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DNA Damage/DNA Repair

DNA Damage/DNA Repair

DNA damage/DNA repair inhibitors are compounds that interfere with the processes involved in detecting and repairing DNA damage. These inhibitors are critical for studying the mechanisms of genomic stability, mutagenesis, and the response to DNA damage. They are also important in cancer research, as many tumors rely on specific DNA repair pathways for survival. By inhibiting these pathways, DNA damage/DNA repair inhibitors can enhance the effectiveness of chemotherapy and radiation therapy. At CymitQuimica, we provide a diverse range of high-quality DNA damage/DNA repair inhibitors to support your research in molecular biology, oncology, and pharmacology.

Subcategories of "DNA Damage/DNA Repair"

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Found 958 products of "DNA Damage/DNA Repair"

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  • Colibactin 742
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    Colibactin 742

    CAS:
    <p>Colibactin 742, a stable derivative of colibactin, efficiently induces DNA interstrand cross-links, activates the Fanconi Anemia DNA repair pathway, and leads</p>
    Formula:C37H42N8O5S2
    Color and Shape:Solid
    Molecular weight:742.91

    Ref: TM-T72817

  • BML-278
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    BML-278

    CAS:
    <p>BML-278 is a SIRT1 activator with an EC150 of 1 μM.BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in parental and maternal prokaryotes, and</p>
    Formula:C24H25NO4
    Purity:99.53%
    Color and Shape:Solid
    Molecular weight:391.46

    Ref: TM-T77697

  • SCR7
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    SCR7

    CAS:
    <p>SCR7, a specific DNA Ligase IV inhibitor, blocks nonhomologous end-joining (NHEJ).</p>
    Formula:C18H14N4OS
    Purity:98%
    Color and Shape:Solid
    Molecular weight:334.4

    Ref: TM-T3340

  • (±)9-HEPE
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    (±)9-HEPE

    CAS:
    <p>(±)9-HEPE is produced by non-enzymatic oxidation of EPA.</p>
    Formula:C20H30O3
    Color and Shape:Solid
    Molecular weight:318.457

    Ref: TM-T36609

  • Tibesaikosaponin V
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    Tibesaikosaponin V

    CAS:
    <p>TKV, a triterpene diglycoside from Bupleurum chinense, curbs lipid build-up and fat content in adipocytes without harm and hinders fat cell differentiation.</p>
    Formula:C42H68O15
    Color and Shape:Solid
    Molecular weight:812.98

    Ref: TM-T75611

  • CymitQuimica logo
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    Melphalan

    CAS:
    <p>Melphalan is an alkylating agent. It has been used in combination with the HDAC inhibitor as a drug for the treatment of multiple myeloma (MM) cell lines and as a chemotherapy agent for breast cancer cell lines.</p>
    Formula:C13H18Cl2N2O2
    Molecular weight:305.21

    Ref: TM-T60710

  • Leriglitazone hydrochloride
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    Leriglitazone hydrochloride

    CAS:
    <p>Leriglitazone hydrochloride, a pioglitazone metabolite, is a PPARγ agonist with Ki of 1.2 μM and EC50 of 680 nM.</p>
    Formula:C19H21ClN2O4S
    Color and Shape:Solid
    Molecular weight:408.90

    Ref: TM-T73842

  • CymitQuimica logo
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    MS9024

    <p>MS9024 is a degrader of DNA methyltransferase 1 (DNMT1), facilitating its degradation in HCT116 cells via the ubiquitin-proteasome pathway, with a DC50 of 35 nM (DC50 values are 254 nM in MDA-MB-468 and 101 nM in H1299). Additionally, MS9024 inhibits DNMT1 with an IC50 of 0.43 μM.</p>
    Color and Shape:Odour Solid

    Ref: TM-T206183

  • Phosphoramide mustard
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    Phosphoramide mustard

    CAS:
    <p>Phosphoramide mustard is a toxic metabolite of cyclophosphamide with anticancer activity and ovarian toxicity that induces DNA damage.</p>
    Formula:C4H11Cl2N2O2P
    Purity:93.00%
    Color and Shape:Solid
    Molecular weight:221.02

