144 (Compound 4B) inhibits EGFR (IC50=0.639 µg/mL) and tubulin polymerization (IC50=7.339 µg/mL). It exhibits cytotoxicity in various cancer cells with a GI50 at the nanomolar level. EGFR-IN-144 reduces the expression of mTOR, TNF-α, and IL-6, causes G1/S phase cell cycle arrest, and induces apoptosis.</p>Formula:C20H17Cl2N3O3Color and Shape:SolidMolecular weight:418.273Pipermethystine
<p>Pipermethystine is a useful organic compound for research related to life sciences and the catalog number is T124340.</p>Formula:C16H17NO4Color and Shape:SolidMolecular weight:287.315(R)-HTS-3
CAS:<p>(R)-HTS-3 is a LPCAT3 inhibitor that remodels the polyunsaturated phospholipid content of human cells and prevents iron death.</p>Formula:C17H18F2N2OPurity:98.89%Color and Shape:SoildMolecular weight:304.33PROTAC EGFR degrader 6
CAS:<p>PROTAC EGFR degrader 6 effectively degrades EGFR Del19 in HCC827 cells (DC50=45.2 nM) and induces apoptosis and G1 arrest.</p>Formula:C49H57FN12O5Color and Shape:SolidMolecular weight:913.05Danburstotug
CAS:<p>Danburstotug (IMC-001), an immunostimulant and antineoplastic [1], is a humanized IgG1-lambda monoclonal antibody targeting CD274 (PDL1, B7 homologue 1, B7H1).</p>Purity:98%Color and Shape:LiquidPoly (I:C):Kanamycin (1:1)
<p>Poly (I:C):Kanamycin (1:1) is an equimolar mixture of Poly(I:C) and kanamycin. TLR3 agonist commonly used as a vaccine adjuvant; enhanced Poly(I:C) stability.</p>Color and Shape:SolidGSK-3β inhibitor 15
<p>GSK-3β inhibitor 15 (Compound 54), with an IC50 of 3.4 nM, effectively suppresses Aβ 1-42-induced phosphorylation of GSK-3β and tau protein, as well as LPS-</p>Formula:C17H16N6OSColor and Shape:SolidMolecular weight:352.41BRD6257
<p>BRD6257 is an orally active inhibitor of protein phosphatase 1D (proteinphosphatase, Mg2+/Mn2+ dependent 1D, PPM1D) with an IC50 of 5 nM. It activates the p53 signaling pathway (EC50 of 51 nM), enhances p21 expression, and inhibits the proliferation of cancer cells MOLM13 (IC50 = 2.8 μM). BRD6257 demonstrates good metabolic stability in human and rat liver microsomes.</p>Formula:C24H22F4N6O3SColor and Shape:SolidMolecular weight:550.532,2'-Dihydroxy chalcone
CAS:<p>2,2'-Dihydroxy chalcone inhibits β-glucuronidase (IC50=1.6 μM) and lysozyme (IC50=1.4 μM), and fights E. coli, S. fowleri, S. albicans, S. aureus.</p>Formula:C15H12O3Purity:99.7%Color and Shape:SolidMolecular weight:240.25Lipustobart
CAS:<p>Lipustobart is an IgG4-kappa humanized monoclonal antibody targeting PDCD1 (programmed cell death 1, PD1, PD-1, CD279), with immunostimulant and antineoplastic</p>Purity:98%Color and Shape:LiquidAntiproliferative agent-42
<p>Antiproliferative Agent-42 (Compound 7m), a dihydrodipyrrolo compound, exhibits antiproliferative activity against the Panc-1 cell line, with an IC 50 of 12.54</p>Color and Shape:Odour SolideIF4E-IN-5
<p>eIF4E-IN-5 (Compound 6n) is a cell-permeable eIF4E inhibitor that binds to capped mRNA, thereby inhibiting cap-dependent translation [1].</p>Formula:C30H39Cl2N6O8PColor and Shape:SolidMolecular weight:713.55Petromurin C
