NF-κB
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a transcription factor that regulates the expression of genes involved in immune responses, inflammation, cell survival, and proliferation. NF-κB is activated in response to various stimuli, including cytokines, pathogens, and stress signals. Dysregulation of NF-κB signaling is associated with chronic inflammatory diseases, cancer, and autoimmune disorders. At CymitQuimica, we offer a comprehensive selection of NF-κB pathway modulators to support your research in inflammation, oncology, and immune regulation.
Found 445 products of "NF-κB"
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Dihydroartemisinin
CAS:<p>Dihydroartemisinin (Artenimol) is an antimalarial drug. High-Quality, Low-Cost!</p>Formula:C15H24O5Purity:98% - 99.41%Color and Shape:White SolidMolecular weight:284.35GLPG2534
CAS:<p>GLPG2534 is an orally active, selective and potent IRAK4 inhibitor with anti-inflammatory activity. GLPG2534 can be used in psoriasis and atopic dermatitis.</p>Formula:C21H24N6O4Purity:99.51% - 99.61%Color and Shape:SolidMolecular weight:424.45CDDO-dhTFEA
CAS:<p>CDDO-dhTFEA, a synthetic oleanane triterpenoid, effectively activates Nrf2 while inhibiting the NF-κB pro-inflammatory transcription factor.</p>Formula:C33H45F3N2O3Purity:95.61% - 99.59%Color and Shape:SolidMolecular weight:574.72Mangiferin
CAS:<p>Mangiferin (Hedysarid) is used for antidiabetes. Extracted from Mangifera indica L.</p>Formula:C19H18O11Purity:99.78% - 99.86%Color and Shape:Light Yellow PowderMolecular weight:422.34Nimbolide
CAS:<p>Nimbolide, from neem, inhibits CDK4/6, NF-κB, Wnt, PI3K-Akt, MAPK, JAK-STAT pathways and induces apoptosis.</p>Formula:C27H30O7Purity:95.84% - 99.4%Color and Shape:SolidMolecular weight:466.52TBK1/IKKε-IN-2
CAS:<p>TBK1/IKKε-IN-2 is a dual inhibitor of TBK1 and IKKε.</p>Formula:C26H27N5O3Purity:98.89%Color and Shape:SolidMolecular weight:457.52α-Lipoic Acid
CAS:<p>α-Lipoic Acid, a sulfur-containing octanoic acid derivative, is biosynthesized from linoleic acid and used in dietary supplements.</p>Formula:C8H14O2S2Purity:98.39% - 99.73%Color and Shape:Forms Yellowish Flakes Light Yellow To Yellow PowderMolecular weight:206.33GSK3145095
CAS:<p>GSK3145095 is an orally active inhibitor of RIPK1 with IC50 of 5 nM, with potential immunomodulatory activities and antineoplastic.</p>Formula:C20H17F2N5O2Purity:99.50%Color and Shape:SolidMolecular weight:397.38Sulfasalazine
CAS:<p>Sulfasalazine (Azulfidine) is a synthetic salicylic acid derivative. Sulfasalazine induces ferroptosis and inhibits NF-κB. Cost effective and quality assured.</p>Formula:C18H14N4O5SPurity:98.00% - 99.28%Color and Shape:Minute Brownish-Yellow CrystalsMolecular weight:398.39Sinomenine hydrochloride
CAS:<p>Sinomenine hydrochloride (Kukoline hydrochloride) is extracted from Sinomenium Acutum Rehderett Wilson.</p>Formula:C19H24ClNO4Purity:99.43%Color and Shape:SolidMolecular weight:365.851Aspirin
CAS:<p>Aspirin (Acetylsalicylic Acid) is a COX inhibitor. Aspirin has anti-inflammatory, antipyretic and analgesic activities. Cost-effective and quality-assured.</p>Formula:C9H8O4Purity:99.78% - 99.91%Color and Shape:White Solid CrystallineMolecular weight:180.16RIPK1-IN-7
