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Kinesin

Kinesin

Kinesin inhibitors target kinesin motor proteins, which are responsible for transporting cellular cargo along microtubules and play a key role in cell division, particularly during mitosis. Kinesins are involved in the movement of chromosomes and other organelles during cell division. Inhibiting kinesins can disrupt these processes, leading to cell cycle arrest and potential cell death, making these inhibitors valuable in cancer research. At CymitQuimica, we offer a diverse range of high-quality kinesin inhibitors to support your research in cell biology, mitosis, and cancer therapy.

Found 66 products of "Kinesin"

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  • BOS-172722

    CAS:
    <p>BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint(IC50 of 2 nM).</p>
    Formula:C24H30N8O
    Purity:99.37%
    Color and Shape:Solid
    Molecular weight:446.55
  • Mps1-IN-3

    CAS:
    <p>Mps1-IN-3 is an effective and selective inhibitor of MPS1 kinase (IC50: 50 nM).</p>
    Formula:C26H31N7O4S
    Purity:99.25%
    Color and Shape:Solid
    Molecular weight:537.63
  • Paprotrain

    CAS:
    <p>Paprotrain ((alphaZ)-alpha-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile) inhibits the ATPase activity of MKLP-2 with an IC50 of 1.35 μM and a Ki of 3.36 μM.</p>
    Formula:C16H11N3
    Purity:99.91%
    Color and Shape:Solid
    Molecular weight:245.28
  • (S)-Monastrol

    CAS:
    <p>Monastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5.</p>
    Formula:C14H16N2O3S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:292.35
  • Mps1-IN-6


    <p>Mps1-IN-6 is a potent Mps1 inhibitor that demonstrates antiproliferative and antitumor activities, exhibiting an IC50 of 2.596 nM [1].</p>
    Formula:C35H39N9O3
    Color and Shape:Solid
    Molecular weight:633.74
  • KIF18A-IN-16

    CAS:
    <p>KIF18A-IN-16 (Compound 15) is a polycyclic KIF18A inhibitor. It is applicable in research related to tumors, including colon cancer, breast cancer, and lung cancer.</p>
    Formula:C30H37N5O4S
    Color and Shape:Solid
    Molecular weight:563.71
  • 11H-Benzo[a]carbazole

    CAS:
    <p>11H-Benzo[a]carbazole is a kinesin-like protein KIF11 inhibitor that can inhibit the viability of HeLa cells.</p>
    Formula:C16H11N
    Purity:99.14%
    Color and Shape:Solid
    Molecular weight:217.27
  • KIF2C-IN-1


    <p>KIF2C-IN-1 (Compound 7S9) is a selective and potent small molecule inhibitor of KIF2C. It stabilizes the interaction between KIF2C and microtubule proteins, preventing the depolymerization of polyglutamylated microtubules. KIF2C-IN-1 enhances the cytotoxicity of Paclitaxel in Paclitaxel-resistant triple-negative breast cancer (TNBC) cells and, when combined with Paclitaxel, significantly reduces tumor growth in mouse models.</p>
    Formula:C36H39ClN4O9S
    Color and Shape:Solid
    Molecular weight:738.21263
  • Solidagonic acid

    CAS:
    <p>Solidagonic acid inhibits HSET, prevents fission yeast cell death, and hinders L. sativa and L. multiflorum seedling growth.</p>
    Formula:C22H34O4
    Color and Shape:Solid
    Molecular weight:362.5
  • KIF18A-IN-14

    CAS:
    <p>KIF18A-IN-14 (Compound Example 81) is an inhibitor of KIF18A that exists in two forms, EX81-A and its enantiomer EX81-B. EX81-A and EX81-B inhibit the viability of OVCAR-3 cells with IC50 values of 0-0.01 μM and 0.01-0.1 μM, respectively. KIF18A-IN-14 can be utilized in tumor research, including studies on colon cancer, breast cancer, and lung cancer.</p>
    Formula:C26H32F3N5O6S
    Color and Shape:Solid
    Molecular weight:599.62
  • Filanesib TFA

    CAS:
    <p>Filanesib (ARRY-520) inhibits KSP, triggering mitotic arrest and cell death in dividing tumor cells.</p>
    Formula:C22H23F5N4O4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:534.5
  • Eg5-IN-1


