
Kinesin
Kinesin inhibitors target kinesin motor proteins, which are responsible for transporting cellular cargo along microtubules and play a key role in cell division, particularly during mitosis. Kinesins are involved in the movement of chromosomes and other organelles during cell division. Inhibiting kinesins can disrupt these processes, leading to cell cycle arrest and potential cell death, making these inhibitors valuable in cancer research. At CymitQuimica, we offer a diverse range of high-quality kinesin inhibitors to support your research in cell biology, mitosis, and cancer therapy.
Found 66 products of "Kinesin"
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BOS-172722
CAS:<p>BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint(IC50 of 2 nM).</p>Formula:C24H30N8OPurity:99.37%Color and Shape:SolidMolecular weight:446.55Mps1-IN-3
CAS:<p>Mps1-IN-3 is an effective and selective inhibitor of MPS1 kinase (IC50: 50 nM).</p>Formula:C26H31N7O4SPurity:99.25%Color and Shape:SolidMolecular weight:537.63Paprotrain
CAS:<p>Paprotrain ((alphaZ)-alpha-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile) inhibits the ATPase activity of MKLP-2 with an IC50 of 1.35 μM and a Ki of 3.36 μM.</p>Formula:C16H11N3Purity:99.91%Color and Shape:SolidMolecular weight:245.28(S)-Monastrol
CAS:<p>Monastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5.</p>Formula:C14H16N2O3SPurity:98%Color and Shape:SolidMolecular weight:292.35Mps1-IN-6
<p>Mps1-IN-6 is a potent Mps1 inhibitor that demonstrates antiproliferative and antitumor activities, exhibiting an IC50 of 2.596 nM [1].</p>Formula:C35H39N9O3Color and Shape:SolidMolecular weight:633.74KIF18A-IN-16
CAS:<p>KIF18A-IN-16 (Compound 15) is a polycyclic KIF18A inhibitor. It is applicable in research related to tumors, including colon cancer, breast cancer, and lung cancer.</p>Formula:C30H37N5O4SColor and Shape:SolidMolecular weight:563.7111H-Benzo[a]carbazole
CAS:<p>11H-Benzo[a]carbazole is a kinesin-like protein KIF11 inhibitor that can inhibit the viability of HeLa cells.</p>Formula:C16H11NPurity:99.14%Color and Shape:SolidMolecular weight:217.27KIF2C-IN-1
<p>KIF2C-IN-1 (Compound 7S9) is a selective and potent small molecule inhibitor of KIF2C. It stabilizes the interaction between KIF2C and microtubule proteins, preventing the depolymerization of polyglutamylated microtubules. KIF2C-IN-1 enhances the cytotoxicity of Paclitaxel in Paclitaxel-resistant triple-negative breast cancer (TNBC) cells and, when combined with Paclitaxel, significantly reduces tumor growth in mouse models.</p>Formula:C36H39ClN4O9SColor and Shape:SolidMolecular weight:738.21263Solidagonic acid
CAS:<p>Solidagonic acid inhibits HSET, prevents fission yeast cell death, and hinders L. sativa and L. multiflorum seedling growth.</p>Formula:C22H34O4Color and Shape:SolidMolecular weight:362.5KIF18A-IN-14