    Ref: TM-T38410

  • GSK3735967
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    GSK3735967

    CAS:
    <p>GSK3735967: DNMT1 inhibitor, IC50 40 nM, dicyanopyridine core, binds hemimethylated CpG, interacts with H4K20me3.</p>
    Formula:C25H31N7OS
    Color and Shape:Solid
    Molecular weight:477.62

    Ref: TM-T74887

  • BRD7586
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    BRD7586

    CAS:
    <p>BRD7586 is a cell-permeable small molecule inhibitor of SpCas9 that enhances SpCas9 specificity.</p>
    Formula:C17H14ClN3O3S2
    Purity:97.70% - 99.03%
    Color and Shape:Solid
    Molecular weight:407.89

    Ref: TM-T73444

  • VK-1727
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    VK-1727

    <p>VK-1727 inhibits EBNA1 DNA binding, reducing proliferation of EBV-positive cells while sparing EBV-negative cells, useful for multiple sclerosis research.</p>
    Formula:C29H25NO4
    Purity:98.074%
    Color and Shape:Solid
    Molecular weight:451.51

    Ref: TM-T78598

  • 2'-Deoxy-2'-fluoro-β-D-arabinocytidine hydrochloride
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    2'-Deoxy-2'-fluoro-β-D-arabinocytidine hydrochloride

    CAS:
    <p>2'-Deoxy-2'-fluoro-beta-D-arabinocytidine HCl inhibits DNA methyltransferase with potential anti-tumor properties.</p>
    Formula:C9H13ClFN3O4
    Purity:99.69%
    Color and Shape:Solid
    Molecular weight:281.67

    Ref: TM-TNU0425

  • (4-NH2)-Exatecan
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    (4-NH2)-Exatecan

    CAS:
    <p>(4-NH2)-Exatecan is a topoisomerase inhibitor with potential anticancer activity for the synthesis of antibody drug conjugates (ADCs).</p>
    Formula:C23H21N3O4
    Purity:99.89%
    Color and Shape:Solid
    Molecular weight:403.43

    Ref: TM-T40159

  • O6BTG-octylglucoside
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    O6BTG-octylglucoside

    CAS:
    O6BTG-octylglucoside is a potent O6-methylguanine-DNAmethyl-transferase (MGMT) inhibitor (IC50s: 10 nM and 32 nM in HeLa S3 cells and in vitro (cell extracts)).
    Formula:C24H34BrN5O7S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:616.53

    Ref: TM-T11419

  • Banoxantrone dihydrochloride
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    Banoxantrone dihydrochloride

    CAS:
    <p>Banoxantrone dihydrochloride (AQ4N dihydrochloride) is a novel hypoxic cytotoxin that selectively kills hypoxic cells through an iNOS-dependent mechanism.</p>
    Formula:C22H30Cl2N4O6
    Purity:99.88%
    Color and Shape:Solid
    Molecular weight:517.4

    Ref: TM-T10459

  • 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine
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    5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine

    CAS:
    <p>5'-O-DMT-dU, a dUTPase inhibitor (Ki &gt; 1 mM) for E. coli, is used in DNA synthesis.</p>
    Formula:C30H30N2O7
    Color and Shape:Solid
    Molecular weight:530.57

    Ref: TM-T39912

  • Heptaplatin
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    Heptaplatin

    CAS:
    <p>Heptaplatin, an anticancer platinum compound, counters many cancers, including cisplatin-resistant types, with a 17% response rate and tolerable toxicity.</p>
    Formula:C11H20N2O6Pt
    Color and Shape:White Crystalline Powder
    Molecular weight:471.36

    Ref: TM-T21307

  • HDAC-IN-4
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    HDAC-IN-4

    CAS:
    <p>HDAC-IN-4 is a selective HDAC6 and HDAC10 inhibitor (pIC50s: 7.2 and 6.8 in BRET assay) with antitumoral activity.</p>
    Formula:C20H21N3O2
    Color and Shape:Solid
    Molecular weight:335.4

