JAK/STAT signaling
JAK/STAT signaling inhibitors are compounds that disrupt the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway, which is involved in cytokine signaling, cell growth, and immune response. These inhibitors are important tools in studying the regulation of this pathway and its role in various diseases, including cancers, immune disorders, and inflammatory conditions. JAK/STAT inhibitors are also being developed as targeted therapies for these diseases. At CymitQuimica, we provide a wide selection of high-quality JAK/STAT signaling inhibitors to support your research in molecular biology, oncology, and immunology.
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Products of "JAK/STAT signaling"
JANEX-1
CAS:202475-60-3
JANEX-1: cell-permeable, reversible Jak3 inhibitor (IC50: 78 μM), ATP-competitive, selective; weak on JAK1/2, Zap/Syk, SRC.
Formula:
C16H15N3O3
Purity:
98% - 99.73%
Color and Shape:
Solid
Molecular weight:
297.31
Ref: TM-T2045
| 1mg | 44.00 € | ||
| 2mg | 55.00 € | ||
| 5mg | 91.00 € | ||
| 10mg | 149.00 € | ||
| 25mg | 245.00 € | ||
| 50mg | 439.00 € | ||
| 100mg | 644.00 € | ||
| 500mg | 1,347.00 € | ||
| 1mL*10mM (DMSO) | 91.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
TP-3654
CAS:1361951-15-6
TP-3654 is a second-generation Pim kinase inhibitor (Ki values against Pim-1/3: 5/42 nM).
Formula:
C22H25F3N4O
Purity:
97.72% - 99.95%
Color and Shape:
Solid
Molecular weight:
418.46
Ref: TM-T4523
| 5mg | 56.00 € | ||
| 10mg | 83.00 € | ||
| 25mg | 148.00 € | ||
| 50mg | 231.00 € | ||
| 100mg | 345.00 € | ||
| 1mL*10mM (DMSO) | 57.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Cerdulatinib
CAS:1198300-79-6
Cerdulatinib (PRT2070) is an novel oral dual Syk/JAK inhibitor.
Formula:
C20H27N7O3S
Purity:
98.74% - 99.64%
Color and Shape:
Solid
Molecular weight:
445.54
Ref: TM-T2487
| 1mg | 44.00 € | ||
| 2mg | 54.00 € | ||
| 5mg | 78.00 € | ||
| 10mg | 104.00 € | ||
| 25mg | 181.00 € | ||
| 50mg | 280.00 € | ||
| 100mg | 429.00 € | ||
| 200mg | 601.00 € | ||
| 500mg | 931.00 € | ||
| 1mL*10mM (DMSO) | 85.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Upadacitinib
CAS:1310726-60-3
Upadacitinib (ABT-494), a selective JAK1 inhibitor, is researched for autoimmune diseases; IC50: 43 nM.
Formula:
C17H19F3N6O
Purity:
99.41% - 99.93%
Color and Shape:
Solid
Molecular weight:
380.37
Ref: TM-T7503
| 1mg | 46.00 € | ||
| 2mg | 61.00 € | ||
| 5mg | 88.00 € | ||
| 10mg | 127.00 € | ||
| 25mg | 217.00 € | ||
| 50mg | 302.00 € | ||
| 100mg | 427.00 € | ||
| 200mg | 650.00 € | ||
| 500mg | 1,142.00 € | ||
| 1mL*10mM (DMSO) | 49.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
BD750
CAS:892686-59-8
BD750 is an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation(IC50 …
Formula:
C14H13N3OS
Purity:
99.02%
Color and Shape:
Solid
Molecular weight:
271.34
Ref: TM-T8546
| 5mg | 51.00 € | ||
| 10mg | 86.00 € | ||
| 25mg | 142.00 € | ||
| 50mg | 231.00 € | ||
| 100mg | 382.00 € | ||
| 1mL*10mM (DMSO) | 57.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
SMI-16a
CAS:587852-28-6
SMI-16a (PIM1/2 Kinase Inhibitor VI) , a cell-permeable thiazolidinedione compound, acts as an effective, ATP-competitive …
Formula:
C13H13NO3S
Purity:
99.05%
Color and Shape:
Solid
Molecular weight:
263.31
Ref: TM-T3989
| 1mg | 35.00 € | ||
| 2mg | 47.00 € | ||
| 5mg | 69.00 € | ||
| 10mg | 96.00 € | ||
| 25mg | 158.00 € | ||
| 50mg | 231.00 € | ||
| 100mg | 346.00 € | ||
| 1mL*10mM (DMSO) | 92.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
WHI-P154
CAS:211555-04-3
WHI-P154 (Jak3 inhibitor ii) is a potent JAK3 inhibitor.
