Immunology and Inflammation
Immunology and inflammation inhibitors are compounds that modulate the immune response and inflammatory processes. These inhibitors are crucial in studying the mechanisms of immune regulation, autoimmunity, and chronic inflammation, as well as in developing treatments for inflammatory diseases, allergies, and immune-related disorders. By targeting key pathways in the immune system, these inhibitors can help reduce excessive or inappropriate immune responses. At CymitQuimica, we provide a comprehensive selection of high-quality immunology and inflammation inhibitors to support your research in immunology, inflammation, and therapeutic development.
Subcategories of "Immunology and Inflammation"
- CCR(135 products)
- CXCR(154 products)
- Cell wall(5 products)
- IL Receptor(85 products)
- IκB/IKK(58 products)
- LTR(3 products)
- MALT(25 products)
- MRP(6 products)
- NADPH-oxidase(1 products)
- NF-κB(407 products)
- NOD(23 products)
- NOS(61 products)
- Nrf2(82 products)
- PGE Synthase(31 products)
- ROS(70 products)
- TGF-beta/Smad(50 products)
- TLR(73 products)
- Thioredoxin(12 products)
- gp120/CD4(2 products)
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Found 3260 products of "Immunology and Inflammation"
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LHC-165
CAS:LHC-165 is an agonist of TLR7. It also has the potential to treat solid tumors.Formula:C29H32F2N3O7PPurity:98%Color and Shape:SolidMolecular weight:603.55IKZF1-degrader-2
CAS:IKZF1-degrader-2 (Compound 3), an IKZF1 degrader, exhibits anticancer activity and low toxicity [1].Formula:C33H30FN5O5Color and Shape:SolidMolecular weight:595.62SB24011
CAS:SB24011, a STING-TRIM29 interaction inhibitor, has an IC₅₀ value of 3.85 μM. It boosts STING immunity by upregulating STING protein levels, thereby enhancing the immunotherapeutic effects of STING agonists and anti-PD-1 antibodies through systemic anticancer immunity [1].Formula:C34H38N4O7Color and Shape:SolidMolecular weight:614.69SARM1-IN-5
CAS:SARM1-IN-5 (compound 1-23-a) is an inhibitor of SARM1, useful for researching diseases related to axonal degeneration, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS).Formula:C18H17FN6OColor and Shape:SolidMolecular weight:352.37TE-11
CAS:TE-11 is a MIF tautomerase inhibitor with an IC50 of 5.63 μM. This compound can alleviate Crohn's-like colitis, reduce MIF-induced migration of eosinophils and neutrophils, and prevent M1 polarization and associated metabolic reprogramming.Formula:C16H13NOColor and Shape:SolidMolecular weight:235.28Antibacterial agent 259
CAS:Antibacterialagent 259 (K3) is a bactericide with EC50 values of 1.5, 1.7, and 4.9 mg/L against Xoo, Xoc, and Xac, respectively. It induces the production of reactive oxygen species (ROS) in pathogens, leading to their death. Antibacterialagent 259 is applicable in research for controlling bacterial diseases in plants.Formula:C7H6ClN3O2SColor and Shape:SolidMolecular weight:231.659Refinicopan
CAS:Refinicopan is a complement factor D inhibitor with an IC50 of 10 nM, demonstrating an inhibition activity on rabbit erythrocyte hemolysis with an IC50 of 41 nM. It possesses excellent pharmacokinetic and pharmacodynamic properties.Formula:C29H32N2O3Color and Shape:SolidMolecular weight:456.58IRAK4-IN-12
IRAK4-IN-12 (compound 37) is a potent inhibitor of IRAK4 (IC50: 0.015 μM) with cellular pIRAK4 potency (IC50: 0.5 μM).Formula:C24H31FN8OColor and Shape:SolidMolecular weight:466.55ALR-27
CAS:ALR-27 serves as an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP and exhibits anti-inflammatory properties. It effectively inhibits 5-LOX product formation (>80%) in pro-inflammatory M1-MDM without significantly inhibiting 5-LOX directly. Additionally, ALR-27 decreases prostaglandin and leukotriene (LT) production in neutrophils and enhances the production of specialized prolytic mediators in certain human macrophage phenotypes [1].Formula:C19H22O3Color and Shape:SolidMolecular weight:298.38CD73-IN-19
CAS:CD73-IN-19 (Compound 4ab) is an inhibitor of CD73, demonstrating a 44% inhibition rate of CD73 enzyme activity at 100 μM. It entirely counters T cell proliferation blockade triggered by TCR activation (induced by CD73 activity) at 10 μM and 100 μM and inhibits hA2A receptor activity in HEK-293 cells with a Ki of 3.31 μM. CD73-IN-19 holds potential for research in the field of immune diseases.