CAS:<p>KIF18A-IN-14 (Compound Example 81) is an inhibitor of KIF18A that exists in two forms, EX81-A and its enantiomer EX81-B. EX81-A and EX81-B inhibit the viability of OVCAR-3 cells with IC50 values of 0-0.01 μM and 0.01-0.1 μM, respectively. KIF18A-IN-14 can be utilized in tumor research, including studies on colon cancer, breast cancer, and lung cancer.</p>Formula:C26H32F3N5O6SColor and Shape:SolidMolecular weight:599.62Filanesib TFA
CAS:<p>Filanesib (ARRY-520) inhibits KSP, triggering mitotic arrest and cell death in dividing tumor cells.</p>Formula:C22H23F5N4O4SPurity:98%Color and Shape:SolidMolecular weight:534.5Eg5-IN-1
<p>Eg5-IN-1 is a potent inhibitor of the kinesin family of motor proteins (Eg5) with an IC50 value of 1.97 µM for Eg5.Eg5-IN-1 can be used in cancer research.</p>Formula:C23H16ClFN4OPurity:98.21%Color and Shape:SolidMolecular weight:418.85KIF18A-IN-15
CAS:<p>KIF18A-IN-15 (Compound Example 36) is a KIF18A inhibitor, available in two forms, EX36-A and its enantiomer EX36-B, both with an IC50 range of 0.01-0.1 μM. These compounds inhibit the viability of OVCAR-3 cells, with IC50 values of 0.01-0.1 μM for EX36-A and 0-0.01 μM for EX36-B. KIF18A-IN-15 is applicable in research on tumors, including colon, breast, and lung cancers.</p>Formula:C25H33F3N6O5SColor and Shape:SolidMolecular weight:586.63AZ82
CAS:<p>AZ82 is an inhibitor of the kinesin-like protein KIFC1, which induces multipolar mitosis and apoptosis in prostate cancer cells.</p>Formula:C28H31F3N4O3SPurity:99.31%Color and Shape:SolidMolecular weight:560.63GW406108X
CAS:<p>GW406108X is a Kif15 and ULK1 inhibitor; IC50: 0.82 µM (ATPase), pIC50: 6.37; blocks autophagy.</p>Formula:C20H11Cl2NO4Purity:98%Color and Shape:SolidMolecular weight:400.21Kinesore
CAS:<p>Kinesore is a cell-permeable modulator that binds to the microtubule motor protein kinesin-1, thereby inhibiting the interaction between KLC2 and SKIP.</p>Formula:C20H16Br2N4O4Purity:97.24%Color and Shape:SolidMolecular weight:536.17AZ3146
CAS:<p>AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM.</p>Formula:C24H32N6O3Purity:97.84% - >99.99%Color and Shape:SolidMolecular weight:452.55GW406108X(Z/E)
CAS:<p>GW406108X(Z/E) is a mixture of different configurations of GW406108X, which is an inhibitor of Kinesin-12 and ULK1 .</p>Formula:C20H11Cl2NO4Purity:98.23%Color and Shape:SolidMolecular weight:400.21Empesertib
CAS:<p>Empesertib (BAY 1161909) is an orally bioavailable and selective inhibitor Mps1(IC50 < 1 nM), with potential antineoplastic activity.</p>Formula:C29H26FN5O4SPurity:97.45% - 99.4%Color and Shape:SolidMolecular weight:559.61BRD9876
CAS:<p>BRD9876 is a selective inhibitor of MM1S growth.</p>Formula:C16H14N2Purity:97.81%Color and Shape:SolidMolecular weight:234.3S-trityl-L-Cysteine
CAS:<p>S-trityl-L-Cysteine is a potent inhibitor of human mitotic kinesin Eg5</p>Formula:C22H21NO2SPurity:97.02%Color and Shape:Almost White To Light Yellow Granular PowderMolecular weight:363.47CW-069
CAS:<p>CW-069 (IC50=75 μM), an allosteric selective inhibitor of microtubule motor protein HSET, exhibits remarkable specificity over KSP.</p>Formula:C23H21IN2O3Purity:97.52% - 99.52%Color and Shape:SolidMolecular weight:500.33SB-743921 hydrochloride
