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Membrane Transporter/Ion Channel

Membrane Transporter/Ion Channel

Membrane transporter and ion channel inhibitors are compounds that block the function of proteins responsible for the transport of ions, nutrients, and other molecules across cell membranes. These inhibitors are crucial for studying the regulation of cellular homeostasis, signal transduction, and neurotransmission. Membrane transporter and ion channel inhibitors are also important in developing treatments for disorders such as epilepsy, cardiovascular diseases, and metabolic syndromes. At CymitQuimica, we provide a diverse selection of high-quality membrane transporter and ion channel inhibitors to support your research in physiology, neuroscience, and pharmacology.

Subcategories of "Membrane Transporter/Ion Channel"

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Found 2293 products of "Membrane Transporter/Ion Channel"

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  • PHP 501 trifluoroacetate
    Targetmol
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    PHP 501 trifluoroacetate

    CAS:
    <p>GABAA antagonist</p>
    Formula:C20H21N3O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:319.4

    Ref: TM-T23152

  • ML-252 hydrochloride
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    ML-252 hydrochloride

    CAS:
    <p>ML-252 is a potent, selective inhibitor of the Kv7.2 voltage-gated potassium channel, demonstrating an IC50 value of 69 nM in patch clamp assays. It exists as the (S)-enantiomer, which is significantly more effective than both its (R)-enantiomer counterpart and the racemic mixture, with respective IC50 values of 944 nM and 160 nM. ML-252 exhibits high selectivity for Kv7.2 over other potassium channel subtypes and shows minimal activity against more than 68 G protein-coupled receptors, various transporters, L- and N-type calcium channels, K_ATP, and hERG potassium channels. However, it does inhibit the melatonin MT1 receptor by 61% at a 10 µM concentration.</p>
    Formula:C20H24N2OHCl
    Color and Shape:Solid
    Molecular weight:344.9

    Ref: TM-T85299

  • JYL-273
    Targetmol
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    JYL-273

    CAS:
    JYL-273 is a TRPV1 agonist.
    Formula:C28H39NO4S
    Color and Shape:Solid
    Molecular weight:485.68

    Ref: TM-T24236

  • Kv3 modulator 3
    Targetmol
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    Kv3 modulator 3

    CAS:
    <p>Kv3 modulator 3 is a selective modulator of Kv3.1 and/or Kv3.2 and/or Kv3.3 channels .has analgesic activity for use in the prophylaxis o or treatment of pain.</p>
    Formula:C19H18N4O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:350.37

    Ref: TM-T11789

  • CGP36216 hydrochloride
    Targetmol
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    CGP36216 hydrochloride

    CAS:
    <p>CGP36216 hydrochloride acts as a selective antagonist at the presynaptic GABA receptor, specifically binding to the GABAB receptor with a Ki value of 0.3 μM. This compound is leveraged in research focused on anxiety and trauma-related disorders [1] [2].</p>
    Formula:C5H15ClNO2P
    Color and Shape:Solid
    Molecular weight:187.6

    Ref: TM-T84878

  • Licostinel
    Targetmol
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    Licostinel

    CAS:
    <p>Licostinel (CGP 63446) is a glutamate receptor antagonist. Licostinel protects against permanent focal cerebral ischemia.</p>
    Formula:C8H3Cl2N3O4
    Purity:98.02%
    Color and Shape:Solid
    Molecular weight:276.03

    Ref: TM-T27828

  • (R)-Vanzacaftor
    Targetmol
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    (R)-Vanzacaftor

    CAS:
    <p>(R)-Vanzacaftor ((R)-VX-121) is a cystic fibrosis transmembrane conductance regulator (CFTR) modulator [1].</p>
    Formula:C32H39N7O4S
    Color and Shape:Solid
    Molecular weight:617.76

    Ref: TM-T84699

  • JT010
    Targetmol
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    JT010

    CAS:
    <p>JT010 is an effective agonist of TRPA1 (EC50 = 0.65 nM).</p>
    Formula:C16H19ClN2O3S
    Purity:99.75%
    Color and Shape:Solid
    Molecular weight:354.85

    Ref: TM-T15628

  • LOE 908 hydrochloride
    Targetmol
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    LOE 908 hydrochloride

    CAS:
    <p>Broad spectrum cation channel blocker</p>
    Formula:C41H49ClN2O9
    Purity:98%
    Color and Shape:Solid
    Molecular weight:749.29

