p38 MAPK
p38 MAPKs are a subgroup of MAPKs that respond to stress signals and are involved in the regulation of inflammation, cell differentiation, apoptosis, and autophagy. p38 MAPK signaling is crucial in immune responses and is implicated in various diseases, including chronic inflammatory conditions, cancer, and neurodegenerative disorders. At CymitQuimica, we provide a comprehensive range of p38 MAPK inhibitors and modulators to support your research in inflammation, stress response, and therapeutic development.
Found 117 products of "p38 MAPK"
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SB220025
CAS:<p>SB220025 is a P38 mitogen-activated protein kinase inhibitor that inhibits p56Lck and PKC, and inhibits angiogenesis.</p>Formula:C18H19FN6Purity:99.44%Color and Shape:SolidMolecular weight:338.38PF-3644022
CAS:<p>PF-3644022 is a selective MK2 inhibitor, effective against TNFα (IC50: 5.2 nM, Ki: 3 nM), with anti-inflammatory properties. Also blocks MK3 and PRAK.</p>Formula:C21H18N4OSPurity:98.13%Color and Shape:SolidMolecular weight:374.46Oxidopamine hydrobromide
CAS:<p>Oxidopamine hydrobromide (6-OHDA hydrobromide) is a neurotransmitter dopamine antagonist.</p>Formula:C8H12BrNO3Purity:98.22% - 99.88%Color and Shape:Beige To Brown Fine Crystalline PowderMolecular weight:250.09AZD7624
CAS:<p>AZD7624 is an p38 inhibitor. It has potent anti-inflammatory activity.</p>Formula:C27H30FN5O3Purity:98.82%Color and Shape:SolidMolecular weight:491.56Hesperetin
CAS:<p>Hesperetin belongs to the flavanone class of flavonoids.</p>Formula:C16H14O6Purity:98.45% - 99.27%Color and Shape:SolidMolecular weight:302.28BI-3406
CAS:<p>BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.</p>Formula:C23H25F3N4O3Purity:99.2% - 99.66%Color and Shape:SolidMolecular weight:462.46Dihydrocaffeic acid
CAS:<p>Dihydrocaffeic acid, a chlorogenic acid metabolite, has antioxidant, anti-Alzheimer's, neuroprotective, and lipid-lowering properties.</p>Formula:C9H10O4Purity:98.63%Color and Shape:SolidMolecular weight:182.17Carbimazole
CAS:<p>Carbimazole, an imidazolium-based thyroid blocker, turns to MMI in the body. Used in Graves' disease research.</p>Formula:C7H10N2O2SPurity:99.98%Color and Shape:SolidMolecular weight:186.23Oxidopamine hydrochloride
CAS:<p>Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) is an neurotransmitter dopamine antagonist.</p>Formula:C8H12ClNO3Purity:98.34% - 99.85%Color and Shape:Physical Description Beige Solid (Ntp 1992)Molecular weight:205.64Dilmapimod
CAS:<p>Dilmapimod (SB-681323) is a potent inhibitor of p38 MAPK ,it potentially suppresses inflammation in chronic obstructive pulmonary disease.</p>Formula:C23H19F3N4O3Purity:97.53%Color and Shape:SolidMolecular weight:456.42Dehydrocorydaline chloride
CAS:<p>Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid with anti-inflammatory and anti-cancer activity. Can improve the activation of p38 MAPK.</p>Formula:C22H24ClNO4Purity:99.53%Color and Shape:SolidMolecular weight:401.88LXH254
CAS:<p>LXH254 is a B/C RAF inhibitor with IC50 values of 0.2 nM and 0.07 nM for inhibiting BRAF and CRAF.Cost-effective and quality-assured.</p>Formula:C25H25F3N4O4Purity:98.3% - 99.92%Color and Shape:SolidMolecular weight:502.49Aspirin
CAS:<p>Aspirin (Acetylsalicylic Acid) is a COX inhibitor. Aspirin has anti-inflammatory, antipyretic and analgesic activities. Cost-effective and quality-assured.</p>Formula:C9H8O4Purity:99.78% - 99.91%Color and Shape:White Solid CrystallineMolecular weight:180.16DB-10
<p>DB-10 serves as a precursor to 3-nbutylphthalide (NBP). It is absorbed by cells in a temperature and energy-dependent manner through the pyrilamine cation transporter. DB-10 enhances cell survival and rapidly converts into an active form in vivo, increasing accumulation within the brain. This compound is applicable in ischemic stroke research.</p>Color and Shape:Odour SolidTalmapimod hydrochloride
CAS:<p>Talmapimod hydrochloride: selective p38α inhibitor, 9 nM IC50, 10x less effective on p38β, >2000-fold selective vs 20+ kinases.</p>Formula:C27H31Cl2FN4O3Purity:98%Color and Shape:SolidMolecular weight:549.46MAP3K5-IN-1
