Immunology and Inflammation

<p>Chitoheptaose heptahydrochloride, a chitosan derivative, enhances wheat growth and photosynthesis, with health-protective traits.</p>

TBK1/IKKε-IN-6 (example 110) is a potent inhibitor of TBK1 and IKKε, with IC50 values of less than 100 nM for both enzymes.

BCL6 PROTAC 1: Selective BCL6 degrader, IC50 8.8 µM, used in DLBCL research.

MTvkPABC-P5d TFA, a TLR7 agonist, functions as an immune stimulant. It is applicable in the synthesis of immune-stimulating antibody conjugates (ISAC).

PSMA–DA1 may be a useful PSMA-targeting radiotheranostic agent.

AM-103 Free Acid is a bio-active chemical.

Ripertamab (SCT-400) is a recombinant human-mouse chimeric monoclonal antibody that targets CD20 and is cytotoxic.

Efmarodocokin alfa, IL-22/IgG4 fusion protein, activates IL-22 pathways, researched for severe COVID-19 pneumonia.

IFN-α Receptor Recognition Peptide 1, associated with receptor interactions, is a peptide of IFN-α.

PROTAC IRAK4 degrader-2 reduces IRAK4 in PBMCs with a DC50 of 36 nM and inhibits cytokines.

Anti bacterial agent 237 (compound Ru-8) acts as a potent antibacterial agent against Staphylococcus aureus, exhibiting minimum inhibitory concentrations (MICs) ranging from 0.78 to 1.56 μg/mL. It works by disrupting bacterial cell membranes, altering their permeability, and inducing the production of reactive oxygen species, which leads to bacterial cell death without promoting resistance. Additionally, Anti bacterial agent 237 demonstrates low hemolytic toxicity towards rabbit erythrocytes and Raw 264.7 cells. It has shown significant antibacterial activity in models of skin wound infections in mice and larval infections by the greater wax moth, effectively combating Staphylococcus aureus infections.

PSMAbinder-3 is a ligand for PSMA.

Ladanetin-6-O-β-D-glucopyranoside, an active flavonoid, exhibits antioxidative effects and has potential for research into cardioprotective effects [1].

(Rac)-γ-Tocopherol (DMPBQ) is an isoform of Vitamin E that undergoes conversion to γ-Tocopherol through the action of tocopherol cyclase.

Tuparstobart (Incagn-02385) is an IgG1κ monoclonal antibody that targets the immune checkpoint receptor protein LAG-3, which is predominantly expressed on

Clazakizumab: monoclonal antibody targeting IL-6, may inhibit COVID-19 cytokine response, researched for PsA and renal rejection.

PSMA-IN-2, an inhibitor of PSMA with a K i value of 1.07 nM, exhibits favorable in vivo NIR imaging (λ EM = 1088 nm, λ ex = 808 nm) and is useful for NIRII image-guided tumor resection surgery in PSMA-positive tumor-bearing mice [1].

<p>Benz-AP: potent photosensitizer, creates singlet oxygen, more toxic in low hCES2 cancer cells, generates ROS via TPE to kill tumors.</p>

Mipeginterferon alfa-2b, an IFNA2b analogue, has 5 modified amino groups out of 11 and weighs 40 kDa.

Somantadine has antiviral activities and can be used for research on preventing and treating coronavirus-related diseases.