    Ref: TM-T22929

  • Oct4 inducer-2
    Targetmol
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    Oct4 inducer-2

    CAS:
    <p>Oct4 Inducer-2, an OCT4 inducer, sustains hiPSC formation by enhancing endogenous OCT4 expression and has applications in anti-aging research [1].</p>
    Formula:C14H16N2O2S
    Color and Shape:Solid
    Molecular weight:276.35

    Ref: TM-T79208

  • P2X3 antagonist 34
    Targetmol
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    P2X3 antagonist 34

    CAS:
    Potent P2X3 antagonist 34, oral, selective for human, rat, guinea pig receptors; IC50s: 25/92/126 nM; strong anti-tussive, no taste change.
    Formula:C24H26F2N4O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:456.48

    Ref: TM-T10560

  • PZ-II-029
    Targetmol
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    PZ-II-029

    CAS:
    <p>PZ-II-029 is a modulator of α6β3γ2-selective GABAA channel.</p>
    Formula:C18H15N3O3
    Purity:99.79%
    Color and Shape:Solid
    Molecular weight:321.33

    Ref: TM-T28479

  • A-1165442
    Targetmol
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    A-1165442

    CAS:
    <p>A-1165442 is a competitive TRPV1 antagonist. For human TRPV, the IC50 values is 9 nM.</p>
    Formula:C22H20ClF2N3O2
    Color and Shape:Solid
    Molecular weight:431.86

    Ref: TM-T14067

  • NaPi2b-IN-2
    Targetmol
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    NaPi2b-IN-2

    CAS:
    <p>NaPi2b-IN-2 (compound 5) serves as a potent inhibitor of the sodium-dependent transport protein 2b (SLC34A2, NaPi2b), exhibiting an IC50 of 38 nM against human</p>
    Formula:C41H47ClF3N5O5S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:814.36

    Ref: TM-T78146

  • Risevistinel
    Targetmol
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    Risevistinel

    CAS:
    <p>Risevistinel (NYX-783), a positive allosteric modulator of the N-methyl-D-aspartate (NMDA) receptor, may mitigate cognitive deficits in neurodegenerative</p>
    Formula:C14H23N3O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:297.35

    Ref: TM-T79857

  • Dimethylamiloride
    Targetmol
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    Dimethylamiloride

    CAS:
    <p>Dimethylamiloride is a specific inhibitor of antiporters [1].</p>
    Formula:C8H12ClN7O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:257.68

    Ref: TM-T78139

  • PF-05105679
    Targetmol
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    PF-05105679

    CAS:
    <p>PF-05105679 is a selective TRPM8 antagonist (IC50 = 103 nM). PF-05105679 can be used in research on cold-related pain.</p>
    Formula:C26H21FN2O3
    Purity:99.84%
    Color and Shape:Solid
    Molecular weight:428.45

    Ref: TM-T16483

  • NO-711ME
    Targetmol
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    NO-711ME

    CAS:
    <p>NO-711ME (N-O711 Methyl ester) is a prodrug of NO-711. It also is a potent and selective GABA uptake inhibitor.</p>
    Formula:C22H24N2O3
    Purity:99.54%
    Color and Shape:Solid
    Molecular weight:364.44

    Ref: TM-T24540

  • mGAT-IN-1
    Targetmol
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    mGAT-IN-1

    CAS:
    <p>mGAT-IN-1 is a potent, non-selective GAT inhibitor that inhibits mGAT3 activity well (IC50: 2.5 μM, pIC50: 5.61).</p>
    Formula:C28H34ClN3O2S2
    Color and Shape:Solid
    Molecular weight:544.17

    Ref: TM-T63832

  • 8-Pcpt-cGMP
    Targetmol
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    8-Pcpt-cGMP

    CAS:
    <p>8-Pcpt-cGMP acts as an agonist for cyclic nucleotide-gated (CNG) channels with an EC50 of 0.5 μM and exhibits good membrane permeability. This compound is utilized in research to explore the role of CNG channels in visual and olfactory signal transduction.</p>
    Formula:C16H15ClN5O7PS
    Color and Shape:Solid
    Molecular weight:487.81

    Ref: TM-T88702

  • CRF1 receptor antagonist-1
    Targetmol
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    CRF1 receptor antagonist-1

