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Cell Cycle/Checkpoint

Cell Cycle/Checkpoint

Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.

Subcategories of "Cell Cycle/Checkpoint"

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Found 3675 products of "Cell Cycle/Checkpoint"

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  • LNA-UTP
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    LNA-UTP

    CAS:
    LNA-UTP is a nucleotide analogue used in the synthesis of oligonucleotides.
    Formula:C10H15N2O15P3
    Color and Shape:Solid
    Molecular weight:496.15

    Ref: TM-TSW-00943

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    2'-F-AMP

    CAS:
    <p>2'-F-AMP is a nucleotide analogue used in the synthesis of oligonucleotides.</p>
    Formula:C10H13FN5O6P
    Molecular weight:349.21

    Ref: TM-TSW-00945

  • PLK1-IN-11
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    PLK1-IN-11

    CAS:
    <p>PLK1-IN-11 (Cluster 4, 16953209) is a PLK1 inhibitor with an IC50 of 1 μM. It is applicable in research on various cancers such as pancreatic, ovarian, breast, and non-small cell lung cancer.</p>
    Formula:C12H11N5O
    Color and Shape:Solid
    Molecular weight:241.249

    Ref: TM-T205548

  • Aurora B inhibitor 1
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    Aurora B inhibitor 1

    CAS:
    <p>Aurora B inhibitor 1 is an Aurora B (Aurora-1) inhibitor (Ki &lt;0.010 uM) with potential anticancer activity for cancer research.</p>
    Formula:C25H26ClF2N7O2
    Purity:98.37%
    Color and Shape:Solid
    Molecular weight:529.97

    Ref: TM-T12010

  • Haspin-IN-2
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    Haspin-IN-2

    CAS:
    <p>Haspin-IN-2 is a potent haspin inhibitor (IC50: 50 nM) and also inhibits CLK1 (IC50: 445 nM) and DYRK1A (IC50: 917 nM).</p>
    Formula:C12H8N4O3
    Color and Shape:Solid
    Molecular weight:256.22

    Ref: TM-T60394

  • 2′-O-MOE-AMP
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    2′-O-MOE-AMP

    CAS:
    2′-O-MOE-AMP is a nucleotide analogue used in the synthesis of oligonucleotides.
    Formula:C13H20N5O8P
    Color and Shape:Solid
    Molecular weight:405.30

    Ref: TM-TSW-00946

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    2'-F-UMP

    CAS:
    <p>2'-F-UMP is a nucleotide analogue used in the synthesis of oligonucleotides.</p>
    Formula:C9H12FN2O8P
    Molecular weight:326.17

    Ref: TM-TSW-00948

  • DS96432529
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    DS96432529

    <p>DS96432529 is a potent and orally active bone anabolic agent through CDK8 inhibition.</p>
    Formula:C18H26N4O3S
    Color and Shape:Soild
    Molecular weight:378.49

    Ref: TM-T61590

  • BBI-355
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    BBI-355

    CAS:
    BBI-355 is an oral, potent, and selective small molecule CHK1 inhibitor with an IC50 of 0.3 nM. It exhibits significant antitumor activity, both as a monotherapy and in combination with targeted therapies, across various ecDNA+ oncogene-amplified tumor models.
    Formula:C19H19N7O2
    Color and Shape:Solid
    Molecular weight:377.40

    Ref: TM-T207786

  • KI-CDK9d-32
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    KI-CDK9d-32

    CAS:
    <p>KI-CDK9d-32 is a CDK9 PROTAC degrader with a DC50 of 0.89 nM. It facilitates the ubiquitination and degradation of CDK9, inhibits the MYC pathway, and disrupts nucleolar homeostasis. KI-CDK9d-32 demonstrates anticancer activity.</p>
    Formula:C39H45N9O4
    Color and Shape:Solid
    Molecular weight:703.83

    Ref: TM-T207184

  • MKLP2-IN-1
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    MKLP2-IN-1

    CAS:
    <p>MKLP2-IN-1 (compound 12a) is an inhibitor of MKLP2 that demonstrates excellent oral bioactivity. In vitro, MKLP2-IN-1 inhibits the ATPase activity stimulated by recombinant MKLP2 microtubules and, in a mouse Calu-6 lung cancer model, it effectively suppresses tumor growth.</p>
    Formula:C23H19BrFN3O2
    Color and Shape:Solid
    Molecular weight:468.318