CAS:<p>Petromurin C, a bis-indolyl benzenoid from P. muricatus, is cytotoxic to NS-1 cells (IC50=33μg/ml) and active against T. foetus (IC50=100μg/ml).</p>Formula:C26H24N2O5Color and Shape:SolidMolecular weight:444.487Disitertide
CAS:<p>Disitertide (P144) is an inhibitor of TGF-β1.</p>Formula:C68H109N17O22S2Purity:98%Color and Shape:SolidMolecular weight:1580.84XM-U-14
<p>XM-U-14 is a selective PROTAC USP7 degrader that induces the degradation of USP7 in the RS4;11 cell line with a DC50 of 0.74 nM. This compound elevates the levels of p53 and p21, and significantly inhibits the growth of acute lymphoblastic leukemia (ALL) cells, with IC50 values of 0.5 nM in RS4;11 cells and 8.3 nM in Reh cells. Moreover, XM-U-14 induces apoptosis and cell cycle arrest, and effectively inhibits tumor growth.</p>Color and Shape:Odour SolidSolanidine
CAS:<p>Solanidine is a cholestane alkaloid isolated from potato species with antitumor effects. Solanidine inhibits proliferation.</p>Formula:C27H43NOPurity:96.83%Color and Shape:SolidMolecular weight:397.64S65487 hydrochloride
CAS:<p>S65487 (VOB560) hydrochloride, a potent and selective Bcl-2 inhibitor, is effective against BCL-2 mutations, including G101V and D103Y.</p>Formula:C41H42Cl2N6O4Color and Shape:SolidMolecular weight:753.73Thalidomide-NH-C6-NH2 TFA
CAS:<p>Thalidomide-based cereblon ligand linked to PROTAC technology as E3 ligase ligand-linker.</p>Formula:C21H25F3N4O6Purity:98%Color and Shape:SolidMolecular weight:486.44BC13
<p>BC13 is a CDK6/BRD4 inhibitor with IC50 values of 234 nM for CDK6 and 36 nM for BRD4. It exhibits antiproliferative properties, induces apoptosis (cell death) and DNA damage, and elevates ROS levels.</p>Formula:C37H39N7O5Color and Shape:SolidMolecular weight:661.75Endoplasmic Reticulum Stress Compound Library
<p>A unique collection of 193 endoplasmic reticulum stress (ER stress) related compounds used for high throughput screening (HTS) and high content screening (HCS);</p>Color and Shape:Odour SolidFisetin quarterhydrate
<p>Fisetin quarterhydrate, a natural flavonol present in numerous fruits and vegetables, exhibits benefits including antioxidant, anticancer, and neuroprotective</p>Formula:C15H10O6H2OColor and Shape:SolidMolecular weight:304.0583Siomycin A
CAS:<p>Siomycin A: thiopeptide antibiotic, selectively inhibits FOXM1, anti-tumor, induces apoptosis.</p>Formula:C71H81N19O18S5Purity:98%Color and Shape:SolidMolecular weight:1648.84tetrathiomolybdate
CAS:<p>Tetrathiomolybdate (TM) promotes the dimerization of the metal-binding domain (WLN4) of the cellular copper efflux protein ATP7B through its characteristic</p>Formula:MoS4Color and Shape:SolidMolecular weight:224.2UAMC-4821
<p>UAMC-4821 is a ferroptosis inhibitor with an IC50 of 5.2 nM. It effectively scavenges free radicals, inhibits lipid peroxidation, and prevents ML162-induced ferroptosis, providing protective effects on HT-1080 cells. With favorable pharmacokinetic properties in mice, UAMC-4821 presents an oral bioavailability of 63% and demonstrates blood-brain barrier permeability.</p>Formula:C15H19N3OColor and Shape:SolidMolecular weight:257.33Antitumor photosensitizer-7