CAS:<p>RIPK1-IN-7: Strong, selective RIPK1 inhibitor (Kd=4 nM, IC50=11 nM) with great antimetastasis effects in B16 melanoma.</p>Formula:C25H22F3N5O2Purity:98.02% - 98.18%Color and Shape:SolidMolecular weight:481.47IRAK4-IN-4
CAS:<p>IRAK4-IN-4 (compound 15) inhibits cyclic GMP-AMP synthase (cGAS) with an IC50 of 2.1 nM.IRAK4-IN-4 is an interleukin-1 receptor–associated kinase 4 (IRAK4)</p>Formula:C22H16N2O2Purity:99.52%Color and Shape:SolidMolecular weight:340.37Urolithin B
CAS:<p>Urolithin B is one of the gut microbial metabolites of ellagitannins and is found in diverse plant foods, including pomegranates, berries, walnuts, tropical</p>Formula:C13H8O3Purity:99.45%Color and Shape:SolidMolecular weight:212.2Guaiacol
CAS:<p>Guaiacol, a flavorant precursor, has medicinal uses and serves as an oxygen indicator turning yellow-brown at 470 nm.</p>Formula:C7H8O2Purity:99.95%Color and Shape:Colourless To Pale Yellow Solid CrystallineMolecular weight:124.14Methylthiouracil
CAS:<p>Methylthiouracil (NSC-193526) is a thiourea antithyroid agent that inhibits the synthesis of thyroid hormone, and it is used to treat hyperthyroidism.</p>Formula:C5H6N2OSPurity:99.89% - >99.99%Color and Shape:Crystals Saturated Aqueous Solution Is Neutral Or Slightly Acidic (Ntp 1992)Molecular weight:142.18AZ1495
CAS:<p>AZ1495: oral IRAK4 inhibitor (IC50: 5 nM), IRAK1 (23 nM), treats MYD88L265P DLBCL.</p>Formula:C21H31N5O2Purity:98.81%Color and Shape:SolidMolecular weight:385.5Theophylline
CAS:<p>Theophylline (1,3-Dimethylxanthine) is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central</p>Formula:C7H8N4O2Purity:99.65% - 99.98%Color and Shape:White Solid PowderMolecular weight:180.16BAY-985
CAS:<p>BAY-985: potent oral TBK1/IKKε inhibitor; IC50s: TBK1 (2/30 nM), IKKε (2 nM); has antitumor properties.</p>Formula:C27H30F3N9OPurity:99.62%Color and Shape:SolidMolecular weight:553.584-Hydroxychalcone
CAS:<p>4-Hydroxychalcone (P-Cinnamoylphenol) attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice.</p>Formula:C15H12O2Purity:99.75%Color and Shape:Yellow PowderMolecular weight:224.25Sodium salicylate
CAS:<p>Sodium salicylate (2-Hydroxybenzoic acid sodium salt), a metabolite of acetylsalicylic acid, can inhibit NF-kB and reduce oxidative stress.</p>Formula:C7H5NaO3Purity:99.36% - 99.92%Color and Shape:White Solid AmorphousMolecular weight:160.11Asatone
CAS:<p>Asatone from Radix et Rhizoma Asari has anti-inflammatory properties, acting on NF-κB and suppressing p-MAPK pathways (ERK, JNK, p38).</p>Formula:C24H32O8Purity:99.84% - 99.92%Color and Shape:SolidMolecular weight:448.51DCZ0415
CAS:<p>DCZ0415: Potent TRIP13 inhibitor; combats myeloma in vitro, in vivo, and in drug-resistant patients; hinders DNA repair and NF-κB activity.</p>Formula:C23H20N2O2Purity:99.34% - 99.95%Color and Shape:SolidMolecular weight:356.42Lidocaine hydrochloride
CAS:<p>Lidocaine HCl: local anesthetic, antiarrhythmic, stronger & longer-lasting than procaine but shorter than bupivacaine/prilocaine.</p>Formula:C14H23ClN2OPurity:99.81% - 99.92%Color and Shape:White Crystal PowderMolecular weight:270.798Sulindac
