Immunology and Inflammation
Immunology and inflammation inhibitors are compounds that modulate the immune response and inflammatory processes. These inhibitors are crucial in studying the mechanisms of immune regulation, autoimmunity, and chronic inflammation, as well as in developing treatments for inflammatory diseases, allergies, and immune-related disorders. By targeting key pathways in the immune system, these inhibitors can help reduce excessive or inappropriate immune responses. At CymitQuimica, we provide a comprehensive selection of high-quality immunology and inflammation inhibitors to support your research in immunology, inflammation, and therapeutic development.
Subcategories of "Immunology and Inflammation"
- CCR(143 products)
- CXCR(158 products)
- Cell wall(5 products)
- IL Receptor(111 products)
- IκB/IKK(57 products)
- LTR(3 products)
- MALT(25 products)
- MRP(6 products)
- NADPH-oxidase(2 products)
- NF-κB(385 products)
- NOD(25 products)
- NOS(61 products)
- Nrf2(81 products)
- PGE Synthase(31 products)
- ROS(71 products)
- TGF-beta/Smad(60 products)
- TLR(76 products)
- Thioredoxin(12 products)
- gp120/CD4(4 products)
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Found 3444 products of "Immunology and Inflammation"
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hCYP1B1-IN-1
hCYP1B1-IN-1 (compound B18) is an inhibitor of hCYP1B1 with an IC50 value of 3.6 nM and also acts as an antagonist of the Aryl Hydrocarbon Receptor.Formula:C18H14ClF3O3Color and Shape:SolidMolecular weight:370.75SU1261
SU1261, an IKK inhibitor, exhibits Ki values of 10 nM for IKKα and 680 nM for IKKβ. It effectively inhibits non-canonical NF-κB signaling in U2OS osteosarcoma cells.Color and Shape:Odour SolidPMX-53
CAS:PMX-53: MrgX2 agonist; C5aR antagonist; lessens atherosclerotic lesions & metastasis in mice; blocks rat hypernociception.Formula:C47H65N11O7Purity:98%Color and Shape:SolidMolecular weight:896.09G3-YSD
CAS:G3-YSD is a G3 terminal Y-shaped short DNA and functions as a cyclic guanosine-adenosine monophosphate synthase (cGAS) agonist. It serves as a minimal immunostimulatory DNA motif, capable of activating the DNA sensor cGAS, which induces type I interferon in a manner dependent on structure and sequence. G3-YSD is applicable for detecting HIV-1 single-stranded DNA.Color and Shape:SolidUbletamig
CAS:Ubletamig is a humanized IgG4κ monoclonal antibody that targets MUC16.Color and Shape:LiquidFITC-labeled ODN 1585 sodium
FITC-labeled ODN 1585 (sodium) effectively induces IFN and TNFα production and serves to assess CpG ODN cellular uptake and localization through confocal laser-Color and Shape:Odour SolidBiotin-labeled ODN 1018 sodium
Biotin-labeled ODN 1018 (sodium), a TLR-9 agonist oligodeoxynucleotide, serves as a tool for assessing cellular uptake and localization of CpG ODNs throughColor and Shape:Odour SolidUlevostinag
CAS:Ulevostinag (MK-1454) is a STING agonist.Formula:C20H22F2N10O9P2S2Color and Shape:SolidMolecular weight:710.52Bivalirudin TFA
CAS:Bivalirudin TFA, a 20-residue synthetic peptide, reversibly inhibits thrombin, affecting platelet aggregation and thrombin generation.Formula:C98H138N24O33·C2HF3O2Color and Shape:SolidMolecular weight:2294.34EX-A5758
