Immunology and Inflammation
Immunology and inflammation inhibitors are compounds that modulate the immune response and inflammatory processes. These inhibitors are crucial in studying the mechanisms of immune regulation, autoimmunity, and chronic inflammation, as well as in developing treatments for inflammatory diseases, allergies, and immune-related disorders. By targeting key pathways in the immune system, these inhibitors can help reduce excessive or inappropriate immune responses. At CymitQuimica, we provide a comprehensive selection of high-quality immunology and inflammation inhibitors to support your research in immunology, inflammation, and therapeutic development.
Subcategories of "Immunology and Inflammation"
- CCR(140 products)
- CXCR(159 products)
- Cell wall(5 products)
- IL Receptor(110 products)
- IκB/IKK(58 products)
- LTR(3 products)
- MALT(25 products)
- MRP(6 products)
- NADPH-oxidase(1 products)
- NF-κB(415 products)
- NOD(23 products)
- NOS(61 products)
- Nrf2(82 products)
- PGE Synthase(31 products)
- ROS(70 products)
- TGF-beta/Smad(63 products)
- TLR(73 products)
- Thioredoxin(12 products)
- gp120/CD4(4 products)
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Found 3385 products of "Immunology and Inflammation"
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mPGES1-IN-5
CAS:mPGES1-IN-5 (compound 18) is a multi-substituted pyrimidine compound that acts as a submicromolar inhibitor of PGE2 production. It primarily exerts its anti-inflammatory effects by inhibiting mPGES-1 and demonstrates significant inhibitory activity in vivo against acute inflammation models.Formula:C27H27N3OColor and Shape:SolidMolecular weight:409.52WK692
CAS:Compound WK692 (compund WK692) is a BCL6 inhibitor that effectively suppresses the growth of diffuse large B-cell lymphoma cells without toxic side effects and acts synergistically with inhibitors of EZH2 and PRMT5.Formula:C26H28Br2N8O5Color and Shape:SolidMolecular weight:692.36Cbl-b-IN-1
CAS:Cbl-b-IN-1 is a potent Cbl-b inhibitor (IC50 <100 nM) with potential anticancer activity for the study of intestinal inflammation.Formula:C29H34N6O2Purity:99.68%Color and Shape:SolidMolecular weight:498.631ASP-8731
CAS:ASP8731 is a selective inhibitor of BACH1 that prevents inflammation and vascular occlusion, and induces fetal hemoglobin in sickle cell disease.Formula:C20H21N5O4Color and Shape:SolidMolecular weight:395.41NLRP3-IN-70
CAS:NLRP3-IN-70 (Compound 5m) is an inhibitor of the NLRP3 inflammasome with low oral bioavailability. It binds directly to the NACHT domain of the NLRP3 protein, thereby blocking its interaction with ASC, which inhibits ASC oligomerization and the assembly of the NLRP3 inflammasome. NLRP3-IN-70 is applicable in studies on sepsis and non-alcoholic steatohepatitis.
Formula:C23H23NO5Color and Shape:SolidMolecular weight:393.432SLC7A11-IN-2
CAS:SLC7A11-IN-2 (Compound 1) is an inhibitor of SLC7A11/xCT. It disrupts the oxidative balance in HeLa cells by decreasing intracellular glutathione levels and increasing oxidative stress, thereby inducing cell death with an IC50 of 10.23 μM. Molecular dynamics simulations have demonstrated that SLC7A11-IN-2 exhibits a stronger binding affinity to SLC7A11 compared to Erastin. This compound is useful for research in the field of cervical cancer.Formula:C19H24N4O3Color and Shape:SolidMolecular weight:356.42BMY-25551
CAS:BMY-25551, a Mitomycin A analog, exhibits cytotoxicity 8 to 20 times greater than Mitomycin C against both murine and human tumor cell lines. It is applicable in research pertaining to cancer and hematological disorders.Formula:C17H21N3O7Color and Shape:SolidMolecular weight:379.36Anti-inflammatory agent 18