CAS:<p>Sulindac (Sulindac sulfoxide) is a sulfinylindene derivative prodrug with potential antineoplastic activity.</p>Formula:C20H17FO3SPurity:99.09% - 99.15%Color and Shape:Yellow SolidMolecular weight:356.41Theophylline monohydrate
CAS:<p>Theophylline monohydrate (Quibron) appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium</p>Formula:C7H8N4O2·H2OPurity:99.78%Color and Shape:SolidMolecular weight:198.185-Aminosalicylic Acid
CAS:<p>5-Aminosalicylic Acid (5-ASA) is a specific PPARγ agonist and also inhibits P21-activated kinase 1 (PAK1) and NF-Κb. High-Quality, Low-Cost!</p>Formula:C7H7NO3Purity:98.88% - 99.49%Color and Shape:Purplish-Tan Solid PowderMolecular weight:153.14NIK SMI1
CAS:<p>NIK SMI1 is an effective and selective NF-κB inducing kinase (NIK) inhibitor. It also inhibits NIK-catalyzed hydrolysis of ATP to ADP (IC50: 0.23±0.17 nM).</p>Formula:C20H19N3O4Purity:99.04% - 99.99%Color and Shape:SolidMolecular weight:365.38Erdosteine
CAS:<p>Erdosteine (RV 144), a mucolytic thiol, modulates mucus and aids expectoration, reduces cough, and protects lungs from smoke damage.</p>Formula:C8H11NO4S2Purity:99.43% - 99.94%Color and Shape:White Or Almost White Crystalline PowderMolecular weight:249.31Oxaprozin
CAS:<p>Oxaprozin (Oxaprozinum) is a Nonsteroidal Anti-inflammatory Drug.</p>Formula:C18H15NO3Purity:98.53%Color and Shape:SolidMolecular weight:293.32(E/Z)-BCI
CAS:<p>(E/Z)-BCI (NSC-150117), a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory properties, reduces LPS-induced inflammatory mediators and ROS</p>Formula:C22H23NOPurity:99.94%Color and Shape:SolidMolecular weight:317.42DMAPT
CAS:<p>DMAPT is a water-soluble PTL analogue, orally active NF-κB inhibitor with 1.7 μM LD50 in acute myeloid leukemia cells.</p>Formula:C17H27NO3Purity:99.91%Color and Shape:SolidMolecular weight:293.4Mevastatin
CAS:<p>Mevastatin (ML236B) is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum.</p>Formula:C23H34O5Purity:99.12%Color and Shape:White-Yellowish To Yellow Powder Solid PowderMolecular weight:390.51Metaxalone
CAS:<p>Metaxalone, sold as Skelaxin by King Pharmaceuticals, is a muscle relaxant for pain from strains and sprains.</p>Formula:C12H15NO3Purity:98.84% - 99.94%Color and Shape:White To Almost White Crystalline Powder SolidMolecular weight:221.25Articaine hydrochloride
CAS:<p>Articaine hydrochloride (Hoe-045) is a thiophene-containing local anesthetic pharmacologically similar to MEPIVACAINE.</p>Formula:C13H21ClN2O3SPurity:99.76%Color and Shape:White Crystalline PowderMolecular weight:320.84DRI-C21045
CAS:<p>Dri-c21045 inhibits NF-kB (IC50=17.1μM) and B cell proliferation (IC50=4.5μM), selectively blocking CD40-CD40L interaction (IC50=0.17μM).</p>Formula:C32H24N2O7SPurity:97.20%Color and Shape:SolidMolecular weight:580.61IMD-0560
CAS:<p>IMD-0560 is a novel inhibitor of IκB kinase β.</p>Formula:C15H8BrF6NO2Purity:99.51%Color and Shape:SolidMolecular weight:428.12Ergolide
CAS:<p>Ergolide, from Inula Britannica, inhibits iNOS and COX-2 by deactivating NF-κB in macrophages.</p>Formula:C17H22O5Purity:99.64%Color and Shape:SolidMolecular weight:306.35Baicalin
