JAK/STAT signaling
JAK/STAT signaling inhibitors are compounds that disrupt the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway, which is involved in cytokine signaling, cell growth, and immune response. These inhibitors are important tools in studying the regulation of this pathway and its role in various diseases, including cancers, immune disorders, and inflammatory conditions. JAK/STAT inhibitors are also being developed as targeted therapies for these diseases. At CymitQuimica, we provide a wide selection of high-quality JAK/STAT signaling inhibitors to support your research in molecular biology, oncology, and immunology.
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Products of "JAK/STAT signaling"
JAK-IN-28
CAS:2445500-22-9
JAK-IN-28 (Compound 111) is a Janus kinase (JAK) inhibitor potentially applicable in the research of …
Formula:
C20H18ClN7O
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
407.86
Ref: TM-T79116
| 25mg | 1,410.00 € | ||
| 50mg | 1,851.00 € | ||
| 100mg | 2,337.00 € |
Estimated delivery in United States, on Friday 24 Jan 2025
SD-1029
CAS:118372-34-2
SD-1029 is a JAK2 inhibitor and a novel Stat3 activation inhibitor that inhibits Stat3 phosphorylation …
Formula:
C25H32Br2Cl2N2O3
Color and Shape:
Solid
Molecular weight:
639.25
Ref: TM-T24774
| 1mg | 89.00 € |
Estimated delivery in United States, on Friday 24 Jan 2025
JBJ-04-125-02
CAS:2060610-53-7
JBJ-04-125-02: Oral EGFR inhibitor, targets EGFRL858R/T790M with 0.26 nM IC50, halts cancer growth, anti-tumor.
Formula:
C29H26FN5O3S
Purity:
98%
Color and Shape:
Solid
Molecular weight:
543.61
Ref: TM-T11714
| 25mg | 1,406.00 € | ||
| 50mg | 1,851.00 € | ||
| 100mg | 2,337.00 € |
Estimated delivery in United States, on Friday 24 Jan 2025
JAK-IN-11
CAS:916742-11-5
JAK-IN-11 (R-348) is a potent and selective inhibitor of JAK, has the potential for the …
Formula:
C23H22FN5O4S
Purity:
99.57%
Color and Shape:
Solid
Molecular weight:
483.52
Ref: TM-T12549
| 1mg | 273.00 € | ||
| 5mg | 547.00 € | ||
| 10mg | 890.00 € | ||
| 25mg | 1,620.00 € | ||
| 50mg | 2,177.00 € | ||
| 1mL*10mM (DMSO) | 621.00 € |
Estimated delivery in United States, on Friday 24 Jan 2025
JAK-IN-10
CAS:916741-98-5
JAK-IN-10 is a JAK inhibitor. JAK-IN-10 can be used for the research of dry eye …
Formula:
C20H18FN5O3S
Purity:
98.88%
Color and Shape:
Solid
Molecular weight:
427.45
Ref: TM-T13571
| 1mg | 85.00 € | ||
| 5mg | 174.00 € | ||
| 10mg | 255.00 € | ||
| 25mg | 420.00 € | ||
| 50mg | 592.00 € | ||
| 100mg | 799.00 € | ||
| 500mg | 1,591.00 € | ||
| 1mL*10mM (DMSO) | 187.00 € |
Estimated delivery in United States, on Friday 24 Jan 2025
M-110
CAS:1395048-49-3
M-110 selectively targets PIM kinases, best at PIM-3 (IC50=47nM), and inhibits prostate cancer cell growth …
Formula:
C22H28ClN5O3
Purity:
98.30%
Color and Shape:
Solid
Molecular weight:
445.94
Ref: TM-T15830
| 5mg | 63.00 € | ||
| 10mg | 90.00 € | ||
| 25mg | To inquire | ||
| 50mg | To inquire | ||
| 1mL*10mM (DMSO) | 64.00 € |
Estimated delivery in United States, on Friday 24 Jan 2025
Lorpucitinib
CAS:2230282-02-5
Lorpucitinib (JNJ-64251330) is a JAK kinase inhibitor used in the study of inflammatory and gastrointestinal …
Formula:
C22H28N6O2
Purity:
99.72%
Color and Shape:
Liquid
Molecular weight:
408.5
Ref: TM-T62053
| 1mg | 212.00 € | ||
| 5mg | 531.00 € | ||
| 10mg | 848.00 € | ||
| 25mg | 1,606.00 € | ||
| 50mg | 2,589.00 € | ||
| 100mg | 3,498.00 € |
Estimated delivery in United States, on Friday 24 Jan 2025
JAK kinase-IN-1
CAS:2698389-43-2
JAK kinase-IN-1 (Example 1) functions as a potent inhibitor targeting the JAK family, which includes …
Formula:
C17H19F2N7OS
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
407.44
Ref: TM-T79807
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Friday 7 Feb 2025
