Cell Cycle/Checkpoint
Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.
Subcategories of "Cell Cycle/Checkpoint"
- Aurora Kinase(115 products)
- CDK(546 products)
- Cell Cycle Arrest(5 products)
- Chk(48 products)
- DYRK(47 products)
- Dynamin(27 products)
- Ferroptosis(227 products)
- HSP(180 products)
- Integrin(269 products)
- Kinesin(87 products)
- LIM Kinase(20 products)
- Microtubule Associated(273 products)
- PKC(126 products)
- PLK(25 products)
- ROCK(62 products)
- Rho(6 products)
- Wee1(14 products)
- c-Myc(76 products)
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Found 3908 products of "Cell Cycle/Checkpoint"
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TC113
TC113, a c(RGDyK)-linked Gemcitabine, targets αvβ3 integrin, entering A549 cells, and inhibits WM266.4 and A549 cell growth.Formula:C37H50F2N12O13Color and Shape:SolidMolecular weight:908.86PROTAC CDK9 degrader-5
CAS:PROTAC CDK9 degrader-5 selectively degrades CDK9 isoforms 42, 55 with DC50 of 0.10μM, 0.14μM via proteasome.Formula:C42H48Cl2N8O9Purity:98%Color and Shape:SolidMolecular weight:879.78AV-153
CAS:AV-153, a 1,4-dihydropyridine, reduces DNA damage, stimulates repair, and has anti-cancer properties.Formula:C14H19NNaO6Color and Shape:SolidMolecular weight:320.297AM5992
CAS:AM5992 (example 195) is a potent CDK4 and CDK6 inhibitor (CDK4, IC50= 0.013 μM). AM5992 can be used for the research of CDK4-mediated disorders.Formula:C27H33FN8OPurity:98%Color and Shape:SoildMolecular weight:504.6Indatuximab
Indatuximab is a chimeric antibody targeting CD13, used in the synthesis of ADC compound Indatuximab ravtansine.Purity:>95%Color and Shape:LiquidMolecular weight:146.1 kDa12R-LOX-IN-2
CAS:12R-LOX-IN-2 is a 12R-LOX inhibitor that inhibits the hyperproliferation of psoriatic cells and can be used in the study of psoriasis and other skin diseases.Formula:C19H13NOPurity:99.92%Color and Shape:SolidMolecular weight:271.31CDK2/PIM1-IN-1
CDK2/PIM1-IN-1 is an inhibitor of the kinases CDK2 (IC50: 0.27 μM) and PIM1 (IC50: 0.67 μM). It can induce apoptosis (cell death) and reduce the expression of TNF-α, which promotes tumors. CDK2/PIM1-IN-1 exhibits antitumor activity.Color and Shape:Odour Solid(+)-Glaucarubinone
(+)-Glaucarubinone is a natural product that can be used as a reference standard.Formula:C25H34O10Color and Shape:SolidMolecular weight:494.537Rev 2'-O-MOE-C(Bz)-5'-amidite
'Rev 2’-O-MOE-C(Bz)-5’-amidite, a purine nucleoside analog, exhibits broad antitumor activity against indolent lymphoid malignancies.Formula:C49H58N5O10PColor and Shape:SolidMolecular weight:907.992'-Deoxy-2'-fluoro-l-uridine
CAS:2'-Deoxy-2'-fluoro-1-uridine: an L-nucleoside, inhibits RNA viruses by blocking viral RNA polymerase.Formula:C9H11FN2O5Color and Shape:SolidMolecular weight:246.193'-β-C-ethynyl-N6-iso-pentenyl adenosine