CAS:<p>Compound 7, also known as 3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine, serves as an inhibitor of protein kinases, displaying IC50 values of 0.092 μM for PKC-α, 0.26 μM for ROCK, and 0.77 μM for ASK1. Additionally, this compound exhibits significant cytotoxicity towards PC-3 cancer cells, with an IC50 of 0.16 μM [1].</p>Formula:C28H24N4O4Color and Shape:SolidMolecular weight:480.51Z16078526
CAS:<p>Z16078526 promotes Ucp1, p38 MAPK, lipolysis, thermogenic genes, and mitochondrial activity in mouse brown adipocytes.</p>Formula:C18H17N3O4SPurity:98.93%Color and Shape:SolidMolecular weight:371.41p38 MAP Kinase Inhibitor Ⅵ
CAS:<p>p38 MAP Kinase Inhibitor Ⅵ is a potent p38 MAP Kinase inhibitor with anti-inflammatory activity.</p>Formula:C16H13FN2OS2Purity:98.53%Color and Shape:SolidMolecular weight:332.42Cyclotraxin B
CAS:<p>TrkB receptor antagonist; inhibits BDNF-TrkB signaling (IC50 = 0.30 nM); alters receptor shape; may reduce anxiety in mice.</p>Formula:C48H73N13O17S3Purity:98%Color and Shape:SolidMolecular weight:1200.36WYE-687
CAS:<p>WYE-687 is a selective mTOR inhibitor (IC50: 7 nM), over 100x more selective for mTOR than PI3Kα/γ, affecting mTORC1/pS6K and mTORC2/P-AKT(S473).</p>Formula:C28H32N8O3Purity:99.93%Color and Shape:SolidMolecular weight:528.61Ro-3201195
CAS:<p>Ro-3201195 is a novel orally available p38 MAPK inhibitor with high selectivity.</p>Formula:C19H18FN3O4Purity:99.15%Color and Shape:SolidMolecular weight:371.36p38α inhibitor 5
CAS:<p>The compound p38α inhibitor5 (compound 1) is a PROTAC-type ligand that targets p38 and is utilized in the synthesis of NR-11c.</p>Formula:C26H23BrF2N2O3Color and Shape:SolidMolecular weight:529.37Esculin sesquihydrate
CAS:<p>Esculin sesquihydrate, a coumarin glucoside with fluorescent properties and a constituent of ash bark, improves cognitive deficits associated with experimental</p>Formula:C15H16O9H2OPurity:98%Color and Shape:SolidMolecular weight:367.31OVA-E1 peptide TFA
CAS:<p>OVA-E1 peptide TFA activates the p38 and JNK cascades similarly in mutant and wild-type thymocytes.</p>Formula:C49H77F3N10O16Purity:98%Color and Shape:SolidMolecular weight:1119.19PDE4-IN-26
<p>PDE4-IN-26 (Compound A5) is an orally active, highly selective inhibitor of PDE4. It exhibits anti-inflammatory properties by inhibiting p38 MAPK phosphorylation. In mouse models of acute lung injury and chronic obstructive pulmonary disease, PDE4-IN-26 reduces lung inflammation, damage, and fibrosis, while promoting sputum secretion and alleviating cough. It is useful for researching lung injury-related diseases.</p>Formula:C22H18F2N4O3SColor and Shape:SolidMolecular weight:456.47p38α inhibitor 3
CAS:<p>p38α inhibitor 3 is a inhibitor of the mitogen-activated protein kinase p38α that can block the effectiveness of myoblast differentiation.</p>Formula:C19H20FNOPurity:99.94%Color and Shape:SoildMolecular weight:297.37R1487 Hydrochloride
CAS:<p>R1487 Hydrochloride (R1487 (Hydrochloride)) is an orally bioavailable and highly selective inhibitors of p38α.</p>Formula:C19H19ClF2N4O3Purity:99.42%Color and Shape:SolidMolecular weight:424.83Adezmapimod
CAS:<p>Adezmapimod (SB 203580) is a p38 MAPK inhibitor (IC50=0.3-0.5 μM) that is selective and ATP-competitive.</p>Formula:C21H16FN3OSPurity:99.42% - 99.93%Color and Shape:White SolidMolecular weight:377.43Ralimetinib dimesylate
CAS:<p>Ralimetinib dimesylate (LY2228820 dimesylate) is a orally available, p38 MAPK inhibitor with potential anti-inflammatory and antineoplastic activities.</p>Formula:C24H29FN6·2CH4O3SPurity:98% - 99.38%Color and Shape:SolidMolecular weight:612.74SR-318
CAS:<p>SR-318 inhibits TNF-α (IC50=283 nM), selectively targets p38 MAPK: IC50 of 5nM (p38α), 32nM (p38β), 6.11μM (p38α/β).</p>Formula:C27H33N5O2Purity:99.74%Color and Shape:SolidMolecular weight:459.58SB 202190
CAS:<p>SB 202190 (FHPI) is a p38 MAPK inhibitor that inhibits p38α and p38β2 (IC50=50/100 nM) selectively and cell-permeably.</p>Formula:C20H14FN3OPurity:98% - 99.84%Color and Shape:Pale YellowMolecular weight:331.34Afatinib Dimaleate