    Ref: TM-T205538

  • Valopicitabine dihydrochloride
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    Valopicitabine dihydrochloride

    CAS:
    Valopicitabine, a NS5B inhibitor, is used potentially for the treatment of HCV infection.
    Formula:C15H25ClN4O6
    Color and Shape:Solid
    Molecular weight:392.84

    Ref: TM-T29094

  • CDK8-IN-14
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    CDK8-IN-14

    CAS:
    <p>CDK8-IN-14 (compound 12) effectively inhibits CDK8, demonstrating an IC50 of 39.2 nM, and exhibits potent anti-AML cell proliferation effects, with a GC50 value of 0.02±0.01μM in MOLM-13 cells and 0.03±0.01μM in MV4-11 cells [1].</p>
    Formula:C18H13N3O2
    Color and Shape:Solid
    Molecular weight:303.31

    Ref: TM-T86031

  • NRTT-IN-1
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    NRTT-IN-1

    CAS:
    <p>NRTT-IN-1 (Compound 1) is an inhibitor of the nucleoside reverse transcriptase translocation (NRTT), effectively blocking HIV DNA synthesis and viral replication.</p>
    Formula:C28H24FN5O5
    Color and Shape:Solid
    Molecular weight:529.519

    Ref: TM-T205482

  • CDK12/13 ligand 1
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    CDK12/13 ligand 1

    CAS:
    ALK-IN-29 (compound 4c) exhibits notable inhibitory activity against tyrosine kinases such as ALK, CDK2/CyclinE1, and FAK, with the strongest inhibition observed against ALK kinase, showing a 40.63% inhibition rate at a concentration of 10 μM. ALK-IN-29 is useful for cancer research.
    Formula:C26H26BrN5O
    Color and Shape:Solid
    Molecular weight:504.42

    Ref: TM-T201159

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    Anticancer agent 30

    <p>Anticancer agent 30 (6f-Z), a 3-arylidene-2-oxindole, selectively inhibits CDK2, showing potent anticancer potential.</p>
    Formula:C22H15ClFNO
    Color and Shape:Solid
    Molecular weight:363.81

    Ref: TM-T61379

  • Polθ-IN-6
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    Polθ-IN-6

    CAS:
    Polθ-IN-6 (Compound 89) is an inhibitor of DNA polymerase theta (Polθ) and exhibits antitumor activity.
    Formula:C25H23N3O3S
    Color and Shape:Solid
    Molecular weight:445.53

    Ref: TM-T200918

  • DHX9-IN-9
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    DHX9-IN-9

    CAS:
    <p>DHX9-IN-9 (509) acts as an inhibitor of the RNA helicase DHX9, demonstrating an EC50 of 0.0177 μM in DHX9 cellular target engagement, primarily utilized in cancer research [1].</p>
    Formula:C21H21ClFN5O3S2
    Color and Shape:Solid
    Molecular weight:510

    Ref: TM-T86205

  • GHP-88309
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    GHP-88309

    CAS:
    <p>GHP-88309 is an orally active, broad-spectrum anti-paramyxovirus agent that targets viral polymerase, interrupting viral RNA synthesis. It effectively inhibits respiratory syncytial virus (RSV), measles virus (MeV), and canine distemper virus (CDV) with an EC50 of 0.06-1.2 μM. In mouse models, GHP-88309 demonstrates significant anti-infective activity.</p>
    Formula:C16H11FN2O
    Color and Shape:Solid
    Molecular weight:266.27

    Ref: TM-T204819

  • WRN inhibitor 12
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    WRN inhibitor 12

    CAS:
    WRN inhibitor 12 (compound 5) serves as an inhibitor for the WRN helicase.
    Formula:C33H33ClF3N9O5
    Color and Shape:Solid
    Molecular weight:728.12

