Immunology and Inflammation
Immunology and inflammation inhibitors are compounds that modulate the immune response and inflammatory processes. These inhibitors are crucial in studying the mechanisms of immune regulation, autoimmunity, and chronic inflammation, as well as in developing treatments for inflammatory diseases, allergies, and immune-related disorders. By targeting key pathways in the immune system, these inhibitors can help reduce excessive or inappropriate immune responses. At CymitQuimica, we provide a comprehensive selection of high-quality immunology and inflammation inhibitors to support your research in immunology, inflammation, and therapeutic development.
Subcategories of "Immunology and Inflammation"
- CCR(142 products)
- CXCR(159 products)
- Cell wall(5 products)
- IL Receptor(110 products)
- IκB/IKK(59 products)
- LTR(2 products)
- MALT(25 products)
- MRP(6 products)
- NADPH-oxidase(1 products)
- NF-κB(444 products)
- NOD(18 products)
- NOS(61 products)
- Nrf2(82 products)
- PGE Synthase(31 products)
- ROS(70 products)
- TGF-beta/Smad(60 products)
- TLR(76 products)
- Thioredoxin(12 products)
- gp120/CD4(4 products)
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Found 3366 products of "Immunology and Inflammation"
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ASP-8731
CAS:ASP8731 is a selective inhibitor of BACH1 that prevents inflammation and vascular occlusion, and induces fetal hemoglobin in sickle cell disease.Formula:C20H21N5O4Color and Shape:SolidMolecular weight:395.41Antioxidant agent-3
Antioxidant agent-3 shows strong DPPH and ABTS+ radical scavenging (IC50: 26.58, 30.31 μM). Boosts ROS, SOD, GSH; lowers LDH in H2O2-exposed HepG2 cells.Formula:C18H14O8Color and Shape:SolidMolecular weight:358.3(S)-MALT1-IN-5
CAS:(S)-MALT1-IN-5: Potent MALT1 protease inhibitor, may help in abnormal T/B-cell signalling and MALT1-linked diseases.Formula:C17H17ClF2N6O3Color and Shape:SolidMolecular weight:426.80STING-IN-11
CAS:STING-IN-11 is a potent, orally bioavailable STING inhibitor (IC₅₀ = 37.8 nM) that blocks STING protein palmitoylation and downstream signaling.Formula:C21H20ClF2N3OPurity:99.84%Color and Shape:SolidMolecular weight:403.85COX-2/PI3K-IN-1
COX-2/PI3K-IN-1 (compound 5d) is a potent inhibitor of PI3K (IC50: 1.14 nM). COX-2/PI3K-IN-1 is a selective inhibitor of COX-2 (Ki: 3.24 nM).Formula:C19H14ClN5S2Color and Shape:SolidMolecular weight:411.93SARM1-IN-4
CAS:SARM1-IN-4 (Compound 7) is an orally active SARM1 inhibitor that reduces plasma neurofilament light chain (NfL) levels in a mouse model following a 50 mg/kg oral dose. By inhibiting the NAD+ hydrolase activity of SARM1, it prevents programmed axon degeneration, making it useful for research in neurodegenerative and neurological diseases such as multiple sclerosis, amyotrophic lateral sclerosis, Parkinson's disease, and peripheral neuropathy.Formula:C13H17F2N3O2Color and Shape:SolidMolecular weight:285.29SLC7A11-IN-2
CAS:SLC7A11-IN-2 (Compound 1) is an inhibitor of SLC7A11/xCT. It disrupts the oxidative balance in HeLa cells by decreasing intracellular glutathione levels and increasing oxidative stress, thereby inducing cell death with an IC50 of 10.23 μM. Molecular dynamics simulations have demonstrated that SLC7A11-IN-2 exhibits a stronger binding affinity to SLC7A11 compared to Erastin. This compound is useful for research in the field of cervical cancer.Formula:C19H24N4O3Color and Shape:SolidMolecular weight:356.42HG-12-6
