JAK/STAT signaling
JAK/STAT signaling inhibitors are compounds that disrupt the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway, which is involved in cytokine signaling, cell growth, and immune response. These inhibitors are important tools in studying the regulation of this pathway and its role in various diseases, including cancers, immune disorders, and inflammatory conditions. JAK/STAT inhibitors are also being developed as targeted therapies for these diseases. At CymitQuimica, we provide a wide selection of high-quality JAK/STAT signaling inhibitors to support your research in molecular biology, oncology, and immunology.
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Products of "JAK/STAT signaling"
Fosifidancitinib
CAS:1237168-58-9
Fosifidancitinib is a potent inhibitor of JAK 1 and JAK 3.
Formula:
C21H21FN5O7P
Purity:
99.55%
Color and Shape:
Solid
Molecular weight:
505.39
Ref: TM-T38624
| 1mg | 95.00 € | ||
| 2mg | 120.00 € | ||
| 5mg | 181.00 € | ||
| 10mg | 273.00 € | ||
| 25mg | 436.00 € | ||
| 50mg | 621.00 € | ||
| 100mg | 836.00 € | ||
| 200mg | 1,118.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Oclacitinib maleate
CAS:1640292-55-2
Oclacitinib maleate is a selective JAK inhibitor (IC50: 10-99 nM; JAK1 cytokines: 36-249 nM), with …
Formula:
C15H23N5O2S·C4H4O4
Purity:
99.17%
Color and Shape:
Solid
Molecular weight:
453.51
Ref: TM-T6914
| 1mg | 39.00 € | ||
| 2mg | 50.00 € | ||
| 5mg | 78.00 € | ||
| 10mg | 97.00 € | ||
| 25mg | 171.00 € | ||
| 50mg | 267.00 € | ||
| 100mg | 446.00 € | ||
| 1mL*10mM (DMSO) | 85.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
(Z)-SMI-4a
CAS:438190-29-5
(Z)-SMI-4a (TCS PIM-1 4a) is a selective ATP-competitive Pim-1 kinase inhibitor with an IC50 of …
Formula:
C11H6F3NO2S
Purity:
97.66% - 99.44%
Color and Shape:
Solid
Molecular weight:
273.23
Ref: TM-T3058
| 5mg | 51.00 € | ||
| 10mg | 71.00 € | ||
| 25mg | 142.00 € | ||
| 50mg | 212.00 € | ||
| 100mg | 318.00 € | ||
| 200mg | 479.00 € | ||
| 1mL*10mM (DMSO) | 52.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Oclacitinib
CAS:1208319-26-9
Oclacitinib (PF-03394197)(PF03394197) is a potent and selective JAKs inhibitor with IC50 of 10-99 nM; not …
Formula:
C15H23N5O2S
Purity:
98% - 98.12%
Color and Shape:
White To Off-White Solid
Molecular weight:
337.44
Ref: TM-T2012
| 5mg | 46.00 € | ||
| 10mg | 60.00 € | ||
| 25mg | 106.00 € | ||
| 50mg | 167.00 € | ||
| 100mg | 271.00 € | ||
| 1mL*10mM (DMSO) | 51.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
AZD-1480
CAS:935666-88-9
AZD1480: JAK2 inhibitor, IC50 0.26 nM; selective vs Tyk2, JAK3; less on JAK1. Used in …
Formula:
C14H14ClFN8
Purity:
97.5% - 98.55%
Color and Shape:
Solid
Molecular weight:
348.77
Ref: TM-T3069
| 5mg | 56.00 € | ||
| 10mg | 88.00 € | ||
| 25mg | 138.00 € | ||
| 50mg | To inquire | ||
| 1mL*10mM (DMSO) | 59.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
JAK-IN-5 hydrochloride
CAS:2751323-21-2
JAK-IN-5 hydrochloride is a JAK inhibitor [1].
Formula:
C27H32ClFN6O
Color and Shape:
Solid
Molecular weight:
511.03
Ref: TM-T11710L
| 25mg | 1,503.00 € | ||
| 50mg | 1,975.00 € | ||
| 100mg | 2,949.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
NVP-BSK805
CAS:1092499-93-8
NVP-BSK805 (BSK 805) is an ATP-competitive JAK2 inhibitor.