Formula:
C16H14BrN3O3
Purity:
98% - 99.6%
Color and Shape:
Solid
Molecular weight:
376.2
Ref: TM-T1985
| 2mg | 46.00 € | ||
| 5mg | 61.00 € | ||
| 10mg | 96.00 € | ||
| 25mg | 174.00 € | ||
| 50mg | 328.00 € | ||
| 100mg | 532.00 € | ||
| 1mL*10mM (DMSO) | 63.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
WHI-P97 HCl
WHI-P97 HCl is a potent and selective JAK-3 inhibitor.
Formula:
C16H14Br2ClN3O3
Purity:
98.55%
Color and Shape:
Solid
Molecular weight:
491.56
Ref: TM-T4657L
| 1mg | 41.00 € | ||
| 5mg | 65.00 € | ||
| 10mg | 112.00 € | ||
| 25mg | 194.00 € | ||
| 50mg | 267.00 € | ||
| 100mg | 381.00 € | ||
| 200mg | 542.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Abrocitinib
CAS:1622902-68-4
Abrocitinib (PF-04965842) (PF-04965842) is a potent, specific and orally-active JAK1 inhibitor (IC50s: 29/803 nM for …
Formula:
C14H21N5O2S
Purity:
99.09% - 99.91%
Color and Shape:
Solid
Molecular weight:
323.41
Ref: TM-TQ0037
| 1mg | 83.00 € | ||
| 2mg | 106.00 € | ||
| 5mg | 164.00 € | ||
| 10mg | 278.00 € | ||
| 25mg | 456.00 € | ||
| 50mg | 677.00 € | ||
| 100mg | 920.00 € | ||
| 1mL*10mM (DMSO) | 187.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
AZD1208
CAS:1204144-28-4
AZD1208 is a novel, orally bioavailable, highly selective PIM kinase inhibitor with single nanomolar potency …
Formula:
C21H21N3O2S
Purity:
97.24% - 98.87%
Color and Shape:
Solid
Molecular weight:
379.48
Ref: TM-T2300
| 2mg | 38.00 € | ||
| 5mg | 51.00 € | ||
| 10mg | 74.00 € | ||
| 25mg | 117.00 € | ||
| 50mg | 210.00 € | ||
| 100mg | 370.00 € | ||
| 200mg | 487.00 € | ||
| 500mg | 778.00 € | ||
| 1mL*10mM (DMSO) | 57.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Atractylenolide I
CAS:73069-13-3
Atractylenolide-I reduces inflammation, improves sepsis, liver, and kidney function, and enhances EOC cell sensitivity to …
Formula:
C15H18O2
Purity:
97.55%
Color and Shape:
Solid
Molecular weight:
230.3
Ref: TM-T5S0167
| 1mg | 42.00 € | ||
| 5mg | 85.00 € | ||
| 10mg | 128.00 € | ||
| 25mg | 237.00 € | ||
| 50mg | 414.00 € | ||
| 100mg | 579.00 € | ||
| 1mL*10mM (DMSO) | 94.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
XL019
CAS:945755-56-6
XL019 is a potent and selective JAK2 inhibitor with IC50 of 2.2 nM, 100 fold …
Formula:
C25H28N6O2
Purity:
99.23%
Color and Shape:
Solid
Molecular weight:
444.53
Ref: TM-T3072
| 5mg | 74.00 € | ||
| 10mg | 119.00 € | ||
| 25mg | 210.00 € | ||
| 50mg | 347.00 € | ||
| 100mg | 515.00 € | ||
| 200mg | 439.00 € | ||
| 1mL*10mM (DMSO) | 82.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
AT9283
CAS:896466-04-9
AT9283 (J-504568) is an effective multi-targeted inhibitor of JAK2(IC50=1.2 nM) and JAK3(IC50=1.1 nM), Aurora A, …
Formula:
C19H23N7O2
Purity:
99.87% - 99.98%
Color and Shape:
Solid
Molecular weight:
381.43
Ref: TM-T3068
| 1mg | 46.00 € | ||
| 2mg | 59.00 € | ||
| 5mg | 93.00 € | ||
| 10mg | 167.00 € | ||
| 25mg | 294.00 € | ||
| 50mg | 488.00 € | ||
| 100mg | 711.00 € | ||
| 1mL*10mM (DMSO) | 96.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Curculigoside
CAS:85643-19-2
1.