Anti-inflammatory agent 18: NO activity blocker (IC50: 15.94 μM), hampers HMGB1-induced inflammation, potential for COVID-19, sepsis study.Formula:C30H50O6Color and Shape:SolidMolecular weight:506.71Factor B-IN-3
CAS:Factor B-IN-3 is a potent inhibitor of complement factor B. Factor B-IN-3 can be used to study inflammatory and immune-related diseases.Formula:C24H29N3O4Color and Shape:SolidMolecular weight:423.5(R)-Ketoprofen
CAS:(R)-Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) that exhibits oral activity and analgesic properties. Unlike its counterpart, (R)-Ketoprofen does not significantly enhance the increase of inflammatory cytokines (such as Tumor Necrosis Factor (TNF) and Interleukin-1 (IL-1)) induced by LPS. However, it can inhibit the anti-inflammatory activity of (S)-Ketoprofen.Formula:C16H14O3Color and Shape:SolidMolecular weight:254.28VS-15
CAS:VS-15 is a selective inhibitor of IDO1, specifically binding to its apo-heme form. Additionally, VS-15 serves as an inhibitor of iNOS.Formula:C29H27N5O3Color and Shape:SolidMolecular weight:493.56NLRP3-IN-53
CAS:NLRP3-IN-53 (compound 1) is an NLRP3 inhibitor with an IC50 of 3.4nM.Formula:C22H27N5O4Color and Shape:SolidMolecular weight:425.48mPGES1-IN-4
CAS:mPGES1-IN-4 (compound 32) is a multi-substituted pyrimidine compound acting as a submicromolar inhibitor of PGE2 production. It primarily exerts its anti-inflammatory effects by inhibiting mPGES-1 and significantly suppresses acute inflammation models in vivo.Formula:C27H25F2N3OColor and Shape:SolidMolecular weight:445.50S-MTC acetate
CAS:S-MTC acetate (S-Methyl-L-thiocitrulline acetate) serves as a potent inhibitor of inducible nitric oxide synthases and is especially effective in inhibiting the constitutive (neuronal) type rather than the inducible (endothelial) type.Formula:C9H19N3O4SColor and Shape:SolidMolecular weight:265.33Cryptopleurine
CAS:Cryptopleurine is an inhibitor of gene products associated with cell proliferation, survival, invasion and angiogenesis. It acts by targeting the NF-κB pathway.Formula:C24H27NO3Purity:98%Color and Shape:SolidMolecular weight:377.48E 5090
CAS:E5090 is a novel orally active inhibitor of IL-1 generation. It also has anti-inflammatory properties.Formula:C19H20O5Purity:98%Color and Shape:SolidMolecular weight:328.36KBD4466
CAS:KBD4466 is a potent oral inhibitor of TLR7 and TLR8, with IC50 values of 0.9 nM and 2.8 nM, respectively. This compound effectively suppresses the inflammatory cytokines IL-6 and IFN-α. KBD4466 has shown to improve disease progression and increase survival rates in the BXSB/MpJ mouse model of systemic lupus erythematosus (SLE). It is suitable for research into autoimmune diseases.Formula:C24H23F3N6OColor and Shape:SolidMolecular weight:468.47SARM1-IN-5
CAS:SARM1-IN-5 (compound 1-23-a) is an inhibitor of SARM1, useful for researching diseases related to axonal degeneration, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS).Formula:C18H17FN6OColor and Shape:SolidMolecular weight:352.37Antibacterial agent 259
CAS:Antibacterialagent 259 (K3) is a bactericide with EC50 values of 1.5, 1.7, and 4.9 mg/L against Xoo, Xoc, and Xac, respectively. It induces the production of reactive oxygen species (ROS) in pathogens, leading to their death. Antibacterialagent 259 is applicable in research for controlling bacterial diseases in plants.Formula:C7H6ClN3O2SColor and Shape:SolidMolecular weight:231.659Refinicopan