CAS:<p>Baicalin (Baicalein 7-O-β-D-glucuronide) is a prolyl endopeptidase inhibitor isolated from scutellaria baicalensis, with antioxidant, anti-tumor, anti-HIV</p>Formula:C21H18O11Purity:90.08% - 99.32%Color and Shape:Yellow PowderMolecular weight:446.36Naringin dihydrochalcone
CAS:<p>Naringin dihydrochalcone (Naringin DC) is an inhibitor of CYP enzymes, used as an artificial sweetener.</p>Formula:C27H34O14Purity:99.07% - 99.73%Color and Shape:Solid PowderMolecular weight:582.55Indacaterol maleate
CAS:<p>Indacaterol maleate (QAB149) is an ultra-long-acting β-adrenoceptor agonist.</p>Formula:C28H32N2O7Purity:99.03% - 99.67%Color and Shape:SolidMolecular weight:508.56SN50 acetate (213546-53-3 free base)
<p>SN50 acetate is a cell permeable inhibitor of NF-κB translocation.</p>Formula:C131H234N36O31SPurity:99.86%Color and Shape:SolidMolecular weight:2841.55Lidocaine
CAS:<p>Lidocaine, an amide local anesthetic, reduces pain and inflammation by dampening ICAM-1, cytokines, and neutrophil influx.</p>Formula:C14H22N2OPurity:99.95% - >99.99%Color and Shape:Needles From Benzene Or Alcohol SolidMolecular weight:234.34Lidocaine Hydrochloride hydrate
CAS:<p>Lidocaine Hydrochloride hydrate is an amide local anesthetic, has anti-inflammatory property.</p>Formula:C14H22N2O·HCl·H2OPurity:99.95%Color and Shape:SolidMolecular weight:288.82TH023
<p>TH023 is an inhibitor of the TLR4 signaling pathway, specifically targeting the formation of TLR4 homodimers. In HEK-Blue hTLR4 cells, TH023 suppresses the secretion of embryonic alkaline phosphatase with an IC50 of 0.354 μM and inhibits NO expression in RAW264.7 cells, with an IC50 of 1.61 μM. Additionally, TH023 inhibits the activation of NF-κB and reduces the nuclear translocation of NF-κB p65. The compound demonstrates anti-inflammatory effects in a mouse model of LPS-induced acute sepsis and improves lung injury in mice.</p>Formula:C22H21ClF2N4OColor and Shape:SolidMolecular weight:430.88Helenalin
CAS:<p>Helenalin: anti-inflammatory sesquiterpene, inhibits NF-κB by alkylating p65 cysteine groups, blocks DNA binding.</p>Formula:C15H18O4Purity:98%Color and Shape:SolidMolecular weight:262.3PROTAC IRAK4 ligand-4
CAS:<p>PROTAC IRAK4 ligand-4, a Ligand for Target Protein for PROTAC (Ligand for Target Protein for PROTAC), exhibits anti-tumor activity and is utilized in synthesizing PROTAC IRAK4 degrader-12. This compound serves as a targeted ligand with specific applications in the development of cancer therapeutics.</p>Formula:C24H26F2N6O3Color and Shape:SolidMolecular weight:484.5IKK-IN-3
CAS:<p>IKK-IN-3: potent IKK2 inhibitor (IC50=19nM), affects IKK1(IC50=400nM).</p>Formula:C17H17N5SColor and Shape:SolidMolecular weight:323.42HS-243
CAS:<p>HS-243 is an inhibitor of IRAK-4 and IRAK-1 with IC50s of 20 and 24 nM. HS-243 shows anti-inflammatory and anticancer activity.</p>Formula:C17H16N4O3Purity:98.62%Color and Shape:SolidMolecular weight:324.33NF-κΒ activator 1
CAS:<p>NF-κΒ activator 1 can activate the nf-kappa Β gene activator, EC50 of 0.9 microns.</p>Formula:C16H11FN2O2SPurity:99.58%Color and Shape:SolidMolecular weight:314.33Coronalolic acid
