Immunology and Inflammation
Immunology and inflammation inhibitors are compounds that modulate the immune response and inflammatory processes. These inhibitors are crucial in studying the mechanisms of immune regulation, autoimmunity, and chronic inflammation, as well as in developing treatments for inflammatory diseases, allergies, and immune-related disorders. By targeting key pathways in the immune system, these inhibitors can help reduce excessive or inappropriate immune responses. At CymitQuimica, we provide a comprehensive selection of high-quality immunology and inflammation inhibitors to support your research in immunology, inflammation, and therapeutic development.
Subcategories of "Immunology and Inflammation"
- CCR(143 products)
- CXCR(158 products)
- Cell wall(5 products)
- IL Receptor(110 products)
- IκB/IKK(57 products)
- LTR(3 products)
- MALT(25 products)
- MRP(6 products)
- NADPH-oxidase(2 products)
- NF-κB(386 products)
- NOD(25 products)
- NOS(61 products)
- Nrf2(81 products)
- PGE Synthase(31 products)
- ROS(70 products)
- TGF-beta/Smad(60 products)
- TLR(76 products)
- Thioredoxin(12 products)
- gp120/CD4(4 products)
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Found 3433 products of "Immunology and Inflammation"
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diABZI-4
CAS:DiABZI-4 is an orally active STING agonist that exhibits broad-spectrum antiviral activity. It functions by activating STING to induce the production of pro-inflammatory cytokines and activation of lymphocytes. This action inhibits the replication of Influenza A virus (IAV), SARS-CoV-2, and Human Rhinovirus (HRV), with an EC50 range of 11.8-199 nM.Formula:C40H51Cl2N13O6Color and Shape:SolidMolecular weight:880.82MAO-B-IN-39
MAO-B-IN-39 (compound11) is a potent inhibitor of monoamine oxidase B (MAO-B), with an IC50 of 3.61 μM. It demonstrates strong NRF2 induction capabilities and exhibits significant anti-inflammatory and neuroprotective effects in oxidative stress-related in vitro models. Additionally, MAO-B-IN-39 shows high liver microsomal stability and favorable pharmacokinetic properties in mice, making it a valuable compound for Parkinson's disease research.Formula:C17H13FN2OColor and Shape:SolidMolecular weight:280.3PMX-53
CAS:PMX-53: MrgX2 agonist; C5aR antagonist; lessens atherosclerotic lesions & metastasis in mice; blocks rat hypernociception.Formula:C47H65N11O7Purity:98%Color and Shape:SolidMolecular weight:896.09Phthalazine
CAS:Compound PDK0135, with CAS No. 253-52-1, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0135 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.Formula:C8H6N2Color and Shape:Yellow SolidMolecular weight:130.14NLRP3-IN-49
NLRP3-IN-49 (compound Z48) is a potent and specific inhibitor of NLRP3, displaying IC50 values of 0.26 μM in THP-1 cells and 0.21 μM in mouse bone marrow-derived macrophages. It directly binds to the NLRP3 protein with a dissociation constant (Kd) of 1.05 μM, effectively preventing the assembly and activation of the NLRP3 inflammasome, thereby exhibiting anti-inflammatory properties. NLRP3-IN-49 is utilized in the research of inflammatory bowel disease.Color and Shape:Odour SolidBiotin-labeled ODN 2088 sodium
Biotin-labeled ODN 2088 (sodium) acts as a potent inhibitor of TLR3, TLR7, and TLR9.Color and Shape:Odour SolidHispaglabridin A
