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JAK/STAT signaling

JAK/STAT signaling

JAK/STAT signaling inhibitors are compounds that disrupt the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway, which is involved in cytokine signaling, cell growth, and immune response. These inhibitors are important tools in studying the regulation of this pathway and its role in various diseases, including cancers, immune disorders, and inflammatory conditions. JAK/STAT inhibitors are also being developed as targeted therapies for these diseases. At CymitQuimica, we provide a wide selection of high-quality JAK/STAT signaling inhibitors to support your research in molecular biology, oncology, and immunology.

Subcategories of "JAK/STAT signaling"

Found 321 products of "JAK/STAT signaling"

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  • Brepocitinib P-Tosylate
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    Brepocitinib P-Tosylate

    CAS:
    <p>Brepocitinib P-Tosylate (PF-06700841 P-Tosylate) is a potent dual inhibitor of Janus kinase 1 (JAK1) and TYK2 (IC50s of 17 nM and 23 nM, respectively).</p>
    Formula:C25H29F2N7O4S
    Purity:99.82% - 99.97%
    Color and Shape:Solid
    Molecular weight:561.6

    Ref: TM-T12427

  • Delgocitinib
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    Delgocitinib

    CAS:
    <p>Delgocitinib is a potent JAK inhibitor (IC50: 2.8-58 nM), treats inflammatory diseases, and is the first topical drug for atopic dermatitis.</p>
    Formula:C16H18N6O
    Purity:99.95%
    Color and Shape:Solid
    Molecular weight:310.35

    Ref: TM-T15096

  • Uzansertib phosphate
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    Uzansertib phosphate

    CAS:
    <p>Uzansertib phosphate (INCB053914 phosphate) is an orally active, ATP-competitive inhibitor of pan-PIM kinase, inhibiting PIM1, PIM2 and PIM3.</p>
    Formula:C26H29F3N5O7P
    Purity:99.75% - 99.79%
    Color and Shape:Solid
    Molecular weight:611.51

    Ref: TM-T12477

  • TAK-901
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    TAK-901

    CAS:
    <p>TAK-901 has been used in trials studying the treatment of Lymphoma, Myelofibrosis, Multiple Myeloma, Myeloid Metaplasia, and Advanced Solid Tumors, among others</p>
    Formula:C28H32N4O3S
    Purity:99.02% - 99.59%
    Color and Shape:Solid
    Molecular weight:504.64

    Ref: TM-T2709

  • Nimucitinib
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    Nimucitinib

    CAS:
    <p>Nimucitinib is a Janus kinase (JAK) inhibitor that can be used to treat dry eye and promote tear production.</p>
    Formula:C25H26F2N6O2
    Purity:98.71%
    Color and Shape:Soild
    Molecular weight:480.51

    Ref: TM-T67907

  • WDR5-IN-6
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    WDR5-IN-6

    CAS:
    <p>WDR5-IN-6 is a WDR5 inhibitor targeting the WBM locus.WDR5-IN-6 is highly synergistic with OICR-9429, a WDR5 inhibitor that targets the WIN locus.WDR5-IN-6</p>
    Formula:C13H8Cl2N2O2S
    Purity:99.69%
    Color and Shape:Soild
    Molecular weight:327.19

    Ref: TM-T77495

  • KT-333
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    KT-333

    CAS:
    <p>KT-333 is a potent, highly selective, heterobifunctional degrader of STAT3 for the treatment of a variety of STAT3-dependent pathologies, antitumor.</p>
    Formula:C60H74ClN10O14PS
    Purity:98.12%
    Color and Shape:Solid
    Molecular weight:1257.78

    Ref: TM-T88358

  • N-(3-Aminopropyl)cyclohexylamine
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    N-(3-Aminopropyl)cyclohexylamine

    CAS:
    <p>N-(3-Aminopropyl)cyclohexylamine inhibits spermine synthase; used in neuro disease research.</p>
    Formula:C9H20N2
    Purity:98.05% - 98.82%
    Color and Shape:Pale Yellow Clear Liquid
    Molecular weight:156.2685

    Ref: TM-T35878

  • Bromisoval
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    Bromisoval

    CAS:
    <p>Bromisoval (Isobromyl) is a mild hypnotic and sedative with potential toxicity.</p>
    Formula:C6H11BrN2O2
    Purity:98.86%
    Color and Shape:Solid
    Molecular weight:223.07

    Ref: TM-T0227

  • JAK2 Inhibitor V
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    JAK2 Inhibitor V