CAS:<p>Coronalolic acid is a natural product extracted from the Gardenia sootepenesis Hutch. It inhibits TNF-α-induced NF-κB activity and NO production.</p>Formula:C30H46O4Purity:98%Color and Shape:SolidMolecular weight:470.68CIB-1476
<p>CIB-1476, a caspase-1 inhibitor, effectively reduces joint swelling in mouse models of arthritis and demonstrates lasting anti-inflammatory effects. This compound achieves its benefits by blocking IL-1β production, NF-κB activation, and GSDMD-mediated pyroptosis, all of which are triggered by the NLRP3 inflammasome.</p>Formula:C28H28N2O6SColor and Shape:SolidMolecular weight:520.6Cyclo(L-Pro-L-Val)
CAS:<p>Cyclo(L-Pro-L-Val), from Mycobacterium spp., has anti-inflammatory effects, hinders phytopathogens, and suppresses IKKα, NF-κB, iNOS, and COX-2 activation.</p>Formula:C10H16N2O2Purity:98.18%Color and Shape:SolidMolecular weight:196.25(R)-(-)-Ibuprofen
CAS:<p>(R)-(-)-Ibuprofen ((R)-Ibuprofen) is the R enantiomer of Ibuprofen and inhibits NF-κB activation.</p>Formula:C13H18O2Purity:99.86%Color and Shape:SolidMolecular weight:206.28EN450
CAS:<p>EN450 is a targeted cysteine degrader of NF-κB with antiproliferative activity and potential anticancer activity for the study of leukemia.</p>Formula:C11H13ClN2O3SPurity:99.72%Color and Shape:SoildMolecular weight:288.75PROTAC IRAK4 degrader-12
CAS:<p>PROTAC IRAK4 degrader-12, a Cereblon ligand-based PROTAC, induces a maximum degradation of IRAK4 in K562 cells at 108.46% with an IC50 value of 4.87 nM. (Structure Note: Pink, IRAK4 Inhibitor; Blue, E3; Black, linker.)</p>Formula:C46H50ClF2N11O6Color and Shape:SolidMolecular weight:926.41RIPK1-IN-27
<p>RIPK1-IN-27 (compound 19) is an inhibitor of RIPK1.</p>Formula:C27H28N4O3Color and Shape:SolidMolecular weight:456.54Gliotoxin
CAS:<p>Gliotoxin, a mycotoxin, inhibits Wnt pathway, causing apoptosis in mutated colorectal cancer cells and blocks NF-κB by preserving IκB.</p>Formula:C13H14N2O4S2Purity:98%Color and Shape:SolidMolecular weight:326.39PROTAC STING degrader-3
<p>PROTACSTING degrader-3 (Compound ST9) is a STINGPROTAC-type degrader with a DC50 of 0.62 μM. It induces STING degradation via the ubiquitin-proteasome pathway. This compound exerts anti-inflammatory effects by inhibiting the STING/TBK1/NF-κB signaling. Additionally, it offers renal protection and can be used in research on acute kidney injury.</p>Color and Shape:Odour SolidAnti-inflammatory agent 51
CAS:<p>Anti-inflammatory agent 51 amide/sulfonamide anti-inflammatory and anti-tumor activity inhibition of NF-κB activation acute lung injury and ulcerative colitis.</p>Formula:C22H22N6O6SPurity:99.46%Color and Shape:SoildMolecular weight:498.51Antidesmone
CAS:<p>Antidesmone from Ajuga decumbens inhibits acute lung injury by modulating MAPK and NF-κB.</p>Formula:C19H29NO3Purity:98%Color and Shape:SolidMolecular weight:319.44SjDX5-271
CAS:<p>SjDX5-271 is a 3 kDa peptide that inhibits the TLR4/MyD88/NF-κB signaling pathway. It induces cell polarization, alleviates liver inflammation, and protects mice from liver ischemia-reperfusion injury.</p>Formula:C137H215N47O49SColor and Shape:SolidMolecular weight:3336.52Aloenin aglycone