CAS:Hispaglabridin A, an effective antioxidant, inhibits lipid peroxidation [1].Formula:C25H28O4Color and Shape:SolidMolecular weight:392.49Sartorypyrone D
CAS:Sartorypyrone D, from N. fischeri, inhibits NFRD (1.7 μM) and NADH oxidase (3 μM), and fights Gram-positive bacteria.Formula:C26H38O4Color and Shape:SolidMolecular weight:414.586E7766 diammonium salt
CAS:E7766 diammonium salt, a macrocycle-bridged STING agonist, exhibits a dissociation constant (Kd) of 40 nM, demonstrating potent pan-genotypic and antitumorFormula:C24H32F2N12O8P2S2Color and Shape:SolidMolecular weight:780.66NLRP3-IN-35
NLRP3-IN-35 (compound 11) is an NLRP3 inhibitor with an IC50 of less than 1 μM.Formula:C26H25FN4O2Molecular weight:444.19615Lemnalol
CAS:Lemnalol, from Lemnalia cervicorni, has anti-inflammatory and analgesic properties.Formula:C15H24OPurity:98%Color and Shape:SolidMolecular weight:220.3519-epi-Scholaricine
CAS:19-epi-Scholaricine: indole alkaloid, taken orally, reduces collagen fibrosis, boosts SOD.Formula:C20H24N2O4Color and Shape:SolidMolecular weight:356.42Sirtuin modulator 2
CAS:Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) exhibits antidiabetic, anti-inflammatory and antitumor activities.Formula:C19H15N3O2SPurity:99.67%Color and Shape:SolidMolecular weight:349.41Inflexuside A
CAS:Inflexuside A, an abietane diterpenoid from Isodon inflexus, and Inflexuside B inhibit NO in LPS-stimulated RAW264.7 cells.Formula:C26H42O9Color and Shape:SolidMolecular weight:498.61PROTAC cGAS degrader-1
PROTAC cGAS degrader-1 (Compound TH35) is a potent and selective cGAS PROTAC degrader, exhibiting DC50 values of 0.9 μM in THP-1 cells and 4.6 μM in RAW 264.7 cells. It effectively inhibits the activation of cGAS signaling induced by dsDNA. PROTAC cGAS degrader-1 also demonstrates anti-inflammatory properties, making it suitable for research into cGAS-related inflammatory diseases. (Pink: cGAS inhibitor; Black: Linker; Blue: E3 ligase ligand)Formula:C36H33Cl2N7O5Color and Shape:SolidMolecular weight:714.6Eritoran Tetrasodium
CAS:Eritoran Tetrasodium, a TLR4 receptor antagonist, is used potentially for the treatment of type 2 diabetes.Formula:C66H122N2Na4O19P2Purity:98%Color and Shape:SolidMolecular weight:1401.58TMV-IN-7
TMV-IN-7 (compound G2) is a potent inhibitor of Tobacco Mosaic Virus (TMV). It exhibits strong hydrophobic interactions that prevent the virus from self-assembling.Formula:C17H15ClN6OSMolecular weight:386.07166Bivalirudin TFA
CAS:Bivalirudin TFA, a 20-residue synthetic peptide, reversibly inhibits thrombin, affecting platelet aggregation and thrombin generation.Formula:C98H138N24O33·C2HF3O2Color and Shape:SolidMolecular weight:2294.34FSL-1 TFA
FSL-1 TFA activates TLR2/6, boosts HSV-2 defense, and triggers MMP-9 via TLR2, NF-κB/AP-1 in THP-1 cells.Color and Shape:Odour SolidVensobafusp alfa
CAS:Vensobafusp alfa (KP-104) is a fusion protein composed of an IgG4 monoclonal antibody targeting complement protein C5, combined with the domains 1-5 of complement factor H (FH1-5). It exhibits anti-inflammatory and immunomodulatory properties. The isotype control for Vensobafusp alfa can be referred to as human IgG4(S228P) kappa.Color and Shape:LiquidXC-12
XC-12 is an orally active, potent small-molecule inhibitor of CD73 (an immune checkpoint), with IC50 values of 12.36 nM for the soluble form and 1.29 nM for the membrane-bound form. XC-12 holds promise for cancer research.Color and Shape:Odour SolidIKZF-IN-1
