DNA Damage/DNA Repair
DNA damage/DNA repair inhibitors are compounds that interfere with the processes involved in detecting and repairing DNA damage. These inhibitors are critical for studying the mechanisms of genomic stability, mutagenesis, and the response to DNA damage. They are also important in cancer research, as many tumors rely on specific DNA repair pathways for survival. By inhibiting these pathways, DNA damage/DNA repair inhibitors can enhance the effectiveness of chemotherapy and radiation therapy. At CymitQuimica, we provide a diverse range of high-quality DNA damage/DNA repair inhibitors to support your research in molecular biology, oncology, and pharmacology.
Subcategories of "DNA Damage/DNA Repair"
- ATM/ATR(72 products)
- DNA Alkylation(13 products)
- DNA Methyltransferase(455 products)
- DNA gyrase(11 products)
- DNA-PK(48 products)
- MTH1(1 products)
- Nucleoside Antimetabolite/Analog(1,421 products)
- Reverse Transcriptase(42 products)
- Sirtuin(88 products)
- Telomerase(33 products)
- Topoisomerase(141 products)
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Found 1034 products of "DNA Damage/DNA Repair"
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canfosfamide hydrochloride
CAS:Canfosfamide HCl, a glutathione analogue, activated by GST P1-1, alkylates tumor DNA to reduce cell proliferation.Formula:C26H41Cl5N5O10PSColor and Shape:SolidMolecular weight:823.93TRF1-TIN2 interaction-IN-1
TRF1-TIN2 interaction-IN-1 (Compound 40) is an inhibitor of the TRF1-TIN2 interaction. It binds to the TRFH domain of TRF1 (KD= 29 μM) and competitively inhibits the binding of the TIN2 peptide (IC50= 67 μM). By occupying a hotspot at the TRF1-TIN2 interface, TRF1-TIN2 interaction-IN-1 disrupts the interaction between TRF1 and TIN2. This compound can remove TRF1 from the shelterin complex, making it useful for research on shelterin-related cancers.Formula:C19H18O6SColor and Shape:SolidMolecular weight:374.41HDAC6-IN-50
<p>HDAC6-IN-50 (Compound 4) is an effective inhibitor of HDAC6 with an IC50 value of 35 nM. It is utilized in the study of Parkinson's disease (PD) and Alzheimer's disease (AD).</p>Color and Shape:Odour SolidCC618
CAS:CC618 is a selective PPARβ/δ antagonist with an IC50 of 10.0 μM.Formula:C20H15F6N3O3S2Purity:99.94%Color and Shape:SolidMolecular weight:523.47Ref: TM-T9767
1mg115.00€5mg249.00€10mg369.00€25mg562.00€50mg787.00€100mg1,054.00€200mg1,406.00€1mL*10mM (DMSO)314.00€DB1255 2TFA
DB1255 2TFA is an ERG/DNA binding inhibitor with an unusual and potent monomer binding pattern at the minor groove site for the study of genetic disorders.Formula:C26H20F6N4O4S2Purity:98.32%Color and Shape:SolidMolecular weight:630.58Elomotecan
CAS:Elomotecan (BN 80927 free base) is a potent inhibitor of topoisomerases I and II.Cost-effective and quality-assured.Formula:C29H32ClN3O4Color and Shape:SolidMolecular weight:522.04DNA gyrase/Topo IV-IN-1
DNA gyrase/Topo IV-IN-1 (Compound 27) is an inhibitor of DNA gyrase and topoisomerase IV with antibacterial properties. It exhibits IC50 values of 11 and 17 nM against the DNA gyrase of Escherichia coli and methicillin-resistant Staphylococcus aureus, respectively, and IC50 values of 83 and 21 nM against topoisomerase IV of the same organisms. DNA gyrase/Topo IV-IN-1 is applicable in anti-infective research.Formula:C44H59NO8Color and Shape:SolidMolecular weight:729.941Tertomotide hydrochloride