CAS:Refinicopan is a complement factor D inhibitor with an IC50 of 10 nM, demonstrating an inhibition activity on rabbit erythrocyte hemolysis with an IC50 of 41 nM. It possesses excellent pharmacokinetic and pharmacodynamic properties.Formula:C29H32N2O3Color and Shape:SolidMolecular weight:456.58hDDAH-1-IN-2 sulfate
hDDAH-1-IN-2: selective oral hDDAH-1 inhibitor with low cell toxicity.Formula:C8H24N4O10S2Color and Shape:SolidMolecular weight:400.43STING agonist-43
CAS:STINGagonist-43 (Compound 67) is a selective STING agonist with an EC50 of 20.53 μM. It selectively enhances the cGAMP-dependent STING pathway activation by modulating STING oligomerization. STINGagonist-43 demonstrates antitumor activity in a B16.F10 mouse melanoma model and can be utilized in cancer immunotherapy research.Formula:C21H23NO4Color and Shape:SolidMolecular weight:353.41CYP1B1-IN-10
CAS:CYP1B1-IN-10 (Compound 15C) is a highly selective inhibitor of human cytochrome P450 1B1 (hCYP1B1) with an IC50 value of 0.11 μM. It shows promise for use in research focused on hormone-dependent tumors, including breast and ovarian cancers.Formula:C23H18N2Color and Shape:SolidMolecular weight:322.40Antifungal agent 134
CAS:Antifungalagent 134 (Compound B13) is an antifungal agent effective against Botrytis cinerea, Alternaria solani, Fusarium graminearum, Rhizoctonia solani, Colletotrichum orbiculare, and Alternaria alternata with EC50 values of 3.24, 1.89, 1.70, 0.36, 4.27, and 1.50 μg/mL, respectively. It disrupts the fungal cell membranes and mitochondria, leading to substantial accumulation of reactive oxygen species (ROS). Additionally, Antifungalagent 134 exhibits significant herbicidal activity on field weeds such as Amaranthus retroflexus L and Abutilon theophrasti Medicus, and is applicable in crop disease and field weed research.Formula:C18H12F4N2O4Color and Shape:SolidMolecular weight:396.29COX-2/15-LOX-IN-5
CAS:COX-2/15-LOX-IN-5 (Compound 4f) functions as a dual inhibitor of COX-2 and 15-LOX, demonstrating both anti-inflammatory and antioxidant properties [1]. This compound effectively reduces NF-κB activation in RAW 264.7 macrophages that is induced by lipopolysaccharide.Formula:C25H21N3O3SColor and Shape:SolidMolecular weight:443.52TrxR-IN-5
TrxR-IN-5 (compound 4f) is an effective inhibitor of thioredoxin reductase (TrxR) with an IC₅₀ of 0.16 μM. anti-proliferative and anti-metastatic.Formula:C26H22O3Color and Shape:SolidMolecular weight:382.46IL-6-IN-2
CAS:IL-6-IN-2 (Compound 15) is an inhibitor of the interaction between IL-6 and IL-6R proteins. The compound's binding free energy (∆G) is −36.50 kcal/mol. In its binding with IL-6, the contributions from Lys66, Phe74, Gln175, Ser176, and Arg179 are -1.10, -8.68, -6.91, -3.69, and -1.72 kcal/mol, respectively. IL-6-IN-2 exhibits low gastrointestinal (GI) absorption rates.Formula:C26H24N4O3Color and Shape:SolidMolecular weight:440.49Factor B-IN-4
CAS:Factor B-IN-4 is a potent inhibitor (IC50: 1 μM) of complement factor B. Factor B-IN-4 can be used to study inflammatory and immune-related diseases.Formula:C27H32N2O4Color and Shape:SolidMolecular weight:448.55Cyazofamid
CAS:Cyazofamid functions as a fungicide by impairing the production of ATP. It inhibits Organic Cation Transporter 3 (OCT3) and OAT1 with IC50 values of 1.54 and 17.3 μM, respectively.Formula:C13H13ClN4O2SColor and Shape:SolidMolecular weight:324.79Z-Val-Val-Nle-diazomethylketone
CAS:Z-Val-Val-Nle-diazomethylketone is an inhibitor of cathepsin S (CATS). It significantly suppresses the upregulation of IFNg-induced MHCII molecules, specifically HLA-DR and Ii-p33/35, while increasing the protein level of Ii-p10. This compound can be utilized for research into skin disorders such as psoriasis, atopic dermatitis, and actinic keratosis.Formula:C25H37N5O5Color and Shape:SolidMolecular weight:487.59AS2690168 hydrochloride