    Ref: TM-T11542

  • SIRT5 inhibitor 3
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    SIRT5 inhibitor 3

    CAS:
    <p>SIRT5 inhibitor 3 is potent and competitive by inhibiting SIRT5 deacetylation, with potential in metabolic, cancer, neurodegenerative, cardiovascular .</p>
    Formula:C22H12FN3O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:401.35

    Ref: TM-T61947

  • Methyl methanesulfonate (Standard)
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    Methyl methanesulfonate (Standard)

    CAS:
    <p>Methyl methanesulfonate (Standard) is a standard material used in the analysis of methyl methanesulfonate, typically referenced in its research and analysis.</p>
    Formula:C2H6O3S
    Color and Shape:Solid
    Molecular weight:110.13

    Ref: TM-T9985BP

  • Balaglitazone
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    Balaglitazone

    CAS:
    <p>Balaglitazone is a PPARγ agonist that regulates blood glucose and is used in studies of heart failure and myocardial infarction.</p>
    Formula:C20H17N3O4S
    Purity:99.74%
    Color and Shape:Solid
    Molecular weight:395.43

    Ref: TM-TQ0272

  • CP-868388 free base
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    CP-868388 free base

    CAS:
    <p>CP-868388 free base (CP-868388) is a PPARα agonist with hypolipidemic and anti-inflammatory activity and is used in the study of dyslipidemia.</p>
    Formula:C26H33NO5
    Purity:99.84%
    Color and Shape:Solid
    Molecular weight:439.54

    Ref: TM-T31083

  • (R)-(+)-Bay-K-8644
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    (R)-(+)-Bay-K-8644

    CAS:
    <p>(R)-(+)-Bay-K-8644, a Ca2+ channel agonist, is a dihydropyridine agonist that induces central respiratory depression and inhibits platelet activation in cats.</p>
    Formula:C16H15F3N2O4
    Purity:96.51% - 96.51%
    Color and Shape:Solid
    Molecular weight:356.3

    Ref: TM-TQ0145

  • Gepotidacin
    Targetmol
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    Gepotidacin

    CAS:
    <p>Gepotidacin is a triazaacenaphthylene antibacterial inhibiting bacterial type II topoisomerase with lower resistance potential than fluoroquinolones.</p>
    Formula:C24H28N6O3
    Purity:99.88%
    Color and Shape:Solid
    Molecular weight:448.52

    Ref: TM-T11391L

  • AMA-37
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    AMA-37

    CAS:
    <p>AMA-37 is a selective, reversible, and ATP-competitive DNA-PK inhibitor.</p>
    Formula:C17H17NO3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:283.32

    Ref: TM-T25069

  • Daun02
    Targetmol
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    Daun02

    CAS:
    <p>Daun02 is the topoisomerase inhibitor Daunorubicin prodrug.</p>
    Formula:C41H44N2O20
    Purity:98%
    Color and Shape:Solid
    Molecular weight:884.79

    Ref: TM-T15054

  • Gancaonin L
    Targetmol
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    Gancaonin L

    CAS:
    <p>Gancaonin L is a natural product that can be used as a reference standard. The CAS number of Gancaonin L is 129145-50-2.</p>
    Formula:C20H18O6
    Color and Shape:Solid
    Molecular weight:354.358

    Ref: TM-T126096

  • 9-Hydroxyellipticin free base
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    9-Hydroxyellipticin free base

    CAS:
    <p>9-hydroxyellipticine is a potent cytotoxic and antitumor agent. 9-hydroxyellipticine is a 9-hydroxy derivative of ellipticine.</p>
    Formula:C17H14N2O
    Color and Shape:Solid
    Molecular weight:262.31

    Ref: TM-T26401

  • Phosphoramide mustard cyclohexanamine
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    Phosphoramide mustard cyclohexanamine