    Ref: TM-T201316

  • Lobucavir
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    Lobucavir

    CAS:
    <p>Lobucavir (BMS-180194; SQ 34514) is a nucleoside analogue and an antiviral agent with broad-spectrum activity against various viruses, including HBV, HIV/AIDS, and α, β, and γ herpesviruses (including CMV, herpes simplex virus, varicella-zoster virus, and Epstein-Barr virus).</p>
    Formula:C11H15N5O3
    Color and Shape:Solid
    Molecular weight:265.27

    Ref: TM-T200820

  • Valopicitabine
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    Valopicitabine

    CAS:
    <p>Valopicitabine is an effective prodrug of the effective anti-HCV drug 2'-C-methylcytidine and can be used as a promising antiviral drug for the study of chronic</p>
    Formula:C15H24N4O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:356.37

    Ref: TM-T13281

  • DNA Gyrase-IN-13
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    DNA Gyrase-IN-13

    CAS:
    <p>DNA Gyrase-IN-13 (compound 1b) is an inhibitor of DNA gyrase with bacteriostatic properties. It exhibits an IC50 of 1.81 μM against Staphylococcus aureus DNA gyrase.</p>
    Formula:C15H21N3O3S
    Color and Shape:Solid
    Molecular weight:323.41

    Ref: TM-T201341

  • Dyrk1A-IN-12
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    Dyrk1A-IN-12

    CAS:
    <p>Dyrk1A-IN-12 (compound S43) is an inhibitor of dual specificity tyrosine phosphorylation regulated kinase 1A (Dyrk1A). It has an IC50 of 95 nM for inhibiting Dyrk1A. The compound demonstrates antiviral activity against EV-A71 (Enterovirus A71) with an EC50 of 4.4 μM, a CC50 of 12.8 μM, and a selectivity index (SI) of 2.9. Additionally, Dyrk1A-IN-12 exhibits potent inhibitory effects on the herpes simplex virus (HSV).</p>
    Formula:C22H16FN3O2S
    Color and Shape:Solid
    Molecular weight:405.445

    Ref: TM-T205530

  • CDK4/9-IN-1
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    CDK4/9-IN-1

    CAS:
    <p>CDK4/9-IN-1 (Compound 29) is a selective dual inhibitor of CDK4 and CDK9, exhibiting IC50 values of 23 nM and 12 nM, respectively. It holds potential for use in cancer research.</p>
    Formula:C22H34N6O2
    Color and Shape:Solid
    Molecular weight:414.544

    Ref: TM-T205312

  • Uridine 3',5'-diphosphate
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    Uridine 3',5'-diphosphate

    CAS:
    <p>Uridine 3′,5′-diphosphate (3′,5′-UDP; Compound pUp) serves as a competitive RNase inhibitor [1].</p>
    Formula:C9H14N2O12P2
    Color and Shape:Solid
    Molecular weight:404.16

    Ref: TM-T87599

  • CDK2-IN-18
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    CDK2-IN-18

    CAS:
    <p>CDK2-IN-18 (compound 8q) serves as a powerful inhibitor of CDK 2/E and CDK 4/D1, showing IC50 values of 8 nM and 46 nM, respectively. It effectively inhibits tumor cell proliferation [1].</p>
    Formula:C21H23N7O2S
    Color and Shape:Solid
    Molecular weight:437.52

    Ref: TM-T86027

  • Ladirubicin
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    Ladirubicin

    CAS:
    Ladirubicin, as an anthracyclines analog is the leading compound of alkylcyclines.
    Formula:C29H31NO11S
    Color and Shape:Solid
    Molecular weight:601.62

    Ref: TM-T32534

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    14α-Demethylase/DNA Gyrase-IN-1

    14α-Demethylase/DNA Gyrase-IN-1 (Compound 7c) is a potent inhibitor of 14α-Demethylase/DNA Gyrase with antibacterial activity.
    Formula:C26H22N4O4
    Color and Shape:Solid
    Molecular weight:454.48

    Ref: TM-T62792

  • WRN inhibitor 11
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    WRN inhibitor 11

    CAS:
    WRN inhibitor 11 (Example 17) is an orally effective inhibitor of WRN helicase, with an IC50 of 63 nM.
    Formula:C34H35ClF3N9O5
    Color and Shape:Solid
    Molecular weight:742.15