CAS:<p>Tertomotide (GV1001) hydrochloride is a peptide vaccine composed of a 16-amino acid sequence from human telomerase reverse transcriptase (hTERT). It exhibits neuroprotective properties and has potential for research in Alzheimer's disease.</p>Formula:C85H147ClN26O21Color and Shape:SolidMolecular weight:1904.69Methylation Compound Library
xnum methylation-related compounds that can be used for high-throughput and high-content screening.Color and Shape:Odour SolidRef: TM-L3510
1mgTo inquire30μL*10mM (DMSO)To inquire50μL*10mM (DMSO)To inquire100μL*10mM (DMSO)To inquire250μL*10mM (DMSO)To inquireTafluposide
CAS:Tafluposide is a DNA topoisomerase inhibitor with anti-tumor activity.Formula:C45H35F10O20PColor and Shape:SolidMolecular weight:1116.7139-Nitrooleate
CAS:<p>Nitrated fatty acids like nitrolinoleate and nitrooleate serve as PPARγ ligands and release NO; found in plasma, they aid adipocyte differentiation.</p>Formula:C18H33NO4Color and Shape:SolidMolecular weight:327.465Melphalan
CAS:Melphalan is an orally bioavailable DNA alkylating agent exhibiting antitumour activity, commonly employed in cancer chemotherapy.Formula:C13H18Cl2N2O2Molecular weight:305.21IC 86621
CAS:IC 86621: DNA-PK ATP-competitive inhibitor, IC50 120 nM, enhances DSB antitumor effects, EC50 68 µM for repair.Formula:C12H15NO3Purity:99.68%Color and Shape:SolidMolecular weight:221.25SIRT-IN-5
SIRT-IN-5, a selective inhibitor of SIRT3 with an IC50 of 2.88 μM, facilitates the differentiation of multiple myeloma cells. This differentiation is associated with increased expression of the differentiation antigens CD49e and human immunoglobulin light chains λ and κ.Color and Shape:Odour SolidElinafide
CAS:Elinafide, a dinaphthylimide cytotoxic agent, is a DNA-targeted anticancer agent that has shown antitumor activity in in vitro and in vivo assays.Formula:C31H28N4O4Purity:97.67%Color and Shape:SolidMolecular weight:520.58Sibiromycin
CAS:Sibiromycin: natural, potent antitumor PBD that binds DNA's minor groove at guanine NH2.Formula:C24H33N3O7Color and Shape:SolidMolecular weight:475.542HDAC-IN-78
HDAC-IN-78 (compound 66a) is an HDAC inhibitor utilized for cancer research.Color and Shape:Odour SolidNU-PRO-1
NU-PRO-1 is a covalent telomerase reverse transcriptase (TERT) PROTAC degrader. While NU-PRO-1 on its own does not cause DNA damage, it significantly delays DNA repair following radiation exposure.Color and Shape:Odour SolidElomotecan hydrochloride
CAS:Elomotecan hydrochloride (BN 80927), a potent hCPT analog, inhibits topoisomerases I/II, outperforming other anticancer drugs.Formula:C29H33Cl2N3O4Color and Shape:SolidMolecular weight:558.5Topo I/II-IN-1
<p>Topo I/II-IN-1 (compound 7t) is an effective dual inhibitor of Topo I and Topo II. It exhibits significant cytotoxicity against the MCF-7 breast cancer cell line, with an IC50 value of 7.45 μM.</p>Formula:C15H13N3S2Color and Shape:SolidMolecular weight:299.414PNU-142586
CAS:PNU-142586 is a bio-active chemical.Formula:C16H20FN3O6Color and Shape:SolidMolecular weight:369.34Amrubicin
