p38 MAPK

Oxidopamine hydrobromide is a neurotransmitter dopamine antagonist.

BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless …

Acetylsalicylic acid is a potent and selective inhibitor of COX with various pharmacological activities, such …

Dilmapimod is a potent inhibitor of p38 MAPK ,it potentially suppresses inflammation in chronic obstructive …

Oxidopamine hydrochloride is an neurotransmitter dopamine antagonist.

Hesperetin belongs to the flavanone class of flavonoids. Hesperetin, in the form of its glycoside …

AZD7624 is an p38 inhibitor. It has potent anti-inflammatory activity.

PF-3644022 is an effective, selective, and ATP-competitive MAPKAPK2 (MK2) inhibitor (IC50: 5.2 nM and a …

Dihydrocaffeic Acid is a natural product containing a catechol group with an α,β-unsaturated carboxylic acid …

Dehydrocorydaline chloride is an alkaloid with anti-inflammatory and anti-cancer activity. Can improve the activation of …

LXH254 is a potent C-Raf and B-Raf inhibitor.

Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 …

AMG-548 is an orally active and selective p38α inhibitor (Ki=0.5 nM), shows slightly selective over …

Apelin-12 acetate possesses a high affinity to orphan receptor APJ receptor. Apelin-12 acetate inhibits the …

3,5-Dicaffeoyl-epi-quinic acid shows anti-inflammatory activity, it may improve mast cell-mediated inflammatory diseases.

Samidin has anti-inflammatory properties through suppression of NF-κB and AP-1-mediated-genes in lipopolysaccharide (LPS)-stimulated RAW 264.7 …

Muramyl dipeptide is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a …

PP58 is an inhibitor of PDGFR, FGFR and Src family.

Lucidenic acid D2 is a nartural product from G. lucidum AF.

Isopedicin has anti-inflammatory functions, it inhibits the O(2)(*)(-) production in human neutrophils by an elevation …

Goshonoside F5 has anti-inflammatory activity, it significantly inhibits the pro-inflammatory response induced by LPS, both …

8-Prenylkaempferol is an effective agent for attenuating pro-inflammatory NO induction, it may be an anti-inflammatory …

2-Hydroxy-3-methylanthraquinone enhances apoptosis of U937 cells,in part,through activation of p-p38MAPK and downregulation of p-ERK1/2; triggers …

15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on …

Broussonin E could suppress inflammation by modulating macrophages activation state via inhibiting the ERK and …

Sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and …

Isochamaejasmine is a biflavonoid isolated from S. chamaejasme L. with inhibition of NF-κB activation. Isochamaejasmine …

Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation …

Torilin is an inhibitor of testosterone 5 alpha-reductase, it (IC50 = 31.7 +/- 4.23 microM) …

p38α inhibitor 1 is an inhibitor of p38α .

WYE-687 is an ATP-competitive and selective inhibitor of mTOR with IC50 of 7 nM; blocks …

Cristacarpin exhibits moderate but selective activity towards DNA repair-deficient yeast mutants. It promotes endoplasmic reticulum …

Manassantin B is a potent inhibitor of NF-κB activation by the suppression of transciptional activity …

Selinidin decreases phosphorylation of phospholipase C-gamma1, p38 mitogen-activated protein kinase, and IkappaB-alpha upon FcepsilonRI stimulation.

Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and …

Nepetoidin B has anti-fungal, anti-bacterial, and antiinflammatory effects, it can inhibit LPS-stimulated NO production possibly …

4-Hydroxycinnamamide has antioxidant activity. 4-Hydroxycinnamamide derivatives are specific inhibitors of tyrosine-specific protein kinases.

Lucidenic acid F as a modulator of JNK and p38, it shows potent inhibitory effects …

Desoxo-narchinol A exhibits protective effects against LPS-induced endotoxin shock and inflammation through p38 deactivation, it …

Trichosanatine and squamosamide, as potential candidates as lead compounds for further study in drug development …

Vincristine binds to tubulin and inhibits the formation of microtubules, thereby inhibiting mitosis of the …

Agrimonolide is a potential α1 adrenergic receptor antagonist, it exerts anti-inflammatory activity, at least in …

Matairesinol has radical and superoxide scavenging activities,; it also has anti-angiogenic activity by suppressing mROS …

OVA-E1 peptide TFA activates the p38 and JNK cascades similarly in mutant and wild-type thymocytes.

Kobophenol A has antimicrobial, and anti-inflammatory activities, it might be a candidate for treatment of …

Pimaric acid has potent anti-atherosclerotic activity with inhibitory action on matrix metalloproteinase-9 production and cell …

Sappanone A is the first homoisoflavanone to be discovered with melanogenesis inhibitory activity. It exerts …

Corylifol C and, to a lesser extent, xanthoangelol are potent protein kinase inhibitors (inhibitory concentration …

Ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid has anti-cancer activity, it induces apoptosis of human malignant cancer cells, it also …

Altholactone may be a potential antimicrobial agent, particularly in ciprofloxacin-refractory S. aureus and E. faecalis …

AMG-548 dihydrochloride is an orally active and selective p38α inhibitor (Ki: 0.5 nM) and shows …

Panaxydol has anti-cancer activity, can inhibit the growth and apoptosis of cancer cells, the signaling …

Rupestonic acid is a compound in Artemisia rupestris L., a well-known traditional Uighur medicine for …

Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic …

FR 167653 (FR 167653 sulfate) is effective in treating inflammation, relieving trauma and ischemia-reperfusion injury …

R1487 (Hydrochloride) is an orally bioavailable and highly selective inhibitors of p38α.

Allicin exerts antioxidant, bactericidal, anti-cancer, anti-inflammatory activities, it exerts an inhibitory immunomodulatory effect on intestinal …

Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value …

p38 MAPK-IN-1 displays sustained levels, low clearance, and good bioavailability. p38 MAPK-IN-1 is a novel …

ITX5061 is a type II inhibitor of p38 MAPK. It also an antagonist of scavenger …

AL 8697 is a selective p38α MAPK inhibitor (IC50 = 6 nM) with 14-fold selectivity …

Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it …

Cytochalasin D is an actin inhibitor, the removal of actin stress fibers is crucial for …

Talmapimod hydrochloride is a selective and ATP-competitive p38α inhibitor (IC50: 9 nM). It also shows …

PF-03715455 potently inhibits LPS-induced TNFα production in human whole blood (IC50=1.7 nM). PF-03715455 is an …

AMG-548 hydrochloride is an orally active and selective p38α inhibitor (Ki: 0.5 nM) and shows …

(-)-Hydroxycitric acid (HCA) can inhibit fat synthesis and reduces food intake, the primary mechanism of …

Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C …

Veraguensin is derived from Magnolia sp.. Veraguensin inhibits bone resorption and shows high antileishmanial activity.

(E)-4-(3,4-dimethoxyphenyl)but-3-en-1-ol may promote melanin synthesis via USF1 dependent fashion and could be used as a …

Esculin is a glucoside found in horse chestnuts.

Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through …

Bakuchiol possesses anti-tumor,and anti-helmenthic properties. It has cytotoxic activity, mainly due to its DNA polymerase1 …