IKZF-IN-1 (Compound I) is a molecular glue that degrades the karos zinc finger family proteins (IKZF) IKZF 1/2/3/4 and is used as an immune modulator in cancer and viral infection research.Formula:C26H28FN5O4Color and Shape:SolidMolecular weight:493.53PROTAC STING degrader-3
PROTACSTING degrader-3 (Compound ST9) is a STINGPROTAC-type degrader with a DC50 of 0.62 μM. It induces STING degradation via the ubiquitin-proteasome pathway. This compound exerts anti-inflammatory effects by inhibiting the STING/TBK1/NF-κB signaling. Additionally, it offers renal protection and can be used in research on acute kidney injury.Color and Shape:Odour SolidMik-β-1
Mik-Beta-1 is a human IgG1-kappa monoclonal antibody targeting IL2RB. For isotype control, refer to Human IgG1 kappa, Isotype Control. Mik-Beta-1 is applicable in research related to the prevention of allograft rejection.Color and Shape:Odour LiquidKTX-497
CAS:KTX-497, an IRAK4 degrader, demonstrates a potent DC50 value of 3 nM. It is utilized in oncology research[1].Formula:C45H49F3N8O6Color and Shape:SolidMolecular weight:854.92STING-IN-12
STING-IN-12 (compound Y2) acts as an inhibitor of STING. It suppresses IFNβ gene expression induced by SR717 with an IC50 of 0.75 μM. Additionally, STING-IN-12 inhibits STING pathway activation induced by the STING agonist SR717 in THP1 cells and by MSA-2 in mice.Color and Shape:Odour SolidPNT2001
CAS:PNT2001 (LY4181530) is an effective prostate-specific membrane antigen (PSMA) ligand with an IC50 of 3.1 nM. It enhances cellular internalization and, when labeled with 177Lu and 225Ac, is applicable for prostate cancer research.Formula:C85H107N15O32Color and Shape:SolidMolecular weight:1850.84Compstatin TFA
Compstatin TFA: 13-residue cyclic peptide, inhibits primate complement C3, species-specific, protease-resistant, IC50=63μM (classical), 12μM (alternative).Formula:C68H100F3N23O19S2Color and Shape:SolidMolecular weight:1664.79Fraxinellone analog 1
Fraxinellone analog 1 (compound 2) is an effective and rapid activator of the Nrf2-mediated antioxidative defense system, providing protection against glutamate-mediated excitotoxicity. It induces the expression of antioxidative genes Gpx4, Sod1, and Nqo1. Additionally, Fraxinellone analog 1 exerts neuroprotective effects and modulates oxidative stress and inflammation, making it suitable for research on neurodegenerative diseases.Color and Shape:Odour SolidNLRP3-IN-76
NLRP3-IN-76 is an orally active NLRP3 inhibitor that suppresses the production of NO and reduces the mRNA levels of pro-inflammatory cytokines (iNOS, IL-6, IL-1β, and TNFα). It exerts anti-inflammatory effects by inhibiting the activation of the NLRP3 inflammasome and the NF-κB signaling pathway. Furthermore, NLRP3-IN-76 can ameliorate DSS-induced colitis and is applicable for studying inflammatory bowel disease (IBD).Color and Shape:Odour SolidNasunin
CAS:Delphanin, also known as Nasunin, is an anthocyanin isolated as purple colored crystals from eggplant peels.Formula:C42H47ClO23Color and Shape:SolidMolecular weight:955.26S7
CAS:S7, an IL-6 receptor antagonist, prevents the interaction between IL-6 and IL-6R, thereby inhibiting angiogenesis and tumor growth [1].Formula:C37H70N10O10Color and Shape:SolidMolecular weight:815.01Iromycin A