    <p>Eg5-IN-1 is a potent inhibitor of the kinesin family of motor proteins (Eg5) with an IC50 value of 1.97 µM for Eg5.Eg5-IN-1 can be used in cancer research.</p>
    Formula:C23H16ClFN4O
    Purity:98.21%
    Color and Shape:Solid
    Molecular weight:418.85
  • KIF18A-IN-15

    CAS:
    <p>KIF18A-IN-15 (Compound Example 36) is a KIF18A inhibitor, available in two forms, EX36-A and its enantiomer EX36-B, both with an IC50 range of 0.01-0.1 μM. These compounds inhibit the viability of OVCAR-3 cells, with IC50 values of 0.01-0.1 μM for EX36-A and 0-0.01 μM for EX36-B. KIF18A-IN-15 is applicable in research on tumors, including colon, breast, and lung cancers.</p>
    Formula:C25H33F3N6O5S
    Color and Shape:Solid
    Molecular weight:586.63
  • AZ82

    CAS:
    <p>AZ82 is an inhibitor of the kinesin-like protein KIFC1, which induces multipolar mitosis and apoptosis in prostate cancer cells.</p>
    Formula:C28H31F3N4O3S
    Purity:99.31%
    Color and Shape:Solid
    Molecular weight:560.63
  • GW406108X

    CAS:
    <p>GW406108X is a Kif15 and ULK1 inhibitor; IC50: 0.82 µM (ATPase), pIC50: 6.37; blocks autophagy.</p>
    Formula:C20H11Cl2NO4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:400.21
  • Kinesore

    CAS:
    <p>Kinesore is a cell-permeable modulator that binds to the microtubule motor protein kinesin-1, thereby inhibiting the interaction between KLC2 and SKIP.</p>
    Formula:C20H16Br2N4O4
    Purity:97.24%
    Color and Shape:Solid
    Molecular weight:536.17
  • AZ3146

    CAS:
    <p>AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM.</p>
    Formula:C24H32N6O3
    Purity:97.84% - >99.99%
    Color and Shape:Solid
    Molecular weight:452.55
  • GW406108X(Z/E)

    CAS:
    <p>GW406108X(Z/E) is a mixture of different configurations of GW406108X, which is an inhibitor of Kinesin-12 and ULK1 .</p>
    Formula:C20H11Cl2NO4
    Purity:98.23%
    Color and Shape:Solid
    Molecular weight:400.21
  • Empesertib

    CAS:
    <p>Empesertib (BAY 1161909) is an orally bioavailable and selective inhibitor Mps1(IC50 &lt; 1 nM), with potential antineoplastic activity.</p>
    Formula:C29H26FN5O4S
    Purity:97.45% - 99.4%
    Color and Shape:Solid
    Molecular weight:559.61
  • BRD9876

    CAS:
    <p>BRD9876 is a selective inhibitor of MM1S growth.</p>
    Formula:C16H14N2
    Purity:97.81%
    Color and Shape:Solid
    Molecular weight:234.3
  • S-trityl-L-Cysteine

    CAS:
    <p>S-trityl-L-Cysteine is a potent inhibitor of human mitotic kinesin Eg5</p>
    Formula:C22H21NO2S
    Purity:97.02%
    Color and Shape:Almost White To Light Yellow Granular Powder
    Molecular weight:363.47
  • CW-069

    CAS:
    <p>CW-069 (IC50=75 μM), an allosteric selective inhibitor of microtubule motor protein HSET, exhibits remarkable specificity over KSP.</p>
    Formula:C23H21IN2O3
    Purity:97.52% - 99.52%
    Color and Shape:Solid
    Molecular weight:500.33
  • SB-743921 hydrochloride

    CAS:
    <p>SB-743921 hydrochloride (SB743921 HCl) is an effective inhibitor of kinesin spindle protein, KSP, (Ki =0.1 nM).</p>
    Formula:C31H34Cl2N2O3
    Purity:95.58% - 99.70%
    Color and Shape:Solid
    Molecular weight:553.52
  • Mps1-IN-3 hydrochloride