CAS:AS2690168 hydrochloride is an orally active inhibitor of RANKL signaling that can suppress RANKL-induced osteoclastogenesis in RAW264 cells. AS2690168 is applicable in research related to pathological bone resorption.Formula:C17H15Cl2F3N4OColor and Shape:SolidMolecular weight:419.228NOTA-FAPI
CAS:NOTA-FAPI is a FAP inhibitor and FAPI-4 analogue used in PET imaging and targeted therapy for FAP-overexpressing pathological conditions.Formula:C36H47F2N9O8Purity:99.748%Color and Shape:SolidMolecular weight:771.81ABZI
CAS:(S)-2-(1-Ethyl-3-methyl-1H-pyrazole-5-carboxamido)-1-(2-hydroxy-2-phenylethyl)-1H-benzo[d]imidazole-5-carboxamide (compound 4) is a STING agonist containing the crucial amide benzimidazole (ABZI) component. It consistently inhibits the binding of 3 H-cGAMP to STING, with an apparent inhibition constant (IC50) of 14 μM. This compound is applicable in tumor research.Formula:C23H24N6O3Color and Shape:SolidMolecular weight:432.48AMC-04
CAS:AMC-04 is a protein response (UPR) activator that initiates the UPR pathway via ROS and p38 MAPK signaling, leading to apoptotic cell death. It is used in cancer research [1].Formula:C26H28N2O3Color and Shape:SolidMolecular weight:416.51a15:0-i15:0 PE
CAS:a15:0-i15:0 PE is a dia-cyl phosphatidylethanolamine with two branched chains. It functions as an atypical TLR2-TLR1 heterodimer agonist and is immunogenic. This compound activates T cell and dendritic cell (DC) signaling, exhibiting anti-inflammatory properties. Additionally, a15:0-i15:0 PE induces the production of TNFα and IL-6. It is a major component of the A. muciniphila lipid membrane, constituting approximately 50%.Formula:C35H70NO8PColor and Shape:SolidMolecular weight:663.91MIF2-IN-1
MIF2-IN-1, potent inhibitor of MIF2 (IC50: 1μM), halts non-small cell lung cancer growth via MAPK pathway.Formula:C26H19F3N2O2SColor and Shape:SolidMolecular weight:480.5IRAK1/4/pan-FLT3 Kinase-IN-2
CAS:IRAK1/4/pan-FLT3 Kinase-IN-2 (compound 27) is a potent dual inhibitor of IRAK1/4 and FLT3 with IC50 values of 10 nM, 0.7 nM, and < 0.5 nM, respectively. This compound enhances survival in mice models of acute myeloid leukemia.Formula:C20H22F3N5OColor and Shape:SolidMolecular weight:405.42COX-2/PI3K-IN-2
COX-2/PI3K-IN-2 (5f): anti-inflammatory & anti-cancer, selectively inhibits COX-2 (Ki=3.02nM), potently blocks PI3K (IC50=2.78nM).Formula:C16H17N5O2Color and Shape:SolidMolecular weight:311.34IRAK4-IN-31
CAS:IRAK4-IN-31 is a crystalline inhibitor of IRAK4. It is applicable in research related to myelodysplastic syndromes (MDS).Formula:C27H33N5O5Color and Shape:SolidMolecular weight:507.58DEG-35
CAS:DEG-35 is a CRBN-dependent bifunctional degrader targeting IKZF2 and CK1α, with DC50 values of 1.4 nM and 4.4 nM for CK1α and IKZF2, respectively. It activates the p53 apoptotic pathway and is applicable for research related to acute myeloid leukemia (AML).Formula:C25H21N3O5Color and Shape:SolidMolecular weight:443.45Anti-inflammatory agent 13
Pentacyclic triterpene, Anti-inflammatory 13 inhibits DAMP/PAMP inflammation models.Formula:C30H48O4Color and Shape:SolidMolecular weight:472.7BCL6 ligand-4
CAS:BCL6ligand-4 is a BCL6 ligand used in the synthesis of PROTACs, such as BCL6PROTAC 1.Formula:C21H25ClN6O3Color and Shape:SolidMolecular weight:444.92IRAK4 modulator-1