CAS:EX-A5758: novel nNOS-NOS1AP inhibitor, reduces pain & enhances paclitaxel's anti-tumor effect.Formula:C10H17NO5Purity:99.67%Color and Shape:SolidMolecular weight:231.25COX-2-IN-48
COX-2-IN-48 (5-25) serves as an inhibitor of COX-2, exhibiting an IC50 of 51.7 nM against human COX-2. It displays anti-inflammatory and analgesic effects in various rodent models through inhibition of the NF-κB pathway. COX-2-IN-48 (5-25) inhibits the degradation of IκB, phosphorylation and nuclear translocation of NF-κB p65, and the expression of COX-2 and iNOS.Color and Shape:Odour SolidAB-680 ammonium
AB-680: potent, reversible CD73 inhibitor, Ki=4.9 pM, >10,000-fold selectivity vs CD39, anti-tumor.Formula:C20H30ClFN6O9P2Color and Shape:SolidMolecular weight:614.89DCFBC
CAS:DCFBC is a low-molecular-weight radiotracer. It targets prostate-specific membrane antigen (PSMA).Formula:C16H19FN2O7SPurity:98%Color and Shape:SolidMolecular weight:402.39MethADP sodium salt
CAS:MethADP is a specific CD73 inhibitor.Formula:C11H17N5NaO9P2Purity:98%Color and Shape:SolidMolecular weight:448.22IL-17 modulator 3
CAS:IL-17 modulator 3 targets IL-17, with potential for inflammation, cancer, autoimmune study.Formula:C31H45N7O4Color and Shape:SolidMolecular weight:579.746C3a (70-77)
CAS:C3a (70-77) is an octapeptide corresponding to the COOH terminus of C3a.Formula:C35H61N13O10Purity:98%Color and Shape:SolidMolecular weight:823.94Ibuprofen impurity 1
CAS:Ibuprofen impurity 1: anti-inflammatory, inhibits COX-1/COX-2 with IC50s of 13 μM/370 μM.
Formula:C12H16O2Color and Shape:SolidMolecular weight:192.258ODN D-SL03
CAS:ODN D-SL03, a C class CpG oligonucleotide, stimulates PBMCs, activating B cells, NK cells & monocytes, and can inhibit tumor growth.Color and Shape:SolidMolecular weight:9345PU23
CAS:PU 23 is an inhibitor of multidrug-resistant protein 4 (MRP4).Formula:C21H19N3O3S2Purity:99.52%Color and Shape:SolidMolecular weight:425.52Ref: TM-T9982
2mg34.00€5mg50.00€1mL*10mM (DMSO)55.00€10mg80.00€25mg155.00€50mg235.00€100mg349.00€200mg495.00€Ladanetin-6-O-β-D-glucopyranoside
CAS:Ladanetin-6-O-β-D-glucopyranoside, an active flavonoid, exhibits antioxidative effects and has potential for research into cardioprotective effects [1].Formula:C22H22O11Color and Shape:SolidMolecular weight:462.4Antitumor agent-185
Antitumor agent-185 (compound 3) exhibits significant antitumor effects, effectively inhibiting tumor growth and extending the survival period of mice in vivo.Formula:C109H199N5O36P2Color and Shape:SolidMolecular weight:2217.71GSK1795091
CAS:GSK1795091, a synthetic TLR4 agonist, boosts immunity and shows antitumor effects, enhancing flu vaccine response.Formula:C81H157N2O16PColor and Shape:SolidMolecular weight:1446.119DZ-837
DZ-837 is a PROTAC that targets the BCL6 protein. The composition of DZ-837 includes the BCL6 ligand-2, the E3 ubiquitin ligase ligand Thalidomide-4-OH, and a PROTAC Linker. The configuration notably features a conjugate of the E3 ubiquitin ligase ligand and the Linker, designated as 2-(2,6-Dioxopiperidin-3-yl)-4-((2-(2-hydroxyethoxy)ethyl)amino)isoindoline-1,3-dione.Formula:C42H44FN9O7SColor and Shape:SolidMolecular weight:837.92TLR7/8 agonist 12
TLR7/8 agonist 12 (compound 9) is a human TLR7/8 agonist with EC50 values of 11 nM for hTLR7 and 150 nM for hTLR8, indicating its potential for immune modulation.
