Apoptosis
Apoptosis inhibitors are compounds that prevent or delay the process of programmed cell death, known as apoptosis. These inhibitors are vital in studying cell survival mechanisms and are used to investigate diseases where apoptosis is dysregulated, such as cancer, neurodegenerative disorders, and autoimmune diseases. By modulating apoptosis, these inhibitors can help in the development of therapies aimed at controlling cell death. At CymitQuimica, we provide a comprehensive selection of high-quality apoptosis inhibitors to support your research in cell biology, oncology, and related fields.
Subcategories of "Apoptosis"
- ASK(9 products)
- BCL(1 products)
- Caspase(154 products)
- FOXO1(2 products)
- IAP(67 products)
- Mdm2(12 products)
- PD-1/PD-L1(127 products)
- PDK(9 products)
- PERK(23 products)
- Serine/threonin kinase(17 products)
- Survivin(14 products)
- TNF(90 products)
- c-RET(61 products)
- p53(63 products)
Show 6 more subcategories
Found 6170 products of "Apoptosis"
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EGFR/BRAFV600E-IN-3
EGFR/BRAFV600E-IN-3 is an inhibitor targeting EGFR, BRAFV600E, and EGFRT790M with IC50 values of 57 nM, 68 nM, and 9.70 nM, respectively.Formula:C25H18N4O3Purity:98%Color and Shape:SolidMolecular weight:422.44BRD4 Inhibitor-39
BRD4 Inhibitor-39 (compound 12m) is an orally active inhibitor of BRD4 with an IC50 of 0.02 μM. It can induce apoptosis and demonstrates antitumor activity.Formula:C24H19BrFN9Color and Shape:SolidMolecular weight:532.37Mcl-1 inhibitor 14
Compound (Ra)-10, also known as Mcl-1 inhibitor 14, is a potent inhibitor of myeloid cell leukemia-1 (MCL-1), exhibiting a K_i of 0.018 nM, and holds potentialFormula:C39H41ClFN5O5SColor and Shape:SolidMolecular weight:746.29DiPT-4
DiPT-4, a dual TOP1/PARP1 inhibitor, effectively induces DNA double-strand breaks (DSBs), cell cycle arrest, and apoptosis in cancer cells, with potential toFormula:C32H22FN5O4SPurity:98%Color and Shape:SolidMolecular weight:591.61Pimagedine
CAS:Pimagedine is a prototype therapeutic agent for the prevention of formation of advanced glycation endproducts.Formula:CH6N4Color and Shape:SolidMolecular weight:74.09Distamycin A
CAS:Distamycin A (NSC-82150), oligopeptide antibiotic, binds A/T rich DNA, affects cleavage sites, enhances apoptosis.Formula:C22H27N9O4Color and Shape:SolidMolecular weight:481.51PH14
PH14, a dual PI3K/HDAC inhibitor, demonstrates potent inhibition with IC50 values of 20.3 nM for PI3Kα and 24.5 nM for HDAC3.Purity:98%Color and Shape:Odour SolidPralnacasan
CAS:Pralnacasan blocks IL-18, IL-1β, IFN-γ. It’s a potent oral enzyme inhibitor with use in arthritis therapy (Ki: 1.4 nM).Formula:C26H29N5O7Purity:98%Color and Shape:SolidMolecular weight:523.54U7D-1
U7D-1: First-class USP7 PROTAC degrader, DC50 33 nM, anticancer, induces apoptosis in Jeko-1.Formula:C53H65N9O7Color and Shape:SolidMolecular weight:940.14Ch282-5
CAS:Ch282-5, an orally active inhibitor targeting the Bcl-2 protein, promotes mitochondria-dependent apoptosis (Apoptosis) by disrupting mitophagy and the mTOR pathway. It demonstrates antiproliferative effects on colorectal cancer cells, effective both in vitro and in vivo, while also inhibiting metastasis. Further, Ch282-5 augments Oxaliplatin-induced autophagy (Autophagy) by downregulating Mcl-1 protein and raising platelet count, which helps mitigate the adverse effects of Navitoclax.Formula:C34H34N2Na2O14S2Color and Shape:SolidMolecular weight:804.75NCT-58
CAS:NCT-58 is a potent HSP90 inhibitor that blocks Akt, downregulates HER family, and induces apoptosis in HER2+ breast cancer without triggering HSR.Formula:C27H34N2O5Purity:99.55%Color and Shape:SolidMolecular weight:466.57Ref: TM-T9996
2mg43.00€5mg80.00€10mg119.00€25mg245.00€50mg394.00€100mg627.00€200mg842.00€1mL*10mM (DMSO)197.00€PTD10
CAS:PTD10 is a BTK-targeting PROTAC degradator, induces apoptosis via caspase-dependent and mitochondrial pathways, B-cell dysregulation.Formula:C49H51N11O8Purity:99.12%Color and Shape:SolidMolecular weight:922.99Rozanolixizumab
CAS:Rozanolixizumab (RYSTIGGO) is a humanized IgG4 monoclonal antibody that targets FcRn in newborns for autoimmune research.
