Apoptosis
Apoptosis inhibitors are compounds that prevent or delay the process of programmed cell death, known as apoptosis. These inhibitors are vital in studying cell survival mechanisms and are used to investigate diseases where apoptosis is dysregulated, such as cancer, neurodegenerative disorders, and autoimmune diseases. By modulating apoptosis, these inhibitors can help in the development of therapies aimed at controlling cell death. At CymitQuimica, we provide a comprehensive selection of high-quality apoptosis inhibitors to support your research in cell biology, oncology, and related fields.
Subcategories of "Apoptosis"
- ASK(9 products)
- BCL(1 products)
- Caspase(154 products)
- FOXO1(2 products)
- IAP(67 products)
- Mdm2(12 products)
- PD-1/PD-L1(127 products)
- PDK(9 products)
- PERK(23 products)
- Serine/threonin kinase(17 products)
- Survivin(14 products)
- TNF(90 products)
- c-RET(61 products)
- p53(63 products)
Show 6 more subcategories
Found 6170 products of "Apoptosis"
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WK369
WK369 is an innovative small molecule inhibitor of BCL6, demonstrating remarkable bioactivity against ovarian cancer by inducing cell cycle arrest and triggering apoptosis. It binds directly to the BCL6-BTB domain, obstructing the interaction between BCL6 and SMRT, which results in the reactivation of p53, ATR, and CDKN1A.Formula:C19H20FN5O2Molecular weight:369.1601NAE-IN-1
NAE-IN-1 (compound X-10) is a potent inhibitor of NAE1. It induces apoptosis and causes cell cycle arrest in the G2/M phase. Furthermore, NAE-IN-1 increases ROS levels and inhibits cell migration, demonstrating antiproliferative activity.Formula:C29H30N4O2SMolecular weight:498.20895RIPK1-IN-22
RIPK1-IN-13 (compound 28) is a selective inhibitor of receptor-interacting serine/threonine-protein kinase 1 (RIPK1), showing a pKi of 7.66 as measured by the ADP-Glo kinase assay. It exhibits inhibitory effects in human leukemia U937 cells with a pIC50 of 7.2.Formula:C22H22N4O3SMolecular weight:422.14126155H1
155H1 (Compound 11) is a stapled peptide that covalently binds to hMcl1 (172-323) with an IC50 of 18 nM.Formula:C79H120FN19O23SMolecular weight:1753.85092WEE1-IN-7
WEE1-IN-7 (compound 12h) is a potent, orally active WEE1 inhibitor with an IC50 value of 2.1 nM. This compound induces apoptosis and causes cell cycle arrest in the S phase, demonstrating antitumor activity.RIP1 kinase inhibitor 9
RIP1 kinase inhibitor 9 (compound SY-1) is a selective inhibitor of RIP kinase. It effectively reduces central inflammatory responses caused by seizures. RIP1 kinase inhibitor 9 also obstructs Z-VAD-FMK-induced necroptosis in HT-29 cells, with an EC50 of 7.04 nM.Formula:C25H21N3O3Molecular weight:411.15829PROTAC PD-L1 degrader-1
PROTACPD-L1 degrader-1 is a CRBN-based PD-L1-PROTAC degrader with significant PD-L1 protein degradation capacity. It demonstrates strong PD-L1 degradation activity in 4T1 cells, with a DC50 of 0.609 μM. This compound is applicable to breast cancer research.ECDD-S16
ECDD-S16 is a potent inhibitor of pyroptosis. It effectively suppresses pyroptosis in Raw264.7 cells activated by surface and endosomal TLR ligands.Formula:C35H31FO12Molecular weight:662.17995Anticancer agent 204