Formula:C29H38N6O3Color and Shape:SolidMolecular weight:518.657-epi Maresin 1
CAS:7-epi Maresin 1 is the inactive 7(S) epimer of Maresin 1 , which contains a 7(R) hydroxyl group. It can be used as an experimental negative control.Formula:C22H32O4Color and Shape:SolidMolecular weight:360.494Interleukin II (60-70)
Interleukin 2 (IL-2) peptide: NH2-LEU-THR-PHE-LYS-PHE-TYR-MET-PRO-LYS-LYS-ALA-COOH, MW 1373.7, immune cytokine.Formula:C68H104N14O14S1Purity:98%Color and Shape:SolidMolecular weight:1373.7VEN-02XX
VEN-02XX is an orally active NLRP3 inhibitor capable of penetrating the brain. It effectively suppresses the release of IL-1β and IL-18, with IC50 values of 0.3 and 0.28 μM, respectively. In the 5XFAD/Rubicon KO mouse model, VEN-02XX aids in restoring memory and cognition, inhibits microgliosis, and alleviates neuroinflammation and tau protein pathology. This compound is valuable for Alzheimer's disease (AD) research.Formula:C18H16ClF3N4OColor and Shape:SolidMolecular weight:396.79Eritoran
CAS:Eritoran: TLR4 antagonist; shields mice from lethal influenza, EBOV, MARV; reduces granulocytosis, eases cytokine storm.Formula:C66H126N2O19P2Color and Shape:SolidMolecular weight:1313.66Crocin-4
CAS:Crocin-4, a saffron carotenoid, is an antioxidant that inhibits Aβ deposits in the brain and may aid Alzheimer's research with anti-tumor effects.
Formula:C27H36O9Color and Shape:SolidMolecular weight:504.576Biotin-labeled ODN 2395 sodium
Biotin-labeled ODN 2395 (sodium), a Class C oligodeoxynucleotide and TLR9 agonist, serves to assess cellular uptake and localization of CpG ODN through a biotinColor and Shape:Odour SolidPVP-037.2
CAS:PVP-037.2 is a TLR7/8 agonist that acts as an adjuvant to enhance vaccine-induced TH1 immune responses and boost the production of antigen-specific antibodies IgG1 and IgG2c.Formula:C23H20F3N5OColor and Shape:SoildMolecular weight:439.43SC691
CAS:SC691 is a PSMA inhibitor that can be labeled with [^68Ga (III)]. SC691 is suitable for imaging and diagnostic studies of prostate cancer.Formula:C43H65IN8O17Color and Shape:SolidMolecular weight:1092.92Camstatin
CAS:An analog of PEP-19 with enhanced binding to and antagonism of calmodulin.Formula:C122H203N39O34Purity:98%Color and Shape:SolidMolecular weight:2760.19COX-2/15-LOX-IN-4
COX-2/15-LOX-IN-4 (compound 5i) is a dual inhibitor with IC50 values of 0.075 μM for COX-2 and 1.97 μM for 15-LOX.Formula:C23H20FN3OSPurity:98%Color and Shape:SolidMolecular weight:405.494-Chlorochalcone