Formula:
C27H28F2N6O
Purity:
98%
Color and Shape:
Solid
Molecular weight:
490.55
Ref: TM-T5049
| 1mg | 61.00 € | ||
| 5mg | 129.00 € | ||
| 10mg | 209.00 € | ||
| 25mg | 402.00 € |
Estimated delivery in United States, on Tuesday 17 Dec 2024
JAK2-IN-9
CAS:2568842-26-0
Compound A8, known as JAK2-IN-9, is a selective JAK2 inhibitor with an IC50 of 5 …
Formula:
C20H24N6O2S
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
412.51
Ref: TM-T79581
| 25mg | 1,410.00 € | ||
| 50mg | 1,851.00 € | ||
| 100mg | 2,337.00 € |
Estimated delivery in United States, on Tuesday 21 Jan 2025
K00135
CAS:869650-21-5
K00135 (IMIDAZOPYRIDAZIN 1) is a selective inhibitor of Pim kinases and can be used in …
Formula:
C18H18N4O
Purity:
97.88%
Color and Shape:
Solid
Molecular weight:
306.36
Ref: TM-T27704
| 1mg | 183.00 € | ||
| 2mg | 275.00 € | ||
| 5mg | 422.00 € | ||
| 10mg | 618.00 € | ||
| 25mg | 926.00 € | ||
| 50mg | 1,304.00 € | ||
| 100mg | 1,763.00 € | ||
| 500mg | 3,509.00 € | ||
| 1mL*10mM (DMSO) | 410.00 € |
Estimated delivery in United States, on Tuesday 21 Jan 2025
JAK3i
CAS:1918238-72-8
JAK3i selectively inhibits JAK3 kinase, targeting the second, vital wave of STAT5 phosphorylation for T …
Formula:
C18H15FN4O3
Purity:
98.61% - 99.81%
Color and Shape:
Solid
Molecular weight:
354.34
Ref: TM-T27650
| 1mg | 326.00 € | ||
| 5mg | 769.00 € | ||
| 10mg | 1,050.00 € | ||
| 25mg | 1,476.00 € | ||
| 50mg | 1,850.00 € | ||
| 1mL*10mM (DMSO) | 658.00 € |
Estimated delivery in United States, on Tuesday 21 Jan 2025
JAK1-IN-4
CAS:2091134-35-7
JAK1-IN-4 selectively blocks JAK1 (IC50 = 85 nM) over JAK2/JAK3 and halts STAT3 phosphorylation in …
Formula:
C26H32FN9O2
Purity:
98%
Color and Shape:
Solid
Molecular weight:
521.59
Ref: TM-T15606
| 25mg | 1,549.00 € | ||
| 50mg | 2,038.00 € | ||
| 100mg | 2,617.00 € |
Estimated delivery in United States, on Tuesday 21 Jan 2025
JAK1-IN-8
CAS:1973485-18-5
JAK1-IN-8, a specific inhibitor of Janus kinase 1 (JAK1, IC50<500 nM).
Formula:
C22H23FN4O3S
Purity:
98.36%
Color and Shape:
Liquid
Molecular weight:
442.51
Ref: TM-T35899
| 5mg | 46.00 € | ||
| 10mg | 80.00 € | ||
| 25mg | 145.00 € | ||
| 50mg | 251.00 € | ||
| 100mg | 426.00 € | ||
| 200mg | 569.00 € | ||
| 1mL*10mM (DMSO) | 52.00 € |
Estimated delivery in United States, on Tuesday 21 Jan 2025
JAK-IN-30
CAS:2891469-99-9
JAK-IN-30 (compound 31) is a water-soluble inhibitor of Janus kinases (JAKs), demonstrating inhibitory potency with …
Formula:
C19H26N8S
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
398.53
Ref: TM-T79235
| 1mg | 123.00 € | ||
| 5mg | 465.00 € | ||
| 10mg | 830.00 € |
Estimated delivery in United States, on Tuesday 21 Jan 2025
Jaspamycin
CAS:22242-96-2
Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα.
