Apoptosis
Apoptosis inhibitors are compounds that prevent or delay the process of programmed cell death, known as apoptosis. These inhibitors are vital in studying cell survival mechanisms and are used to investigate diseases where apoptosis is dysregulated, such as cancer, neurodegenerative disorders, and autoimmune diseases. By modulating apoptosis, these inhibitors can help in the development of therapies aimed at controlling cell death. At CymitQuimica, we provide a comprehensive selection of high-quality apoptosis inhibitors to support your research in cell biology, oncology, and related fields.
Subcategories of "Apoptosis"
- ASK(9 products)
- BCL(1 products)
- Caspase(154 products)
- FOXO1(2 products)
- IAP(67 products)
- Mdm2(12 products)
- PD-1/PD-L1(127 products)
- PDK(9 products)
- PERK(23 products)
- Serine/threonin kinase(17 products)
- Survivin(14 products)
- TNF(90 products)
- c-RET(61 products)
- p53(63 products)
Show 6 more subcategories
Found 6170 products of "Apoptosis"
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Osajin
CAS:Osajin is the major bioactive iso avone present in the fruit of Maclura pomifera. It has antitumor, antioxidant, and anti-inflammatory activities.Formula:C25H24O5Purity:98%Color and Shape:SolidMolecular weight:404.46Targaprimir-96
CAS:Targaprimir-96 is a potent microRNA-96 (miR-96) processing inhibitor.Formula:C77H102N18O7Purity:98%Color and Shape:SolidMolecular weight:1391.75HLDA-212
CAS:HLDA-212 (Compound 43) is a bifunctional small molecule designed to target HaloTag-tagged protein (target protein, TP) and Aurora kinase A/B (AURKA/B, effector protein, EP). By binding TP and EP, it forms a stable ternary complex (TP:RIPTAC:EP) that inhibits the cell survival functions of EP, inducing apoptosis in cancer cells expressing TP. In 293_HFL cells, HLDA-212 demonstrates antiproliferative activity with a GI50 of 0.011 μM. This compound holds promise for treating cancers with high TP expression, such as prostate cancer and hematological malignancies.Formula:C70H90BrFN8O19SColor and Shape:SolidMolecular weight:1478.47CTP-347
CAS:CTP-347, a deuterated version of paroxetine, is potentially the best non-hormonal drug in its class for the treatment of hot flashes.Formula:C19H20FNO3Color and Shape:SolidMolecular weight:331.38ATWLPPRAANLLMAAS
CAS:ATWLPPRAANLLMAAS is a chimeric peptide with anti-angiogenic and potent antitumor capabilities. It effectively inhibits the proliferation, viability, migration, and invasion of human hepatocellular carcinoma cells, and induces apoptosis (apoptosis).Formula:C76H123N21O20SMolecular weight:1682.98Thalidomide-O-amido-PEG3-C2-NH2
CAS:Thalidomide-O-amido-PEG3-C2-NH2 is a cereblon ligand-linker for PROTACs with a 3-unit PEG.Formula:C23H30N4O9Purity:98%Color and Shape:SolidMolecular weight:506.51Ecdysone
CAS:Ecdysone is a major steroid hormone in insects and herbs.Formula:C27H44O6Purity:99.22%Color and Shape:PowderMolecular weight:464.63β-Amyloid (1-40) (rat)
CAS:Rat form of the beta-Amyloid (1-40) peptideFormula:C190H291N51O57SPurity:98%Color and Shape:SolidMolecular weight:4233.76Spexin
CAS:Potent GAL2/GAL3 agonist (EC50 = 45.7, 112.2 nM), inactive at GAL1. Reduces appetite, fatty acid uptake in adipocytes, and LH in goldfish; anxiolytic in vivo.Formula:C74H114N20O19SPurity:98%Color and Shape:SolidMolecular weight:1619.9Z-DQMD-FMK
CAS:Caspase-3 inhibitor. Inhibits MG 132-induced small cell lung cancer cell death in vitro.