Formula:
C22H26O11
Purity:
99.85%
Color and Shape:
Solid
Molecular weight:
466.44
Ref: TM-T6S1966
| 1mg | 46.00 € | ||
| 5mg | 69.00 € | ||
| 10mg | 94.00 € | ||
| 25mg | 156.00 € | ||
| 50mg | 221.00 € | ||
| 100mg | 333.00 € | ||
| 1mL*10mM (DMSO) | 71.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Pim1/AKK1-IN-1
CAS:1093222-27-5
Pim1/AKK1-IN-1: LKB1/AAK1 inhibitor with Kd 35/53/75/380 nM for Pim1/AKK1/MST2/LKB1, also targets MPSK1, TNIK.
Formula:
C20H13N5O
Purity:
97.84% - 98.69%
Color and Shape:
Solid
Molecular weight:
339.35
Ref: TM-T5093
| 1mg | 88.00 € | ||
| 2mg | 129.00 € | ||
| 5mg | 180.00 € | ||
| 10mg | 273.00 € | ||
| 25mg | 479.00 € | ||
| 50mg | 697.00 € | ||
| 100mg | 978.00 € | ||
| 1mL*10mM (DMSO) | 201.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
CEP-33779
CAS:1257704-57-6
CEP-33779 is a novel and selective inhibitor of JAK2 with an IC50 of 1.8±0.6 nM.
Formula:
C24H26N6O2S
Purity:
98.81% - ≥95%
Color and Shape:
Solid
Molecular weight:
462.57
Ref: TM-T6122
| 1mg | 45.00 € | ||
| 2mg | 59.00 € | ||
| 5mg | 87.00 € | ||
| 10mg | 143.00 € | ||
| 25mg | 241.00 € | ||
| 50mg | 372.00 € | ||
| 100mg | 553.00 € | ||
| 500mg | 1,194.00 € | ||
| 1mL*10mM (DMSO) | 96.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Pacritinib
CAS:937272-79-2
Pacritinib (SB1518) (SB1518) is an effective and specific inhibitor of JAK2 and FLT3 (IC50: 23/22 …
Formula:
C28H32N4O3
Purity:
99.27% - ≥95%
Color and Shape:
Solid
Molecular weight:
472.58
Ref: TM-T6020
| 2mg | 40.00 € | ||
| 5mg | 59.00 € | ||
| 10mg | 96.00 € | ||
| 25mg | 148.00 € | ||
| 50mg | 222.00 € | ||
| 100mg | 368.00 € | ||
| 500mg | 866.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Baricitinib phosphate
CAS:1187595-84-1
Baricitinib phosphate (INCB028050) is a selective orally bioavailable JAK1/JAK2 inhibitor.
Formula:
C16H20N7O6PS
Purity:
98.87% - 99.68%
Color and Shape:
Solid
Molecular weight:
469.41
Ref: TM-T2360
| 5mg | 47.00 € | ||
| 10mg | 62.00 € | ||
| 25mg | 91.00 € | ||
| 50mg | 113.00 € | ||
| 100mg | 142.00 € | ||
| 500mg | 343.00 € | ||
| 1mL*10mM (DMSO) | 55.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Quercetagetin
CAS:90-18-6
Quercetagetin, a flavonoid from Citrus unshiu, inhibits pim-1 kinase (IC50: 0.34 μM), cell-permeable.
Formula:
C15H10O8
Purity:
99.65% - 99.76%
Color and Shape:
Solid
Molecular weight:
318.24
Ref: TM-T8114
| 1mg | 87.00 € | ||
| 5mg | 198.00 € | ||
| 10mg | 297.00 € | ||
| 25mg | 498.00 € | ||
| 50mg | 719.00 € | ||
| 100mg | 975.00 € | ||
| 500mg | 1,941.00 € | ||
| 1mL*10mM (DMSO) | 213.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
SC99
CAS:882290-02-0
SC99 inhibits JAK2-STAT3, reducing STAT3 genes, platelet activity, and has anti-myeloma, anti-thrombotic effects.
Formula:
C15H8Cl2FN3O
Purity:
99.56%
Color and Shape:
Solid
Molecular weight:
336.15
Ref: TM-T8719
| 1mg | 44.00 € | ||
| 5mg | 90.00 € | ||
| 10mg | 136.00 € | ||
| 25mg | 232.00 € | ||
| 50mg | 350.00 € | ||
| 100mg | 436.00 € | ||
| 200mg | 608.00 € | ||
| 1mL*10mM (DMSO) | 96.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