3’-Beta-C-ethynyl-N6-iso-pentenyl adenosine is an adenosine analog.Formula:C17H21N5O4Color and Shape:SolidMolecular weight:359.387-TFA-ap-7-Deaza-ddG
CAS:Compound 19d, a nucleotide derivative, is used to make thiotriphosphate dye terminators for DNA sequencing.Formula:C16H16F3N5O4Color and Shape:SolidMolecular weight:399.33N4-Benzoyl-2'-deoxy-2'-fluoro-β-D-arabinocytidine
N4-Benzoyl-2’-deoxy-2’-fluoro-β-D-arabinocytidine, a purine nucleoside analog, exhibits widespread antitumor activity, particularly against indolent lymphoidFormula:C16H16FN3O5Color and Shape:SolidMolecular weight:349.31MM41
CAS:MM41 is a human telomeric and gene promoter DNA quadruplex stabilizer with an IC50 of <10 nM against the MIA PaCa-2 pancreatic cancer cell line.Formula:C44H66N10O6Purity:99.25%Color and Shape:SolidMolecular weight:831.06Ref: TM-T60028
1mg50.00€5mg110.00€1mL*10mM (DMSO)152.00€10mg170.00€25mg278.00€50mg371.00€100mg494.00€200mg675.00€PF07104091
CAS:PF07104091 inhibits CDK2, which may lead to cell cycle arrest, induce apoptosis and inhibit tumor cell proliferation. Cost-effective and quality-assured.Formula:C19H28N6O4Purity:99.49% - 99.59%Color and Shape:SolidMolecular weight:404.46Ref: TM-T9712
1mg334.00€2mg492.00€5mg780.00€1mL*10mM (DMSO)867.00€10mg1,144.00€25mg1,701.00€50mg2,295.00€100mg3,087.00€GS-443902
CAS:Remdesivir triphosphate (GS-443902) inhibits RSV/HCV RdRp with IC50s: 1.1/5 µM.Formula:C12H16N5O13P3Purity:98%Color and Shape:SolidMolecular weight:531.2DENV-IN-2
CAS:DENV-IN-2 inhibits dengue virus replication (EC50: 0.016 nM), affects all serotypes (EC50: 0.013-0.029 nM). Derived from WO2018215315A1 6AB.Formula:C29H26ClF3N2O6Color and Shape:SolidMolecular weight:590.98CSI86
CSI86 is a PROTAC degrader targeting MYC, exhibiting antiproliferative activity (IC50: 13-18 μM).Formula:C48H50F9N7O7SColor and Shape:SolidMolecular weight:1040CHK1-IN-12
CHK1-IN-12 (Compound example 1-5) is a highly selective and orally active checkpoint kinase 1 (CHK1) inhibitor, demonstrating an in vitro enzyme IC50 of ≤10 nM and a cellular IC50 of ≤50 nM. This compound suppresses the phosphorylation activity of CHK1 kinase, disrupts DNA damage response pathways, and induces tumor cell cycle arrest and apoptosis. CHK1-IN-12 shows promise for cancer research applications.Formula:C19H19N7O2Color and Shape:SolidMolecular weight:377.16002Olsutamig
CAS:Olsutamig is a bivalent humanized IgG4κ monoclonal antibody inhibitor targeting FOLH1/PSMA and CD3E. It is capable of binding simultaneously to PSMA on tumor cell surfaces and CD3E on T cell surfaces, leading to significant activation of T cells and the specific destruction of prostate cancer cells.Color and Shape:LiquidPROTAC CDK9 degrader-11