    <p>Mps1-IN-3 HCl: potent Mps1 inhibitor (IC50: 50 nM), hampers glioblastoma growth, enhances vincristine efficacy in vivo.</p>
    Formula:C26H32ClN7O4S
    Color and Shape:Solid
    Molecular weight:574.09
  • Mps1-IN-1 dihydrochloride

    CAS:
    <p>Mps1-IN-1 dihydrochloride, a potent ATP-competitive inhibitor of Mps1 kinase, exhibits an IC50 of 367 nM.</p>
    Formula:C28H35Cl2N5O4S
    Color and Shape:Solid
    Molecular weight:608.58
  • Ispinesib

    CAS:
    <p>Ispinesib (SB-715992), a selective, effectvie and reversible inhibitor of kinesin spindle protein (KSP), is derived from quinazolinone, with antineoplastic</p>
    Formula:C30H33ClN4O2
    Purity:98% - 99.09%
    Color and Shape:Solid
    Molecular weight:517.06
  • GSK-923295

    CAS:
    <p>GSK923295 is a selective allosteric inhibitor of CENP-E kinesin motor ATPase(Ki=3.2 nM).</p>
    Formula:C32H38ClN5O4
    Purity:96.22% - 98.02%
    Color and Shape:Solid
    Molecular weight:592.13
  • BTB-1

    CAS:
    <p>BTB-1 (NSC156750) is a novel small molecule inhibitor of the mitotic motor protein Kif18A.</p>
    Formula:C12H8ClNO4S
    Purity:99.71%
    Color and Shape:Solid
    Molecular weight:297.71
  • Sovilnesib

    CAS:
    <p>Sovilnesib is a kinesin-like protein KIF18A inhibitor. Sovilnesib can be used for the cancer research.</p>
    Formula:C26H34F2N6O4S
    Purity:99.57%
    Color and Shape:Solid
    Molecular weight:564.65
  • K858 (Racemic)

    CAS:
    <p>K858 Racemic (K858) is a selective mitotic kinesin Eg5 inhibitor which acts in an ATP-noncompetitive manner.</p>
    Formula:C13H15N3O2S
    Purity:>99.99%
    Color and Shape:Solid
    Molecular weight:277.34
  • Monastrol

    CAS:
    <p>Monastrol ((±)-Monastrol) is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5.</p>
    Formula:C14H16N2O3S
    Purity:98.02% - 98.59%
    Color and Shape:Solid
    Molecular weight:292.35
  • Dimethylenastron

    CAS:
    <p>Dimethylenastron, an Eg5 inhibitor, arrests cells with monopolar spindles to which all chromosomes attach in a syntelic manner.</p>
    Formula:C16H18N2O2S
    Purity:98.07%
    Color and Shape:Solid
    Molecular weight:302.39
  • ARQ 621

    CAS:
    <p>ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Phase 1.</p>
    Formula:C28H24Cl2FN5O2
    Purity:97.01% - 98.38%
    Color and Shape:Solid
    Molecular weight:552.43
  • Mps1-IN-2

    CAS:
    <p>Mps1-IN-2 is a potent, selective and ATP-competitive dual Mps1/Plk1 inhibitor.</p>
    Formula:C26H36N6O3
    Purity:96.24% - 99.75%
    Color and Shape:Solid
    Molecular weight:480.6
  • Mps1-IN-1

    CAS:
    <p>Mps1-IN-1 is a potent, selective and ATP-competitive inhibitor of Mps1 kinase (IC50 : 367 nM )</p>
    Formula:C28H33N5O4S
    Purity:98.33%
    Color and Shape:Solid
    Molecular weight:535.66
  • BAY1217389

    CAS:
    <p>BAY 1217389 is an effective and selective inhibitor of the monopolar spindle 1 (MPS1) kinase (IC50&lt;10 nM).</p>
    Formula:C27H24F5N5O3
    Purity:98.14% - 99.42%
    Color and Shape:Solid
    Molecular weight:561.5
  • SR31527

    CAS:
    <p>SR31527 chloride: potent KIFC1 inhibitor (IC50 6.6 µM), moderately impairs cell viability &amp; colony growth.</p>
    Formula:C15H14ClN3OS
    Purity:98%
    Color and Shape:Solid
    Molecular weight:319.81
  • Eg5 Inhibitor V, trans-24