CAS:4-Chlorochalcone is achalcone inhibit human MAO-B and ROS/RNS production and is able to inhibit the growth of CAL51 cells.Formula:C15H11ClOPurity:98.08%Color and Shape:SolidMolecular weight:242.7HMK22769
CAS:Adenosine 5'-methylenediphosphate (sodium salt) is also referred to as an inhibitor of ecto-5'-nucleotidase.Formula:C11H14N5Na3O9P2Color and Shape:SolidMolecular weight:491.17Diprovocim-1
CAS:Diprovocim-1: TLR1/2 agonist; triggers TNF-α in THP-1 cells; boosts ovalbumin IgG1 & CTLs against tumors with anti-PD-L1 in mice.Formula:C56H56N6O6Color and Shape:SolidMolecular weight:909.1E7766 disodium
CAS:E7766 disodium, a macrocycle-bridged STING agonist, exhibits a binding affinity (Kd) of 40 nM, demonstrating potent pan-genotypic and antitumor effects.Formula:C24H26F2N10Na2O8P2S2Color and Shape:SolidMolecular weight:792.58Keap1-Nrf2-IN-9
CAS:Keap1-Nrf2-IN-9 inhibits Keap1-Nrf2 PPI with 0.575 µM IC50, boosts Nrf2 genes, non-toxic in ARPE19 cells.Formula:C31H30N2O11S2Color and Shape:SolidMolecular weight:670.71Amfenac sodium
CAS:Amfenac is a nonsteroidal anti-inflammatory drug. Amfenac also has acetic acid moiety.Formula:C15H12NNaO3Purity:98%Color and Shape:SolidMolecular weight:277.26Croconazole
CAS:Croconazole exhibited dose-dependent inhibitory activity on the 5-lipoxygenase (5-LOX) of neutrophils.Formula:C18H15ClN2OPurity:99.71%Color and Shape:SolidMolecular weight:310.78Ref: TM-T9878
1mg54.00€1mL*10mM (DMSO)90.00€5mg92.00€10mg137.00€25mg215.00€50mg316.00€100mg470.00€500mg1,054.00€FSL-1 TFA
FSL-1 TFA activates TLR2/6, boosts HSV-2 defense, and triggers MMP-9 via TLR2, NF-κB/AP-1 in THP-1 cells.Color and Shape:Odour SolidHPPD-IN-1
HPPD-IN-1 (compound II-3), a potent HPPD inhibitor, exhibits inhibitory activity against Arabidopsis thaliana HPPD (AtHPPD) with an IC50 of 0.248 μM, surpassingFormula:C12H6F3NO4Color and Shape:SolidMolecular weight:285.18N-Acetyldopamine dimer-2
CAS:Compound 2, an N-acetyldopamine dimer from Periostracum Cicadae, exhibits antioxidant and anti-inflammatory properties.Formula:C20H20N2O6Color and Shape:SolidMolecular weight:384.38Perfluorododecanoic acid
CAS:Perfluorododecanoic acid (PFDoA) is a PFAS pollutant causing ROS increase, mitochondrial damage, and neuronal cytotoxicity.Formula:C12HF23O2Purity:98.42%Color and Shape:SolidMolecular weight:614.1M0324
M0324 is a MUC-1 conditional CD40 agonist composed of an anti-MUC-1 IgG and two identical CD40-targeting camelid VHH domains, selectively activate immune cells.Color and Shape:Odour LiquidExosome Compound Library
76 exosome-related compounds that can be used for high-throughput and high-content screening.