    CAS:
    <p>Phosphoramide mustard cyclohexanamine is active metabolite of cyclophosphamide, an alkylating agent that cross-links DNA strands,causes cell death, antitumor.</p>
    Formula:C10H24Cl2N3O2P
    Purity:95%
    Color and Shape:Solid
    Molecular weight:320.2

    Ref: TM-T36701

  • RPR121056
    Targetmol
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    RPR121056

    CAS:
    <p>RPR121056 is a Irinotecan metabolite, which is generated by CYP3A4. Irinotecan is an antineoplastic agent that inhibits topoisomerase type I.</p>
    Formula:C33H38N4O8
    Purity:98%
    Color and Shape:Solid
    Molecular weight:618.68

    Ref: TM-T12766

  • Gatifloxacin mesylate
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    Gatifloxacin mesylate

    CAS:
    <p>Gatifloxacin mesylate, a 4th-gen fluoroquinolone antibiotic, inhibits DNA gyrase and topoisomerase IV.</p>
    Formula:C20H26FN3O7S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:471.5

    Ref: TM-T22797

  • Gatifloxacin sesquihydrate
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    Gatifloxacin sesquihydrate

    CAS:
    <p>Gatifloxacin sesquihydrate, a bacterial DNA gyrase inhibitor, is used to treat tuberculosis and pneumonia.</p>
    Formula:C19H24FN3O5
    Color and Shape:Solid
    Molecular weight:393.41

    Ref: TM-T1293L

  • Telomerase-IN-3
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    Telomerase-IN-3

    CAS:
    <p>Telomerase-IN-3 is an inhibitor of telomerase.</p>
    Formula:C19H16ClN5O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:397.82

    Ref: TM-T13116

  • Epitalon
    Targetmol
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    Epitalon

    CAS:
    <p>Epithalon (also known as Epitalon or Epithalone) is the synthetic version of the polypeptide Epithalamin which is naturally produced in the pineal gland.</p>
    Formula:C14H22N4O9
    Purity:98%
    Color and Shape:Solid
    Molecular weight:390.35

    Ref: TM-TP1456

  • (R)-GSK-3685032
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    (R)-GSK-3685032

    CAS:
    <p>(R)-GSK-3685032 is a selective, reversible DNMT1 inhibitor, non-covalent, IC50: 0.036 μM; reduces DNA methylation, inhibits cancer growth.</p>
    Formula:C22H24N6OS
    Color and Shape:Solid
    Molecular weight:420.54

    Ref: TM-T39648

  • Ciprofloxacin hydrochloride monohydrate
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    Ciprofloxacin hydrochloride monohydrate

    CAS:
    <p>Ciprofloxacin hydrochloride monohydrate (Bay-09867 hydrochloride monohydrate) is a fluoroquinolone antibiotic with potent antibacterial activity.</p>
    Formula:C17H21ClFN3O4
    Purity:99.23% - 99.85%
    Color and Shape:White Or Yellowish Crystalline Powder
    Molecular weight:385.82

    Ref: TM-T8130

  • PTGR2-IN-1
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    PTGR2-IN-1

    CAS:
    <p>PTGR2-IN-1 is a potent inhibito of PTGR2r. PTGR2-IN-1 increases 15-keto-PGE2-dependent PPARγ transcriptional activity in PTGR2-transfected HEK293T cells.</p>
    Formula:C19H22N2O2
    Purity:99.13%
    Color and Shape:Solid
    Molecular weight:310.39

    Ref: TM-T8763

  • YK-3-237
    Targetmol
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    YK-3-237

    CAS:
    <p>YK-3-237 (B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid) reduces acetylation of mtp53 and exhibits anti-proliferative</p>
    Formula:C19H21BO7
    Purity:99.47%
    Color and Shape:Solid
    Molecular weight:372.18

    Ref: TM-T9320

  • Pentamidine dihydrochloride
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    Pentamidine dihydrochloride

    CAS:
    <p>Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an aromatic diamidine agent with activity against a number of microorganisms including protozoa (</p>
    Formula:C19H26Cl2N4O2
    Purity:99.80%
    Color and Shape:Solid
    Molecular weight:413.34