CAS:<p>Afatinib Dimaleate (BIBW 2992MA2) is an orally bioavailable anilino-quinazoline derivative and inhibitor of the EGFR family, with antineoplastic activity.</p>Formula:C32H33ClFN5O11Purity:98.11% - 99.87%Color and Shape:SolidMolecular weight:718.08Skepinone-L
CAS:<p>Skepinone-L (CBS3830) is a selective p38 mitogen-activated protein kinase inhibitor.</p>Formula:C24H21F2NO4Purity:99.56% - >99.99%Color and Shape:SolidMolecular weight:425.42UM-164
CAS:<p>UM-164 (DAS-DFGO-II), a highly potent c-Src inhibitor with a dissociation constant (Kd) of 2.7 nM, also effectively inhibits p38α and p38β.</p>Formula:C30H31F3N8O3SPurity:98.72% - 99.52%Color and Shape:SolidMolecular weight:640.68ASK1-IN-1
CAS:<p>ASK1-IN-1 inhibits apoptosis kinase 1, crucial in cell stress responses, with 21 nM IC50.</p>Formula:C19H19N9O2Purity:99.92%Color and Shape:SolidMolecular weight:405.41Paris saponin VII
CAS:<p>Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.</p>Formula:C51H82O21Purity:99.51% - 99.63%Color and Shape:SolidMolecular weight:1031.18Cornuside
CAS:<p>Cornuside boosts immunity, reduces inflammation, protects heart and liver, and guards against brain injury by modulating stress responses.</p>Formula:C24H30O14Purity:99.86% - >99.99%Color and Shape:SolidMolecular weight:542.49Rotundic acid
CAS:<p>Rotundic acid fights various cancers: HepG2, A375, NCI-H446, MCF-7, and HT-29.</p>Formula:C30H48O5Purity:96.91% - 99.97%Color and Shape:SolidMolecular weight:488.7Andrograpanin
CAS:<p>Andrograpanin (19-HYDROXY-8(17),13-LABDADIEN-16,15-OLIDE) is a bioactive compound from Andrographis paniculata.</p>Formula:C20H30O3Purity:99.03% - 99.457%Color and Shape:SolidMolecular weight:318.45TA-02
CAS:<p>TA-02 is a p38 MAPK inhibitor with IC50 of 20 nM.TA-02 especially inhibits TGFBR-2.</p>Formula:C20H13F2N3Purity:99.35% - 99.79%Color and Shape:SolidMolecular weight:333.33Sertaconazole
CAS:<p>Sertaconazole is a broad-spectrum antifungal.</p>Formula:C20H15Cl3N2OSPurity:99.483%Color and Shape:SolidMolecular weight:437.77Gypenoside L
CAS:<p>Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release.</p>Formula:C42H72O14Purity:99.42% - 99.65%Color and Shape:SolidMolecular weight:801.01TA-01
CAS:<p>TA-01 is a potent CK1 and p38 MAPK inhibitor, with IC50s of 6.4 nM, 6.8 nM, 6.7 nM for CK1ε, CK1δ and p38 MAPK, respectively.</p>Formula:C20H12F3N3Purity:99.55% - 99.94%Color and Shape:SolidMolecular weight:351.32SB 239063
CAS:<p>SB 239063 (SB239063) is a potent and selective p38 MAPKα/β inhibitor with IC50 of 44 nM, showing no activity against the γ- and δ-kinase isoforms.</p>Formula:C20H21FN4O2Purity:99.42% - 99.81%Color and Shape:SolidMolecular weight:368.4Pexmetinib
CAS:<p>Pexmetinib (ARRY-614) is an orally bioavailable dual p38 MAPK/Tie-2 inhibitor.Cost-effective and quality-assured.</p>Formula:C31H33FN6O3Purity:99.07% - 99.66%Color and Shape:SolidMolecular weight:556.63Kaempferol-3-O-glucorhamnoside
CAS:<p>Kaempferol-3-O-glucorhamnoside (Kaempferol 3-glucorhamnoside), a flavonoid derived from plant Thesium chinense Turcz, inhibits inflammatory responses via MAPK</p>Formula:C27H30O15Purity:96.96% - 98.17%Color and Shape:SolidMolecular weight:594.5Sertaconazole nitrate
CAS:<p>Sertaconazole nitrate, a broad-spectrum topical antifungal, treats skin and mucosal infections.</p>Formula:C20H15Cl3N2OS·HNO3Purity:98.66% - 99.65%Color and Shape:SolidMolecular weight:500.78BMS-582949 hydrochloride
CAS:<p>The BMS-582949 hydrochloride (BMS-582949 HCl) is a highly specific p38α MAPK inhibitor (IC50: 13 nM).</p>Formula:C22H27ClN6O2Purity:97.57% - 98.75%Color and Shape:SolidMolecular weight:442.95Nitidine chloride
CAS:<p>1.</p>Formula:C21H18ClNO4Purity:96.59% - 98.91%Color and Shape:SolidMolecular weight:383.82Neflamapimod
CAS:<p>Neflamapimod (VX-745) , a specific and effective inhibitor of p38α(IC50=10 nM), is 22-fold greater specificity against p38β and no inhibition activity to p38γ.</p>Formula:C19H9Cl2F2N3OSPurity:97.88% - 99.75%Color and Shape:SolidMolecular weight:436.26