Color and Shape:Odour SolidMTvkPABC-P5
MTvkPABC-P5d, functioning as a TLR7 agonist, serves as an immune stimulant and is utilized in the synthesis of immune-stimulating antibody conjugates (ISACs) [1Formula:C52H73N11O14Color and Shape:SolidMolecular weight:1076.2R-HP210
R-HP210 blocks LPS-triggered IL-1β, IL-6, COX-2 gene transcription and has a 3.80 μM IC50 for NF-κB inhibition without activating GCs.Formula:C22H19N3O2S2Color and Shape:SolidMolecular weight:421.542-Isopropyl-1H-imidazole
CAS:2-Isopropyl-1H-imidazole is a weak inhibitor of NO synthase and can be used in related research in the field of life sciences.Formula:C6H10N2Purity:99.71%Color and Shape:SolidMolecular weight:110.16Dihydromyristicin
CAS:Dihydromyristicin, a plant flavonoid, curbs inflammation by inhibiting ROS and PI3K/Akt/NF-κB pathways.Formula:C11H14O3Color and Shape:SolidMolecular weight:194.23Anti-inflammatory agent 38
Compound 23d, an Nrf2/HO-1 inhibitor, with IC50 of 0.38 μM for NO, reduces cellular ROS for anti-inflammatory research.Formula:C36H46N2O13SColor and Shape:SolidMolecular weight:746.82N(G)-Nitroarginine-4-nitroanilide
CAS:N(G)-Nitroarginine-4-nitroanilide is an anti-nociceptive in mice.Formula:C12H17N7O5Purity:98%Color and Shape:SolidMolecular weight:339.31Cridanimod sodium
CAS:Cridanimod boosts PR expression and may help treat endometrial cancer by inhibiting estrogen production.Formula:C15H11NNaO3Purity:98%Color and Shape:SolidMolecular weight:276.24BM213
CAS:BM213 is a useful organic compound for research related to life sciences and the catalog number is T35399.Formula:C43H70N12O10Purity:98%Color and Shape:SoildMolecular weight:915.09Iromycin A
CAS:Iromycin A: a bacterial metabolite inhibiting NOS III over NOS I, blocks NADH oxidation, IC50 = 0.461 µM.Formula:C19H29NO2Color and Shape:SolidMolecular weight:303.44P2X7-IN-2 TFA
P2X7-IN-2 TFA inhibits IL-Iβ release (IC50=0.01nM), used in autoimmunity, inflammation & cardiovascular research.Formula:C24H22F7N3O4Color and Shape:SolidMolecular weight:549.44β-Aminoarteether
CAS:β-Aminoarteether (SM934 free base), an orally active derivative of Artemisinin, serves a pivotal role in the research of inflammation and autoimmune disorders,Formula:C17H29NO5Purity:96.09% - 97.02%Color and Shape:SolidMolecular weight:327.42Ref: TM-T38723
1mg138.00€5mg334.00€1mL*10mM (DMSO)340.00€10mg537.00€25mg888.00€50mg1,243.00€100mg1,701.00€200mg2,277.00€Schisanchinin D
CAS:Schisanchinin D is a useful organic compound for research related to life sciences. The catalog number is T125682 and the CAS number is 1614245-13-4.Formula:C23H30O6Color and Shape:SolidMolecular weight:402.487AM-103 Free Acid
CAS:AM-103 Free Acid is a bio-active chemical.Formula:C36H39N3O4SColor and Shape:SolidMolecular weight:609.78HNW005
HNW005 is a dual inhibitor targeting the NLRP3 inflammasome and urate transporter 1 (URAT1). It exhibits an inhibition constant (KD) of 204.6 nM and an IC50 of 1.7 μM for NLRP3 inflammasome activation, while demonstrating an IC50 of 6.4 μM for inhibiting uric acid transmembrane transport. At an administered dose of 2 mg/kg in vivo, HNW005 achieves a uric acid reduction rate of 64.8%, effectively providing anti-inflammatory, analgesic, and urate-lowering effects by inhibiting NLRP3 inflammasome activation and uric acid transport. HNW005 is applicable for research in gouty arthritis.Color and Shape:Odour SolidSTING-IN-13
STING-IN-13 is a selective STING inhibitor that effectively suppresses downstream signaling of the STING pathway and STING-mediated inflammation. It exhibits low toxicity and is suitable for research related to STING-associated inflammatory and autoimmune diseases.Color and Shape:Odour SolidNLRP3-IN-14
CAS:NLRP3-IN-14, potent selective NLRP3 inhibitor, KD 5.87μM; IC50 0.131μM for IL-1β; for inflammation research.Formula:C27H28N2O4Color and Shape:SolidMolecular weight:444.52Factor B-IN-1
CAS:Factor B-IN-1 is a Factor B inhibitor.Formula:C19H16N4O2Color and Shape:SolidMolecular weight:332.3559DA-E 5090
CAS:DA-E 5090, an active metabolite of E 5090, inhibits IL-1 production in human monocytes.Formula:C17H18O4Purity:98%Color and Shape:SolidMolecular weight:286.32CHBO4
CAS:CHBO4 is an hMAO-B inhibitor that is potent, reversible, competitive and selective.The IC50 value of CHBO4 against hMAO-B in the CHBO assay was 0.031 μM, and
Formula:C15H10BrFOPurity:98.14%Color and Shape:SolidMolecular weight:305.14BR102910
CAS:BR102910: Selective FAP inhibitor, features 4-thiazolecarboxamide with cyano-difluoro-pyrrolidine and dichlorophenyl elements.