    Ref: TM-T201262

  • APE1-IN-3
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    APE1-IN-3

    CAS:
    <p>APE1-IN-3 (Compound 1), an APE1 inhibitor, is utilized in cancer research.</p>
    Formula:C17H16O4
    Color and Shape:Solid
    Molecular weight:284.31

    Ref: TM-T89919

  • Kolavenic acid analog
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    Kolavenic acid analog

    CAS:
    KAA, an anticancer compound, inhibits centrosome clustering and targets HSET+ yeast and cancer cells.
    Formula:C25H38O4
    Color and Shape:Solid
    Molecular weight:402.57

    Ref: TM-T61970

  • CDK2 degrader 4
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    CDK2 degrader 4

    CAS:
    <p>CDK2 degrader4 (compound 104) is a potent degrader of CDK2, showing promise for cancer research applications.</p>
    Formula:C23H26ClN3O5
    Color and Shape:Solid
    Molecular weight:459.923

    Ref: TM-T204856

  • LZ9
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    LZ9

    CAS:
    <p>LZ9 is an ATP-competitive inhibitor of CDK1 and CDK2, with potential applications in colorectal cancer (CRC) research.</p>
    Formula:C17H11F3N4O2
    Color and Shape:Solid
    Molecular weight:360.29

    Ref: TM-T204957

  • WEE1-IN-11
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    WEE1-IN-11

    CAS:
    WEE1-IN-11 (Compound 13) serves as a potent CDK2 inhibitor with an IC50 of 2.0 nM. It exhibits inhibitory effects on several cell lines, including NCI-H446, A427, OVCAR3, C33A, and WiDr, with respective IC50 values of 93.9, 34.5, 86.7, 23.1, and 85 nM.
    Formula:C26H29FN8OS2
    Color and Shape:Solid
    Molecular weight:552.69

    Ref: TM-T200924

  • CDK2-IN-31
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    CDK2-IN-31

    CAS:
    CDK2-IN-31 (compound I-125A) is an inhibitor of CDK2 and is utilized in cancer research.
    Formula:C37H52N6O5
    Color and Shape:Solid
    Molecular weight:660.85

    Ref: TM-T201156

  • DNA ligase-IN-2
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    DNA ligase-IN-2

    CAS:
    <p>DNA ligase-IN-2 (compound 2) acts as a potent LigA inhibitor, effectively hindering the DNA-independent spontaneous adenylation activity of full-length LigA and the truncated enzyme LigA:AD with an IC50 of 29 nM. It also significantly suppresses the in vitro growth of Staphylococcus aureus, showing MIC values of 1 μg/mL for S. aureus ATCC 29213 and S. aureus ATCC 700699, while the MIC for Escherichia coli (E. coli) ATCC 25922 is &gt;64 μg/mL.</p>
    Formula:C13H8FN3O3
    Color and Shape:Solid
    Molecular weight:273.219

    Ref: TM-T204415

  • PKMYT1-IN-2
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    PKMYT1-IN-2

    CAS:
    <p>PKMYT1-IN-2 (compound 2) serves as a powerful inhibitor of PKMYT1, exhibiting an IC 50 of 5.7 nM. Additionally, it effectively suppresses the proliferation of HCC1569 cells with an IC 50 of 22 nM [1].</p>
    Formula:C22H19N5O2
    Color and Shape:Solid
    Molecular weight:385.42

    Ref: TM-T87219

  • BWC0977
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    BWC0977

    CAS:
    BWC0977 is an effective topoisomerase inhibitor that disrupts bacterial DNA replication by targeting both DNA gyrase and topoisomerase IV. The minimum inhibitory concentration (MIC90) of BWC0977 against MDR (multi-drug resistant) Gram-negative bacteria ranges from 0.03 to 2 µg/mL.
    Formula:C22H21FN6O5
    Color and Shape:Solid
    Molecular weight:468.44

    Ref: TM-T201074

  • SGC-CLK-1
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    SGC-CLK-1

    CAS:
    SGC-CLK-1 is a potent and selective inhibitor of Cdc2-like kinases CLK1, CLK2, and CLK4. It effectively inhibits the growth of melanoma and glioblastoma cells.
    Formula:C19H15F3N6O2
    Color and Shape:Solid
    Molecular weight:416.36