Anticanceragent 204 (Compound 6) is a fluorinated derivative of cinnamamides with anticancer activity. It can arrest the cell cycle of HepG2 cells in the G1 phase and induces apoptosis by reducing mitochondrial membrane polarization (MMP) levels.Formula:C26H18FN5O3SMolecular weight:499.11144Necrosis inhibitor 2 (hydrocholide)
Necrosis inhibitor 2 hydrochloride (Compound B19) is an agent that inhibits cellular necrosis. It is useful for researching diseases associated with necrotic pathways, including inflammation, cancer, metabolic disorders, and neurodegenerative diseases.Formula:C24H26ClN5O5Molecular weight:499.16225EGFR-PK/JNK-2-IN-1
EGFR-PK/JNK-2-IN-1 (Compound 6c) is a dual inhibitor of EGFR-PK and JNK-2, with IC50 values of 2.7 and 3.0 μM, respectively. It can induce apoptosis and cause cell cycle arrest at various stages. This compound is applicable in cancer research.Formula:C22H17ClN4O3SMolecular weight:452.07099Thalidomide-N-C3-O-C4-O-C3-OH
Thalidomide-N-C3-O-C4-O-C3-OH is a conjugate of an E3 ligase ligand and a linker, used in the synthesis of the Aster-APROTAC degrader.Formula:C23H31N3O7Molecular weight:461.2162HDAC6-IN-28
HDAC6-IN-28 (compound 10C) is a potent inhibitor of HDAC6 with an IC50 of 261 nM. It significantly induces apoptosis in B16-F10 cells and causes S phase arrest. Additionally, HDAC6-IN-28 effectively increases the expression of acetylated-α-tubulin both in vitro and in vivo.Formula:C23H16FN3O2Molecular weight:385.12265LC-1-40
LC-1-40 is a PROTAC that selectively degrades NUDT1 (DC50=0.97 nM). In mouse models, LC-1-40 selectively inhibits tumor growth induced by MYCN and induces nucleotide damage and apoptosis (cell death) in MYCN-associated tumors. It is applicable for cancer research.Formula:C49H48N8O6Molecular weight:844.36968Chlopynostat
Chlopynostat (Compound 6c) is an HDAC1 inhibitor with an IC50 value of 67 nM. It induces apoptosis by inhibiting HDAC1, thereby reversing STAT4/p66Shc defects.Formula:C22H17ClN4O2Molecular weight:404.104RIPK2-IN-4
RIPK2-IN-4 is a potent and specific inhibitor of RIPK2 with an IC50 value of 5 nM.Formula:C16H10N6S2Molecular weight:350.04084Thalidomide-NH-amido-C6-NH2 hydrochloride
Thalidomide-NH-amido-C6-NH2 hydrochloride is a synthetic E3 ligase ligand-linker conjugate that includes a thalidomide-based cereblon ligand and a linker, designed for the synthesis of PROTAC.Formula:C21H28ClN5O5Molecular weight:465.1779Camrelizumab
CAS:Camrelizumab (SHR-1210) is a human IgG4-κ monoclonal antibody with high affinity and directed against PD-1.Camrelizumab binds PD-1 with a binding affinity of up
Purity:95% - 98.6%Color and Shape:LiquidMolecular weight:143.7 kDaLw13
Lw13 is a PROTAC targeting Hsp90, exhibiting maximal degradation efficacy at a concentration of 0.05 μM in Siha cells. Lw13 induces apoptosis and demonstrates potent antitumor activity both in vitro and in vivo.Formula:C46H55F3N8O8Molecular weight:904.4095SB 699551
CAS:SB 699551 is a selective 5-HT5A antagonist (Ki=6.31 nM) that enhances 5-HT neuronal function. It inhibits SERT (Ki=25.12 nM),inhibit breast cancer.Formula:C34H45N3OPurity:99.83%Color and Shape:SoildMolecular weight:511.74Ref: TM-T23325L
1mg190.00€5mg471.00€10mg662.00€25mg1,036.00€50mg1,429.00€100mg1,821.00€200mg2,489.00€Feladilimab
CAS:Feladilimab (GSK3359609) is an IgG4 monoclonal antibody that is an ICOS agonist.
