JAK/STAT signaling
JAK/STAT signaling inhibitors are compounds that disrupt the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway, which is involved in cytokine signaling, cell growth, and immune response. These inhibitors are important tools in studying the regulation of this pathway and its role in various diseases, including cancers, immune disorders, and inflammatory conditions. JAK/STAT inhibitors are also being developed as targeted therapies for these diseases. At CymitQuimica, we provide a wide selection of high-quality JAK/STAT signaling inhibitors to support your research in molecular biology, oncology, and immunology.
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Products of "JAK/STAT signaling"
RO495
CAS:1258296-60-4
RO495 (CS-2667), a potent inhibitor of TYK2, inhibits TYK2 with IC50 of 1.5nM as tested …
Formula:
C17H14Cl2N6O
Purity:
99.4%
Color and Shape:
Solid
Molecular weight:
389.24
Ref: TM-T22416
| 1mg | 61.00 € | ||
| 2mg | 83.00 € | ||
| 5mg | 112.00 € | ||
| 10mg | 176.00 € | ||
| 25mg | 340.00 € | ||
| 50mg | 499.00 € | ||
| 100mg | 672.00 € | ||
| 200mg | 904.00 € | ||
| 1mL*10mM (DMSO) | 135.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
LFM-A13
CAS:244240-24-2
LFM-A13(IC50=2.5 μM), a specific Bruton's tyrosine kinase (BTK), is more than 100-fold specificity than other …
Formula:
C11H8Br2N2O2
Purity:
99.9%
Color and Shape:
Solid
Molecular weight:
360
Ref: TM-T6217
| 5mg | 35.00 € | ||
| 10mg | 51.00 € | ||
| 25mg | 95.00 € | ||
| 50mg | 161.00 € | ||
| 100mg | 263.00 € | ||
| 200mg | 383.00 € | ||
| 1mL*10mM (DMSO) | 35.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
HJ-PI01
CAS:6192-43-4
HJ-PI01 (HJ-PI01) is a Pim-2 inhibitor. HJ-PI01 (HJ-PI01) induces apoptosis and autophagic cell death in …
Formula:
C14H11NO2
Purity:
99.55%
Color and Shape:
Solid
Molecular weight:
225.24
Ref: TM-T9583
| 1mg | 35.00 € | ||
| 5mg | 78.00 € | ||
| 10mg | 112.00 € | ||
| 25mg | 251.00 € | ||
| 50mg | 370.00 € | ||
| 100mg | 526.00 € | ||
| 200mg | 714.00 € | ||
| 1mL*10mM (DMSO) | 75.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide
CAS:1258292-64-6
2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide (GDC046), a potent lead analog, has good kinase selectivity and physicochemical properties.
Formula:
C16H13Cl2N3O2
Purity:
98.77%
Color and Shape:
Solid
Molecular weight:
350.2
Ref: TM-T22338
| 1mg | 60.00 € | ||
| 5mg | 118.00 € | ||
| 10mg | 184.00 € | ||
| 25mg | 423.00 € | ||
| 50mg | 611.00 € | ||
| 100mg | 852.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Gandotinib
CAS:1229236-86-5
LY2784544(Gandotinib (LY2784544)) is a potent JAK2 inhibitor (IC50: 3 nM), effective in JAK2V617F(Ki: 0.245 nM).
Formula:
C23H25ClFN7O
Purity:
99.16% - 99.86%
Color and Shape:
Solid
Molecular weight:
469.94
Ref: TM-T2638
| 5mg | 51.00 € | ||
| 10mg | 86.00 € | ||
| 25mg | 158.00 € | ||
| 50mg | 290.00 € | ||
| 100mg | 460.00 € | ||
| 500mg | 1,012.00 € | ||
| 1mL*10mM (DMSO) | 57.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Filgotinib
CAS:1206161-97-8
Filgotinib (GLPG0634) is a selective JAK1 inhibitor. The IC50 values against JAK1, JAK2, JAK3, and …
Formula:
C21H23N5O3S
Purity:
98.03% - ≥95%
Color and Shape:
Solid
Molecular weight:
425.5
Ref: TM-T1929
| 1mg | 38.00 € | ||
| 5mg | 77.00 € | ||
| 10mg | 109.00 € | ||
| 25mg | 161.00 € | ||
| 50mg | 241.00 € | ||
| 100mg | 318.00 € | ||
| 1mL*10mM (DMSO) | 78.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Fedratinib
CAS:936091-26-8
Fedratinib (TG-101348) (TG101348) is an ATP-competitive inhibitor of JAK2 (IC50: 3 nM) with significantly less …
Formula:
C27H36N6O3S
Purity:
98.23% - 99.96%
Color and Shape:
Solid
Molecular weight:
524.68
Ref: TM-T1995
| 1g | 613.00 € | ||
| 5mg | 49.00 € | ||
| 10mg | 68.00 € | ||
| 50mg | 111.00 € | ||
| 100mg | 132.00 € | ||
| 200mg | 213.00 € | ||
| 500mg | 463.00 € | ||
| 1mL*10mM (DMSO) | 57.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Tofacitinib Citrate
CAS:540737-29-9
Tofacitinib Citrate (CP-690550 citrate) is a a potent, cell-permeable inhibitor of JAK1/2/3 (IC50s: 1/20/112 nM).