CAS:<p>Aloenin aglycone (compound 13), an inhibitor of NF-κB, can be sourced from aloe exudate.</p>Formula:C13H12O5Purity:98%Color and Shape:SolidMolecular weight:248.23NBD peptide
CAS:<p>NBD peptide inhibits the NF-κB signaling pathway by preventing the binding of the NEMO-IKK complex. It exhibits anti-inflammatory activity by blocking the production of pro-inflammatory cytokines. Additionally, NBD peptide demonstrates immunosuppressive effects through the regulation of immune cells. It enhances transmembrane capacity by conjugating with the cell-penetrating peptide HIV-TAT.</p>Formula:C62H88N14O20Color and Shape:SolidMolecular weight:1349.44SU1261
<p>SU1261, an IKK inhibitor, exhibits Ki values of 10 nM for IKKα and 680 nM for IKKβ. It effectively inhibits non-canonical NF-κB signaling in U2OS osteosarcoma cells.</p>Color and Shape:Odour SolidPS 1145 dihydrochloride
CAS:<p>IκB kinase (IKK) inhibitor</p>Formula:C17H13Cl3N4OPurity:98%Color and Shape:SolidMolecular weight:395.67Anti-osteoporosis agent-8
<p>Anti-osteoporosis agent-8 (Compound 4aa) is a RANKL inhibitor, capable of preventing RANKL-induced osteoclastogenesis and osteoclast differentiation, with an IC50 of 2.41 μM. Furthermore, Anti-osteoporosis agent-8 has been shown to mitigate bone loss in an ovariectomized (OVX) mouse model.</p>Formula:C18H19F3N2O2SeMolecular weight:432.05638LY2409881
CAS:<p>LY2409881 is a selective IκB kinase β ( IKK2 ) inhibitor with an IC 50 of 30 nM.</p>Formula:C24H29ClN6OSColor and Shape:SolidMolecular weight:485.05Salicortin
CAS:<p>Salicortin, a phenolic glycoside from Populus and Salix, has anti-adipogenic, anti-amnesic, and immune effects.</p>Formula:C20H24O10Purity:98%Color and Shape:SolidMolecular weight:424.40TBK1/IKKε-IN-6
CAS:<p>TBK1/IKKε-IN-6 (example 110) is a potent inhibitor of TBK1 and IKKε, with IC50 values of less than 100 nM for both enzymes.</p>Formula:C31H36F2N8O4Color and Shape:SolidMolecular weight:622.678Siegesbeckialide I
<p>Siegesbeckialide I effectively suppresses LPS-induced NO production in RAW264.7 murine macrophages by directly interacting with IKKα/β.</p>Formula:C20H28O6Color and Shape:SolidMolecular weight:364.43Diprovocim-1
CAS:<p>Diprovocim-1: TLR1/2 agonist; triggers TNF-α in THP-1 cells; boosts ovalbumin IgG1 & CTLs against tumors with anti-PD-L1 in mice.</p>Formula:C56H56N6O6Color and Shape:SolidMolecular weight:909.1SN50 TFA
<p>SN50 TFA is an inhibitor of NF-κB and attenuates alveolar hypercoagulation and fibrinolysis inhibition. SN50 TFA can be used in studies about ARDS.</p>Formula:C129H230N36O29S·XCF3COOHColor and Shape:SolidMolecular weight:2781.5 (free base)Sootepin D
CAS:<p>Sootepin D is a triterpene from the apical bud of Gardenia sootepensis, and is TNF-α-induced NF-κB inhibitor(IC50 of 8.3μM),with anti-inflammatory activity.</p>Formula:C31H48O4Purity:98%Color and Shape:SolidMolecular weight:484.71Mesalamine impurity P
CAS:<p>Mesalamine impurity P, a 5-Aminosalicylic acid derivative, is a PPARγ agonist, inhibiting PAK1 and NF-κB.</p>Formula:C13H11NO6SColor and Shape:SolidMolecular weight:309.30Licoagrochalcone C