Formula:C29H40FN5O11SPurity:98%Color and Shape:SolidMolecular weight:685.72ZZM-1220
ZZM-1220, a covalent inhibitor of histone lysine methyltransferase G9a/GLP, exhibits IC50 values of 458 nM for G9a and 924 nM for GLP.Formula:C25H29N5O3Purity:98%Color and Shape:SolidMolecular weight:447.53Fuscin
CAS:Fuscin, a quinonoid from O. fuscum, inhibits ADP/ATP translocase, depletes glutathione, disrupts NADH oxidation, and blocks MIP-1α/CCR5 binding (IC50: 21µM).Formula:C15H16O5Color and Shape:SolidMolecular weight:276.288Chloranil
CAS:Chloranil (tetrachloro-p-benzoquinone) induces inflammation and neurological dysfunction and can be used to model inflammation in mice.Formula:C6Cl4O2Purity:98.03%Color and Shape:SolidMolecular weight:245.88KWCN-41
CAS:KWCN-41, Selective RIPK1 inhibitor (IC50=88 nM), inhibits necrosis specifically, anti-inflammatory effects.Formula:C18H17N3O2Color and Shape:SolidMolecular weight:307.35DC-Y13-27
Dc-y13-27, a derivative of DC-Y13, is a potent YTHDF2 inhibitor (KD: 37.9 μM).
Formula:C14H10N2O2SPurity:99.75%Color and Shape:SoildMolecular weight:270.31AVJ16
CAS:AVJ16 as a member of the insulin growth factor 2 mRNA-binding protein family, binds to the mRNA of certain genes to regulate protein translation.Formula:C28H27N3O4Purity:98.87% - 99.72%Color and Shape:SolidMolecular weight:469.53Ref: TM-T9980
1mg130.00€5mg313.00€10mg500.00€25mg807.00€50mg1,108.00€100mg1,485.00€200mg1,998.00€1mL*10mM (DMSO)323.00€PROTAC Bcl2 degrader-1
CAS:PROTAC Bcl2 degrader-1 is a PROTAC, which potently and selectively induces the degradation of Mcl-1 (IC50: 11.81 μM) and Bcl-2 (IC50: 4.94 μM; DC50: 3.0 μM).Formula:C45H45BrN6O10SPurity:98%Color and Shape:SolidMolecular weight:941.84Mcl-1 inhibitor 16
Mcl-1 Inhibitor 16 (Compound 9), a platinum-based mitochondrial-targeting agent, inhibits Mcl-1 and induces Bax/Bak-dependent apoptosis in cancer cells.Formula:C25H29Cl2N3PtColor and Shape:SolidMolecular weight:637.51MYC-RIBOTAC
MYC-RIBOTAC, a ribonuclease-targeting chimera (RIBOTAC) specific to the MYC internal ribosome entry site (IRES), comprises an MYC mRNA-binding element tetheredFormula:C55H58N10O11SPurity:98%Color and Shape:SolidMolecular weight:1067.17TAPI 0
CAS:ADAM-17 (TACE) and MMP inhibitor; attenuates TNF-α processing. Acts in concert with GM6001 to inhibit Chlamydia trachomatis growth.Formula:C24H32N4O5Purity:98%Color and Shape:SolidMolecular weight:456.54(-)-Mcl-1 inhibitor 21
CAS:(-)-Mcl-1 inhibitor 21 (Example 1-38) is an Mcl-1 inhibitor with an IC50 of 7.51 μM. It exhibits pro-apoptotic and anti-proliferative activity against SUDHL5 and SUDHL10 cell lines, making it useful for cancer research.