Formula:C18H14Cl2F2N4O2SPurity:97%Color and Shape:SolidMolecular weight:459.3NHEJ inhibitor-1
NHEJ inhibitor-1 (C2) is a Pt(II) complex that targets DSB repair to combat Cisplatin-resistant NSCLC by hindering Ku70/Rad51 and inducing ROS.Formula:C30H35N7O8PtSColor and Shape:SolidMolecular weight:848.79Aloenin aglycone
CAS:Aloenin aglycone (compound 13), an inhibitor of NF-κB, can be sourced from aloe exudate.Formula:C13H12O5Purity:98%Color and Shape:SolidMolecular weight:248.23Arginase inhibitor 7
CAS:Arginase Inhibitor 7 (compound A17), an inhibitor of arginase (ARG1), exhibits an IC 50 value of 0.16 μM and possesses high oral bioavailability [1].Formula:C14H29BN6O5Color and Shape:SolidMolecular weight:372.231-Hydroxy-ibuprofen
CAS:1-Hydroxy Ibuprofen, a metabolite in P. australis, targets COX-1/COX-2 with IC50s: 13 μM/370 μM.Formula:C13H18O3Color and Shape:SolidMolecular weight:222.2802ROS inducer 6
ROS inducer 6 (compound 9) acts as a reactive oxygen species (ROS) inducer by depleting intracellular glutathione, thereby functioning as an antitumor agent.Formula:C32H26N2O3Color and Shape:SolidMolecular weight:486.56Enpp-1/3-IN-1
Enpp-1/3-IN-1 (Compound 5j) serves as an inhibitor for ENPP1 and ENPP3, with IC50 values of 0.59 μM for h-ENPP1 and 0.62 μM for h-ENPP3, respectively. This compound also inhibits e5′NT (CD73) and TNAP, exhibiting IC50 values of 0.89 μM for h-e5′NT, 5.12 μM for r-e5′NT, and 1.68 μM for h-TNAP. Enpp-1/3-IN-1 is applicable in cancer research.Color and Shape:Odour SolidSTING (WT/R232) activity regulator 126
CAS:STING (WT/R232) activity regulator 126 is a STING modulator with antibacterial and antiviral effects.