ABBV-712
CAS:2368945-27-9
ABBV-712 is a selective Tyrosine Kinase 2 (TYK2) inhibitor, demonstrating an IC50 value of 0.195 …
Formula:
C24H28N4O5
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
452.5
Ref: TM-T83218
| 5mg | 1,354.00 € | ||
| 10mg | 1,824.00 € | ||
| 25mg | 2,435.00 € | ||
| 50mg | 3,070.00 € |
Estimated delivery in United States, on Friday 7 Feb 2025
JAK1-IN-11
CAS:2427608-43-1
JAK1-IN-11 (compound 11) serves as a potent inhibitor of Janus kinases, exhibiting nanomolar inhibitory concentrations …
Formula:
C26H36N6O4S
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
528.67
Ref: TM-T79079
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Friday 7 Feb 2025
STAT3-IN-18
CAS:2668267-41-0
STAT3-IN-18 (compound SPP), a platinum (IV) complex featuring an axial ligand from sandalwood, suppresses the …
Formula:
C18H24Cl2N2O6Pt
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
630.38
Ref: TM-T79609
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Friday 7 Feb 2025
JAK-IN-34
CAS:2068766-90-3
JAK-IN-34 (compound 11n) is a potent inhibitor of Janus kinases (JAKs), demonstrating IC50 values of …
Formula:
C27H26N6O
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
450.53
Ref: TM-T82017
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Friday 7 Feb 2025
FD1024
CAS:1422456-47-0
FD1024 is a potent PIM inhibitor, displaying inhibitory concentrations (IC50s) of 1.96 nM, 38.9 nM, …
Formula:
C21H20F2N4O2S
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
430.47
Ref: TM-T79456
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Friday 7 Feb 2025
Lepzacitinib
CAS:2321488-47-3
Lepzacitinib, a Janus kinase inhibitor, specifically targets JAK 1/3.
Formula:
C18H21N5O3
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
355.39
Ref: TM-T78207
| 2mg | 91.00 € |
Estimated delivery in United States, on Friday 7 Feb 2025
TCS 21311
CAS:1260181-14-3
TCS 21311 (NIBR3049) selectively inhibits JAK3 (IC50: 8 nM) and PKCα/θ & GSK3β; >100x selective …
Formula:
C27H25F3N4O4
Purity:
≥98%
Color and Shape:
Solid
Molecular weight:
526.51
Ref: TM-T17019
| 1mg | 96.00 € |
Estimated delivery in United States, on Friday 7 Feb 2025
JAK1-IN-10
CAS:2416858-88-1
JAK1-IN-10 (compound 9), a cyano-substituted cyclic hydrazine derivative, functions as a potent and selective inhibitor …
Formula:
C15H17N7
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
295.34
Ref: TM-T79078
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Friday 7 Feb 2025
JAK-IN-26
CAS:2417134-93-9
JAK-IN-26 (compound 2) is an orally active inhibitor of the Janus kinase (JAK) enzyme with …
Formula:
C22H24N6O3
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
420.46
Ref: TM-T78189
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Friday 7 Feb 2025
Pim-1 kinase inhibitor 5
CAS:2928606-67-9
Pim-1 kinase inhibitor 5 (Compound 4c), with an IC50 of 0.61 μM, exhibits cytotoxicity against …
Formula:
C22H13Cl2N3O
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
406.26
Ref: TM-T78980
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Friday 7 Feb 2025
JAK-IN-3
CAS:1400876-94-9
JAK-IN-3 is a potent JAK inhibitor that inhibits JAK3, JAK1, TYK2, and JAK2, and can …
Formula:
C18H20N4O3
Purity:
98.04% - 98.04%
Color and Shape:
Solid
Molecular weight:
340.38
Ref: TM-T11704
| 1mg | 176.00 € | ||
| 25mg | 1,688.00 € | ||
| 50mg | 2,228.00 € | ||
| 100mg | 2,902.00 € |
Estimated delivery in United States, on Friday 7 Feb 2025
PIM1-IN-1
CAS:1417630-95-5
PIM1-IN-1 inhibits PIM1/3 with IC50s: PIM1 (7 nM), PIM2 (5530 nM), PIM3 (70 nM); it …
Formula:
C25H30N8O2
Purity:
98%
Color and Shape:
Solid
Molecular weight:
474.56
Ref: TM-T12474
| 25mg | 1,058.00 € | ||
| 50mg | 1,385.00 € | ||
| 100mg | 2,258.00 € |
Estimated delivery in United States, on Friday 7 Feb 2025