CAS:PROTAC CDK9 degrader-11 (Compound C3) is an orally active PROTAC CDK9 degrader with a DC50 of 1.09 nM. This compound exhibits cytotoxicity in small cell lung cancer (SCLC) cells, with IC50 values in the nanomolar range. It induces cell cycle arrest at the G0/G1 phase and inhibits cell invasion in DMS114 and DMS53 cells. In addition, PROTAC CDK9 degrader-11 shows antitumor activity in an NCI-H446 xenograft mouse model. (Pink: ligand for target protein CDK9 ligand 3; Black: linker; Blue: ligand for E3 ligase Cereblon E3 ligase Ligand 56)Formula:C39H48Cl2N10O5Color and Shape:SolidMolecular weight:807.768m7GpppCpG
CAS:m7GpppCpG, a trinucleotide cap analogue, is used for synthesizing RNA with cap 0 or cap 1 structures.Formula:C30H41N13O25P4Color and Shape:SolidMolecular weight:1107.61N1-Methyl-2'-deoxy-2'-fluoroarabinoguanosine
Nucleoside Derivatives - Fluoro-modified nucleosides; N-Methylated alkylated nucleosidesColor and Shape:SoildRef: TM-TNU0546
5mgTo inquire10mgTo inquire25mgTo inquire50mgTo inquire100mgTo inquire500mgTo inquirems2i6A
CAS:ms2i6A is a mitochondrial tRNA-specific modification, which regulates efficient mitochondrial translation and energy metabolism in mammals.Formula:C16H23N5O4SColor and Shape:SolidMolecular weight:381.452',3',5'-Tri-O-benzoyl-5-iodouridine
CAS:Nucleoside Derivatives - Halo-Nucleosides, 5-Modified pyrimidine nucleosidesFormula:C30H23IN2O9Color and Shape:SolidMolecular weight:682.42Ref: TM-TNU0905
5mgTo inquire10mgTo inquire25mgTo inquire50mgTo inquire100mgTo inquire500mgTo inquire2,6-Bis(4-morpholinyl)-9-b-D-ribofuranosyl-9H-purine
Nucleoside Derivatives –6-Subtituted nucleosides；2-Substituted nucleosidesColor and Shape:SoildRef: TM-TNU1411
5mgTo inquire10mgTo inquire25mgTo inquire50mgTo inquire100mgTo inquire500mgTo inquire5-Iodo-2'-O-methylcytidine
CAS:5-Iodo-2'-O-methylcytidine is a Halo-nucleoside; 2'-O-Methyl nucleoside.Formula:C10H14IN3O5Color and Shape:SolidMolecular weight:383.14Ref: TM-TNU0018
5mgTo inquire10mgTo inquire25mgTo inquire50mgTo inquire100mgTo inquire500mgTo inquire2-Amino-6-methythio-9-(β-D-ribofuranosyl)-9H-purine
CAS:2-Amino-6-methythio-9-(beta-D-ribofuranosyl)-9H-purine is a Nucleoside Derivative - 6-Modified purine nucleoside; Thio-nucleoside.Formula:C11H15N5O4SColor and Shape:SolidMolecular weight:313.33Ref: TM-TNU0491
5mgTo inquire10mgTo inquire25mgTo inquire50mgTo inquire100mgTo inquire500mgTo inquire5-Phenylcytidine
CAS:5-Phenylcytidine is a Nucleoside Derivative - 5-Modified pyrimidine nucleoside.Formula:C15H17N3O5Color and Shape:SolidMolecular weight:319.31Ref: TM-TNU0150
5mgTo inquire10mgTo inquire25mgTo inquire50mgTo inquire100mgTo inquire500mgTo inquire2-Chloro-6-methoxypurine -9-β-D-(2'-deoxy-2'-fluoro)-arabinoriboside
CAS:Fluoro-modified nucleoside; Halo-nucleoside; 2/6/8-Modified purine nucleoside; Arabino-nucleoside;Formula:C11H12ClFN4O4Color and Shape:SolidMolecular weight:318.69Ref: TM-TNU0104
5mgTo inquire10mgTo inquire25mgTo inquire50mgTo inquire100mgTo inquire500mgTo inquire8-Benzyloxy-2'-deoxyguanosine
CAS:8-Benzyloxy-2'-deoxyguanosine is a Nucleoside Derivative - 8-Modified purine nucleoside.Formula:C17H19N5O5Color and Shape:SolidMolecular weight:373.36Ref: TM-TNU0931
