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JAK/STAT signaling

JAK/STAT signaling

JAK/STAT signaling inhibitors are compounds that disrupt the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway, which is involved in cytokine signaling, cell growth, and immune response. These inhibitors are important tools in studying the regulation of this pathway and its role in various diseases, including cancers, immune disorders, and inflammatory conditions. JAK/STAT inhibitors are also being developed as targeted therapies for these diseases. At CymitQuimica, we provide a wide selection of high-quality JAK/STAT signaling inhibitors to support your research in molecular biology, oncology, and immunology.

Subcategories of "JAK/STAT signaling"

Found 321 products of "JAK/STAT signaling"

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  • Filgotinib
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    Filgotinib

    CAS:
    <p>Filgotinib (GLPG0634) is a selective JAK1 inhibitor. The IC50 values against JAK1, JAK2, JAK3, and TYK2 are 10 nM, 28 nM, 810 nM, and 116 nM, respectively.</p>
    Formula:C21H23N5O3S
    Purity:98.03% - ≥95%
    Color and Shape:Solid
    Molecular weight:425.5

    Ref: TM-T1929

  • AT9283
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    AT9283

    CAS:
    <p>AT9283 (J-504568) is an effective multi-targeted inhibitor of JAK2(IC50=1.2 nM) and JAK3(IC50=1.1 nM), Aurora A, Aurora B and Abl(T315I).</p>
    Formula:C19H23N7O2
    Purity:99.83% - 99.98%
    Color and Shape:Solid
    Molecular weight:381.43

    Ref: TM-T3068

  • Hispidulin
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    Hispidulin

    CAS:
    <p>Hispidulin, a natural flavone with a broad spectrum of biological activities, is a Pim-1 inhibitor (IC50: 2.71 μM).</p>
    Formula:C16H12O6
    Purity:98.53% - 99.87%
    Color and Shape:Solid
    Molecular weight:300.26

    Ref: TM-TQ0201

  • Ruxolitinib phosphate
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    Ruxolitinib phosphate

    CAS:
    <p>Ruxolitinib phosphate (INCB18424 phosphate) is a JAK1/2 inhibitor with IC50 of 3.3 nM/2.8 nM. Cost-effective and quality-assured.</p>
    Formula:C17H21N6O4P
    Purity:98% - >99.99%
    Color and Shape:Solid
    Molecular weight:404.36

    Ref: TM-T3043

  • AZD1208
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    AZD1208

    CAS:
    <p>AZD1208 is a novel, orally bioavailable, highly selective PIM kinase inhibitor with single nanomolar potency against all three PIM kinases.</p>
    Formula:C21H21N3O2S
    Purity:97.24% - 99.83%
    Color and Shape:Solid
    Molecular weight:379.48

    Ref: TM-T2300

  • Momelotinib
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    Momelotinib

    CAS:
    <p>Momelotinib (LM-1149), an oral JAK1/2 inhibitor with IC50s 11/18 nM, blocks ATP binding, disrupting JAK-STAT pathway and reducing tumor growth.</p>
    Formula:C23H22N6O2
    Purity:97.47% - 99.56%
    Color and Shape:Solid
    Molecular weight:414.46

    Ref: TM-T1849

  • Fedratinib
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    Fedratinib

    CAS:
    <p>Fedratinib (TG-101348) (TG101348) is an ATP-competitive inhibitor of JAK2 (IC50: 3 nM) with significantly less potent activity against JAK3.</p>
    Formula:C27H36N6O3S
    Purity:97.31% - 99.96%
    Color and Shape:Solid
    Molecular weight:524.68

    Ref: TM-T1995

  • TP-3654
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    TP-3654

    CAS:
    <p>TP-3654 is a second-generation Pim kinase inhibitor (Ki values against Pim-1/3: 5/42 nM).</p>
    Formula:C22H25F3N4O
    Purity:99.8% - 99.95%
    Color and Shape:Solid
    Molecular weight:418.46

    Ref: TM-T4523

  • HJ-PI01
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    HJ-PI01

    CAS:
    <p>HJ-PI01 (HJ-PI01) is a Pim-2 inhibitor. HJ-PI01 (HJ-PI01) induces apoptosis and autophagic cell death in triple-negative human breast cancer.</p>
    Formula:C14H11NO2
    Purity:98.92%
    Color and Shape:Solid
    Molecular weight:225.24