CAS:<p>Licoagrochalcone C, a flavonoid, inhibits NF-κB and NO production effectively.</p>Formula:C21H22O5Color and Shape:SolidMolecular weight:354.47-O-Methylaloeasinol
CAS:<p>7-O-Methylaloeasinol is a useful organic compound for research related to life sciences. The catalog number is T126468 and the CAS number is 105317-69-9.</p>Formula:C20H26O9Color and Shape:SolidMolecular weight:410.419Anti-inflammatory agent 7
<p>Anti-inflammatory Agent 7 suppresses proinflammatory cytokines by hindering the NF-κB/MAPK signaling pathway in both LPS-treated RAW 264.7 cells and mice.</p>Formula:C36H40N4O9Color and Shape:SolidMolecular weight:672.72Nasunin
CAS:<p>Delphanin, also known as Nasunin, is an anthocyanin isolated as purple colored crystals from eggplant peels.</p>Formula:C42H47ClO23Color and Shape:SolidMolecular weight:955.26COX-2-IN-48
<p>COX-2-IN-48 (5-25) serves as an inhibitor of COX-2, exhibiting an IC50 of 51.7 nM against human COX-2. It displays anti-inflammatory and analgesic effects in various rodent models through inhibition of the NF-κB pathway. COX-2-IN-48 (5-25) inhibits the degradation of IκB, phosphorylation and nuclear translocation of NF-κB p65, and the expression of COX-2 and iNOS.</p>Color and Shape:Odour SolidNLRP3-IN-51
<p>NLRP3-IN-51 (Compound 3q) is an effective activator of the cholinergic anti-inflammatory pathway (CAP). This compound demonstrates potential for treating gouty arthritis as it inhibits the production of IL-1β in THP-1 cells induced by monosodium urate (MSU). Furthermore, NLRP3-IN-51 suppresses the phosphorylation of NF-κBp65 triggered by MSU without impacting the self-cleavage and activation of NLRP3, pro-caspase 1, or the second messenger caspase-1. Therefore, the initial stage of NLRP3 inhibition by NLRP3-IN-51 occurs through the activation of CAP.</p>Color and Shape:Odour SolidNF-κB-IN-9
<p>NF-κB-IN-9, a nuclear factor kappa B (NF-κB) targeting sonosensitizer with excitation and emission wavelengths (λex/λem) of 489/628 nm, features dual</p>Formula:C62H50N4O4SColor and Shape:SolidMolecular weight:947.15Murrayafoline A
CAS:<p>Murrayafoline A is a useful organic compound for research related to life sciences. The catalog number is T124835 and the CAS number is 4532-33-6.</p>Formula:C14H13NOColor and Shape:SolidMolecular weight:211.264Ginger extract
CAS:<p>Ginger extract demonstrates (exhibits) anti-cancer, anti-inflammatory, and chemotherapeutic properties in living organisms (in vivo).</p>Color and Shape:Solid12-Oxo phytodienoic acid
CAS:<p>12-oxo PDA boosts alkaloid production in E. californica, enhances B. dioica tendril curls, and blocks JA-induced cell death in A. fru mutants.</p>Formula:C18H28O3Purity:98%Color and Shape:SolidMolecular weight:292.41MRT67307
CAS:<p>Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy.</p>Formula:C26H36N6O2Purity:99.25% - 99.84%Color and Shape:SolidMolecular weight:464.63-(2-Hydroxyethyl) thio withaferin A
<p>3-(2-Hydroxyethyl) thio withaferin A, a steroidal lactone, blocks NF-kB, targets vimentin, and inhibits EPCR shedding.</p>Formula:C30H44O7SColor and Shape:SolidMolecular weight:548.73RIPK1-IN-25