5mgTo inquire10mgTo inquire25mgTo inquire50mgTo inquire100mgTo inquire500mgTo inquire9-(3-Deoxy-3-fluoro-β-D-ribofuranosyl)-6-[5-(propyn-1-yl)pyridin-3-yl]purine
CAS:9-(3-Deoxy-3-fluoro-β-D-ribofuranosyl)-6-[5-(propyn-1-yl)pyridin-3-yl]purine is a Nucleoside Derivative - Fluoro-modified nucleoside, 6-Modified purineFormula:C18H16FN5O3Color and Shape:SolidMolecular weight:369.35Ref: TM-TNU0735
5mgTo inquire10mgTo inquire25mgTo inquire50mgTo inquire100mgTo inquire500mgTo inquire5-Methyl-2-thio-xylo-uridine
CAS:Nucleoside Derivatives - Xylo-nucleosides; Thio-nucleosidesFormula:C10H14N2O5SColor and Shape:SolidMolecular weight:274.29Ref: TM-TNU0433
5mgTo inquire10mgTo inquire25mgTo inquire50mgTo inquire100mgTo inquire500mgTo inquire2'-Deoxy-N4,N4-dimethylcytidine
CAS:2'-Deoxy-N4,N4-dimethylcytidine is a Nucleoside Derivative - N-Methylated nucleoside.Formula:C11H17N3O4Color and Shape:SolidMolecular weight:255.27Ref: TM-TNU1206
5mgTo inquire10mgTo inquire25mgTo inquire50mgTo inquire100mgTo inquire500mgTo inquire2-Chloro-2'-C-methyl-6-N,N-dimethyladenosine
CAS:2’-C-Methyl nucleoside; Halo-nucleoside; 2/6/8-Modified purine nucleosideFormula:C13H18ClN5O4Color and Shape:SolidMolecular weight:343.77Ref: TM-TNU0111
5mgTo inquire10mgTo inquire25mgTo inquire50mgTo inquire100mgTo inquire500mgTo inquire5'-O-DMT-dT
CAS:5'-O-DMT-dT (5'-O-(4,4'-Dimethoxytrityl)thymidine) is a nucleoside derivative that finds utility in oligonucleotide synthesis.Formula:C31H32N2O7Color and Shape:White PowderMolecular weight:544.595'-O-Acetyl-2',3'-dideoxy-2',3'-didehydro-uridine
CAS:Nucleoside Derivatives - Didehydro-nucleosidesFormula:C11H12N2O5Color and Shape:SolidMolecular weight:252.22Ref: TM-TNU0993
5mgTo inquire10mgTo inquire25mgTo inquire50mgTo inquire100mgTo inquire500mgTo inquire5'-O-(4,4'-Dimethoxytrityl)-5-methoxyuridine
CAS:Nucleoside Derivatives - 5-Modified pyrimidine nucleosideFormula:C31H32N2O9Color and Shape:SolidMolecular weight:576.59Ref: TM-TNU0852
5mgTo inquire10mgTo inquire25mgTo inquire50mgTo inquire100mgTo inquire500mgTo inquire8-Chloro-2'-β-C-methyl inosine
CAS:Nucleoside Derivatives - 2’-Modified nucleosides; 8-Modified purine nucleosides; Halo-nucleosidesFormula:C11H13ClN4O5Color and Shape:SolidMolecular weight:316.7Ref: TM-TNU0553
5mgTo inquire10mgTo inquire25mgTo inquire50mgTo inquire100mgTo inquire500mgTo inquire7-Cyclopropylmethyl-7,8-dihydro-8-oxo-9-(b-D-xylofuranosyl) guanine
CAS:Nucleoside Derivatives - Xylo-nucleosides; 8-Modified purine nucleosides; N-Methylated alkylated nucleosidesFormula:C14H19N5O6Color and Shape:SolidMolecular weight:353.33Ref: TM-TNU0388
5mgTo inquire10mgTo inquire25mgTo inquire50mgTo inquire100mgTo inquire500mgTo inquire2-Amino-2'-deoxyadenosine
CAS:2-Amino-2'-deoxyadenosine is a deoxyribonucleoside used for the oligonucleotide synthesis.Formula:C10H14N6O3Color and Shape:SolidMolecular weight:266.265-Hydroxymethyl xylo-uridine