CAS:The compound is a synthetic anthracycline antibiotic. It inhibits DNA topoisomerase II.Formula:C25H25NO9Purity:98%Color and Shape:SolidMolecular weight:483.47Ciprofibrate impurity A
CAS:<p>Ciprofibrate impurity A is an impurity of Ciprofibrate. Ciprofibrate is a PPARα agonist[1].</p>Formula:C12H14O3Color and Shape:SolidMolecular weight:206.241MCC-555
CAS:MCC-555 (Isaglitazone) is a PPARα and PPARγ agonist exerting antihyperglycemic effects.Formula:C21H16FNO3SPurity:99.07% - 99.82%Color and Shape:SolidMolecular weight:381.42Ref: TM-T21764
5mg70.00€10mg111.00€25mg226.00€50mg376.00€100mg560.00€500mg1,216.00€1mL*10mM (DMSO)77.00€Becatecarin
CAS:Becatecarin, water-soluble and anti-cancer, inhibits topoisomerases I/II and induces DNA cleavage and apoptosis; has myelosuppressive effects; ABCG2 substrate.Formula:C33H34Cl2N4O7Color and Shape:SolidMolecular weight:669.56Way 120744
CAS:Way 120744 is a new naphthyl 3h -1,2,3,5-oxadiazole 2-oxide.Formula:C12H9ClN2O2SColor and Shape:SolidMolecular weight:280.73(±)9-HEPE
CAS:<p>(±)9-HEPE is produced by non-enzymatic oxidation of EPA.</p>Formula:C20H30O3Color and Shape:SolidMolecular weight:318.457Antitumor agent-28
CAS:Antitumor agent-28 inhibits ATM kinase, blocking ATM disease progression and showing anti-cancer effects.Formula:C25H32N6O4SColor and Shape:SolidMolecular weight:512.63Tet1 peptide
CAS:Tet1peptide is a neuron-specific ligand for GT1B ganglioside. It can serve as a ligand for the targeted delivery of functionalized polymers.Formula:C73H114N20O17Color and Shape:SolidMolecular weight:1543.8120-HEPE
CAS:20-HEPE, a metabolite of EPA, is formed by CYP ω-oxidases. It activates PPARα and mTRPV1 but not antinociceptive in rats.Formula:C20H30O3Color and Shape:SolidMolecular weight:318.4574-oxo Cyclophosphamide
CAS:4-oxo Cyclophosphamide: inactive cyclophosphamide metabolite formed via 4-hydroxy intermediate.Formula:C7H13Cl2N2O3PColor and Shape:SolidMolecular weight:275.07Topoisomerase I/II inhibitor 5
TopoisomeraseI/II inhibitor 5 (compound 1) stabilizes G4 structures through binding and concurrently inhibits the relaxation activities of TopoI and II.Color and Shape:Odour SolidMonascin
CAS:Monascin: azaphilonoid in red-mold rice; anti-tumor and anti-inflammatory.Formula:C21H26O5Purity:98%Color and Shape:SolidMolecular weight:358.431-Methyladenosine-d3
1-Methyladenosine-d3 hydrochloride is the hydrochloride salt form of deuterium-labeled 1-Methyladenosine. This compound is a modification of RNA that serves as a biomarker for tumors, with elevated levels in the body linked to cancer development. Upon methylation, 1-Methyladenosine upregulates the expression of PPARδ, regulates cholesterol metabolism, and activates the Hedgehog signaling pathway, thereby driving the onset of liver tumors.Color and Shape:Odour SolidGW 1929 hydrochloride
CAS:Oral PPARγ agonist with pEC50 of 8.05; low affinity for PPARα, PPARδ. Reduces blood glucose, fatty acids, triglycerides in vivo.Formula:C30H30ClN3O4Color and Shape:SolidMolecular weight:532.04WAY-323061
CAS:WAY-323061 is a SIRT2 inhibitor.Formula:C25H21N5O2SPurity:99.33%Color and Shape:SolidMolecular weight:455.53FKB04
