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Cell Cycle/Checkpoint

Cell Cycle/Checkpoint

Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.

Subcategories of "Cell Cycle/Checkpoint"

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Found 3482 products of "Cell Cycle/Checkpoint"

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  • 5'-DMT-5-F-2'-dU Phosphoramidite

    CAS:
    <p>5'-DMT-5-F-2'-dU Phosphoramidite is a nucleoside phosphoramidite analog employed in oligonucleotide synthesis. It plays a crucial role in developing therapeutic oligonucleotides, which are used in crafting drugs for cancer treatment.</p>
    Formula:C39H46FN4O8P
    Color and Shape:Solid
    Molecular weight:748.777
  • CDK9 autophagic degrader 1

    CAS:
    <p>CDK9 autophagic degrader 1 (Compound 28) is an ATTEC degrader used to target and degrade CDK9, also impacting the levels of its associated Cyclin T1. At a concentration of 100 nM, it exhibits over 80% inhibition of CDK9.</p>
    Formula:C34H39N7O4S2
    Color and Shape:Solid
    Molecular weight:673.848
  • 7-Methylguanosine 5′-monophosphate

    CAS:
    <p>7-Methylguanosine 5′-monophosphate (7-Methylguanylic acid) is a component of nucleic acids.</p>
    Formula:C11H16N5O8P
    Color and Shape:Solid
    Molecular weight:377.25
  • LNA-GDP

    CAS:
    <p>LNA-GDP is a nucleotide analog utilized in the synthesis of oligonucleotides.</p>
    Formula:C11H15N5O11P2
    Color and Shape:Solid
    Molecular weight:455.21
  • AB25583

    CAS:
    <p>AB25583 is a small molecule inhibitor of Polθ helicase (Polθ-hel) with an IC50 of 6 nM. It selectively kills cells deficient in BRCA1/2 and synergizes with Olaparib in cancer cells harboring pathogenic BRCA1/2 mutations. AB25583 can be utilized in tumor research.</p>
    Formula:C22H17ClN4O3S
    Color and Shape:Solid
    Molecular weight:452.91
  • CDK4/6-IN-3

    CAS:
    <p>CDK4/6-IN-3 is a brain-penetrant CDK4/CDK6 inhibitor (Kis: &lt;0.3 nM and 2.2 nM) used for the treatment of glioblastoma. It inhibits CDK1 with a Ki of 110 nM.</p>
    Formula:C25H31FN8
    Purity:98%
    Color and Shape:Solid
    Molecular weight:462.57
  • MtTMPK-IN-8


    <p>MtTMPK-IN-8 inhibits MtbTMPK, has low cytotoxicity, shows 0.78-9.4 μM activity against Mycobacterium, useful for tuberculosis research.</p>
    Formula:C24H24N6O7
    Color and Shape:Solid
    Molecular weight:508.48
  • 12(S)-HETE

    CAS:
    <p>Enpatoran hydrochloride (M5049 hydrochloride) is a TLR7/8 inhibitor with antiviral activity that is used in the study of autoimmune diseases.</p>
    Formula:C20H32O3
    Color and Shape:Solid
    Molecular weight:320.47
  • LIMK1 inhibitor 2

    CAS:
    <p>LIMK1 inhibitor 2 (compound 41) is a LIMK1 inhibitor with an IC50 value of 9 μM.</p>
    Formula:C10H11N3OS
    Color and Shape:Solid
    Molecular weight:221.279
  • Metesind Glucuronate

    CAS:
    <p>Metesind Glucuronate is an antineoplastic. It also is a specific thymidylate synthase inhibitor.</p>
    Formula:C29H34N4O10S
    Color and Shape:Solid
    Molecular weight:630.67
  • Valopicitabine dihydrochloride

    CAS:
    <p>Valopicitabine, a NS5B inhibitor, is used potentially for the treatment of HCV infection.</p>
    Formula:C15H25ClN4O6
    Color and Shape:Solid
    Molecular weight:392.84
  • Antibacterial agent 110


    <p>Compound 4e, an antibacterial against P. aeruginosa, disrupts cell membranes (MIC: 1 μg/ml).</p>
    Formula:C22H21N5O4S
    Color and Shape:Solid
    Molecular weight:451.5
  • CDK4/9-IN-1

    CAS:
    <p>CDK4/9-IN-1 (Compound 29) is a selective dual inhibitor of CDK4 and CDK9, exhibiting IC50 values of 23 nM and 12 nM, respectively. It holds potential for use in cancer research.</p>
    Formula:C22H34N6O2
    Color and Shape:Solid
    Molecular weight:414.544
  • Antiangiogenic agent 2


    <p>Antiangiogenic agent 2 (compound 3b) is a potent inhibitor of thymidine phosphorylase (IC50: 39.71 μM) and exhibits anti-angiogenic effects.</p>
    Formula:C26H26FN3O4
    Color and Shape:Solid
    Molecular weight:463.5
  • P162-0948

    CAS:
    <p>P162-0948 is a selective CDK8 inhibitor with an IC50 value of 50.4 nM. It reduces cell migration and the expression of EMT-related proteins in the A549 human alveolar epithelial cell line. Furthermore, P162-0948 decreases Smad phosphorylation, indicating disruption of the TGF-β/Smad signaling pathway, making it a promising compound for pulmonary fibrosis research.</p>
    Formula:C20H15FN4O2
    Color and Shape:Solid
    Molecular weight:362.357
  • 2'-O-MOE-UTP

    CAS:
    <p>2'-O-MOE-UTP is a nucleotide analog employed in the synthesis of oligonucleotides.</p>
    Formula:C12H21N2O16P3
    Color and Shape:Solid
    Molecular weight:542.22
  • 5-Methylcytosine hydrochloride

    CAS:
    <p>5-Methylcytosine hydrochloride plays a critical role in regulating gene expression, promoting genomic imprinting, and inhibiting transposon factors. It is also closely associated with translation fidelity and tRNA recognition.</p>
    Formula:C5H8ClN3O
    Color and Shape:Solid
    Molecular weight:161.59
  • JY-3-094

    CAS:
    <p>JY-3-094 is a selective Myc inhibitor that targets the hydrophobic domain of Myc and inhibits the formation of the Myc-Max heterodimer, with an IC50 of 33 μM, and can be used for cancer research.</p>
    Formula:C13H8N4O5
    Purity:98.72%
    Color and Shape:Solid
    Molecular weight:300.23
  • CDK7-IN-17

    CAS:
    <p>CDK7-IN-17, a pyrimidine-based CDK7 inhibitor, shows promise for various cancers, especially with abnormal transcription.</p>
    Formula:C24H26F3N6OP
    Color and Shape:Solid
    Molecular weight:502.47
  • IIP0943

    CAS:
    <p>IIP0943 is a selective PLK1 (polo-like kinase 1) inhibitor with an IC50 of 5.1 nM for PLK1. It also exhibits inhibitory activity on the proliferation of HCT116 cells, with an IC50 of 0.22 µM. IIP0943 shows potential for research in the field of oncology.</p>
    Formula:C26H28N6O3S
    Color and Shape:Solid
    Molecular weight:504.604