    CAS:
    <p>Eg5 Inhibitor V, trans-24 is a specific and potent Eg5 inhibitor that can be used in cancer research with an IC50 value of 0.65 uM.</p>
    Formula:C26H21N3O3
    Purity:99.75%
    Color and Shape:Solid
    Molecular weight:423.46
  • Litronesib Racemate

    CAS:
    <p>Litronesib is a selective, allosteric inhibitor of kinesin Eg5.Litronesib (Racemate) is the racemate of litronesib.</p>
    Formula:C23H37N5O4S2
    Color and Shape:Solid
    Molecular weight:511.7
  • Syntelin

    CAS:
    <p>Syntelin: a selective CENP-E inhibitor with an IC50 of 160 nM; distinct from GSK923295, effective on resistant mutants.</p>
    Formula:C21H20N6O2S3
    Color and Shape:Solid
    Molecular weight:484.62
  • EMD534085

    CAS:
    <p>EMD534085 is an effective and selective mitotic kinesin-5 inhibitor (IC50: 8 nM).</p>
    Formula:C25H31F3N4O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:476.53
  • HR22C16

    CAS:
    <p>HR22C16 is an effective, selective, and cell-permeable mitotic kinesin Eg5 inhibitor.</p>
    Formula:C23H23N3O3
    Color and Shape:Solid
    Molecular weight:389.45
  • Mps1-IN-4

    CAS:
    <p>Mps1-IN-4 is a compound that selectively inhibits Monopolar spindle 1 (Mps1), exhibiting antiproliferative properties useful in cancer research.</p>
    Formula:C26H31F3N6O2
    Color and Shape:Solid
    Molecular weight:516.56
  • KIF18A-IN-3

    CAS:
    <p>KIF18A-IN-3 is a KIF18A inhibitor (IC50=61 nM) that causes significant mitotic arrest and increases the number of mitotic cells in tumor tissues.</p>
    Formula:C28H38N4O5S2
    Purity:98.45%
    Color and Shape:Solid
    Molecular weight:574.76
  • (R)-Filanesib

    CAS:
    <p>(R)-Filanesib is the R-enantiomer of ARRY-520. (R)-Filanesib is a synthetic kinesin spindle protein (KSP) inhibitor (IC50: 6 nM).</p>
    Formula:C20H22F2N4O2S
    Color and Shape:Solid
    Molecular weight:420.48
  • TC-Mps1-12

    CAS:
    <p>TC-Mps1-12 is an effective and selective inhibitor of monopolar spindle 1 (IC50: 6.4 nM) .</p>
    Formula:C17H20N6O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:324.38
  • Kif15-IN-1

    CAS:
    <p>Kif15-IN-1 is a Kif15 inhibitor with antiproliferative and potential anticancer activity, which can be used to study gastric cancer.</p>
    Formula:C20H22N4O5S
    Purity:99.39% - 99.39%
    Color and Shape:Solid
    Molecular weight:430.48
  • Mps-BAY2b

    CAS:
    <p>Mps-BAY2b is a novel MPS1 inhibitor.</p>
    Formula:C20H23N5O
    Color and Shape:Solid
    Molecular weight:349.43
  • PF-2771

    CAS:
    <p>PF-2771: potent CENP-E inhibitor, IC50 of 16.1 nM, used in cancer treatment.</p>
    Formula:C29H36ClN5O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:554.08
  • UMK57

    CAS:
    <p>UMK57 is a CENP-Ei and MCAK enhancer, selectively promoting k-MT attachment error correction to inhibit chromosome missegregation of small molecule compounds,</p>
    Formula:C17H17N3S
    Purity:99.81%
    Color and Shape:Solid
    Molecular weight:295.4
  • KSP-IA

    CAS:
    <p>KSP-IA is a potent, specific, allosteric, and cell-active KSP inhibitor.</p>
    Formula:C21H22F2N2O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:356.41
  • Luvixasertib hydrochloride

    CAS:
    <p>CFI-402257 hydrochloride, a highly selective and orally bioavailable inhibitor targeting TTK/Mps1, demonstrates an in vitro IC50 value of 1.7 nM against TTK. This compound exhibits anti-cancer activity [1].</p>
    Formula:C28H31ClN6O3
    Color and Shape:Solid
    Molecular weight:535.04
  • MC-Val-Cit-PAB-Ispinesib

