Immunology and Inflammation
Immunology and inflammation inhibitors are compounds that modulate the immune response and inflammatory processes. These inhibitors are crucial in studying the mechanisms of immune regulation, autoimmunity, and chronic inflammation, as well as in developing treatments for inflammatory diseases, allergies, and immune-related disorders. By targeting key pathways in the immune system, these inhibitors can help reduce excessive or inappropriate immune responses. At CymitQuimica, we provide a comprehensive selection of high-quality immunology and inflammation inhibitors to support your research in immunology, inflammation, and therapeutic development.
Subcategories of "Immunology and Inflammation"
- CCR(142 products)
- CXCR(159 products)
- Cell wall(5 products)
- IL Receptor(110 products)
- IκB/IKK(59 products)
- LTR(2 products)
- MALT(25 products)
- MRP(6 products)
- NADPH-oxidase(1 products)
- NF-κB(443 products)
- NOD(18 products)
- NOS(61 products)
- Nrf2(82 products)
- PGE Synthase(31 products)
- ROS(70 products)
- TGF-beta/Smad(60 products)
- TLR(76 products)
- Thioredoxin(12 products)
- gp120/CD4(4 products)
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Found 3365 products of "Immunology and Inflammation"
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TBK1/IKKε-IN-1
CAS:TBK1/IKKε-IN-1 is a dual inhibitor of TBK1 and IKKε (IC50s of <100 nM).Formula:C28H26N4O5Purity:98%Color and Shape:SolidMolecular weight:498.53CPDT
CAS:CPDT is an orally active and potent inducer of phase 2 enzymes as well as an activator of Nrf2. CPDT enhances the activity of critical phase 2 enzymes, such as glutathione S-transferase, NAD(P)H:quinone oxidoreductase 1, and gamma-glutamylcysteine synthetase, and increases glutathione levels both in the bladder of rats and in bladder cells in vitro.Formula:C6H6S3Color and Shape:SolidMolecular weight:174.307α-Gracinoic acid
CAS:α-Gracinoic acid acts as an inhibitor of mPGES-1, exhibiting anti-inflammatory properties.Formula:C29H42O4Color and Shape:SolidMolecular weight:454.64IRAK4 modulator-1
CAS:IRAK4 Modulator-1 (example 161), an IRAK4 modulator with an IC50 of 4.647 μM, is employed in the investigation of IRAK-mediated disorders [1].Formula:C19H13ClN4O2Color and Shape:SolidMolecular weight:364.79Galectin-3-IN-2
Galectin-3-IN-2 inhibits galactose lectin-3 (Gal-3) with an 8.3 μM IC50, impacting cancer-related metabolism.Formula:C24H30FN3O10SColor and Shape:SolidMolecular weight:571.57COX-1/2-IN-2
COX-1/2-IN-2, a potent dual inhibitor, has IC50s: COX-1 at 9.7μM & COX-2 at 4.6μM.Formula:C15H10ClIN2OColor and Shape:SolidMolecular weight:396.61Galectin-8-IN-1
Galectin-8-IN-1 selectively binds galectin-8N with 48 μM affinity, 15x more than galectin-3.Formula:C16H18N2O6Color and Shape:SolidMolecular weight:334.32RuDiOBn
CAS:<p>RuDiOBn exhibits low antioxidant activity by scavenging DPPH and ABTS free radicals with scavenging rates of 13.2% and 5.9% at a concentration of 100 μg/mL. It inhibits collagen glycation and reduces the formation of advanced glycation end-products (AGE) with an IC50 of 2.45 μg/mL. RuDiOBn also enhances fibroblast proliferation and migration, stimulates collagen synthesis, and aids in skin repair and regeneration while inhibiting collagenase.</p>Formula:C29H22O7Color and Shape:SolidMolecular weight:482.481IKZF1-degrader-2