CAS:Iromycin A: a bacterial metabolite inhibiting NOS III over NOS I, blocks NADH oxidation, IC50 = 0.461 µM.Formula:C19H29NO2Color and Shape:SolidMolecular weight:303.44CD73-IN-17
CD73-IN-17 (compound 19) is an inhibitor of CD73 with an IC50 of 0.1 μM against hCD73. It is applicable in cancer research.Color and Shape:Odour SolidAMY-101
CAS:AMY-101 TFA is a C3 complement inhibitor with high affinity (KD: 0.5 nM) and promising anti-inflammatory effects in severe COVID-19.Formula:C83H117N23O18S2Purity:98%Color and Shape:SolidMolecular weight:1789.111-Ethoxycarbonyl-β-carboline
CAS:1-Ethoxycarbonyl-β-carboline is a natural product for research related to life sciences. The catalog number is TN7072 and the CAS number is 72755-19-2.Formula:C28H23N4O4Color and Shape:SolidMolecular weight:479.516Amaroswerin
CAS:Amaroswerin, a secoiridoid glucoside, has anti-inflammatory, antidiabetic, and other medicinal properties; it inhibits NO release at IC50 of 5.42 μg/mL.Formula:C29H30O14Color and Shape:SolidMolecular weight:602.54CNTO4088
CNTO4088 is a monoclonal antibody inhibitor that targets interleukin-23 (IL-23). It holds potential for research in autoimmune diseases such as psoriasis and rheumatoid arthritis.Color and Shape:Odour LiquidOVA Peptide(257-264) TFA
CAS:OVA Peptide (257-264) TFA, an octameric peptide epitope from ovalbumin, is presented by the class I MHC molecule, H-2Kb, showcasing a class I (Kb)-restrictedFormula:C47H75F3N10O15Purity:98%Color and Shape:SolidMolecular weight:1077.15IL-1β-IN-1
CAS:IL-1β-IN-1, a cannabidiol derivative, acts as a potent inhibitor of IL-1β, exhibiting significant anti-inflammatory and pain relief properties [1].Formula:C22H34O2Color and Shape:SolidMolecular weight:330.58-Nitroguanine
CAS:8-Nitroguanine is a product of DNA nitration damage caused by reactive nitrogen species and may be a potential biomarker for the progression of malignantFormula:C5H4N6O3Color and Shape:SolidMolecular weight:196.12PSB-24000
PSB-24000 (Compound 27) is a selective ecto-5'-nucleotidase (CD73) inhibitor with a Ki value of 563 nM for inhibiting human CD73, and a Ki of 481 nM in membrane-bound CD73 in triple-negative breast cancer cells. It disrupts CD73’s recognition and action on substrate AMP, preventing AMP-induced immunosuppressive and pro-cancer adenosine production. PSB-24000 is promising for cancer research.Color and Shape:Odour SolidHPK1-IN-58
HPK1-IN-58 is an inhibitor of HPK1 (IC50: 2.6 nM) and SLP76 (IC50: 20 nM). It enhances IL-2 secretion, thereby reversing PGE2-induced immunosuppression. HPK1-IN-58 is applicable for research in antitumor immunity.Formula:C26H30N8OColor and Shape:SolidMolecular weight:470.25426Photosensitizer-4
Compound PS-I (Photosensitizer-4) is an effective photosensitizer that can efficiently kill cancer cells and inhibit tumor growth under light exposure.Color and Shape:Odour SolidMEDI-7836
MEDI-7836 is a humanized monoclonal antibody inhibitor that targets the interleukin-13 (interleukin-13 receptor) receptor. It shows potential for research into diseases associated with inflammation.Color and Shape:Odour LiquidAM-103 Free Acid
CAS:AM-103 Free Acid is a bio-active chemical.Formula:C36H39N3O4SColor and Shape:SolidMolecular weight:609.78ZL-1102
ZL-1102 is a humanized monoclonal antibody inhibitor targeting interleukin-17A (IL-17A). SCH-900117 is being investigated for its potential use in the treatment of autoimmune diseases such as psoriasis and rheumatoid arthritis.Color and Shape:Odour LiquidSTING-IN-14