Formula:
C22H28N6O8
Purity:
99.19% - 99.75%
Color and Shape:
Solid
Molecular weight:
504.49
Ref: TM-T2398
| 5mg | 38.00 € | ||
| 10mg | 54.00 € | ||
| 50mg | 69.00 € | ||
| 100mg | 90.00 € | ||
| 200mg | 124.00 € | ||
| 500mg | 204.00 € | ||
| 1mL*10mM (DMSO) | 55.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Ruxolitinib (S enantiomer)
CAS:941685-37-6
Ruxolitinib S enantiomer (INCB18424) is the S-enantiomer of Ruxolitinib. Ruxolitinib is the first potent, selective …
Formula:
C17H18N6
Purity:
99.5% - 99.79%
Color and Shape:
Solid
Molecular weight:
306.36
Ref: TM-T6156
| 5mg | 63.00 € | ||
| 10mg | 74.00 € | ||
| 50mg | 113.00 € | ||
| 100mg | 151.00 € | ||
| 1mL*10mM (DMSO) | 64.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
SAR-20347
CAS:1450881-55-6
SAR-20347 is an inhibitor of TYK2, JAK1/2/3 (IC50: 0.6/23/26/41 nM).
Formula:
C21H18ClFN4O4
Purity:
99.35% - 99.77%
Color and Shape:
Solid
Molecular weight:
444.84
Ref: TM-T4210
| 1mg | 36.00 € | ||
| 5mg | 78.00 € | ||
| 10mg | 113.00 € | ||
| 25mg | 221.00 € | ||
| 50mg | 344.00 € | ||
| 100mg | 573.00 € | ||
| 200mg | 808.00 € | ||
| 1mL*10mM (DMSO) | 86.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Ritlecitinib
CAS:1792180-81-4
Ritlecitinib (PF-06651600) is an orally available, selective JAK3 inhibitor and does not affect the activity …
Formula:
C15H19N5O
Purity:
98.82% - 99.92%
Color and Shape:
Solid
Molecular weight:
285.34
Ref: TM-T5382
| 2mg | 46.00 € | ||
| 5mg | 69.00 € | ||
| 10mg | 109.00 € | ||
| 25mg | 212.00 € | ||
| 50mg | 325.00 € | ||
| 100mg | 485.00 € | ||
| 200mg | 690.00 € | ||
| 500mg | 1,047.00 € | ||
| 1mL*10mM (DMSO) | 76.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Cucurbitacin I
CAS:2222-07-3
Cucurbitacin I (JSI-124), a natural compound, is a selective inhibitor of JAK2/STAT3 with anti-cancer activity.