Formula:
C12H12N4O5
Color and Shape:
Solid
Molecular weight:
292.25
Ref: TM-T11711
| 5mg | 278.00 € | ||
| 25mg | 916.00 € | ||
| 50mg | 1,273.00 € | ||
| 100mg | 1,741.00 € | ||
| 1mL*10mM (DMSO) | 301.00 € |
Estimated delivery in United States, on Tuesday 21 Jan 2025
JAK3/BTK-IN-1
CAS:2674036-91-8
JAK3/ BTk-in-1 is a dual JAK3/BTK inhibitor that specifically targets and inhibits Janus kinase 3 …
Formula:
C25H28N8O
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
456.54
Ref: TM-T9814
| 1mg | 225.00 € | ||
| 5mg | 560.00 € | ||
| 10mg | 797.00 € | ||
| 25mg | 1,234.00 € | ||
| 50mg | 1,561.00 € | ||
| 100mg | 2,350.00 € |
Estimated delivery in United States, on Tuesday 21 Jan 2025
JAK-STAT-IN-1
CAS:1236666-76-4
JAK-STAT-IN-1 is a specific JAK-STAT inhibitor indicated for the study of autoimmune diseases.
Formula:
C21H21N5O2
Purity:
99.21%
Color and Shape:
Solid
Molecular weight:
375.42
Ref: TM-T78607
| 1mg | 183.00 € | ||
| 5mg | 452.00 € | ||
| 10mg | 647.00 € | ||
| 25mg | 1,009.00 € | ||
| 50mg | 1,392.00 € | ||
| 100mg | 1,841.00 € |
Estimated delivery in United States, on Tuesday 21 Jan 2025
Izencitinib
CAS:2051918-33-1
Izencitinib (JNJ-8398) is a JAK inhibitor with potential anti-inflammatory activity for the study of ulcerative …
Formula:
C22H26N8
Purity:
99.82%
Color and Shape:
Liquid
Molecular weight:
402.50
Ref: TM-T35898
| 1mg | 88.00 € | ||
| 5mg | 185.00 € | ||
| 10mg | 294.00 € | ||
| 25mg | 590.00 € | ||
| 50mg | 925.00 € | ||
| 100mg | 1,490.00 € | ||
| 200mg | 2,042.00 € | ||
| 1mL*10mM (DMSO) | 204.00 € |
Estimated delivery in United States, on Tuesday 21 Jan 2025
JAK3/BTK-IN-2
CAS:2674036-93-0
JAK3/ BTk-in-2 is a potent JAK3/BTK inhibitor.
Formula:
C25H32N8O2
Purity:
98%
Color and Shape:
Solid
Molecular weight:
476.57
Ref: TM-T9813
| 25mg | 1,234.00 € | ||
| 50mg | 1,605.00 € | ||
| 100mg | 2,419.00 € |
Estimated delivery in United States, on Tuesday 21 Jan 2025
Momelotinib Mesylate
CAS:1056636-07-7
Momelotinib Mesylate is an ATP-competitive JAK1/JAK2 inhibitor (IC50: 11 nM/18 nM). It has 10-fold selectivity …
Formula:
C24H26N6O5S
Purity:
98%
Color and Shape:
Solid
Molecular weight:
510.57
Ref: TM-T15037
| 25mg | 1,410.00 € |
Estimated delivery in United States, on Tuesday 21 Jan 2025
CX-6258
CAS:1202916-90-2
CX-6258 is an orally valid Pim 1/2/3 kinase(IC50=5 nM/25 nM/16 nM) inhibitor. It has good …
Formula:
C26H24ClN3O3
Purity:
95.88%
Color and Shape:
Solid
Molecular weight:
461.94
Ref: TM-T1834
| 1mg | 37.00 € | ||
| 5mg | 79.00 € | ||
| 10mg | 105.00 € | ||
| 25mg | 206.00 € | ||
| 50mg | 308.00 € | ||
| 100mg | 465.00 € | ||
| 200mg | 650.00 € | ||
| 1mL*10mM (DMSO) | 80.00 € |
Estimated delivery in United States, on Tuesday 21 Jan 2025