<p>FKB04 is a telomeric repeat binding factor 2 (TRF2) inhibitor that exerts its antitumor activity by disrupting the telomere maintenance mechanisms in hepatocellular carcinoma cells. This leads to T-loop defects, inducing telomere shortening and cellular senescence. Additionally, FKB04 inhibits tumor growth in a human liver cancer xenograft mouse model (by implanting Huh-7 cells in BALB/c mice). This compound is utilized in research focused on liver cancer.</p>Color and Shape:Odour SolidATR-IN-9
CAS:ATR-IN-9 from patent WO2020087170A1 is a potent ATR kinase inhibitor with an IC50 of 10 nM.Formula:C22H27N7O2Color and Shape:SolidMolecular weight:421.505Stearolic acid
CAS:Stearolic acid is a useful organic compound for research related to life sciences. The catalog number is T124753 and the CAS number is 506-24-1.Formula:C18H32O2Color and Shape:SolidMolecular weight:280.452AsCas12a Nuclease
AsCas12a Nuclease is a CRISPR nuclease capable of specifically cleaving double-stranded DNA. It is used in gene editing research.Heliotrine N-oxide
CAS:Heliotrine N-oxide, a PA N-oxide, triggers pyrrolic DNA adducts and may cause liver tumors.Formula:C16H27NO6Color and Shape:SolidMolecular weight:329.39SpCas9 D10A Nickase
SpCas9 D10A Nickase is a variant of the Cas9 protein. This mutation retains the functionality of one cleavage domain of the Cas9 nuclease, allowing it to specifically nick a target single strand. Additionally, SpCas9 D10A Nickase is effective in reducing off-target effects.CUDA disodium
CUDA disodium is an effective, soluble epoxide hydrolase (sEH) inhibitor, with IC50 values of 11.1 nM for murine sEH and 112 nM for human sEH. It selectively enhances the activity of peroxisome proliferator-activated receptor PPARalpha. CUDA disodium may be valuable for cardiovascular disease research.Color and Shape:Odour SolidAnticancer agent 177
<p>Anticanceragent 177 (Compound 11b) is an NAMPT inhibitor and DNA alkylating agent with antitumor activity both in vitro and in vivo.</p>Formula:C28H36Cl2N4O2Molecular weight:530.22153PPARγ-IN-3
PPARγ-IN-3 (compound 9ga), a potent and orally active PPARγ inhibitor, effectively reduces triglyceride (TG) accumulation and exhibits low cytotoxicity. Additionally, it prevents excessive body weight gain, lessens fat and liver mass, and decreases lipid accumulation in both the liver and blood. PPARγ-IN-3 holds promise for research into diet-induced obesity.Formula:C23H28FN7O3Color and Shape:SolidMolecular weight:469.51GW590735
CAS:GW590735: PPARα agonist, EC50=4 nM, >500x selective over PPARδ/γ, for dyslipidemia research.Formula:C23H21F3N2O4SPurity:99.53%Color and Shape:SolidMolecular weight:478.48Ref: TM-T9766
1mg95.00€5mg202.00€10mg298.00€25mg507.00€50mg730.00€100mg1,026.00€1mL*10mM (DMSO)213.00€Diflomotecan
CAS:Diflomotecan (BN 80915) is a strong oral topoisomerase I inhibitor with high plasma stability and significant preclinical anti-cancer efficacy.Formula:C21H16F2N2O4Color and Shape:SolidMolecular weight:398.36ABP/PPAR modulator 1