CAS:IRAK4 Modulator-1 (example 161), an IRAK4 modulator with an IC50 of 4.647 μM, is employed in the investigation of IRAK-mediated disorders [1].Formula:C19H13ClN4O2Color and Shape:SolidMolecular weight:364.79VVD-130037
CAS:VVD-130037 is a KEAP1 activator with potential antitumor activity.VVD-130037 inhibits tumor growth in advanced solid tumors by degrading NRF2.Formula:C17H17ClN4O2Purity:99.01% - 99.92%Color and Shape:SolidMolecular weight:344.8Ref: TM-T88838
1mg141.00€5mg339.00€10mg494.00€25mg789.00€50mg1,046.00€100mg1,429.00€1mL*10mM (DMSO)370.00€Evixapodlin
CAS:Evixapodlin (PD-1/PD-L1-IN 7) is a human PD-1/PD-L1 protein/protein interaction inhibitor (IC50: 0.213).Evixapodlin has anticancer and antiviral activities.Formula:C34H36Cl2N8O4Purity:97.02%Color and Shape:SolidMolecular weight:691.61Ref: TM-T36487
1mg111.00€5mg264.00€10mg424.00€25mg747.00€50mg1,008.00€100mg1,359.00€200mg1,833.00€1mL*10mM (DMSO)405.00€UBS109
CAS:UBS109, a curcumin analog, is a DNA demethylating agent in pancreatic cancer that promotes osteoblast differentiation and mineralization.Formula:C18H17N3OPurity:99.48%Color and Shape:SolidMolecular weight:291.35Ref: TM-T88314
2mg38.00€5mg57.00€10mg92.00€25mg166.00€50mg254.00€100mg389.00€200mg566.00€1mL*10mM (DMSO)63.00€Antiproliferative agent-22
CAS:Antiproliferative agent-22 is an anticancer compound that shows antiproliferative activity on MCF-7, MDA-MB-231 and MDA-MB-468 cells.Formula:C17H13N3O3Purity:99.20% - 99.27%Color and Shape:SolidMolecular weight:307.3HOIPIN-8 sodium
CAS:HOIPIN-8 sodium is a LUBAC inhibitor for the study of inflammatory and immune diseases.Formula:C23H15F2N4NaO3Purity:97.34%Color and Shape:SolidMolecular weight:456.38Ref: TM-T62826
1mg70.00€5mg154.00€10mg235.00€25mg378.00€50mg540.00€100mg747.00€200mg1,026.00€1mL*10mM (DMSO)155.00€Dazostinag disodium
CAS:Dazostinag disodium (TAK-676) is a synthetic novel interferon gene (STING) agonist.Cost-effective and quality-assured.
Formula:C21H20F2N8Na2O10P2S2Purity:98.84% - 99.96%Color and Shape:SolidMolecular weight:754.48AM103
CAS:AM103 is an effective and selective inhibitor of FLAP (IC50 = 4.2 nM).Formula:C36H38N3NaO4SPurity:99.75%Color and Shape:SolidMolecular weight:631.76KI696
CAS:KI696 is a high-affinity probe that potently inhibits the interaction of Keap1 and NRF2.Formula:C28H30N4O6SPurity:99.74%Color and Shape:SolidMolecular weight:550.63Ref: TM-T11758L
1mg137.00€5mg281.00€10mg423.00€25mg707.00€50mg1,018.00€100mg1,468.00€200mg1,963.00€1mL*10mM (DMSO)341.00€Veledimex
CAS:Veledimex is an oral activator ligand for a proprietary gene therapy promoter system. It is also a moderate inhibitor of and substrate for CYP3A4/5.Formula:C27H38N2O3Purity:98%Color and Shape:SolidMolecular weight:438.6NSC23925
CAS:NSC23925 is a selective and effective inhibitor of P-glycoprotein (Pgp).Formula:C22H26Cl2N2O2Purity:98%Color and Shape:SolidMolecular weight:421.362-Selenouracil
CAS:2-Selenouracil is a specialized photosensitizer for photodynamical therapy.Formula:C4H4N2OSeColor and Shape:SolidMolecular weight:175.05PSB-12379
CAS:PSB-12379 is a potent inhibitor of Ecto-5'-Nucleotidase (CD73)(Kis of 9.03 nM (rat) and 2.21 nM (human)).Formula:C18H23N5O9P2Purity:98%Color and Shape:SolidMolecular weight:515.3511β,17α,21-Trihydroxypregna-1,4-diene-3,20-dione
CAS:Formula:C21H28O5Purity:98%Color and Shape:SolidMolecular weight:360.4440α-Terpineol
CAS:Terpineol possesses antifungal activity against Trichophyton mentagrophytes, it also exhibits strong antimicrobial activity against periodontopathic and cariogenic bacteria. α-Terpineol (Terpineol) shows anticonvulsant, and anti-inflammatory activities, it inhibits the gene expression of the IL-6 receptor.