CAS:<p>SB-743921 hydrochloride (SB743921 HCl) is an effective inhibitor of kinesin spindle protein, KSP, (Ki =0.1 nM).</p>Formula:C31H34Cl2N2O3Purity:95.58% - 99.70%Color and Shape:SolidMolecular weight:553.52Mps1-IN-3 hydrochloride
<p>Mps1-IN-3 HCl: potent Mps1 inhibitor (IC50: 50 nM), hampers glioblastoma growth, enhances vincristine efficacy in vivo.</p>Formula:C26H32ClN7O4SColor and Shape:SolidMolecular weight:574.09Mps1-IN-1 dihydrochloride
CAS:<p>Mps1-IN-1 dihydrochloride, a potent ATP-competitive inhibitor of Mps1 kinase, exhibits an IC50 of 367 nM.</p>Formula:C28H35Cl2N5O4SColor and Shape:SolidMolecular weight:608.58Ispinesib
CAS:<p>Ispinesib (SB-715992), a selective, effectvie and reversible inhibitor of kinesin spindle protein (KSP), is derived from quinazolinone, with antineoplastic</p>Formula:C30H33ClN4O2Purity:98% - 99.09%Color and Shape:SolidMolecular weight:517.06GSK-923295
CAS:<p>GSK923295 is a selective allosteric inhibitor of CENP-E kinesin motor ATPase(Ki=3.2 nM).</p>Formula:C32H38ClN5O4Purity:96.22% - 98.02%Color and Shape:SolidMolecular weight:592.13BTB-1
CAS:<p>BTB-1 (NSC156750) is a novel small molecule inhibitor of the mitotic motor protein Kif18A.</p>Formula:C12H8ClNO4SPurity:99.71%Color and Shape:SolidMolecular weight:297.71Sovilnesib
CAS:<p>Sovilnesib is a kinesin-like protein KIF18A inhibitor. Sovilnesib can be used for the cancer research.</p>Formula:C26H34F2N6O4SPurity:99.57%Color and Shape:SolidMolecular weight:564.65K858 (Racemic)
CAS:<p>K858 Racemic (K858) is a selective mitotic kinesin Eg5 inhibitor which acts in an ATP-noncompetitive manner.</p>Formula:C13H15N3O2SPurity:>99.99%Color and Shape:SolidMolecular weight:277.34Monastrol
CAS:<p>Monastrol ((±)-Monastrol) is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5.</p>Formula:C14H16N2O3SPurity:98.02% - 98.59%Color and Shape:SolidMolecular weight:292.35Dimethylenastron
CAS:<p>Dimethylenastron, an Eg5 inhibitor, arrests cells with monopolar spindles to which all chromosomes attach in a syntelic manner.</p>Formula:C16H18N2O2SPurity:98.07%Color and Shape:SolidMolecular weight:302.39ARQ 621
CAS:<p>ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Phase 1.</p>Formula:C28H24Cl2FN5O2Purity:97.01% - 98.38%Color and Shape:SolidMolecular weight:552.43Mps1-IN-2
CAS:<p>Mps1-IN-2 is a potent, selective and ATP-competitive dual Mps1/Plk1 inhibitor.</p>Formula:C26H36N6O3Purity:96.24% - 99.75%Color and Shape:SolidMolecular weight:480.6Mps1-IN-1
CAS:<p>Mps1-IN-1 is a potent, selective and ATP-competitive inhibitor of Mps1 kinase (IC50 : 367 nM )</p>Formula:C28H33N5O4SPurity:98.33%Color and Shape:SolidMolecular weight:535.66BAY1217389
CAS:<p>BAY 1217389 is an effective and selective inhibitor of the monopolar spindle 1 (MPS1) kinase (IC50<10 nM).</p>Formula:C27H24F5N5O3Purity:98.14% - 99.42%Color and Shape:SolidMolecular weight:561.5SR31527
CAS:<p>SR31527 chloride: potent KIFC1 inhibitor (IC50 6.6 µM), moderately impairs cell viability & colony growth.</p>Formula:C15H14ClN3OSPurity:98%Color and Shape:SolidMolecular weight:319.81Eg5 Inhibitor V, trans-24