ABP/PPAR modulator 1 is an orally active multi-regulator of FABP and PPAR, exhibiting IC50 values of 0.65 μM for FABP1 and 1.08 μM for FABP4, and EC50 values of 9.19 μM, 2.20 μM, and 1.58 μM for PPARα, PPARγ, and PPARδ, respectively. It demonstrates potent activity against metabolic dysfunction-associated steatohepatitis (MASH). Additionally, ABP/PPAR modulator 1 dose-dependently improves various pathological features of fatty liver in a WD + Carbon tetrachloride-induced MASH mouse model.Formula:C33H39NO7Color and Shape:SolidMolecular weight:561.67Gimatecan HCl
Gimatecan HCl (ST1481 HCL) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity.Formula:C25H26ClN3O5Purity:97.04%Color and Shape:SoildMolecular weight:483.94Drupanin
CAS:Drupanin, isolated from green propolis, selectively inhibits the AKR1C3 enzyme and shows promise for breast cancer research [1].Formula:C14H16O3Color and Shape:SolidMolecular weight:232.28Multi-target kinase inhibitor 4
<p>Multi-target kinase inhibitor 4 (Compound 2) is a PI3K/DNA-PK inhibitor and a potent chemosensitizer that enhances the number of DNA double-strand breaks induced by Doxorubicin. It serves as an effective multidrug resistance (MDR) inhibitor, demonstrating inhibitory activity against P-glycoprotein (P-gp) mediated drug efflux. Multi-target kinase inhibitor 4 can be encapsulated in PEG-coated lipid nanoparticles.</p>Color and Shape:Odour SolidHippeastrine
CAS:<p>Hippeastrine is an alkaloid that inhibits Top I dose-dependently with a 7.25 μg/mL IC50 and has anticancer properties.</p>Formula:C17H17NO5Color and Shape:SolidMolecular weight:315.32PPAR agonist 6
PPAR agonist6 (compound 5a) acts as an agonist for PPAR, exhibiting EC50 values of 3.6 μM and 2.6 μM for PPARα and PPARβ/δ respectively. Additionally, PPAR agonist6 inhibits the transactivation of a TNFα-dependent NF-κB-driven reporter gene in L929 cells [1].Color and Shape:Odour Solid17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic Acid
CAS:Aspirin-enhanced COX-2 metabolite of DHA, activates Nrf2 and PPARγ, inhibits inflammation, with EC50 ~200 nM, effective at 5-25 μM.Formula:C22H30O3Color and Shape:SolidMolecular weight:342.479Abd110
CAS:Abd110 (compound 42i), a Lenalidomide-based PROTAC ATR kinase degrader, selectively reduces levels of ATR and phospho-ATR while not impacting the related kinases ATM and DNA-PKcs [1].Formula:C41H42N8O7SColor and Shape:SolidMolecular weight:790.89Mca-VDQVDGW-Lys(Dnp)-NH2
Mca-VDQVDGW-Lys(Dnp)-NH2, a fluorogenic substrate specific to caspase-7, facilitates the quantification of caspase-7 activity.Formula:C60H74N14O21Color and Shape:SolidMolecular weight:1327.31CH-0793076
CAS:<p>CH-0793076: hexacyclic camptothecin, TP300 metabolite, targets BCRP, inhibits DNA topo I (IC50: 2.3 μM).</p>Formula:C26H26N4O4Purity:98%Color and Shape:SolidMolecular weight:458.51(±)4(5)-DiHDPA lactone
CAS:(±)5(6)-DiHET lactone is a 1,5 cyclic ester derived from (±)5(6)-DiHET , which, in turn, is a potential derivative of epoxidation of arachidonic acid at the α-5Formula:C22H32O3Color and Shape:SolidMolecular weight:344.495Gemfibrozil 1-O-β-glucuronide
CAS:Gemfibrozil 1-O-β-Glucuronide, a metabolite of Gemfibrozil , is a potent and competitive P450 (CYP) isoform CYP2C8 inhibitor with an IC50 of 4.07 μM.Formula:C21H30O9Purity:98%Color and Shape:SolidMolecular weight:426.46Topoisomerase IIα-IN-9
CAS:Compound EN300-20599, with CAS No. 16346-97-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound EN300-20599 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.Formula:C14H14O4SColor and Shape:SolidMolecular weight:278.32Dichlorogelignate