    CAS:
    <p>JAK2 Inhibitor V (JAK2 Inhibitor V Z3) is a novel specific inhibitor of Jak2, inhibiting Jak2-V617F and Jak2-WT autophosphorylation in a dose-dependent manner.</p>
    Formula:C23H24N2O
    Purity:98.36% - 99.15%
    Color and Shape:Solid
    Molecular weight:344.45

    Ref: TM-T3042

  • Gusacitinib
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    Gusacitinib

    CAS:
    <p>Gusacitinib (ASN-002) (ASN-002) is spleen tyrosine kinase (SYK) and janus kinase (JAK) inhibitor (IC50: 5-46 nM).</p>
    Formula:C24H28N8O2
    Purity:98.06% - 99.94%
    Color and Shape:Solid
    Molecular weight:460.53

    Ref: TM-T14331

  • Ilginatinib maleate
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    Ilginatinib maleate

    CAS:
    <p>Ilginatinib maleate (NS-018 maleate) is a highly active and orally bioavailable inhibitor of JAK2.</p>
    Formula:C25H24FN7O4
    Purity:99.74% - 99.82%
    Color and Shape:Solid
    Molecular weight:505.5

    Ref: TM-T12266L

  • Pim-1 kinase inhibitor 8
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    Pim-1 kinase inhibitor 8

    CAS:
    <p>Pim-1 kinase inhibitor 8 is a Pim-1 kinase inhibitor with anticancer activity that inhibits cell migration and can be studied in breast cancer.</p>
    Formula:C14H17N3O3
    Purity:99.81%
    Color and Shape:Soild
    Molecular weight:275.3

    Ref: TM-T83627

  • Ilginatinib
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    Ilginatinib

    CAS:
    <p>Ilginatinib (NS-018) is a highly active and orally bioavailable inhibitor of JAK2.</p>
    Formula:C21H20FN7
    Purity:98.4% - 99.01%
    Color and Shape:Solid
    Molecular weight:389.43

    Ref: TM-T12266

  • Golidocitinib
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    Golidocitinib

    CAS:
    <p>Golidocitinib (AZD4205) is a selective JAK1 inhibitor (IC50: 73 nM) and weakly inhibits JAK2/JAK3 (IC50: &gt;14.7, &gt;30 μM).</p>
    Formula:C25H31N9O2
    Purity:98.87% - 99.88%
    Color and Shape:Solid
    Molecular weight:489.57

    Ref: TM-T10431

  • Ilginatinib hydrochloride
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    Ilginatinib hydrochloride

    CAS:
    <p>Ilginatinib hydrochloride (NS-018 hydrochloride) is a highly active and orally bioavailable inhibitor of JAK2.</p>
    Formula:C21H21ClFN7
    Purity:99.55%
    Color and Shape:Solid
    Molecular weight:425.89

    Ref: TM-T12266L2

  • PM-81I
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    PM-81I

    CAS:
    <p>PM-81I: Potent STAT6 inhibitor for allergic and pulmonary conditions, cancer research. Reduces STAT6 phosphorylation.</p>
    Formula:C43H58F2N3O10P
    Color and Shape:Solid
    Molecular weight:845.91

    Ref: TM-T74646

  • JAK1/TYK2-IN-1
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    JAK1/TYK2-IN-1

    CAS:
    <p>JAK1/TYK2-IN-1 is a dual inhibitor of TYK2 and JAK1 ( IC 50 = 29 and 41 nM respectively).</p>
    Formula:C18H20F3N7O
    Color and Shape:Solid
    Molecular weight:407.401

    Ref: TM-T39314

  • Fulipiftide
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    Fulipiftide

    CAS:
    <p>Fulipiftide is a short peptide derived from pigment epithelium-derived factor (PEDF). It stimulates the amplification of nuclear stem cell factor+TSPC by activating the ERK2 and STAT3 signaling pathways. Fulipiftide also exhibits anti-inflammatory properties and is applicable in research on acute tendon injuries.</p>
    Formula:C144H227N41O47
    Color and Shape:Solid
    Molecular weight:3284.59

    Ref: TM-TP3262

  • CymitQuimica logo
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    TYK2 activator-1

    <p>TYK2activator-1 (16b) is a TYK2 activator with an EC50 value of 1.78 μM. It inhibits JAK2 and JAK3 with IC50 values of 6.8 μM and 6.3 μM, respectively.</p>
    Formula:C23H21FN4O2
    Color and Shape:Solid
    Molecular weight:404.16485

    Ref: TM-T207637