CAS:<p>Eg5 Inhibitor V, trans-24 is a specific and potent Eg5 inhibitor that can be used in cancer research with an IC50 value of 0.65 uM.</p>Formula:C26H21N3O3Purity:99.75%Color and Shape:SolidMolecular weight:423.46Litronesib Racemate
CAS:<p>Litronesib is a selective, allosteric inhibitor of kinesin Eg5.Litronesib (Racemate) is the racemate of litronesib.</p>Formula:C23H37N5O4S2Color and Shape:SolidMolecular weight:511.7Syntelin
CAS:<p>Syntelin: a selective CENP-E inhibitor with an IC50 of 160 nM; distinct from GSK923295, effective on resistant mutants.</p>Formula:C21H20N6O2S3Color and Shape:SolidMolecular weight:484.62EMD534085
CAS:<p>EMD534085 is an effective and selective mitotic kinesin-5 inhibitor (IC50: 8 nM).</p>Formula:C25H31F3N4O2Purity:98%Color and Shape:SolidMolecular weight:476.53HR22C16
CAS:<p>HR22C16 is an effective, selective, and cell-permeable mitotic kinesin Eg5 inhibitor.</p>Formula:C23H23N3O3Color and Shape:SolidMolecular weight:389.45Mps1-IN-4
CAS:<p>Mps1-IN-4 is a compound that selectively inhibits Monopolar spindle 1 (Mps1), exhibiting antiproliferative properties useful in cancer research.</p>Formula:C26H31F3N6O2Color and Shape:SolidMolecular weight:516.56KIF18A-IN-3
CAS:<p>KIF18A-IN-3 is a KIF18A inhibitor (IC50=61 nM) that causes significant mitotic arrest and increases the number of mitotic cells in tumor tissues.</p>Formula:C28H38N4O5S2Purity:98.45%Color and Shape:SolidMolecular weight:574.76(R)-Filanesib
CAS:<p>(R)-Filanesib is the R-enantiomer of ARRY-520. (R)-Filanesib is a synthetic kinesin spindle protein (KSP) inhibitor (IC50: 6 nM).</p>Formula:C20H22F2N4O2SColor and Shape:SolidMolecular weight:420.48TC-Mps1-12
CAS:<p>TC-Mps1-12 is an effective and selective inhibitor of monopolar spindle 1 (IC50: 6.4 nM) .</p>Formula:C17H20N6OPurity:98%Color and Shape:SolidMolecular weight:324.38Kif15-IN-1
CAS:<p>Kif15-IN-1 is a Kif15 inhibitor with antiproliferative and potential anticancer activity, which can be used to study gastric cancer.</p>Formula:C20H22N4O5SPurity:99.39% - 99.39%Color and Shape:SolidMolecular weight:430.48Mps-BAY2b
CAS:<p>Mps-BAY2b is a novel MPS1 inhibitor.</p>Formula:C20H23N5OColor and Shape:SolidMolecular weight:349.43PF-2771
CAS:<p>PF-2771: potent CENP-E inhibitor, IC50 of 16.1 nM, used in cancer treatment.</p>Formula:C29H36ClN5O4Purity:98%Color and Shape:SolidMolecular weight:554.08UMK57
CAS:<p>UMK57 is a CENP-Ei and MCAK enhancer, selectively promoting k-MT attachment error correction to inhibit chromosome missegregation of small molecule compounds,</p>Formula:C17H17N3SPurity:99.81%Color and Shape:SolidMolecular weight:295.4KSP-IA
CAS:<p>KSP-IA is a potent, specific, allosteric, and cell-active KSP inhibitor.</p>Formula:C21H22F2N2OPurity:98%Color and Shape:SolidMolecular weight:356.41Luvixasertib hydrochloride
CAS:<p>CFI-402257 hydrochloride, a highly selective and orally bioavailable inhibitor targeting TTK/Mps1, demonstrates an in vitro IC50 value of 1.7 nM against TTK. This compound exhibits anti-cancer activity [1].</p>Formula:C28H31ClN6O3Color and Shape:SolidMolecular weight:535.04MC-Val-Cit-PAB-Ispinesib