Purity:SDS-PAGE:97.2%;SEC-HPLC:95.9%Color and Shape:LiquidMolecular weight:145.19 kDaAntitumor agent-116
Antitumor Agent-116 (Compound 6C) is an anti-tumor agent that exhibits anti-proliferative properties and induces apoptosis.Formula:C31H23BrN4O4SPurity:98%Color and Shape:SolidMolecular weight:627.51Verdinexor
CAS:Verdinexor (KPT-335) (KPT-335), a specific XPO1/CRM1 inhibitor, are orally bioavailable.Formula:C18H12F6N6OPurity:98% - 99.68%Color and Shape:SolidMolecular weight:442.32Ref: TM-T6123
1mg35.00€5mg111.00€10mg187.00€25mg341.00€50mg567.00€100mg905.00€200mg1,216.00€1mL*10mM (DMSO)123.00€HTR2A antagonist 1
HTR2A antagonist 1 (Compound 15f) is an HTR2A antagonist with an IC50 of 42.79 nM. It induces sub-G1 cell cycle arrest and apoptosis in colorectal cancer cells by activating the p53/p21/caspase 3 signaling pathway. HTR2A antagonist 1 exhibits good liver microsomal stability and is useful for colorectal cancer research.Formula:C35H43Cl2F2N5O4Color and Shape:SolidMolecular weight:706.65ROS inducer 4
Compound TE3, also known as ROS inducer 4, serves as a mitochondrial inhibitor. This compound induces a variety of mitochondria-related physiological alterations in tumors, including mitochondrial fragmentation, intense generation and accumulation of ROS, reduced mitochondrial membrane potential, and lower ATP content. Additionally, it activates ROS-mediated apoptotic signaling within mitochondria.Formula:C49H62BrO4PColor and Shape:SolidMolecular weight:825.89Topoisomerase I/II inhibitor 6
TopoisomeraseI/II inhibitor 6 (compound 3i) acts as an effective inhibitor of topoisomerase I and II, with IC50 values of 4.77 µM and 15 µM, respectively. Additionally, it exhibits antiproliferative activity against the human melanoma cell line LOX IMVI, demonstrating IC50 values of 26.7 µM and 25.4 µM.Formula:C31H28F2N4O6SColor and Shape:SolidMolecular weight:622.64PRMT5-IN-31
PRMT5-IN-31 (Compound 3m), a selective PRMT5 inhibitor (IC50: 0.31 μM), increases hnRNP E1 protein levels by occupying the substrate site of PRMT5 andFormula:C21H24N2O2Purity:98%Color and Shape:SolidMolecular weight:336.43Streptonigrin
CAS:Streptonigrin, from Streptomyces flocculus, has anti-tumor and anti-bacterial properties, inhibiting PAD1-4.Formula:C25H22N4O8Purity:98%Color and Shape:SolidMolecular weight:506.46(E/Z)-10-Hydroxy-2-decenoic acid
CAS:(E/Z)-10-Hydroxy-2-decenoic acid is a useful organic compound for research related to life sciences.Formula:C10H18O3Color and Shape:SolidMolecular weight:186.251S65487 hydrochloride
CAS:S65487 (VOB560) hydrochloride, a potent and selective Bcl-2 inhibitor, is effective against BCL-2 mutations, including G101V and D103Y.Formula:C41H42Cl2N6O4Color and Shape:SolidMolecular weight:753.73Enterodiol
Enterodiol is a natural product that can be used as a reference standard.Formula:C18H22O4Color and Shape:SolidMolecular weight:302.37Toremifene citrate
CAS:Toremifene citrate is a selective estrogen receptor modulator (SERM). It is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on the mammary and uterine tissue.Formula:C32H36ClNO8Purity:99.83% - >99.99%Color and Shape:White Or Almost White PowderMolecular weight:598.08Thalidomide-NH-C6-NH2 TFA