CAS:STING-IN-14 is a STING inhibitor with an IC50 of 0.6 nM. It effectively suppresses the activation of the IRF pathway in THP1-DualTM cells. This compound is applicable in research related to autoimmune diseases.Formula:C46H43F2N11O5Color and Shape:SolidMolecular weight:867.901G3-C12
CAS:G3-C12 shows anticancer activity. is a galectin-3 binding peptide, with Kd of 88 nM.Formula:C74H115N23O23S2Purity:98%Color and Shape:SolidMolecular weight:1758.99FITC-labeled ODN TTAGGG sodium
FITC-labeled ODN TTAGGG (sodium) is an inhibitory oligonucleotide that functions as an antagonist of TLR9, AIM2, and cGAS.Color and Shape:Odour SolidTLR8 agonist 7
CAS:TLR8 agonist7 is an agonist of Toll-like receptor 8 (TLR8) with an EC50 of less than 250 nM. It remains stable in human and mouse plasma and induces the secretion of the cytokine TNFα with an EC50 of less than 1 μM. In the MC38-HER2 xenograft mouse model, TLR8 agonist7 demonstrates antitumor activity, achieving a tumor growth inhibition (TGI) rate of 98%.Formula:C54H63N9O16Color and Shape:SolidMolecular weight:1094.13(R)-Zadavotide guraxetan
CAS:Zadavotide guraxetan (PSMAI&T; PNT-2002) is an inhibitor of prostate-specific membrane antigen (PSMA) with potential antitumor activity, and it is useful for research targeting prostate cancer.Formula:C63H92IN11O23Color and Shape:SolidMolecular weight:1498.37N-decanoyl-L-Homoserine lactone
CAS:C10-HSL, an AHL from Pseudomonas cremoris ND07, stunts Arabidopsis roots by raising Ca2+, ROS, MPK6 activity, and NO levels.Formula:C14H25NO3Purity:99.92%Color and Shape:SolidMolecular weight:255.35Ref: TM-T37739
5mg44.00€1mL*10mM (DMSO)48.00€10mg71.00€25mg144.00€50mg234.00€100mg376.00€500mg853.00€Ubletamig
CAS:Ubletamig is a humanized IgG4κ monoclonal antibody that targets MUC16.Color and Shape:LiquidNLRP3-IN-46
NLRP3-IN-46 (Compound 3k) activates the cholinergic anti-inflammatory pathway involved in neuro-immune modulation, thereby inhibiting the activation of the NLRP3 inflammasome. Furthermore, NLRP3-IN-46 suppresses the production of IL-1β in THP-1 cells induced by Uric acid sodium, making it relevant for research in gouty arthritis.Color and Shape:Odour SolidTimosaponin E2
CAS:Timosaponin E2 is an anti-inflammatory agent that inhibits active oxygen production [1].Formula:C46H78O20Color and Shape:SolidMolecular weight:951.1L-156,602
CAS:L-156,602 has a wide range of applications in life science related research.Formula:C38H64N8O13Color and Shape:SolidMolecular weight:840.973MCI
MCI, a chemical compound demonstrating significant anti-inflammatory effects, particularly in collagen-induced arthritis (CIA) models, modulates inflammationFormula:C45H52ClN7O13Purity:98%Color and Shape:SolidMolecular weight:934.39NLRP3 modulators 1
CAS:Compound 107 (WO2017184746A1) is a potent NLRP3 modulator, useful for studying diseases linked to NLRP3 activity.Formula:C17H18N6OColor and Shape:SolidMolecular weight:322.372CD73-IN-16
CD73-IN-16 (compound 18) acts as an inhibitor of hCD73, exhibiting an IC50 value of 0.28 μM.Color and Shape:Odour SolidPF-06426779
CAS:PF-06426779 is a potent and selective inhibitor of interleukin 1 receptor associated kinase 4 (IRAK4) , with an IC 50 of 0.3 nM.Formula:C17H18FN3O4Color and Shape:SolidMolecular weight:347.346ZM640