<p>RIPK1-IN-25 (WL8) is a RIPK1 inhibitor with blood-brain barrier permeability, displaying an EC50 of 19.9 nM and a Kd of 25 nM. It is utilized in the research of neurodegenerative diseases.</p>Color and Shape:Odour SolidPratensein
CAS:<p>Pratensein as a novel transcriptional up-regulator of scavenger receptor class B type I in HepG2 cells.</p>Formula:C16H12O6Purity:99.90%Color and Shape:SolidMolecular weight:300.26Transcription Factor-Targeted Compound Library
<p>Well-chosen xnum compounds with unique structures targeting transcription factor;</p>Color and Shape:Odour SolidMJ210
<p>MJ210 is an orally active and blood-brain barrier-permeable modulator of the NF-κB and MAPK pathways, exhibiting neuroprotective properties. In vitro, 5 μM MJ210 can increase the survival rate of rotenone-treated SH-SY5Y cells to 81.9% and reduce levels of ROS. In vivo, 5 mg/kg MJ210 improves motor dysfunction in rat models of Parkinson's disease. MJ210 is useful for research in neurological disorders, including Parkinson's disease.</p>Color and Shape:Odour SolidIKKγ NBD Inhibitory Peptide
CAS:<p>A cell-permeable synthetic peptide NEMO-binding domain peptide (NBD peptide) corresponding to the NEMO amino-terminal alpha-helical region is shown to block TNF</p>Formula:C170H259N49O42S1Purity:98%Color and Shape:SolidMolecular weight:3693.3R-HP210
<p>R-HP210 blocks LPS-triggered IL-1β, IL-6, COX-2 gene transcription and has a 3.80 μM IC50 for NF-κB inhibition without activating GCs.</p>Formula:C22H19N3O2S2Color and Shape:SolidMolecular weight:421.54CAY10512
CAS:<p>CAY10512, a resveratrol analog, is 100x more potent, inhibiting NF-κB with an IC50 of 0.15 μM versus resveratrol's 20 μM.</p>Formula:C15H13FOColor and Shape:SolidMolecular weight:228.266NF-κB Signaling Compound Library
<p>A unique collection of xnum compounds targeting NF-κB signaling for high throughput screening and high content screening;</p>Color and Shape:Odour Solid17-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid
CAS:<p>DPA metabolite 17-oxo-DPA, found in fish oil, spurs antioxidant genes, modulates inflammation, and activates PPARγ (EC50 ≈ 200 nM).</p>Formula:C22H32O3Color and Shape:SolidMolecular weight:344.495CAY10657
CAS:<p>CAY10657 has a wide range of applications in life science related research.</p>Formula:C17H20N4O3SColor and Shape:SolidMolecular weight:360.43Lemnalol
CAS:<p>Lemnalol, from Lemnalia cervicorni, has anti-inflammatory and analgesic properties.</p>Formula:C15H24OPurity:98%Color and Shape:SolidMolecular weight:220.35R1-ICR-5
CAS:<p>R1-ICR-5 is a selective PROTAC degrader targeting serine/threonine-protein kinase 1 (RIPK1). Mediated by VHL, R1-ICR-5 promotes the degradation of RIPK1, disrupting the TNFR1 and TLR3/4 signaling hubs, enhancing NF-κB, MAPK, and IFN signal output, and facilitating RIPK3 activation and necroptosis induction. R1-ICR-5 holds potential for research in cancer and inflammatory diseases.</p>Formula:C54H70N8O7S2Color and Shape:SolidMolecular weight:1007.31N-Acetyldopamine dimer-2
CAS:<p>Compound 2, an N-acetyldopamine dimer from Periostracum Cicadae, exhibits antioxidant and anti-inflammatory properties.</p>Formula:C20H20N2O6Color and Shape:SolidMolecular weight:384.38