Purity:SDS-PAGE:95% SEC-HPLC:98%Color and Shape:LiquidMolecular weight:145.24 kDaPacmilimab
CAS:Pacmilimab (CX-072) is a Probody immune checkpoint inhibitor targeting programmed death ligand 1 (PD-L1) with anti-tumor activity for the study of solid tumors.Purity:98.8% (SDS-PAGE); 96.3% (SEC-HPLC) - 98.8% (SDS-PAGE); 96.3% (SEC-HPLC)Color and Shape:LiquidMolecular weight:153.3 kDaPoly (I:C):Kanamycin (1:1)
Poly (I:C):Kanamycin (1:1) is an equimolar mixture of Poly(I:C) and kanamycin. TLR3 agonist commonly used as a vaccine adjuvant; enhanced Poly(I:C) stability.
Color and Shape:SolidWF 10129
CAS:WF 10129 is a new angiotensin converting enzyme inhibitor generated by a fungus, Doratomyces putredinis.Formula:C20H28N2O8Purity:98%Color and Shape:SolidMolecular weight:424.45C188
CAS:C188, a naphthol-based STAT3 inhibitor, blocks IL-6-induced STAT3 activity in HepG2 cells, sparing STAT1.Formula:C19H15NO7S2Color and Shape:SolidMolecular weight:433.45MBC-11 triethylamine
MBC-11 triethylamine, a first-in-class etidronate-araC conjugate, may treat TIBD.Formula:C17H35N4O14P3Purity:98%Color and Shape:SolidMolecular weight:612.4Ro 48-8071
CAS:Oxidosqualene cyclase inhibitorFormula:C23H27BrFNO2Purity:98%Color and Shape:SolidMolecular weight:448.37Solanidine
CAS:Solanidine is a cholestane alkaloid isolated from potato species with antitumor effects. Solanidine inhibits proliferation.Formula:C27H43NOPurity:96.83%Color and Shape:SolidMolecular weight:397.64BKM1644
CAS:BKM1644 is an effective inhibition of the proliferation of metastatic, castration-resistant PCa (mCRPC) cells.Formula:C34H37Cl2F5N2O9P2Purity:98%Color and Shape:SolidMolecular weight:845.51Antitumor photosensitizer-7
Antitumor photosensitizer-7 (compound 15), a photosensitizer possessing anti-cancer properties, demonstrates substantial cytotoxic effects on the G361 melanoma cell line when exposed to 414 nm blue light irradiation.Formula:C23H20N2O3Color and Shape:SolidMolecular weight:372.42Linsidomine hydrochloride
CAS:SIN-1 chloride is a moxidomine metabolite with vasodilatory, anti-platelet, and antianginal effects, reducing myocardial ischemia-related damage.Formula:C6H11ClN4O2Purity:99.27% - 99.67%Color and Shape:White Solid CrystallineMolecular weight:206.63Isorhamnetin 3-glucuronide
Isorhamnetin 3-glucuronide is a useful organic compound for research related to life sciences and the catalog number is T124938.Formula:C22H20O13Color and Shape:SolidMolecular weight:492.3892-Chloronaphthalene
CAS:2-Chloronaphthalene is an organochlorine chemical compound and is a chlorinated derivative of naphthalene. The compound is an isomer for 1-chloronaphthalene.Formula:C10H7ClPurity:98%Color and Shape:SolidMolecular weight:162.62Lambertianic acid
CAS:Lambertianic acid is a bioactive chemical that has anti-allergic and antibacterial effects.Formula:C20H28O3Purity:98%Color and Shape:SolidMolecular weight:316.441Fludioxonil
CAS:Fludioxonil (CGA 173506), a phenylpyrrole fungicide, inhibits the growth of B. cinerea from strawberry and blackberry crops.Formula:C12H6F2N2O2Purity:99.971%Color and Shape:SolidMolecular weight:248.18Aspochalasin D
CAS:Aspochalasin D, isolated from A. microcysticus, shows antibacterial properties and cytotoxicity affecting Ba/F3-V12 cells, with IC50s of 0.49 and 1.9 μg/ml.