CAS:HG-12-6 is a type II IRAK4 inhibitor, targeting its inactive form with an IC50 of 165 nM, and is used in autoimmunity and inflammation.Formula:C29H27F3N6O2SPurity:98%Color and Shape:SolidMolecular weight:580.62BMY-25551
CAS:BMY-25551, a Mitomycin A analog, exhibits cytotoxicity 8 to 20 times greater than Mitomycin C against both murine and human tumor cell lines. It is applicable in research pertaining to cancer and hematological disorders.Formula:C17H21N3O7Color and Shape:SolidMolecular weight:379.36AIM4
CAS:<p>AIM4 is a compound known for inhibiting TDP-43 aggregation. It demonstrates good biocompatibility and anti-inflammatory activity, making it a valuable agent in research for diseases such as amyotrophic lateral sclerosis (ALS).</p>Formula:C25H23Br2N5O4Color and Shape:SolidMolecular weight:617.289Nrf2 activator-6
CAS:Nrf2 activator-6, a tetrahydroisoquinoline, inhibits Kelch-Nrf2 at 5 nM IC50 (WO2021214470A1).Formula:C31H37ClFN5O5Color and Shape:SolidMolecular weight:614.11ALR-27
CAS:<p>ALR-27 serves as an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP and exhibits anti-inflammatory properties. It effectively inhibits 5-LOX product formation (>80%) in pro-inflammatory M1-MDM without significantly inhibiting 5-LOX directly. Additionally, ALR-27 decreases prostaglandin and leukotriene (LT) production in neutrophils and enhances the production of specialized prolytic mediators in certain human macrophage phenotypes [1].</p>Formula:C19H22O3Color and Shape:SolidMolecular weight:298.38CD73-IN-12
CD73-IN-12, a compound from CN114437038A, shows strong anti-tumor activity by effectively inhibiting CD73 enzyme.Formula:C17H14F2N4O2Color and Shape:SolidMolecular weight:344.32Methoxyurea
CAS:Methoxyurea (Compound 3) is a potential modulator of nitric oxide (NO) donors, interacting with hemoglobin forms such as oxyhemoglobin (OxyHb) and methemoglobin (MetHb). It holds promise for use in research on sickle cell disease (SCD).Formula:C2H6N2O2Color and Shape:SolidMolecular weight:90.081COX-2-IN-9
COX-2-IN-9: potent oral COX-2 blocker, selective over Celecoxib, IC50 10.17 μM, less ulcers, strong anti-inflammatory.Formula:C25H23N5O4S2Color and Shape:SolidMolecular weight:521.61COX-2/NO-IN-1
COX-2/NO-IN-1: oral iNOS & NO blocker (IC50=3.52μM), COX-2 supressor, anti-inflammatory, protects kidneys.Formula:C15H15NO3Color and Shape:SolidMolecular weight:257.28Anti-inflammatory agent 6
Anti-inflammatory agent 6 blocks IKKα/β, IκBα, and NF-κB p65 phosphorylation, key to controlling inflammation.Formula:C22H20O12Color and Shape:SolidMolecular weight:476.39(R)-Ketoprofen
CAS:(R)-Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) that exhibits oral activity and analgesic properties. Unlike its counterpart, (R)-Ketoprofen does not significantly enhance the increase of inflammatory cytokines (such as Tumor Necrosis Factor (TNF) and Interleukin-1 (IL-1)) induced by LPS. However, it can inhibit the anti-inflammatory activity of (S)-Ketoprofen.Formula:C16H14O3Color and Shape:SolidMolecular weight:254.28OP-5244 sodium
OP-5244 sodium: potent oral CD73 inhibitor (IC50: 0.25 nM), potential in cancer research by hindering adenosine, reversing immunosuppression.Formula:C19H28ClN5NaO9PColor and Shape:SolidMolecular weight:559.87COX-2-IN-13
COX-2-IN-13 is a potent, selective COX-2 inhibitor with 0.98 μM IC50; shows strong anti-inflammatory properties and low acute toxicity.Formula:C19H18N2O5SColor and Shape:SolidMolecular weight:386.42