ZM640 is an NLRP3 inhibitor that promotes IL-1β release mediated by NLRP3 inflammasome activation in THP-1 cells. It demonstrates low cytotoxicity.Formula:C28H36F3NO8SMolecular weight:603.21137QX-005N
QX 005N is a humanized monoclonal anti-CD124/IL4R/IL-4Rα antibody. It is applicable in research related to asthma.Color and Shape:Odour LiquidAnti-inflammatory agent 59
Anti-inflammatory agent 58 is characterized by its ability to inhibit IL-1β with an IC50 value of 2.28 μM.Color and Shape:Odour SolidSU1261
SU1261, an IKK inhibitor, exhibits Ki values of 10 nM for IKKα and 680 nM for IKKβ. It effectively inhibits non-canonical NF-κB signaling in U2OS osteosarcoma cells.Color and Shape:Odour SolidSericin
Sericin is a globular protein isolated from silkworm cocoons. It has cognitive enhancement and pain-relieving properties. Additionally, Sericin serves as a cryoprotectant, potentially replacing fetal bovine serum or dimethyl sulfoxide (DMSO). It helps reduce oxidative stress and reactive oxygen species (ROS). Sericin aids in wound repair by promoting collagen production and exhibits activities such as antioxidant, antidiabetic, antihyperlipidemic, anti-inflammatory, moisturizing, wound healing promotion, antibacterial, and antitumor effects.Color and Shape:Odour SolidhCYP1B1-IN-1
hCYP1B1-IN-1 (compound B18) is an inhibitor of hCYP1B1 with an IC50 value of 3.6 nM and also acts as an antagonist of the Aryl Hydrocarbon Receptor.Formula:C18H14ClF3O3Color and Shape:SolidMolecular weight:370.75HPK1-IN-57
HPK1-IN-57 (Compound 10c) is an inhibitor of hematopoietic progenitor kinase 1 (HPK1) with an IC50 of 0.09 nM. It suppresses the activity of HPK1 kinase, inhibits the phosphorylation of downstream adaptor protein SLP76 (IC50 of 33.74 nM), and effectively induces the secretion of the T cell activation marker IL-2 (EC50 of 84.24 nM). HPK1-IN-57 holds promise for research in tumor immunotherapy.Formula:C30H36F2N8O3Color and Shape:SolidMolecular weight:594.655NLRP3-IN-12
NLRP3-IN-12 inhibits NLRP3 inflammasome, curbing IL-1β release with 0.45 μM IC50, for inflammatory bowel disease research.Formula:C27H32ClNO7Color and Shape:SolidMolecular weight:518C2 Ceramide (d14:1/2:0)
CAS:C2 Ceramide (d14:1/2:0), a bioactive sphingolipid, causes lipotoxic cardiomyopathy when fed to Drosophila at 100 μM.Formula:C16H31NO3Color and Shape:SolidMolecular weight:285.42Prezalumab
CAS:Prezalumab (AMG 557) is a human IgG2 monoclonal antibody against ICOSL and BAFF.Purity:> 95%Color and Shape:LiquidMolecular weight:145.42 kDaCOX-2-IN-48
COX-2-IN-48 (5-25) serves as an inhibitor of COX-2, exhibiting an IC50 of 51.7 nM against human COX-2. It displays anti-inflammatory and analgesic effects in various rodent models through inhibition of the NF-κB pathway. COX-2-IN-48 (5-25) inhibits the degradation of IκB, phosphorylation and nuclear translocation of NF-κB p65, and the expression of COX-2 and iNOS.Color and Shape:Odour SolidBiotin-labeled ODN 1018 sodium
Biotin-labeled ODN 1018 (sodium), a TLR-9 agonist oligodeoxynucleotide, serves as a tool for assessing cellular uptake and localization of CpG ODNs throughColor and Shape:Odour SolidTLR8 agonist 8
CAS:TLR8 agonist8 (Compound II-72) is an agonist of Toll-like receptor 8 (TLR8) with an EC50 of 0.25-1 μM. It demonstrates stability in both human and mouse plasma and induces the secretion of the cytokine TNFα with an EC50 of less than 1 μM. In the MC38-HER2 xenograft mouse model, TLR8 agonist8 exhibits antitumor activity, achieving a tumor growth inhibition (TGI) rate of 89%.Formula:C53H63N11O10Color and Shape:SolidMolecular weight:1014.14PROTAC IRAK4 degrader-4