Formula:C10H18OPurity:97.55%Color and Shape:Colorless LiquidMolecular weight:154.259a-Fluoro-11b,17a,21-trihydroxy-16b-methylpregna-1,4-diene-3,20-dione
CAS:Formula:C22H29FO5Purity:99%Color and Shape:SolidMolecular weight:392.4611(11β,16α)-9-Fluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione
CAS:Formula:C24H31FO6Purity:99%Color and Shape:SolidMolecular weight:434.4977Ref: IN-DA0039HQ
Discontinued product11β,17α,21-Trihydroxypregn-4-ene-3,20-dione
CAS:Formula:C21H30O5Purity:98%Color and Shape:SolidMolecular weight:362.4599Ref: IN-DA003AAY
Discontinued productRef: IN-DA0034OW
Discontinued productNogapendekin alfa inbakicept
CAS:Nogapendekin alfa inbakicept is an IL-15 superagonist that enhances anti-tumor immune responses by activating NK cells and T cells. It is being studied for use in non-muscle invasive bladder cancer (NMIBC).Color and Shape:SolidElamipretide acetate
Elamipretide acetate (MTP 131), a small tetrapeptide, targets mitochondria to reduce toxic species and stabilize cardiolipin.
Formula:C34H53N9O7Purity:99.76%Color and Shape:SoildMolecular weight:699.84Ref: TM-TP1095L
Discontinued productXibornol
CAS:Xibornol (Nanbacine) 具有广谱的抗菌和抗病毒活性，可用于研究革兰氏阳性菌感染和人呼吸道合胞病毒与人冠状病毒229E感染。Formula:C18H26OColor and Shape:SolidMolecular weight:258.4Ref: TM-T35177
Discontinued productRIDR-PI-103
CAS:RIDR-PI-103 is a reactive oxygen species (ROS)-induced drug release prodrug featuring an autocyclized portion connected to the pan-PI3K inhibitor (PI-103). In MDA-MB-361 and MDA-MB-231 cells, Doxorubicin and RIDR-PI-103 exhibited synergistic inhibition of cancer cell proliferation.Formula:C27H25N7O4Color and Shape:SolidMolecular weight:511.53Aurothioglucose
CAS:Aurothioglucose is a active-site TrxR1 inhibitor.Formula:C6H11AuO5SPurity:98%Color and Shape:Yellow Crystals SolidMolecular weight:392.18STING agonist-22
CAS:STING agonist-22 (CF501) boosts vaccines by activating STING, inducing IFN-I and cytokines, aiding in SARS-CoV-2 research.
Formula:C40H48N14O6Color and Shape:SolidMolecular weight:820.9Di-O-methyldemethoxycurcumin
CAS:Di-O-methyldemethoxycurcumin is a Curcumin analog isolated from medicinal plant turmeric di-orthomethyldemethoxycurcumin, anti-inflammatory and antioxidant properties Inhibition of IL-6 production, EC50 is 16.20μg/mL.Formula:C22H22O5Purity:98%Color and Shape:SolidMolecular weight:366.41Racemic Naproxen
CAS:Racemic Naproxen is a biochemical substance.Formula:C14H14O3Purity:98%Color and Shape:Crystals From Acetone-Hexane White SolidMolecular weight:230.26Icatolimab
Icatolimab (JS-004) is a humanized antibody targeting BTLA/CD272 for the study of lymphomas and solid tumors.