    Ref: TM-T201181

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    Haspin-IN-1

    Haspin-IN-1 blocks haspin (IC50: 119 nM) and inhibits CLK1, DYRK1A, CDK9 with potential as an anticancer drug.
    Formula:C12H8N4O2S
    Color and Shape:Solid
    Molecular weight:272.28

    Ref: TM-T60477

  • Polθ-IN-5
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    Polθ-IN-5

    CAS:
    Polθ-IN-5 (Compound 139) is an inhibitor of DNA polymerase theta (Polθ) that exhibits antitumor activity.
    Formula:C23H18ClF2N7O3S
    Color and Shape:Solid
    Molecular weight:545.95

    Ref: TM-T200913

  • DB18
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    DB18

    CAS:
    DB18 serves as a potent, selective inhibitor of CDC2-like kinases (CLKs), exhibiting IC50 values between 10-30 nM for CLK1, CLK2, and CLK4. Additionally, it possesses anti-tumor activity [1].
    Formula:C24H18ClN7O3
    Color and Shape:Solid
    Molecular weight:487.9

    Ref: TM-T86165

  • WRN inhibitor 7
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    WRN inhibitor 7

    CAS:
    <p>WRN inhibitor 7 (Compound h6), a potent inhibitor of Werner syndrome helicase, demonstrates effective suppression of WRN's helicase and ATPase activities with IC50 values of 9.8 μM and 15.8 μM, respectively. This compound is utilized in the study of microsatellite instable (MSI) cancers [1].</p>
    Formula:C27H23N3O6
    Color and Shape:Solid
    Molecular weight:485.49

    Ref: TM-T87635

  • SF0166
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    SF0166

    CAS:
    SF0166: potent αvβ3 antagonist, IC50: 0.6 nM. Blocks cell adhesion, IC50: 7.6 pM-76 nM. Reduces neovascularization in mice.
    Formula:C23H27F2N5O4
    Color and Shape:Solid
    Molecular weight:475.49

    Ref: TM-T70368

  • TY-011
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    TY-011

    CAS:
    <p>TY-011 is an inhibitor of Aurora A/B kinases. This compound induces DNA damage and cell apoptosis (Apoptosis) in human gastric cancer cells by promoting abnormal microtubule-kinetochore attachments, effectively suppressing cancer cell proliferation. The IC50 values for TY-011 in human gastric cancer cell lines range from 0.11-4.49 μM. It is utilized in research focused on gastric cancer.</p>
    Formula:C18H16ClN5
    Color and Shape:Solid
    Molecular weight:337.81

    Ref: TM-T89833

  • CDK2 degrader 6
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    CDK2 degrader 6

    CAS:
    CDK2 degrader6 (compound 6) is an orally active CDK2 degrader with a DC50 of 46.5 nM, and is applicable in breast cancer research.
    Formula:C23H22F5N5O3
    Color and Shape:Solid
    Molecular weight:511.44

    Ref: TM-T207287

  • INX-315
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    INX-315

    CAS:
    INX-315 is an orally active, selective CDK2 inhibitor that induces cell cycle arrest and senescence in solid tumours, suppresses E2F target gene expression.
    Formula:C19H21N7O3S
    Purity:99.88%
    Color and Shape:Solid
    Molecular weight:427.48

    Ref: TM-T86723

  • 2'-F-CDP
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    2'-F-CDP

    CAS:
    2'-F-CDP is a nucleotide analog that can be utilized in the synthesis of oligonucleotides.
    Formula:C9H14FN3O10P2
    Color and Shape:Solid
    Molecular weight:405.17

    Ref: TM-TSW-00957

  • Dmf-dg
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    Dmf-dg

    CAS:
    <p>Dmf-dg (2'-Deoxy-N2-dimethylaminomethylene-guanosine) is a nucleoside of deoxyguanosine (dG) with a dimethylaminomethylene (DMF) base protection, employed in the synthesis of oligonucleotides.</p>
    Formula:C13H18N6O4
    Color and Shape:Solid
    Molecular weight:322.32

    Ref: TM-TSW-00950