Formula:C24H35NO4Color and Shape:SolidMolecular weight:401.54Linearol
CAS:Linearol: diterpene from Sideritis L. with antioxidant, anti-inflammatory, anti-apoptotic effects.Formula:C22H34O4Purity:98%Color and Shape:SolidMolecular weight:362.50spisulosine
CAS:spisulosine is a natural product for research related to life sciences. The catalog number is T9664 and the CAS number is 196497-48-0.
Formula:C18H39NOColor and Shape:SolidMolecular weight:285.5161-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE
CAS:Phospholipid with stearic acid and 15(S)-HpETE boosts ferroptosis in MEFs upon GPX4 inhibition.
Formula:C43H78NO10PColor and Shape:SolidMolecular weight:800.068Albicanol
CAS:Albicanol is a biochemical.Formula:C15H26OColor and Shape:SolidMolecular weight:222.372Ceftiofur hydrochloride
CAS:Ceftiofur hydrochloride (U-67279A) is a stable, broad-spectrum 3rd-gen cephalosporin with antibacterial properties.Formula:C19H17N5O7S3·HClPurity:99.51%Color and Shape:Off-White SolidMolecular weight:560.02NQO2-IN-1
CAS:NQO2-IN-1, a resveratrol analog, is a potent NQO2 inhibito,antitumor,generation of ROS and up-regulation of DR5 (death receptor 5) to promote apoptosis.Formula:C18H18N2O3Purity:99.83%Color and Shape:SoildMolecular weight:310.35RET-IN-28
CAS:RET-IN-28 (Compound 16) is an inhibitor of RET (a transmembrane receptor tyrosine kinase). It specifically inhibits the activity of a mutant RET enzyme (RET-V804M) and is utilized in cancer research.Formula:C26H29N9Color and Shape:SolidMolecular weight:467.57Azadirone
CAS:Azadirone, a limonoid, sensitizes cancer cells to TRAIL by modulating DR4/DR5, survival, and apoptotic proteins.
Formula:C9H15N3O5Color and Shape:SolidMolecular weight:245.23Resolvin D2 n-3 DPA
CAS:RvD2 n-3 DPA is an SPM made from docosapentaenoic acid in human leukocytes, inhibiting neutrophil chemotaxis and adhesion.
Formula:C22H34O5Color and Shape:SolidMolecular weight:378.509Vonlerolizumab
CAS:Vonlerolizumab (MOXR 0916) is a humanized IgG OX40 agonist monoclonal antibody with potential in cancer and immune disease research.Purity:SDS-PAGE:97.3%;SEC-HPLC:99.4%Color and Shape:LiquidMolecular weight:145.25 kDaConophylline
CAS:Conophylline, an alkaloid from Ervatamia microphylla, induces pancreatic cell differentiation and apoptosis, and suppresses HSC.Formula:C44H50N4O10Purity:98%Color and Shape:SolidMolecular weight:794.89(R)-JAK2/STAT3-IN-10a
CAS:(R)-JAK2/STAT3-IN-10a is the R-isomer of JAK2/STAT3-IN-1.JAK2/STAT3-IN-1 is a structural domain inhibitor of GP130 D1 with antitumor activity.
Formula:C34H35BrF3N5O2Purity:97.99%Color and Shape:SoildMolecular weight:682.57WKYMVM
CAS:WKYMVM is a N-formyl peptide receptor (FPR1) agonist.Formula:C41H61N9O7S2Purity:98%Color and Shape:SolidMolecular weight:856.11Ac-IEPD-AFC
CAS:Ac-IEPD-AFC (IEPD) is a fluorescent substrate for granzyme B and can be used to measure granzyme B activity.Formula:C32H38F3N5O11Purity:99.16%Color and Shape:SolidMolecular weight:725.67