<p>Antitumor photosensitizer-7 (compound 15), a photosensitizer possessing anti-cancer properties, demonstrates substantial cytotoxic effects on the G361 melanoma cell line when exposed to 414 nm blue light irradiation.</p>Formula:C23H20N2O3Color and Shape:SolidMolecular weight:372.42Linsidomine hydrochloride
CAS:<p>SIN-1 chloride is a moxidomine metabolite with vasodilatory, anti-platelet, and antianginal effects, reducing myocardial ischemia-related damage.</p>Formula:C6H11ClN4O2Purity:99.27% - 99.67%Color and Shape:White Solid CrystallineMolecular weight:206.63CQ1373
<p>CQ1373 is a potent RET inhibitor that demonstrates cellular activity against BaF3 cells expressing CCDC6-RET, CCDC6-RET-G810C, and CCDC6-RET-G810R, with IC50 values of 13.0, 25.7, and 28.4 nM, respectively. It shows excellent selectivity for wild-type RET and solvent front mutants G810C/R, with IC50 values of 4.2, 7.1, and 32.4 nM. CQ1373 inhibits RET phosphorylation and downstream signaling through SHC. Additionally, it induces apoptosis (Apoptosis) and cell cycle arrest in BaF3 cells. CQ1373 possesses antitumor efficacy, making it a candidate for cancer research.</p>Formula:C25H22ClF3N6O3Color and Shape:SolidMolecular weight:546.93Carubicin
CAS:<p>Carubicin, an anthracycline antibiotic from Actinomadura carminata, disrupts DNA replication and repair by intercalating DNA and inhibiting topoisomerase II.</p>Formula:C26H27NO10Purity:98%Color and Shape:SolidMolecular weight:513.491-(4-chloro-3-(trifluoromethyl)phenyl)-3-(7-(1-methyl-1H-pyrazol-4-yl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl)urea
CAS:<p>1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(7-(1-methyl-1H-pyrazol-4-yl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl)urea 是一种能够激动 TNF-α的化合物，可以诱导细胞分泌 TNF-α。</p>Formula:C24H21ClF3N5OPurity:98.37% - 98.57%Color and Shape:SoildMolecular weight:487.9Polyinosinic-polycytidylic acid potassium
CAS:<p>Poly(I:C) potassium is a synthetic RNA analog, activates TLR3/RIG-I, used as a vaccine adjuvant, and induces apoptosis in cancer cells.</p>Formula:(C10H13N4O8P)x·(C9H14N3O8P)x·xKColor and Shape:SolidMY-943
<p>MY-943, a potent inhibitor of tubulin polymerization and LSD1, exhibits anticancer properties by inducing G2/M phase arrest, promoting apoptosis, and</p>Formula:C30H36N4O6S2Color and Shape:SolidMolecular weight:612.76Aromatase-IN-5
<p>Aromatase-IN-5 (Compound 10) is a potent inhibitor of aromatase with an IC50 value of 0.06 μM. It effectively blocks estrogen production and inhibits the proliferation of breast cancer cell lines such as MCF-7, arresting the cell cycle in the G1 phase and inducing apoptosis. Aromatase-IN-5 shows promise for breast cancer research.</p>Color and Shape:Odour SolidNYY-6a
<p>NYY-6a is a ferroptosis (Ferroptosis) inhibitor, demonstrating significant suppression of RSL3-induced ferroptosis in 786-O and HT-1080 cells, with EC50 values of 52 nM and 50 nM, respectively. As a radical-trapping antioxidant (RTA), NYY-6a effectively reduces lipid peroxidation, comparable to ferrostatin-1 and liproxstatin-1, making it useful for research into ferroptosis-related pathologies.</p>Formula:C23H22N2O3Color and Shape:SolidMolecular weight:374.43Angiogenesis inhibitor 3