Formula:C18H17N3O3SColor and Shape:SolidMolecular weight:355.411MAO-B-IN-7
MAO-B-IN-7 inhibits MAO-B/AChE, crossing the blood-brain barrier; IC50: 41/87 nM (h/eel AChE), 0.3 μM (MAO-B). Reduces oxidative stress and neuroinflammation.Formula:C25H31NO4Color and Shape:SolidMolecular weight:409.52ODN 21158
CAS:ODN 21158 is a potent, non-cytotoxic inhibitor of G-modified TLR3 and TLR9. ODN 21158 dose-dependently inhibits IFN-α secretion.Color and Shape:SolidhDDAH-1-IN-2 sulfate
hDDAH-1-IN-2: selective oral hDDAH-1 inhibitor with low cell toxicity.Formula:C8H24N4O10S2Color and Shape:SolidMolecular weight:400.43STING agonist-43
CAS:STINGagonist-43 (Compound 67) is a selective STING agonist with an EC50 of 20.53 μM. It selectively enhances the cGAMP-dependent STING pathway activation by modulating STING oligomerization. STINGagonist-43 demonstrates antitumor activity in a B16.F10 mouse melanoma model and can be utilized in cancer immunotherapy research.Formula:C21H23NO4Color and Shape:SolidMolecular weight:353.41CYP1B1-IN-10
CAS:CYP1B1-IN-10 (Compound 15C) is a highly selective inhibitor of human cytochrome P450 1B1 (hCYP1B1) with an IC50 value of 0.11 μM. It shows promise for use in research focused on hormone-dependent tumors, including breast and ovarian cancers.Formula:C23H18N2Color and Shape:SolidMolecular weight:322.40IRAK4-IN-14
CAS:IRAK4-IN-14 is a selective, potent, orally active IRAK4 inhibitor (IC50: 0.003 μM) with favorable PK parameters in rats and mice. effect.Formula:C25H28FN9OColor and Shape:SolidMolecular weight:489.55CD73-IN-13
CD73-IN-13, a potent CD73 inhibitor, may be developed for tumor-related disease treatment.Formula:C13H11F3N4O2Color and Shape:SolidMolecular weight:312.25STING agonist-21
CAS:STING agonist-21 (compound 1), possessing an EC 50 of 592.8 nM, functions as a STING agonist. It is applicable in cancer research [1].Formula:C17H11F6N5O2Color and Shape:SolidMolecular weight:431.29Anti-inflammatory agent 102
CAS:Anti-inflammatory agent 102 (Compound 11a) is an orally effective anti-inflammatory compound. It exerts its effects by inhibiting the activation of the ASK1/p38 MAPKs/NF-κB signaling pathway. This agent displays significant anti-inflammatory activity by suppressing the release of NO, ROS, and inflammatory cytokines such as IL-6, TNF-α, and IL-1β. Anti-inflammatory agent 102 is applicable in research concerning inflammatory diseases, including ulcerative colitis (UC).Formula:C16H16ClN3O3Color and Shape:SolidMolecular weight:333.77MALT1-IN-5
CAS:MALT1-IN-5 is a potent inhibitor of the MALT1 protease and can be used in cancer research.Formula:C17H17ClF2N6O3Color and Shape:SolidMolecular weight:426.80