CAS:PROTAC IRAK4 degrader-4 is a targeted Cereblon-based molecule for degrading IRAK4.Formula:C41H38F3N11O10Color and Shape:SolidMolecular weight:901.817Balekafusp alfa
CAS:Balekafusp alfa is a human IgG1κ antibody targeting IL-2, known for its antitumor properties.Color and Shape:LiquidLL-37 GKE acetate
LL-37 GKE acetate, a peptide and active structural domain of LL-37, inhibits lps-induced vascular nitric oxide production,less toxic,antimicrobial，sepsis.Formula:C121H206N38O30Purity:99.88%Color and Shape:SolidMolecular weight:2673.17BCL6 PROTAC 1
CAS:BCL6 PROTAC 1: Selective BCL6 degrader, IC50 8.8 µM, used in DLBCL research.Formula:C45H52ClN9O12Color and Shape:SolidMolecular weight:946.4KTX-612
CAS:KTX-612 is a compound that serves as an orally active IRAK4 degrader, exhibiting a DC50 value of 7 nM. It is primarily utilized in oncology research [1].Formula:C46H51F3N8O6Color and Shape:SolidMolecular weight:868.94STING agonist-13
CAS:STING agonist-13 boosts cancer immunity by activating STING pathway, reducing tumors, and enhancing immune memory.Formula:C45H53N15O7Color and Shape:SolidMolecular weight:9165-LOX/sEH-IN-1
Compound 8o (5-LOX/sEH-IN-1) is a dual inhibitor with cardioprotective properties, targeting both 5-LOX and sEH with IC50 values of 3.05 μM and 2.20 nM respectively. It also inhibits the activity of COX-2 (IC50=10.50 μM). Possessing analgesic and anti-inflammatory properties, 5-LOX/sEH-IN-1 reduces ulcerogenicity, making it a potential candidate for developing anti-inflammatory agents with fewer gastrointestinal and cardiovascular side effects.Color and Shape:Odour SolidHis-Pro
CAS:His-Pro is a dipeptide consisting of histidyl and proline.Formula:C11H16N4O3Purity:98%Color and Shape:SolidMolecular weight:252.27TLR8 agonist 2 hydrochloride
CAS:TLR8 agonist 2 hydrochloride: potent for human TLR8 (EC50 3 nM), weak for TLR7 (EC50 33.33 μM).Formula:C16H22N8·xHClColor and Shape:SolidHPPD-IN-1
HPPD-IN-1 (compound II-3), a potent HPPD inhibitor, exhibits inhibitory activity against Arabidopsis thaliana HPPD (AtHPPD) with an IC50 of 0.248 μM, surpassingFormula:C12H6F3NO4Color and Shape:SolidMolecular weight:285.18Exosome Compound Library
76 exosome-related compounds that can be used for high-throughput and high-content screening.
Color and Shape:Odour Solid3-(2-Hydroxyethyl) thio withaferin A
3-(2-Hydroxyethyl) thio withaferin A, a steroidal lactone, blocks NF-kB, targets vimentin, and inhibits EPCR shedding.Formula:C30H44O7SColor and Shape:SolidMolecular weight:548.73BRD5075
BRD5075 is an effective activator of GPR65, stimulating the production of cAMP in a GPR65-dependent manner. Additionally, it reduces the gene expression of IL-1, IL-2, TNF, and chemokines. BRD5075 holds potential for researching multiple sclerosis and inflammatory bowel disease (IBD).Color and Shape:Odour SolidMTvkPABC-P5
MTvkPABC-P5d, functioning as a TLR7 agonist, serves as an immune stimulant and is utilized in the synthesis of immune-stimulating antibody conjugates (ISACs) [1Formula:C52H73N11O14Color and Shape:SolidMolecular weight:1076.2STING agonist-24
CAS:CF504: non-nucleotide STING agonist, boosts STING, TBK1, IRF3 phosphorylation; raises IFN-β, IL-6, CXCL-10, TNF-α; active against SARS-CoV strains.Formula:C34H37N13O5Color and Shape:SolidMolecular weight:707.74Mifamurtide