Formula:C23H18ClFN2O2SPurity:99.75%Color and Shape:SolidMolecular weight:440.92IKKγ NBD Inhibitory Peptide
CAS:A cell-permeable synthetic peptide NEMO-binding domain peptide (NBD peptide) corresponding to the NEMO amino-terminal alpha-helical region is shown to block TNF
Formula:C170H259N49O42S1Purity:98%Color and Shape:SolidMolecular weight:3693.3Pepinh-MYD
CAS:Pepinh-MYD, a MyD88 inhibitor, incorporates both a domain sequence from MyD88 TIR and a protein transduction sequence to facilitate cell membrane penetration. This compound disrupts MyD88-mediated TLR signaling pathways, effectively inhibiting associated immune responses. Its design is particularly useful for investigating MyD88's function in viral infections.Formula:C151H248N50O35S2Color and Shape:SolidMolecular weight:3388.03TLR7/8 agonist 4 TFA
CAS:TLR7/8 agonist 4 TFA (compound 41) is a highly potent TLR7/8 agonist that exhibits significant anti-cancer activity.Formula:C20H25F3N6O2Color and Shape:SolidMolecular weight:438.45Halleridone
CAS:Halleridone, a natural product, is identified in Teuanchum decipiens and Abeliophyllum distichum.Formula:C8H10O3Color and Shape:SolidMolecular weight:154.165BMX-010
CAS:BMX-010, also known as AEOL-10113, is Porphyrin-Based SOD Mimic.Formula:C48H44Cl5MnN8Color and Shape:SolidMolecular weight:965.12R1-ICR-5
CAS:R1-ICR-5 is a selective PROTAC degrader targeting serine/threonine-protein kinase 1 (RIPK1). Mediated by VHL, R1-ICR-5 promotes the degradation of RIPK1, disrupting the TNFR1 and TLR3/4 signaling hubs, enhancing NF-κB, MAPK, and IFN signal output, and facilitating RIPK3 activation and necroptosis induction. R1-ICR-5 holds potential for research in cancer and inflammatory diseases.Formula:C54H70N8O7S2Color and Shape:SolidMolecular weight:1007.31JAK-STAT Compound Library
A unique collection of 252 JAK/STAT signaling targeted compounds for high throughput and high content screening;Color and Shape:Odour SolidRef: TM-L3700
1mgTo inquire30μL*10mM (DMSO)To inquire50μL*10mM (DMSO)To inquire100μL*10mM (DMSO)To inquire250μL*10mM (DMSO)To inquireAnti-inflammatory agent 58
Anti-inflammatory agent 58 exhibits IL-1β inhibition with an IC50 value of 1.08 μM and suppresses pro-inflammatory gene expression, protein secretion, and NF-κBColor and Shape:Odour SolidOATD-02 hydrochloride
OATD-02 hydrochloride is the hydrochloride salt form of OATD-02. It is an orally effective, competitive, reversible, and non-covalent dual inhibitor of Arginase1 and Arginase2. OATD-02 hydrochloride serves as a sustained-release inhibitor that efficiently blocks the activity of intracellular arginases, with IC50 values of 20 nM (hARG1), 39 nM (hARG2), 39 nM (mARG1), and 28 nM (rARG1). It effectively eliminates tumor-induced immunosuppression caused by both types of arginases. This compound is utilized in research studies on melanoma.Color and Shape:Odour SolidDiplacol
CAS:Diplacol, a geranylated flavanone isolated from Paulownia trees (Paulownia coreana UYEKI), exhibits anti-inflammatory properties by inhibiting NO production in LPS-stimulated Raw264.7 cells with an IC50 value of 4.53 μM [1].Formula:C25H28O7Color and Shape:SolidMolecular weight:440.49Tilsotolimod sodium
CAS:Tilsotolimod sodium, a synthetic Toll-like receptor 9 (TLR9) agonist, has shown antitumor activity in preclinical models.Formula:C223H262N74Na22O115P22S22Color and Shape:SolidMolecular weight:7711.51S217879
CAS:S217879 is a potent and selective activator of NRF2 that disrupts the KEAP1-NRF2 interaction, resulting in significant activation of the NRF2 pathway.Formula:C30H32N4O7SColor and Shape:SolidMolecular weight:592.67Histamine & Melatonin Receptor-Targeted Compound Library
A unique collection of xnum compounds targeting histaminergic receptor and melatonin receptor for high throughput screening (HTS) and high content screening (HCS