CAS:<p>Angiogenesis Inhibitor 3 (compound 8) is a potent anti-cancer agent, blocking HUVEC/HCT-15 cell growth and inducing apoptosis.</p>Formula:C44H42BrN3O9Color and Shape:SolidMolecular weight:836.72Apoptosis inducer 13
<p>Apoptosis Inducer 13 (Compound Ru4) promotes apoptosis in cancer cells while also suppressing their migration and invasion.</p>Formula:C59H54ClF6N8O4PRuPurity:98%Color and Shape:SolidMolecular weight:1220.6Methyl-4-oxoretinoate
CAS:<p>Methyl-4-oxoretinoate is a synthetic retinoid with anticancer properties, used for skin conditions and potential ocular treatments.</p>Formula:C21H28O3Purity:98.07%Color and Shape:SolidMolecular weight:328.45OA-Br-1
<p>OA-Br-1 is an orally active, selective inhibitor of PTP1B with an IC50 value of 7.08 μM. It induces apoptosis and exhibits broad-spectrum anti-cancer cell proliferation activity. OA-Br-1 exerts anti-breast cancer effects both in vitro and in vivo through the PTP1B/PI3K/AKT signaling pathway.</p>Formula:C43H70BrNO8Color and Shape:SolidMolecular weight:808.92Fludarabine triphosphate
CAS:<p>Fludarabine triphosphate inhibits key enzymes, causing cell death.</p>Formula:C10H15FN5O13P3Color and Shape:SolidMolecular weight:525.173-Hydroxyterphenyllin
CAS:<p>3-Hydroxyterphenyllin from A. candidus is a fungal compound with antioxidant, anticancer, antibacterial, and antiviral effects.</p>Formula:C20H18O6Color and Shape:SolidMolecular weight:354.35XIAP BIR2/BIR2-3 inhibitor-1
CAS:<p>XIAP BIR2/BIR2-3 inhibitor-1 (compound 3) serves as a potent dual inhibitor targeting BIR2 and BIR2-3 domains, with IC50 values of 1.9 nM and 0.8 nM, respectively. This compound is utilized in cancer research studies [1].</p>Formula:C72H96N16O14Color and Shape:SolidMolecular weight:1409.63spisulosine
CAS:<p>spisulosine is a natural product for research related to life sciences. The catalog number is T9664 and the CAS number is 196497-48-0.</p>Formula:C18H39NOColor and Shape:SolidMolecular weight:285.516Linearol
CAS:<p>Linearol: diterpene from Sideritis L. with antioxidant, anti-inflammatory, anti-apoptotic effects.</p>Formula:C22H34O4Purity:98%Color and Shape:SolidMolecular weight:362.50HDAC6-IN-16
<p>HDAC6-IN-16 (compound 5c), a quinazolin-4(3H)-one-based inhibitor of histone deacetylase 6 (HDAC6), demonstrates an anticancer effect by inhibiting colony</p>Formula:C23H19N3O3SPurity:98%Color and Shape:SolidMolecular weight:417.48AS-99 TFA
<p>AS-99 TFA: potent ASH1L inhibitor, IC50=0.79 μM, combats leukemia, inhibits cell growth, induces apoptosis.</p>Color and Shape:SolidERK-IN-6
<p>ERK-IN-6, a potent agent, inhibits ESCC growth and induces apoptosis through the ERK pathway.</p>Formula:C19H18BrN3O3SColor and Shape:SolidMolecular weight:448.33PAA5
<p>PAA5, a polynuclear Au(I) cluster, triggers ferroptosis and has anticancer effects by increasing pH2AX over time.</p>Formula:C14H8Au5B2F8N2Color and Shape:SolidMolecular weight:1348.66Bim BH3, Peptide IV
CAS:<p>This Bim peptide belongs to the pro-apoptotic group of the Bcl-2 family of proteins.</p>Formula:C145H222N44O41SPurity:98%Color and Shape:SolidMolecular weight:3269.65