CAS:Mifamurtide is a drug against osteosarcoma, is an immunomodulator with antitumor effects.Formula:C59H109N6O19PPurity:98%Color and Shape:SolidMolecular weight:1237.5AB-680 ammonium
AB-680: potent, reversible CD73 inhibitor, Ki=4.9 pM, >10,000-fold selectivity vs CD39, anti-tumor.Formula:C20H30ClFN6O9P2Color and Shape:SolidMolecular weight:614.89TLR7 agonist 17
CAS:TLR7 agonist 17 (compound 20) functions as a highly effective TLR7 agonist, exhibiting EC 50 values of 12 nM for hTLR7 and 17 nM for mTLR7. Additionally, this compound has demonstrated anticancer activity [1].Formula:C25H37N7O3Color and Shape:SolidMolecular weight:483.61PROTAC STING degrader-4
PROTACSTING degrader-4 is a covalent STINGPROTAC degrader free of nitro groups, exhibiting a DC50 of 3.23 μM. It effectively inhibits STING and its downstream signaling pathways, including p-TBK1 and p-NF-κB (p-P65), as well as immune-inflammatory cytokines. Additionally, PROTACSTING degrader-4 mitigates renal and blood inflammation in mouse models of Cisplatin-induced acute kidney injury (AKI).Formula:C39H42Cl2N8O9Color and Shape:SolidMolecular weight:836.24518M133 peptide
The M133 peptide is a coronavirus-specific CD4 T cell epitope. In mice infected with the neurotropic coronavirus (strain JHM of mouse hepatitis virus), the M133 peptide demonstrates immunodominance. It activates CD4 T cells by forming an MHC/peptide complex through binding with MHC II molecules, which is recognized by specific TCRs.Formula:C84H130N20O25Molecular weight:1818.9516FSL-1
CAS:TLR2/6 agonist, may bind TLR10. Activates NF-κB, triggers IL-8, IL-1β, CCL20, TNF-α. Boosts IFNγ-induced CXCL10 in melanoma.Formula:C84H140N14O18SPurity:98%Color and Shape:SolidMolecular weight:1666.16Firefly luciferase-IN-1
CAS:(E)-6-(4-methylbenzylidene) tetrahydronaphthone is a firefly luciferase inhibitor.Formula:C19H16O3Purity:99.90%Color and Shape:SolidMolecular weight:292.33Ref: TM-T9943
1mg109.00€1mL*10mM (DMSO)225.00€5mg235.00€10mg349.00€25mg532.00€50mg745.00€100mg999.00€200mg1,333.00€HNW005
HNW005 is a dual inhibitor targeting the NLRP3 inflammasome and urate transporter 1 (URAT1). It exhibits an inhibition constant (KD) of 204.6 nM and an IC50 of 1.7 μM for NLRP3 inflammasome activation, while demonstrating an IC50 of 6.4 μM for inhibiting uric acid transmembrane transport. At an administered dose of 2 mg/kg in vivo, HNW005 achieves a uric acid reduction rate of 64.8%, effectively providing anti-inflammatory, analgesic, and urate-lowering effects by inhibiting NLRP3 inflammasome activation and uric acid transport. HNW005 is applicable for research in gouty arthritis.Color and Shape:Odour SolidKetoprofen lysine salt
CAS:Ketoprofen lysine salt is a lysine salt of ketoprofen, a Non-Steroidal Anti-Inflammatory DrugFormula:C22H28N2O5Color and Shape:SolidMolecular weight:400.48BR102910
CAS:BR102910: Selective FAP inhibitor, features 4-thiazolecarboxamide with cyano-difluoro-pyrrolidine and dichlorophenyl elements.
Formula:C18H14Cl2F2N4O2SPurity:97%Color and Shape:SolidMolecular weight:459.3SIN 14
SIN 14 is an HO-1 activator that targets and activates HO-1 through an allosteric mechanism. Additionally, SIN 14 can induce the polarization of macrophages from the M1 phenotype to the M2 phenotype.Formula:C20H22ClNO4Color and Shape:SolidMolecular weight:375.12374