CAS:Dichlorogelignate (compound 4) acts as a selective inhibitor of topoisomerase II (Topo II), achieving 100% inhibition at 50 μM [1].Formula:C32H34O18Color and Shape:SolidMolecular weight:706.64-oxo Docosahexaenoic Acid
CAS:4-oxo DHA, potential DHA metabolite, has anti-cancer properties and activates PPARγ with EC50 of 8-16 μM.Formula:C22H30O3Color and Shape:SolidMolecular weight:342.479Saroglitazar Magnesium
CAS:<p>Saroglitazar Magnesium: a PPAR agonist, strong on PPARα (EC50 0.65pM), moderate on PPARγ (EC50 3nM).</p>Formula:C50H56MgN2O8S2Purity:98.1%Color and Shape:SolidMolecular weight:901.4325-Hydroxytachysterol3
CAS:25-Hydroxytachysterol3 is a metabolite of Vitamin D3 that inhibits the proliferation of epidermal keratinocytes and dermal fibroblasts while promoting the differentiation of keratinocytes and the expression of antioxidant-related genes. It activates receptors including the vitamin D receptor (VDR), aryl hydrocarbon receptor (AhR), liver X receptor α/β (LXRα/β), and peroxisome proliferator-activated receptor γ (PPARγ), and enhances the expression of CYP24A1.Formula:C27H44O2Color and Shape:SolidMolecular weight:400.64Corydamine
Corydamine is a useful organic compound for research related to life sciences and the catalog number is T124768.Formula:C20H18N2O4Color and Shape:SolidMolecular weight:350.374Et-29
CAS:<p>Et-29 is a selective inhibitor of SIRT5 inhibitor with a Ki of 40 nM.</p>Formula:C34H46N6O6SPurity:99.52%Color and Shape:SolidMolecular weight:666.83Banoxantrone (D12)
CAS:Banoxantrone D12, deuterium-labeled version, reduces to AQ4 - a stable DNA-targeting topoisomerase II inhibitor.Formula:C22H28N4O6Purity:98%Color and Shape:SolidMolecular weight:456.55PR-104 sodium
CAS:PR-104 sodium: hypoxia-activated, tumor-targeting pre-prodrug; turns into PR-104A for research.Formula:C14H19BrN4NaO12PSColor and Shape:SolidMolecular weight:601.25Banoxantrone-d12 dihydrochloride
CAS:Banoxantrone D12, a deuterium-labeled version, transforms into DNA-binding topoisomerase II inhibitor AQ4 upon reduction.Formula:C22H30Cl2N4O6Purity:98%Color and Shape:SolidMolecular weight:529.4815-deoxy-Δ-12,14-Prostaglandin J2
CAS:15-deoxy-Δ-12,14-Prostaglandin J2 is a PPARγ agonist.Formula:C20H28O3Purity:98%Color and Shape:Neat OilMolecular weight:316.43DST Crosslinker
CAS:DST is a cleavable, bifunctional crosslinker; it doesn't disrupt protein disulfides, breaks with oxidizers.Formula:C12H12N2O10Color and Shape:SolidMolecular weight:344.232HDAC-IN-52
CAS:HDAC-IN-52: Pyridine-based inhibitor for HDAC1/2/3/10 with IC50s 0.189-0.446 μM, used in cancer studies.Formula:C24H20N4O2Purity:99.47%Color and Shape:SolidMolecular weight:396.44Ref: TM-T67878
1mg81.00€5mg162.00€10mg234.00€25mg356.00€50mg487.00€100mg658.00€200mg884.00€1mL*10mM (DMSO)178.00€nTZDpa
CAS:nTZDpa is an antibiotic with antimicrobial activity.Formula:C22H15Cl2NO2SColor and Shape:SolidMolecular weight:428.33MS9024
MS9024 is a degrader of DNA methyltransferase 1 (DNMT1), facilitating its degradation in HCT116 cells via the ubiquitin-proteasome pathway, with a DC50 of 35 nM (DC50 values are 254 nM in MDA-MB-468 and 101 nM in H1299). Additionally, MS9024 inhibits DNMT1 with an IC50 of 0.43 μM.Color and Shape:Odour SolidAntitumor agent-63