    CAS:
    <p>MC-Val-Cit-PAB-Ispinesib (Compound 509) is a potent Eg5 inhibitor and a click chemistry reagent [1].</p>
    Formula:C59H71ClN10O10
    Color and Shape:Solid
    Molecular weight:1115.71
  • CCT251455

    CAS:
    <p>CCT251455, the mitotic kinase monopolar spindle 1 (MPS1/TTK) inhibitor, is a potent (IC50=3 nM) and specific chemical tool.</p>
    Formula:C26H26ClN7O2
    Purity:99.1% - 99.1%
    Color and Shape:Solid
    Molecular weight:503.98
  • Kif15-IN-2

    CAS:
    <p>Kif15-IN-2 is a kinesin Kif15 inhibitor with potential anticancer activity and can be used in prostate cancer research.</p>
    Formula:C20H20N6O4S
    Purity:98.17%
    Color and Shape:Solid
    Molecular weight:440.48
  • NTRC 0066-0

    CAS:
    <p>NTRC 0066-0 is a TTK inhibitor that can be used in cancer research.</p>
    Formula:C33H39N7O2
    Purity:98.30%
    Color and Shape:Solid
    Molecular weight:565.71
  • Litronesib

    CAS:
    <p>Litronesib is a selective inhibitor of mitosis-specific kinesin Eg5. It also has antitumor activity.</p>
    Formula:C23H37N5O4S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:511.7
  • PVZB1194

    CAS:
    <p>PVZB1194, a biphenyl-type inhibitor of Kinesin spindle protein Eg5 (KIF11), exhibits anticancer potential by inducing cell cycle arrest and apoptosis through</p>
    Formula:C13H9F4NO2S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:319.28
  • SB-743921 free base

    CAS:
    <p>SB-743921, a kinesin spindle protein (KSP) inhibitor, is used potentially for the treatment of non-Hodgkin's lymphoma (NHL).</p>
    Formula:C31H33ClN2O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:517.06
  • CCT-271850

    CAS:
    <p>CCT-271850 is an inhibitor of the spindle checkpoint function of Monospindle 1.</p>
    Formula:C24H29N7O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:431.53
  • CFI-402257

    CAS:
    <p>CFI-402257 is a selective inhibitor of Mps1/TTK kinase (Mps1 Ki = 0.09 nM; EC50 = 6.5 nM)and can be used in studies about hepatocellular carcinoma diseases.</p>
    Formula:C28H30N6O3
    Purity:96.66% - 99.51%
    Color and Shape:Solid
    Molecular weight:498.58
  • Mps1-IN-8

    CAS:
    <p>Mps1-IN-8, a Mps1 inhibitor, can be utilized in the study of various tumors [1].</p>
    Formula:C35H47N8O6P
    Color and Shape:Solid
    Molecular weight:706.77
  • RMS-07

    CAS:
    <p>RMS-07, a covalent MPS1/TTK inhibitor, has an IC50 of 13.1 nM, targeting a kinase hinge cysteine.</p>
    Formula:C35H40N8O2
    Color and Shape:Solid
    Molecular weight:604.74
  • MKLP2-IN-1

    CAS:
    <p>MKLP2-IN-1 (compound 12a) is an inhibitor of MKLP2 that demonstrates excellent oral bioactivity. In vitro, MKLP2-IN-1 inhibits the ATPase activity stimulated by recombinant MKLP2 microtubules and, in a mouse Calu-6 lung cancer model, it effectively suppresses tumor growth.</p>
    Formula:C23H19BrFN3O2
    Color and Shape:Solid
    Molecular weight:468.318
  • Terpendole E

    CAS:
    <p>Terpendole E is an atypical L5 site inhibitor.</p>
    Formula:C28H39NO3
    Color and Shape:Solid
    Molecular weight:437.61
  • Kolavenic acid analog

    CAS:
    <p>KAA, an anticancer compound, inhibits centrosome clustering and targets HSET+ yeast and cancer cells.</p>
    Formula:C25H38O4
    Color and Shape:Solid
    Molecular weight:402.57