    Ref: TM-T9583

  • Cucurbitacin I
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    Cucurbitacin I

    CAS:
    <p>Cucurbitacin I (JSI-124), a natural compound, is a selective inhibitor of JAK2/STAT3 with anti-cancer activity.</p>
    Formula:C30H42O7
    Purity:96.69% - 99.8%
    Color and Shape:Solid
    Molecular weight:514.65

    Ref: TM-TQ0196

  • Deucravacitinib
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    Deucravacitinib

    CAS:
    <p>Deucravacitinib (BMS-986165) is a highly selective, orally bioavailable, allosteric TYK2 inhibitor.Cost-effective and quality-assured.</p>
    Formula:C20H19D3N8O3
    Purity:98.52% - >99.99%
    Color and Shape:Solid
    Molecular weight:425.46

    Ref: TM-T14687

  • RO495
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    RO495

    CAS:
    <p>RO495 (CS-2667), a potent inhibitor of TYK2, inhibits TYK2 with IC50 of 1.5nM as tested in cell-based pharmacological assays</p>
    Formula:C17H14Cl2N6O
    Purity:97.94%
    Color and Shape:Solid
    Molecular weight:389.24

    Ref: TM-T22416

  • AG490
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    AG490

    CAS:
    <p>AG490 inhibits EGFR (0.1 μM IC50), 135x &gt; selective than ErbB2, blocks JAK2, spares Lyn, Lck, Syk, Btk, Src.</p>
    Formula:C17H14N2O3
    Purity:98.6% - 99.39%
    Color and Shape:Yellow Solid
    Molecular weight:294.3

    Ref: TM-T2600

  • WHI-P154
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    WHI-P154

    CAS:
    <p>WHI-P154 (Jak3 inhibitor ii) is a potent JAK3 inhibitor.</p>
    Formula:C16H14BrN3O3
    Purity:98% - 99.67%
    Color and Shape:Solid
    Molecular weight:376.2

    Ref: TM-T1985

  • Niclosamide sodium
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    Niclosamide sodium

    CAS:
    <p>Niclosamide (BAY2353) sodium: oral antihelminthic, STAT3 inhibitor (IC50 0.25 μM), anti-cancer, and DNA replication blocker.</p>
    Formula:C13H7Cl2N2NaO4
    Color and Shape:Solid
    Molecular weight:349.1

    Ref: TM-T72519

  • Protosappanin A
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    Protosappanin A

    CAS:
    <p>Protosappanin A combats brain inflammation, suppresses rat heart transplant rejection, fights MRSA, and inhibits HIV with a 12.6 uM IC50.</p>
    Formula:C15H12O5
    Purity:99.42% - 99.82%
    Color and Shape:Solid
    Molecular weight:272.25

    Ref: TM-TJS1779

  • BMS-911543
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    BMS-911543

    CAS:
    <p>BMS-911543 is a potent and selective inhibitor of JAK2 with IC50 of 1.1 nM, ~350-, 75- and 65-fold selective to JAK1, JAK3 and TYK2, respectively. Phase 1/2.</p>
    Formula:C23H28N8O
    Purity:97.69% - 99.98%
    Color and Shape:Solid
    Molecular weight:432.52

    Ref: TM-T6790

  • SHR0302
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    SHR0302

    CAS:
    <p>SHR0302 (ARQ252) is a JAK inhibitor that binds JAK1 with stronger affinity than others (Selectivity for JAK1 is more than 10 times for JAK2, 77 times for JAK3,</p>
    Formula:C18H22N8O2S
    Purity:99.11%
    Color and Shape:Solid
    Molecular weight:414.48

    Ref: TM-T9195

  • JANEX-1
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    JANEX-1

    CAS:
    <p>JANEX-1: cell-permeable, reversible Jak3 inhibitor (IC50: 78 μM), ATP-competitive, selective; weak on JAK1/2, Zap/Syk, SRC.</p>
    Formula:C16H15N3O3
    Purity:98% - 99.81%
    Color and Shape:Solid
    Molecular weight:297.31

    Ref: TM-T2045

  • ZM39923 hydrochloride
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    ZM39923 hydrochloride

    CAS:
    <p>ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor, almost no activity to JAK2 and modestly potent to EGFR; also is sensitive to transglutaminase.</p>
    Formula:C23H25NO·HCl
    Purity:98.05%
    Color and Shape:Solid
    Molecular weight:367.91

    Ref: TM-T6145