CAS:Nucleoside Derivatives - Xylo-nucleosides; 5-Modified pyrimidine nucleosidesFormula:C10H14N2O7Color and Shape:SolidMolecular weight:274.23Ref: TM-TNU0484
5mgTo inquire10mgTo inquire25mgTo inquire50mgTo inquire100mgTo inquire500mgTo inquire5-(2-Hyroxyethyl)-2'-deoxyuridine
CAS:5-(2-Hyroxyethyl)-2'-deoxyuridine is a Nucleoside Derivative - 5-Modified pyrimidine nucleoside.Formula:C11H16N2O6Color and Shape:SolidMolecular weight:272.25Ref: TM-TNU1280
5mgTo inquire10mgTo inquire25mgTo inquire50mgTo inquire100mgTo inquire500mgTo inquire5'-DMT-3'-TBDMS-Bz-rA
CAS:5'-DMT-3'-TBDMS-Bz-rA is a nucleoside with protective and modification effects.Formula:C44H49N5O7SiColor and Shape:SolidMolecular weight:787.975-O-benzoyl-1,2-O-isopropylidene-α-D-erythro-pent-3-ulofuranose
CAS:5-O-benzoyl-1,2-O-isopropylidene-alpha-D-erythro-pent-3-ulofuranose is a Carbohydrate; Used for modified nucleoside.Formula:C15H16O6Color and Shape:SolidMolecular weight:292.28Ref: TM-TNU0608
5mgTo inquire10mgTo inquire25mgTo inquire50mgTo inquire100mgTo inquire500mgTo inquireN1-Propargylpseudouridine
CAS:N1-Propargylpseudouridine is a Nucleoside Derivative - C-nucleoside; N-Alkylated nucleoside.Formula:C12H14N2O6Color and Shape:SolidMolecular weight:282.25Ref: TM-TNU0079
5mgTo inquire10mgTo inquire25mgTo inquire50mgTo inquire100mgTo inquire500mgTo inquire3'-O-(2-Azidoethyl)adenosine
Nucleoside Derivatives - 3’-Modified nucleosides; Azido-nucleosidesColor and Shape:SoildRef: TM-TNU0177
5mgTo inquire10mgTo inquire25mgTo inquire50mgTo inquire100mgTo inquire500mgTo inquire2'-Deoxy-2'-fluoroarabino inosine
CAS:2'-Deoxy-2'-fluoroarabino inosine is a Nucleoside Derivative - 2'-Modified nucleoside, Fluoro-modified nucleoside.Formula:C10H11FN4O4Color and Shape:SolidMolecular weight:270.22Ref: TM-TNU1502
5mgTo inquire10mgTo inquire25mgTo inquire50mgTo inquire100mgTo inquire500mgTo inquireMethotrexate Diglutamate
CAS:Methotrexate Diglutamate Small molecule compound present in the liver that acts as a partially purified human dihydrofolate reductase inhibitor.Formula:C25H29N9O8Purity:98.51%Color and Shape:SolidMolecular weight:583.552-Chloro-9-[(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)]-9H-purine
CAS:2-Chloro-9-[(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)]-9H-purine is a Nucleoside Derivative - Halo-nucleoside, 6-Deaminopurine nucleoside.Formula:C16H17ClN4O7Color and Shape:SolidMolecular weight:412.78Ref: TM-TNU1210
5mgTo inquire10mgTo inquire25mgTo inquire50mgTo inquire100mgTo inquire500mgTo inquire
![9-(3-Deoxy-3-fluoro-β-D-ribofuranosyl)-6-[5-(propyn-1-yl)pyridin-3-yl]purine](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTM%2Fthumb-webp%2FTNU0735.webp&w=3840&q=75)
![2-Chloro-9-[(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)]-9H-purine](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTM%2Fthumb-webp%2FTNU1210.webp&w=3840&q=75)