Purity:98.7% (SDS-PAGE); 95.6% (SEC-HPLC) - 98.7% (SDS-PAGE); 95.6% (SEC-HPLC)Color and Shape:LiquidMolecular weight:145.5 kDaRef: TM-T77490
Discontinued productJH-X-119-01 hydrochloride
CAS:JH-X-119-01 hydrochloride is a potent, selective inhibitor of interleukin-1 receptor-associated kinase 1 (IRAK1) that effectively alleviates lipopolysaccharide (LPS)-induced sepsis in mice.Formula:C25H21ClN6O3Color and Shape:SolidMolecular weight:488.93Magnesium citrate
CAS:Magnesium citrate is a useful organic compound for research related to life sciences. The catalog number is T64455 and the CAS number is 3344-18-1.Formula:C12H10Mg3O14Color and Shape:SolidMolecular weight:451.113Pam2CSK4 TFA
Pam2CSK4 TFA (PUL-042 TFA) is a potent dual agonist of TLR2 and TLR6, a peptide that mimics bacterial lipoproteins.Pam2CSK4 TFA promotes platelet aggregation, and can be used to study the effects of lipoproteins on the periodontium.Formula:C67H127F3N10O14SPurity:99.90%Color and Shape:SoildMolecular weight:1385.84TLR7/8/9 antagonist 2
CAS:TLR7/8/9 antagonist 2 is an orally active and highly bioavailable vTLR7/8/9 antagonist. It inhibits HEK/hTLR7, HEK/hTLR8, and HEK/hTLR9 with IC50s of 0.011 μM, 0.029 μM, and 0.052 μM, respectively. TLR7/8/9 antagonist 2 can be used to study auto-inflammatory diseases such as systemic lupus erythematosus or lupus nephritis.Formula:C23H31N7Purity:98%Color and Shape:SoildMolecular weight:405.54Tacalcitol
CAS:Tacalcitol (1,24(R)-Dihydroxyvitamin D3; 1.alpha.,24R-Dihydroxyvitamin D3) promotes normal bone development by regulating calcium and modulates immunological and inflammatory processes.Formula:C27H44O3Purity:98%Color and Shape:SolidMolecular weight:416.64gp91ds-tat
gp91ds-tat is a useful organic compound for research related to life sciences and the catalog number is T35393.
Purity:98%Color and Shape:SolidTripeptide-41
CAS:Tripeptide-41 (CG-Lipoxyn) is a bioactive peptide known for its ability to reduce fat accumulation.Formula:C29H30N4O5Purity:98%Color and Shape:SolidMolecular weight:514.57TLQP-21 TFA
TLQP-21 TFA is a VGF-derived peptide, C3aR1 agonist (mouse EC50: 10.3μM; human EC50: 68.8μM), that raises intracellular Ca2+ for nociception research.
Purity:98%Color and Shape:Liquid2,3-Bis(3-indolylmethyl)indole
CAS:2,3-Bis(3-indolylmethyl)indole exhibits a concentration-dependent inhibition of RANKL-induced osteoclastogenesis, actin ring formation, and bone resorption.Formula:C26H21N3Color and Shape:SolidMolecular weight:375.475ARGX-112
CAS:Temtokibart is a humanized IgG1 λ2 antibody that specifically targets IL22RA1, and is expressed by cells that are deficient in the glutamine synthetase gene.
Color and Shape:Odour LiquidALPK1-IN-2
CAS:ALPK1-IN-2 is a potent inhibitor of ALPK1 (α-kinase 1) (IC50: 95 nM). ALPK1-IN-2 inhibits NF-κB (IC50: 1.31 μM).
Formula:C20H18F2N4O2SColor and Shape:SolidMolecular weight:416.44L-NIO dihydrochloride
CAS:L-NIO dihydrochloride, a potent and non-selective NADPH-dependent nitric oxide synthase (NOS) inhibitor, consistently induces focal ischemic infarct in rats. It exhibits inhibitory constants (Kis) of 1.7, 3.9, and 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS) forms, respectively.Formula:C7H16ClN3O2Purity:98%Color and Shape:SolidMolecular weight:209.67ALPK1-IN-1
CAS:ALPK1-IN-1 (A001) strongly inhibits ALPK1, key for innate immunity & NF-κB signaling via TIFA/TRAF.
Formula:C25H32N6O2SColor and Shape:SolidMolecular weight:480.63ALPK1-IN-3
CAS:ALPK1-IN-3,serves as an ALPK1 inhibitor that dampens proinflammatory gene expression in the kidney and enhances survival in animal models of sepsis-induced
Formula:C20H16F2N4OSPurity:98%Color and Shape:SolidMolecular weight:398.43
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