    Ref: TM-T23132

  • Pixantrone dimaleate
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    Pixantrone dimaleate

    CAS:
    <p>Pixantrone dimaleate (Pixantrone Maleate) (BBR 2778 dimaleate) is an experimental antineoplastic drug.</p>
    Formula:C25H27N5O10
    Purity:98.70% - 99.11%
    Color and Shape:Solid
    Molecular weight:557.21

    Ref: TM-T2394

  • Silver sulfadiazine
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    Silver sulfadiazine

    CAS:
    <p>Silver sulfadiazine (Dermazin) is a sulfonamide-based topical agent with antibacterial and antifungal activity.</p>
    Formula:C10H9AgN4O2S
    Purity:99.04% - 99.58%
    Color and Shape:Solid
    Molecular weight:357.14

    Ref: TM-T3279

  • BYK204165
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    BYK204165

    CAS:
    <p>BYK204165 (RT-017290) is a potent PARP inhibitor (PARP1; IC50 = 44.67 nM for human recombinant PARP1 in an enzyme assay)</p>
    Formula:C15H12N2O2
    Purity:99.61%
    Color and Shape:Solid
    Molecular weight:252.27

    Ref: TM-T7896

  • AK-7
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    AK-7

    CAS:
    <p>AK-7 is a brain-permeable SIRT2 inhibitor and to characterize its cholesterol-reducing properties in neuronal models with an IC50 of 15.5 μM.</p>
    Formula:C19H21BrN2O3S
    Purity:98.43% - 99.34%
    Color and Shape:Solid
    Molecular weight:437.35

    Ref: TM-T5490

  • Voxtalisib
    Targetmol
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    Voxtalisib

    CAS:
    <p>Voxtalisib (XL765) (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.</p>
    Formula:C13H14N6O
    Purity:98.21% - 99.69%
    Color and Shape:Solid
    Molecular weight:270.29

    Ref: TM-T7014

  • Remetinostat
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    Remetinostat

    CAS:
    <p>Remetinostat (SHP-141), a hydroxamic acid-based inhibitor of histone deacetylase enzymes, is currently being developed for the treatment of cutaneous T-cell</p>
    Formula:C16H21NO6
    Purity:98.67%
    Color and Shape:Solid
    Molecular weight:323.34

    Ref: TM-T16729

  • Pixantrone hydrochloride
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    Pixantrone hydrochloride

    CAS:
    <p>Pixantrone hydrochloride is a topoisomerase II inhibitor and DNA intercalator with anti-tumor properties.</p>
    Formula:C17H20ClN5O2
    Color and Shape:Solid
    Molecular weight:361.83

    Ref: TM-T61351

  • PJ34
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    PJ34

    CAS:
    <p>PJ34 HCl is the hydrochloride salt of PJ34, which is a PARP inhibitor with EC50 of 20 nM and is equally potent to PARP1/2.</p>
    Formula:C17H17N3O2
    Purity:95.05% - 99.85%
    Color and Shape:Solid
    Molecular weight:295.34

    Ref: TM-T6197

  • Resminostat hydrochloride
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    Resminostat hydrochloride

    CAS:
    <p>Resminostat hydrochloride (RAS2410 hydrochloride) is an effective inhibitor of HDAC1/HDAC3/HDAC6 (IC50: 42.5/50.1/71.8 nM), respectively, and shows less potent</p>
    Formula:C16H20ClN3O4S
    Purity:97.63% - 99.68%
    Color and Shape:Solid
    Molecular weight:385.86

    Ref: TM-T4370

  • L67
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    L67

    CAS:
    <p>L67 (DNA Ligase Inhibitor) is a competitive human DNA ligase inhibitor, inhibits DNA ligases I and III (IC50: 10 μM).</p>
    Formula:C16H14Br2N4O4
    Purity:98.34% - 99.56%
    Color and Shape:Solid
    Molecular weight:486.11

    Ref: TM-T3103