CAS:Thalidomide-based cereblon ligand linked to PROTAC technology as E3 ligase ligand-linker.Formula:C21H25F3N4O6Purity:98%Color and Shape:SolidMolecular weight:486.44HDAC-IN-77
HDAC-IN-77 (HL-5s), an HDAC inhibitor, has the capability to induce ferroptosis and suppress the Nrf2/HO-1 signaling pathway. This compound is utilized in cancer research.Formula:C22H26N4O2SColor and Shape:SolidMolecular weight:410.53Verproside
CAS:Verproside is a useful organic compound for research related to life sciences. The catalog number is T124745 and the CAS number is 50932-20-2.Formula:C22H26O13Color and Shape:SolidMolecular weight:498.437AS-99 TFA
AS-99 TFA: potent ASH1L inhibitor, IC50=0.79 μM, combats leukemia, inhibits cell growth, induces apoptosis.Color and Shape:SolidPROTAC KDM4 degrader-1
PROTACKDM4 degrader-1 (Compound 11) is a proteolysis-targeting chimera (PROTAC) degrader specifically designed for KDM4. It effectively degrades KDM4A-C while sparing KDM4D. In esophageal cancer cells, PROTACKDM4 degrader-1 demonstrates strong antiproliferative activity, inducing apoptosis and cell cycle arrest, and inhibits lysine demethylation of histone H3.Color and Shape:Odour SolidNQO2-IN-1
CAS:NQO2-IN-1, a resveratrol analog, is a potent NQO2 inhibito,antitumor,generation of ROS and up-regulation of DR5 (death receptor 5) to promote apoptosis.Formula:C18H18N2O3Purity:99.83%Color and Shape:SoildMolecular weight:310.35Aphidicolin
CAS:Aphidicolin blocks DNA synthesis, hinders herpes virus growth, and stimulates apoptosis in leukemia cells; it's a mold-derived DNA polymerase inhibitor.Formula:C20H34O4Purity:>99.99%Color and Shape:SolidMolecular weight:338.48Thalidomide-O-amido-PEG4-azide
CAS:Thalidomide-O-amido-PEG4-azide is a polyethylene glycol (PEG) derivative serving as a linker for Proteolysis Targeting Chimeras (PROTACs) synthesis [1].Formula:C25H32N6O10Purity:98%Color and Shape:SolidMolecular weight:576.56CS4
CS4 is a selective HDAC inhibitor, with IC50 values for HDAC1, HDAC6, HDAC8, HDAC4, and HDAC11 reported as 38 nM, 12 nM, 5.8 μM, 19 μM, and 61 μM, respectively. It enhances the acetylation of α-tubulin and histone 3 (histone 3). Additionally, CS4 activates PPARγ and blocks glycolysis (glycolysis). It induces cell cycle arrest at the G2 phase and triggers apoptosis (apoptosis), exhibiting anticancer effects both in vitro and in vivo.Color and Shape:Odour SolidCRA-026440 hydrochloride
CAS:CRA-026440 hydrochloride is a potent and broad-spectrum HDAC inhibitor.Formula:C23H25ClN4O4Purity:99.78%Color and Shape:SoildMolecular weight:456.92Ref: TM-T10883L
1mg115.00€5mg274.00€10mg432.00€25mg735.00€50mg1,159.00€100mg1,568.00€1mL*10mM (DMSO)47.00€YN14-H
YN14-H is a PROTAC degrader that targets KRASG12C. It effectively inhibits the growth of NCI-H358 and MIA PaCa-2 cells, with IC50 values of 0.042 μM and 0.021 μM, respectively, and DC50 values of 28.9 nM and 18.1 nM. YN14-H significantly induces apoptosis and suppresses cell migration. It demonstrates favorable pharmacokinetics and excellent in vivo antitumor activity.Color and Shape:Odour SolidPD1-PDL1-IN 1 TFA