CAS:Compound 40, a non-toxic 20(S)-O-CPT glycoconjugate, is stable, with low Topo I inhibition.Formula:C38H46N4O18Color and Shape:SolidMolecular weight:846.79CP 84364
CAS:CP 84364 is a metabolite of CP-80794.Formula:C14H18N2O4Color and Shape:SolidMolecular weight:278.301-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC
CAS:Phospholipid with stearic and docosahexaenoic acids used in membrane studies; decreases in ALS mouse model.Formula:C48H84NO8PColor and Shape:SolidMolecular weight:834.16PDPH Crosslinker
CAS:PDPH crosslinker(SPDP Hydrazide) is a lytic heterobisfunctional protein crosslinker.Formula:C8H11N3OS2Color and Shape:SolidMolecular weight:229.32ACT-387042
CAS:ACT-387042 is a Bacterial Topoisomerase Inhibitor, it has broad-spectrum activity against Gram-positive and Gram-negative bacteria.Formula:C23H26FN5O4SColor and Shape:SolidMolecular weight:487.55CL2-MMT-SN38
CAS:<p>CL2-MMT-SN38 is a derivative of SN-38, which is a potent anticancer agent and the active metabolite of Irinotecan (CPT-11), a Topoisomerase I inhibitor.</p>Formula:C102H122N12O24Color and Shape:SolidMolecular weight:1900.158GpC Methyltransferase
<p>GpC Methyltransferase (GpC) is an enzyme that methylates DNA, specifically targeting cytosine residues within GpC dinucleotides of non-nucleosomal DNA in vitro.</p>17-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid
CAS:<p>DPA metabolite 17-oxo-DPA, found in fish oil, spurs antioxidant genes, modulates inflammation, and activates PPARγ (EC50 ≈ 200 nM).</p>Formula:C22H32O3Color and Shape:SolidMolecular weight:344.495Amorfrutin B
CAS:Amorfrutin B is a useful organic compound for research related to life sciences. The catalog number is T124211 and the CAS number is 78916-42-4.Formula:C26H32O4Color and Shape:SolidMolecular weight:408.538Prednimustine
CAS:Prednimustine (Leo 1031; NSC 134087), an ester of Prednisolone and Chlorambucil, is used in leukemia and lymphoma studies.Formula:C35H45Cl2NO6Color and Shape:SolidMolecular weight:646.64Silatecan
CAS:Silatecan is a useful organic compound for research related to life sciences. The catalog number is T67968 and the CAS number is 220913-32-6.Formula:C26H30N2O5SiColor and Shape:SoildMolecular weight:478.61Wistin
CAS:Wistin, isolated from Caragana sinica roots, is a PPARα and PPARγ agonist [1] [2] .Formula:C23H24O10Color and Shape:SolidMolecular weight:460.43WAY-620472
CAS:WAY-620472 is a PPAR regulator that can be used to alter the lifespan of eukaryotes.Formula:C23H21N5OSPurity:98.99%Color and Shape:SolidMolecular weight:415.51TAK1 inhibitor
CAS:<p>TAK1 inhibitor is an inhibitor, which can inhibit MCF-7, A549, DU-145 and MDA MB-231, with IC50 of 0.021, 0.14, 0.064 and 0.19, respectively.</p>Formula:C22H19ClN6O2SPurity:98%Color and Shape:SoildMolecular weight:466.94GSK3735967
CAS:GSK3735967: DNMT1 inhibitor, IC50 40 nM, dicyanopyridine core, binds hemimethylated CpG, interacts with H4K20me3.Formula:C25H31N7OSColor and Shape:SolidMolecular weight:477.62STAT3/HDAC-IN-2