CAS:IKZF1-degrader-2 (Compound 3), an IKZF1 degrader, exhibits anticancer activity and low toxicity [1].Formula:C33H30FN5O5Color and Shape:SolidMolecular weight:595.62COX-2-IN-12
COX-2-IN-12: Potent, selective COX-2 inhibitor, IC50=19.98μM, safe anti-inflammatory with low acute toxicity.Formula:C17H19NO3Color and Shape:SolidMolecular weight:285.34SB24011
CAS:SB24011, a STING-TRIM29 interaction inhibitor, has an IC₅₀ value of 3.85 μM. It boosts STING immunity by upregulating STING protein levels, thereby enhancing the immunotherapeutic effects of STING agonists and anti-PD-1 antibodies through systemic anticancer immunity [1].Formula:C34H38N4O7Color and Shape:SolidMolecular weight:614.69TE-11
CAS:TE-11 is a MIF tautomerase inhibitor with an IC50 of 5.63 μM. This compound can alleviate Crohn's-like colitis, reduce MIF-induced migration of eosinophils and neutrophils, and prevent M1 polarization and associated metabolic reprogramming.Formula:C16H13NOColor and Shape:SolidMolecular weight:235.28Cyclic-di-GMP sodium
c-di-GMP sodium: STING activator, regulates bacteria biofilm, motility, virulence.Formula:C20H24N10NaO14P2Color and Shape:SolidMolecular weight:713.08464COX-2-IN-10
COX-2-IN-10 is a potent COX-2 inhibitor, reducing IL-6, TNF-α, IL-1β, PGE2 (IC50=2.54 μM), and iNOS expression.Formula:C31H32FN5O2SColor and Shape:SolidMolecular weight:557.68Amilo-5MER
CAS:Amilo-5MER (5-MP) is an orally active and selective inhibitor of serum amyloid A (SAA). It specifically suppresses the release of pro-inflammatory cytokines IL-6 and IL-1β in SAA-activated cells. Amilo-5MER reduces chronic inflammation and alleviates symptoms of diseases such as rheumatoid arthritis (RA), inflammatory bowel disease (IBD), and multiple sclerosis (MS). It holds potential for research in autoimmune and chronic inflammatory diseases.Formula:C23H40N6O9SColor and Shape:SolidMolecular weight:576.664cGAS-IN-4
CAS:cGAS-IN-4 (Compound 36) is an orally active inhibitor of cyclic GMP-AMP synthase (cGAS) with IC50 values of 32 nM for human cGAS (h-cGAS) and 5.8 nM for mouse cGAS (m-cGAS). In THP-1 cells, cGAS-IN-4 inhibits cGAMP with an IC50 of 60 nM, enhancing cellular potency. Additionally, cGAS-IN-4 exhibits anti-inflammatory effects in a mouse model of Concanavalin A-induced acute liver injury.Formula:C19H18Cl2N4O3Color and Shape:SolidMolecular weight:421.277IRAK4-IN-30
CAS:<p>IRAK4-IN-30 (Compound I) is an inhibitor of IRAK4, with an IC50 of 0.6 nM.</p>Formula:C27H33N5O5Color and Shape:SolidMolecular weight:507.581mPGES1-IN-5
CAS:mPGES1-IN-5 (compound 18) is a multi-substituted pyrimidine compound that acts as a submicromolar inhibitor of PGE2 production. It primarily exerts its anti-inflammatory effects by inhibiting mPGES-1 and demonstrates significant inhibitory activity in vivo against acute inflammation models.Formula:C27H27N3OColor and Shape:SolidMolecular weight:409.52NLRP3-IN-7
NLRP3-IN-7 (Compound 36) is a selective inhibitor of the NLRP3 inflammasome and is able to assemble the NLRP3 inflammasome.Formula:C18H15ClN2O4S3Color and Shape:SolidMolecular weight:454.97WK692
CAS:Compound WK692 (compund WK692) is a BCL6 inhibitor that effectively suppresses the growth of diffuse large B-cell lymphoma cells without toxic side effects and acts synergistically with inhibitors of EZH2 and PRMT5.Formula:C26H28Br2N8O5Color and Shape:SolidMolecular weight:692.36