CAS:<p>MC-Val-Cit-PAB-Ispinesib (Compound 509) is a potent Eg5 inhibitor and a click chemistry reagent [1].</p>Formula:C59H71ClN10O10Color and Shape:SolidMolecular weight:1115.71CCT251455
CAS:<p>CCT251455, the mitotic kinase monopolar spindle 1 (MPS1/TTK) inhibitor, is a potent (IC50=3 nM) and specific chemical tool.</p>Formula:C26H26ClN7O2Purity:99.1% - 99.1%Color and Shape:SolidMolecular weight:503.98Kif15-IN-2
CAS:<p>Kif15-IN-2 is a kinesin Kif15 inhibitor with potential anticancer activity and can be used in prostate cancer research.</p>Formula:C20H20N6O4SPurity:98.17%Color and Shape:SolidMolecular weight:440.48NTRC 0066-0
CAS:<p>NTRC 0066-0 is a TTK inhibitor that can be used in cancer research.</p>Formula:C33H39N7O2Purity:98.30%Color and Shape:SolidMolecular weight:565.71Litronesib
CAS:<p>Litronesib is a selective inhibitor of mitosis-specific kinesin Eg5. It also has antitumor activity.</p>Formula:C23H37N5O4S2Purity:98%Color and Shape:SolidMolecular weight:511.7PVZB1194
CAS:<p>PVZB1194, a biphenyl-type inhibitor of Kinesin spindle protein Eg5 (KIF11), exhibits anticancer potential by inducing cell cycle arrest and apoptosis through</p>Formula:C13H9F4NO2SPurity:98%Color and Shape:SolidMolecular weight:319.28SB-743921 free base
CAS:<p>SB-743921, a kinesin spindle protein (KSP) inhibitor, is used potentially for the treatment of non-Hodgkin's lymphoma (NHL).</p>Formula:C31H33ClN2O3Purity:98%Color and Shape:SolidMolecular weight:517.06CCT-271850
CAS:<p>CCT-271850 is an inhibitor of the spindle checkpoint function of Monospindle 1.</p>Formula:C24H29N7OPurity:98%Color and Shape:SolidMolecular weight:431.53CFI-402257
CAS:<p>CFI-402257 is a selective inhibitor of Mps1/TTK kinase (Mps1 Ki = 0.09 nM; EC50 = 6.5 nM)and can be used in studies about hepatocellular carcinoma diseases.</p>Formula:C28H30N6O3Purity:96.66% - 99.51%Color and Shape:SolidMolecular weight:498.58Mps1-IN-8
CAS:<p>Mps1-IN-8, a Mps1 inhibitor, can be utilized in the study of various tumors [1].</p>Formula:C35H47N8O6PColor and Shape:SolidMolecular weight:706.77RMS-07
CAS:<p>RMS-07, a covalent MPS1/TTK inhibitor, has an IC50 of 13.1 nM, targeting a kinase hinge cysteine.</p>Formula:C35H40N8O2Color and Shape:SolidMolecular weight:604.74MKLP2-IN-1
CAS:<p>MKLP2-IN-1 (compound 12a) is an inhibitor of MKLP2 that demonstrates excellent oral bioactivity. In vitro, MKLP2-IN-1 inhibits the ATPase activity stimulated by recombinant MKLP2 microtubules and, in a mouse Calu-6 lung cancer model, it effectively suppresses tumor growth.</p>Formula:C23H19BrFN3O2Color and Shape:SolidMolecular weight:468.318Terpendole E
CAS:<p>Terpendole E is an atypical L5 site inhibitor.</p>Formula:C28H39NO3Color and Shape:SolidMolecular weight:437.61Kolavenic acid analog
CAS:<p>KAA, an anticancer compound, inhibits centrosome clustering and targets HSET+ yeast and cancer cells.</p>Formula:C25H38O4Color and Shape:SolidMolecular weight:402.57