Formula:C32H33N3O4Color and Shape:SolidMolecular weight:523.622Thalidomide-O-C8-NH2
CAS:Thalidomide-O-C8-NH2 is a synthetic cereblon ligand & PROTAC linker, serving as an E3 ligase ligand-linker.Formula:C21H27N3O5Color and Shape:SolidMolecular weight:401.463Cyanoacetamide
CAS:Cyanoacetamide has inhibitory activity against the myeloid leukaemia cell differentiation protein Mcl-1Formula:C3H4N2OPurity:97.04%Color and Shape:Needles From Alcohol White To Light Cream Crystalline PowderMolecular weight:84.08Zalypsis
CAS:Zalypsis, a transcription factor inhibitor, is used potentially for the treatment of lymphoma, and cervical carcinoma.Formula:C37H38F3N3O8Color and Shape:SolidMolecular weight:709.71Tubulin/MMP-IN-3
Tubulin/MMP-IN-3 (Compound 15j) is a dual inhibitor of tubulin polymerization and MMP, effectively inhibiting MMP-2 and MMP-9 with IC50 values of 21.13 μM and 19.24 μM, respectively. It disrupts the NF-κB signaling pathway, leading to mitochondrial dysfunction and mitochondrial-dependent apoptosis. Tubulin/MMP-IN-3 shows antiproliferative activity in various cancer cells by causing cell cycle arrest at the G2/M phase and demonstrates antitumor effects in mouse models.Formula:C38H41N2O12PColor and Shape:SolidMolecular weight:748.712HG-7-85-01
CAS:HG-7-85-01 is a novel ATP-competitive and type II tyrosine kinase inhibitor targeting both wild-type and watchman mutant BCR-ABL, PDGFRα, Kit, and Src kinases.Formula:C31H31F3N6O2SPurity:98.08%Color and Shape:SolidMolecular weight:608.68GPLGIAGQ
CAS:GPLGIAGQ, a MMP2-cleavable polypeptide, is used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers for MMP2-triggered tumor targeting.Formula:C31H53N9O10Purity:98%Color and Shape:SolidMolecular weight:711.81EGFR-IN-86
EGFR-IN-86 (compound 4i), an EGFR inhibitor (IC50: 1.5 nM), demonstrates potent activity against glioblastoma by inducing apoptosis and causing G2/M phase cellFormula:C20H21N7O2SPurity:98%Color and Shape:SolidMolecular weight:423.49Anticancer agent 102
CAS:Anticancer Agent 102, a tetracaine derivative, exhibits anti-cancer activity by inducing apoptosis [1].Formula:C20H19F6N3OColor and Shape:SolidMolecular weight:431.37HDAC3-IN-6
HDAC3-IN-6 (Compound SC26) is a selective HDAC3 inhibitor with an IC50 of 53 nM. It induces PD-L1 expression in a dose-dependent manner and leads to significant apoptosis and reactive oxygen species (ROS) production. HDAC3-IN-6 exhibits strong antitumor efficacy against colorectal cancer.Formula:C23H23N5O3Color and Shape:SolidMolecular weight:417.46CAY10678
CAS:CAY10678 is an mPGES-1 inhibitor that inhibits PD-1.CAY10678 reduces collagen deposition and T-cell depletion, and may be used to study melanoma.CASHIPSFormula:C23H34N4OPurity:99.66%Color and Shape:SolidMolecular weight:382.54Apoptolidin
CAS:Apoptolidin, from Nocardiopsis, induces apoptosis, targets mitochondrial ATPase (Ki 4-5 μM), kills glial cells, and has antibiotic and antifungal properties.Formula:C58H96O21Color and Shape:SolidMolecular weight:1129.385Z-VDVA-(DL-Asp)-FMK
CAS:Z-VDVA-(DL-Asp)-FMK is a derivative compound of Z-VDVAD-FMK specifically designed as an inhibitor targeting caspase-2.Formula:C32H46FN5O11Color and Shape:SolidMolecular weight:695.742Thalidomide-O-amido-C6-NH2
CAS:Thalidomide-O-amido-C6-NH2 is a synthetic E3 ligase used for PROTAC creation, containing cereblon ligand and linker.Formula:C21H26N4O6Color and Shape:SolidMolecular weight:430.45BCMA72-80
CAS:BCMA72-80: HLA-A2-specific peptide with high affinity; used in multiple myeloma and other BCMA+ tumor research.Formula:C59H97N13O11SPurity:98%Color and Shape:SolidMolecular weight:1196.55Enpp/Carbonic anhydrase-IN-1