Color and Shape:Odour SolidNOX4-IN-1
NOX4-IN-1 (Compound 14m) is an inhibitor of NADPH oxidase 4 (NOX4) that reduces the production of reactive oxygen species (ROS). It also inhibits the TGF-β1/Smad signaling pathway, leading to decreased expression of fibrosis-related proteins. Additionally, NOX4-IN-1 impedes the migration of NRK-49F cells.Formula:C26H16ClN3O3Color and Shape:SolidMolecular weight:453.877Ara-F-NAD+ sodium
Ara-F-NAD+ sodium, an arabino analogue of NAD+, serves as a potent, reversible, and slow-binding inhibitor of the CD38 NADase [1] [2].Formula:C21H25FN7NaO13P2Color and Shape:SolidMolecular weight:687.4Rabelomycin
CAS:Rabelomycin is an angucycline group antibiotic.Formula:C19H14O6Color and Shape:SolidMolecular weight:338.31Diprovocim-X
Diprovocim-X, a potent TLR1/2 agonist, has EC50s of 0.14nM (hTLR) and 0.75nM (mTLR), enhances mice's adaptive immunity.Formula:C66H83N7O10Color and Shape:SolidMolecular weight:1134.41JAB-BX102
JAB-BX102 is a human monoclonal antibody (mAb) that targets NT5E/CD73. It is applicable in research studies involving breast cancer, pancreatic cancer, prostate cancer, and other cancers.Color and Shape:Odour LiquidAnticancer agent 15
CAS:Anticancer agent 15 raises ROS, causing necroptosis in melanoma cells.Formula:C35H40Cl2N2O5Color and Shape:SolidMolecular weight:639.61Cys-PKHB1
CAS:Cys-PKHB1 (Cys-txCD47) is a polypeptide consisting of a cysteine (Cys) residue coupled with PKHB1, which is a CD47 agonist peptide that acts as a thrombospondin-1 peptide mimetic with anti-tumor properties. In breast cancer cells, PKHB1 induces mitochondrial changes, ROS production, intracellular Ca+ accumulation, and calcium-dependent cell death. Additionally, PKHB1 activates the immune system by inducing immunogenic cell death in breast cancer cells.Formula:C71H110N18O13S2Color and Shape:SolidMolecular weight:1487.886-Amyl-2-pyrone
CAS:6-Amyl-2-pyrone exhibits inhibitory activity against tyrosinase, antibacterial and antiviral activity against Penicillium vulpinum and Aspergillus flavus, and antifungal activity against Sclerotinia sp.Formula:C10H14O2Purity:99.00%Color and Shape:SolidMolecular weight:166.22TAB-004
TAB-004 is a human monoclonal antibody targeting MUC1. It specifically identifies the tMUC1 present in all major subtypes of breast cancer without affecting normal breast epithelial cells. Additionally, TAB-004 is applicable for research on triple-negative breast cancer (TNBC).Color and Shape:Odour LiquidBQ0413
CAS:BQ0413 exhibits high affinity for PSMA, with a dissociation constant (KD) of 89 pM. It demonstrates effective uptake and internalization, with an internalization rate of 44% in PC3-pip cells. After being labeled with [99mTc], BQ0413 can serve as an imaging agent for tumors.Formula:C69H96N12O24SColor and Shape:SolidMolecular weight:1509.63Englumafusp alfa
Englumafusp alfa (CD19-4-1BBL; RO7227166) is a fusion protein combining a CD19-specific antibody domain with trimerized extracellular domains of human 4-1BBL,Color and Shape:Odour LiquidInhibitor Library
A unique collection of 8328 inhibitors for research in cell signaling, high throughput screening (HTS) and high content screening (HCS) for new drugs;Color and Shape:Odour SolidRef: TM-L2000
1mgTo inquire30μL*10mM (DMSO)To inquire50μL*10mM (DMSO)To inquire100μL*10mM (DMSO)To inquire250μL*10mM (DMSO)To inquireAChE-IN-85
AChE-IN-85 (Compound 7k) is an acetylcholinesterase inhibitor with an IC50 of 0.083 μM. It reduces nitric oxide (NO) release, the production of TNF-α and IL-1β, as well as levels of LDH and ROS, and inhibits Aβ42 aggregation. AChE-IN-85 exhibits anti-inflammatory and neuroprotective effects and is applicable for research on diseases such as Alzheimer's.Color and Shape:Odour Solid