PD1-PDL1-IN 1 TFA (compound 16) is a potent inhibitor of programmed cell death 1 (PD-1), functioning as an immune modulator [1].Formula:C16H24F3N7O8Color and Shape:SolidMolecular weight:499.4Dehydroaltenusin
CAS:Dehydroaltenusin is a selective eukaryotic DNA polymerase α inhibitor and a type of antibiotic produced by a fungus (IC50: 0.68 μM).Formula:C15H12O6Purity:98%Color and Shape:SolidMolecular weight:288.255Albanol B
CAS:Albanol B, from mulberries, combats Alzheimer's, bacteria, and oxidation, hinders cancer growth, and triggers cell arrest and apoptosis.Formula:C34H22O8Color and Shape:SolidMolecular weight:558.53A947
CAS:A947 is a potent and selective SMARCA2 PROTAC that induces the degradation of SMARCA2, with significant antitumor activity in SMARCA4-mutant NSCLC cells.Formula:C61H76N12O7SPurity:98.84%Color and Shape:SolidMolecular weight:1121.4VEGFR/PARP-IN-1
VEGFR/PARP-IN-1 (Compound 14b) is a dual inhibitor of VEGFR and PARP with IC50 values of 191 nM and 60.9 nM, respectively.Formula:C29H27N9OPurity:98%Color and Shape:SolidMolecular weight:517.583MB-PP1
CAS:3MB-PP1 is a bulky purine analog and a Polo-like kinase 1 (Plk1) inhibitor.Formula:C17H21N5Purity:99.96%Color and Shape:White SolidMolecular weight:295.38Ref: TM-T21678
5mg50.00€10mg92.00€25mg166.00€50mg255.00€100mg374.00€500mgTo inquire1mL*10mM (DMSO)55.00€dTAG-47
CAS:dTAG-47 targets FKBP12 F36V for protein degradation, useful in basal-like breast cancer research.Formula:C59H73N5O14Color and Shape:SolidMolecular weight:1076.24ICy-OH
CAS:ICy-OH, an iodinated anticancer photosensitizer, excels in deep tissue imaging (640 nm excitation) and triggers pyroptosis in pancreatic cancer cells.Formula:C26H25I2NO2Color and Shape:SolidMolecular weight:637.29Avotaciclib hydrochloride
Avotaciclib hydrochloride, a CDK1 inhibitor, is the hydrochloride salt of Avotaciclib and exhibits potential therapeutic use in specific malignancies, includingFormula:C13H12ClN7OPurity:98%Color and Shape:SolidMolecular weight:317.73PZ703b TFA
PZ703b TFA, a Bcl-xl PROTAC degradation agent, promotes apoptosis and halts bladder cancer cell proliferation, making it a pertinent investigative compound forFormula:C82H103ClF6N10O13S4Purity:98%Color and Shape:SolidMolecular weight:1714.46BMf-BH3
BMf-BH3 is a Bcl-2 family peptide, key in HDAC inhibition affecting acetylation balance.Formula:C131H214N45O35SPurity:98%Color and Shape:SolidMolecular weight:3012.5dPDL1-4
dPDL1-4 is a potent and selective eHSPTAC eHSP90PD-L1 degrader, with DC50 values of 7.77 μM (HeLa) and 6.52 μM (B16F10). It links eHSP90 to target proteins, inducing lysosomal degradation. dPDL1-4 effectively degrades PD-L1 and inhibits tumor growth, making it useful for research in cervical cancer and melanoma.Color and Shape:Odour SolidThalidomide-O-PEG4-azide
CAS:Thalidomide-O-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].Formula:C23H29N5O9Purity:98%Color and Shape:SolidMolecular weight:519.5SC-2001
CAS:SC-2001 inhibits MCL-1 and STAT3, enhances SHP-1, induces apoptosis in breast cancer, and counters STAT3-driven sorafenib resistance in liver cancer.Formula:C18H14BrN3OPurity:98%Color and Shape:SolidMolecular weight:368.23