CAS:Enpp/Carbonic anhydrase-IN-1 (compound 1e) is a potent inhibitor of Enpp and carbonic anhydrase.Formula:C23H25NO4SPurity:99.96%Color and Shape:SoildMolecular weight:411.51Spiroplatin
CAS:Spiroplatin (TNO-6) is a novel platinum-containing analogue with antitumor activity that is commonly used in the study of solid tumors.Formula:C8H18N2O4PtSPurity:≥98%Color and Shape:SolidMolecular weight:433.39BC011
BC011 is a human monoclonal antibody (mAb) targeting TNFRSF1B. It enhances the proliferation of CD8+ T cells and depletes Treg cells, resulting in an increased proportion of effector T cells within the tumor microenvironment. BC011 is applicable in the study of tumor immunology.Color and Shape:Odour LiquidGanoderic acid Mk
CAS:GA-Mk is a triterpenoid from Ganoderma lucidum mycelia, inhibits HeLa cell growth, and induces apoptosis via mitochondria; used in cervical cancer studies.Formula:C34H50O7Color and Shape:SolidMolecular weight:570.76YW-N-7 TFA
YW-N-7 (TFA) is a PROTAC designed to target, inhibit, and degrade RET kinase, demonstrating a DC50 of 88 nM. It exhibits antitumor activity in xenograft mouse models driven by KIF5B-RET, making it a valuable compound for cancer research.Formula:C58H63F3N12O9Color and Shape:SolidMolecular weight:1129.19GB-223
GB-223 is a human monoclonal antibody (mAb) that targets TNFSF11/RANKL/CD254. It is applicable in the study of giant cell tumors of bone and postmenopausal osteoporosis.Color and Shape:Odour LiquidGSK2800528
GSK2800528 is a human monoclonal antibody (mAb) targeting TNFSF2/TNFa, utilized for research related to inflammation and psoriasis.Color and Shape:Odour LiquidPlaculumab
CAS:Placulumab (ART621), an anti-TNF α monoclonal antibody, targets inflammation, potentially aiding arthritis treatment.Color and Shape:LiquidFerumoxytol
CAS:Ferumoxytol is an iron oxide nanoparticle with anti-leukemia properties, specifically against acute myeloid leukemia (AML) cells with low ferroportin (FPN) expression. By increasing intracellular iron levels, Ferumoxytol induces the Fenton reaction to produce reactive oxygen species (ROS), resulting in oxidative stress and ferroptosis. It selectively kills leukemia cells with low FPN expression while sparing normal cells, making it useful for studying leukemia targeting iron metabolism abnormalities.Color and Shape:SolidBaminercept
CAS:Baminercept (BG 9924) is a lymphotoxin-β receptor-immunoglobulin fusion protein that blocks the lymphotoxin-letter/LIGHT axis.Purity:95% (SDS-PAGE); 98.3% (SEC-HPLC) - 95% (SDS-PAGE); 98.3% (SEC-HPLC)Color and Shape:LiquidMolecular weight:46.88 kDaDazodalibep
CAS:Dazodalibep (MEDI 4920; VIB 4920) is a monoclonal antibody that specifically targets CD40LG/TNFSF5 and is fused to human serum albumin (ALB/HSA) [1].Color and Shape:LiquidPROTAC RIPK degrader-6
CAS:PROTAC RIPK degrader-6 (example 1) is a PROTAC designed for the targeted degradation of RIP Kinase, featuring a RIP2 kinase inhibitor connected through a linkerFormula:C43H48N6O11S2Color and Shape:SolidMolecular weight:889.01Rosamultic acid
Rosamultic acid is a useful organic compound for research related to life sciences and the catalog number is T125342.Formula:C30H46O5Color and Shape:SolidMolecular weight:486.693Lodapolimab
CAS:Lodapolimab (LY3300054) is an IgGλ anti- PD-1 monoclonal antibody [1] .Color and Shape:LiquidHematein
CAS:Hematein blocks Akt/PKB, Wnt signaling, promotes apoptosis in lung cancer, is a dye from hematoxylin, and inhibits casein kinase II (IC50: 0.74 μM).Formula:C16H12O6Purity:98%Color and Shape:Dark Brown Crystalline PowderMolecular weight:300.26