Formula:
C30H42O7
Purity:
96.69% - 98.2%
Color and Shape:
Solid
Molecular weight:
514.65
Ref: TM-TQ0196
| 1mg | 83.00 € | ||
| 5mg | 172.00 € | ||
| 10mg | 222.00 € | ||
| 25mg | 367.00 € | ||
| 50mg | 546.00 € | ||
| 1mL*10mM (DMSO) | 184.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Ruxolitinib phosphate
CAS:1092939-17-7
Ruxolitinib phosphate (INCB18424 phosphate) is a JAK1/2 inhibitor with IC50 of 3.3 nM/2.8 nM. Cost-effective …
Formula:
C17H21N6O4P
Purity:
100% - 99.91%
Color and Shape:
Solid
Molecular weight:
404.36
Ref: TM-T3043
| 1g | 604.00 € | ||
| 5mg | 52.00 € | ||
| 10mg | 64.00 € | ||
| 25mg | 81.00 € | ||
| 50mg | 95.00 € | ||
| 100mg | 144.00 € | ||
| 200mg | 223.00 € | ||
| 500mg | 408.00 € | ||
| 1mL*10mM (DMSO) | 59.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
GLPG0634 analog
CAS:1206101-20-3
GLPG0634 analog (GLPG0634 analogue) is a specific JAK1 inhibitor with IC50 of 10/28/810/116 nM for …
Formula:
C23H18N6O2
Purity:
100% - 99.22%
Color and Shape:
Solid
Molecular weight:
410.43
Ref: TM-T3076
| 1mg | 40.00 € | ||
| 2mg | 52.00 € | ||
| 5mg | 87.00 € | ||
| 10mg | 143.00 € | ||
| 25mg | 260.00 € | ||
| 50mg | 460.00 € | ||
| 100mg | 650.00 € | ||
| 500mg | 1,352.00 € | ||
| 1mL*10mM (DMSO) | 87.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Mollugin
CAS:55481-88-4
Mollugin could be a JAK2 inhibitor, anti-inflammatory, chemotherapeutic agent in OSCCs, bone disorder therapy, and …
Formula:
C17H16O4
Purity:
98.31% - ≥95%
Color and Shape:
Solid
Molecular weight:
284.31
Ref: TM-T3673
| 5mg | 46.00 € | ||
| 10mg | 78.00 € | ||
| 25mg | 123.00 € | ||
| 50mg | 184.00 € | ||
| 100mg | 276.00 € | ||
| 500mg | 681.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Prim-O-glucosylcimifugin
CAS:80681-45-4
Prim-O-glucosylcimifugin (Cimifugin 7-glucoside) can inhibit the proliferation of SMC stimulated by TNF-alpha, increase the proportion …
Formula:
C22H28O11
Purity:
99.47% - 99.92%
Color and Shape:
Solid
Molecular weight:
468.45
Ref: TM-T3805
| 1mg | 60.00 € | ||
| 5mg | 118.00 € | ||
| 10mg | 208.00 € | ||
| 25mg | 349.00 € | ||
| 50mg | 516.00 € | ||
| 100mg | 733.00 € | ||
| 1mL*10mM (DMSO) | 123.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
RO8191
CAS:691868-88-9
RO8191 (CDM-3008) (CDM-3008) is an agonist of interferon (IFN) receptor.
Formula:
C14H5F6N5O
Purity:
98.85% - ≥98%
Color and Shape:
Solid
Molecular weight:
373.21
Ref: TM-T22142
| 1mg | 45.00 € | ||
| 2mg | 58.00 € | ||
| 5mg | 96.00 € | ||
| 10mg | 142.00 € | ||
| 25mg | 301.00 € | ||
| 50mg | 478.00 € | ||
| 100mg | 698.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
JAK3-IN-6
CAS:1443235-95-7
JAK3-IN-6 is irreversible Janus Associated Kinase 3 (JAK3) inhibitor, with an IC50 of 0.15 nM
Formula:
C19H18N4O3
Purity:
97.46% - 99.94%
Color and Shape:
Solid
Molecular weight:
350.37
Ref: TM-T5492
| 2mg | 40.00 € | ||
| 5mg | 59.00 € | ||
| 10mg | 93.00 € | ||
| 25mg | 153.00 € | ||
| 50mg | 237.00 € | ||
| 100mg | 370.00 € | ||
| 1mL*10mM (DMSO) | 67.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
RGB-286638 free base
CAS:784210-88-4
RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.
Formula:
C29H35N7O4
Purity:
97.29% - 99.91%
Color and Shape:
Solid
Molecular weight:
545.63
Ref: TM-T2378
| 1mg | 46.00 € | ||
| 2mg | 60.00 € | ||
| 5mg | 87.00 € | ||
| 10mg | 144.00 € | ||
| 25mg | 263.00 € | ||
| 50mg | 396.00 € | ||
| 100mg | 554.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
FLLL32
CAS:1226895-15-3
FLLL32 is an effective JAK2/STAT3 inhibitor (IC50 of <5 μM).
Formula:
C28H32O6
Purity:
96.39% - 99.8%
Color and Shape:
Solid
Molecular weight:
464.55
Ref: TM-T6838
| 2mg | 45.00 € | ||
| 5mg | 66.00 € | ||
| 10mg | 92.00 € | ||
| 25mg | 122.00 € | ||
| 50mg | 193.00 € | ||
| 100mg | 343.00 € | ||
| 500mg | 822.00 € | ||
| 1mL*10mM (DMSO) | 72.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