STAT3/HDAC-IN-2 (compound 18), a dual inhibitor of STAT3 and HDAC, promotes autophagy and apoptosis. This compound features an amphiphilic hydroxamic acid hybrid structure, derived from the natural product isopropanol lactone (IAL), and functions as a nanoscale anticancer agent. It has the ability to self-assemble into nanoparticles in aqueous environments, leading to enhanced tumor tissue accumulation, increased cellular uptake, and improved anticancer efficacy compared to its free state.Formula:C28H32N2O7Color and Shape:SolidMolecular weight:508.5623-epi-26-Deoxyactein
CAS:23-epi-26-Deoxyactein is a naturally occurring compound exhibiting anti-obesity and anti-cancer properties when administered orally [1] [2] [3].Formula:C37H56O10Color and Shape:SolidMolecular weight:660.83Leriglitazone
CAS:Leriglitazone, pioglitazone's metabolite, is a PPARγ agonist (Ki:1.2μM, EC50:680nM), enhancing transcription and stabilizing AF-2.Formula:C19H20N2O4SPurity:98%Color and Shape:SolidMolecular weight:372.44ARN24139
ARN24139: a topoisomerase II poison; IC50=7.3μM. Inhibits DU145, HeLa, A549 cell growth; IC50s=4.7, 3.8, 3.1μM.Color and Shape:SolidDNA Damage & Repair Compound Library
<p>A unique collection of xnum DNA Damage &amp; Repair related compounds for high throughput screening (HTS) and high content screening (HCS);</p>Color and Shape:Odour SolidSIRT3 activator 2
SIRT3 activator2 (compound 2a) acts as an activator of SIRT3. It is presumed to bind directly with SIRT3 in SH-SY5Y cells, as inferred through thermal stability, facilitating the SIRT3-dependent clearance of α-Syn. Furthermore, SIRT3 activator2 enhances motor functions in Parkinsonian mice and dose-dependently prevents the loss of dopaminergic (DA) neurons in the substantia nigra.Formula:C22H24N2O9SColor and Shape:SolidMolecular weight:492.5SMPB Crosslinker
CAS:SMPB crosslinker reacts with sulfhydryl/amino groups, has a longer chain than MBS, and a non-cleavable spacer arm.Formula:C18H16N2O6Purity:98%Color and Shape:SolidMolecular weight:356.3320-carboxy Arachidonic Acid
CAS:20-COOH-AA, 20-HETE metabolite, inhibits kidney ion transport, relaxes constricted vessels, and activates PPARα/γ.Formula:C20H30O4Color and Shape:SolidMolecular weight:334.456Hippeastrine Hydrobromide
CAS:Hippeastrine hydrobromide is a natural alkaloid which demonstrates significant cytotoxicity against a panel of human and murine tumor cell lines.Formula:C17H18BrNO5Color and Shape:SolidMolecular weight:396.237PPARγ/GR modulator 1
PPARγ/GR Modulator 1, an orally active dual agonist for the Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) and Glucocorticoid Receptor (GR), exhibitsFormula:C14H10FNO4Color and Shape:SolidMolecular weight:275.23HDAC-IN-76
HDAC-IN-76 (compound 6i), a histone deacetylase (HDAC) inhibitor, demonstrates robust antimalarial activity, particularly against the asexual blood stages of Plasmodium. The compound exhibits potent efficacy with IC 50 values of 30 nM and 98 nM against Pf3D7 (chloroquine drug-susceptible strain) and PfDd2 (chloroquine drug-resistant strain), respectively. Moreover, HDAC-IN-76 shows selective inhibition towards parasites, displaying IC 50 values of 7 nM and 9 nM against human HDAC1 and HDAC6, respectively, and effectively inhibits PfHDAC1.Formula:C27H26N4O4Color and Shape:SolidMolecular weight:470.52