    CAS:
    <p>CRF1 Receptor Antagonist-1 (Compound 2), a CRF1 receptor antagonist, is utilized in research pertaining to congenital adrenal hyperplasia (CAH) [1].</p>
    Formula:C27H28ClFN2O2S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:499.04

    Ref: TM-T79793

  • SCS
    Targetmol
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    SCS

    CAS:
    <p>SCS is a GABAA receptor antagonist.</p>
    Formula:C14H12N2O3
    Purity:99.73%
    Color and Shape:Solid
    Molecular weight:256.26

    Ref: TM-T23339

  • CLP257
    Targetmol
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    CLP257

    CAS:
    <p>CLP257 is a selective K+-Cl− cotransporter KCC2 activator (EC50: 616 nM) and it is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4.</p>
    Formula:C14H14FN3O2S
    Purity:99.5%
    Color and Shape:Solid
    Molecular weight:307.34

    Ref: TM-T14984

  • CS-526
    Targetmol
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    CS-526

    CAS:
    <p>CS-526 is a reversible proton pump inhibitor targeting the K+ site on H+,K+-ATPase, reducing gastric acid secretion and preventing mucosal lesions.</p>
    Formula:C20H22FN3O
    Color and Shape:Solid
    Molecular weight:339.41

    Ref: TM-T27092

  • Pumaprazole
    Targetmol
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    Pumaprazole

    CAS:
    <p>Pumaprazole (BY-841) is an antagonist of a reversible proton pump.</p>
    Formula:C19H22N4O2
    Purity:99.91%
    Color and Shape:Solid
    Molecular weight:338.4

    Ref: TM-T16682

  • Caroverine
    Targetmol
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    Caroverine

    CAS:
    Caroverine is a potential chemotherapeutical agent in HNSCC cell lines.
    Formula:C22H27N3O2
    Color and Shape:Solid
    Molecular weight:365.47

    Ref: TM-T9133L

  • L 691121
    Targetmol
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    L 691121

    CAS:
    <p>L 691121 is a class III antiarrhythmic compound. It also blocks potassium currents.</p>
    Formula:C22H25ClN4O5S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:492.98

    Ref: TM-T24339

  • TCS 46b
    Targetmol
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    TCS 46b

    CAS:
    <p>TCS 46b is a NR1A/NR2B NMDA receptor antagonist with oral activity.</p>
    Formula:C22H23N3O
    Purity:99.78% - 99.78%
    Color and Shape:Solid
    Molecular weight:345.44

    Ref: TM-T23449

  • BPO-27 racemate
    Targetmol
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    BPO-27 racemate

    CAS:
    BPO-27 racemate (BPO-27 (racemate)) is an effective CFTR inhibitor with IC50 of 8 nM.
    Formula:C26H18BrN3O6
    Purity:97.67% - 98.86%
    Color and Shape:Solid
    Molecular weight:548.34

    Ref: TM-T10591

  • Diproqualone
    Targetmol
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    Diproqualone

    CAS:
    <p>Diproqualone, analogous to methaqualone, exhibits sedative, anxiolytic, anti-inflammatory, and analgesic properties [1].</p>
    Formula:C12H14N2O3
    Color and Shape:Solid
    Molecular weight:234.255

    Ref: TM-T85285

  • XR9051 Hydrochloride
    Targetmol
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    XR9051 Hydrochloride

    CAS:
    <p>XR9051 Hydrochloride, a potent modulator of P-glycoprotein-mediated multidrug resistance (MDR), inhibits the binding of cytotoxics to P-glycoprotein.</p>
    Formula:C39H39ClN4O5
    Color and Shape:Solid
    Molecular weight:679.21

    Ref: TM-T29169

  • Iganidipine HCl
    Targetmol
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    Iganidipine HCl

    CAS:
    NKY-722 (HCl), also known as Iganidipine, is a calcium channel blocker potentially for the treatment of glaucoma.
    Formula:C28H40Cl2N4O6
    Color and Shape:Solid
    Molecular weight:599.55

    Ref: TM-T71333

  • NPBA
    Targetmol
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    NPBA

    CAS:
    <p>NPBA, a potassium K2P channel TASK-3 (KCNK9) agonist, concurrently functions as a blocker of the tandem pore domain weak inward rectifying K+ channel (TWIK2). This compound effectively inhibits NLRP3 inflammasome activation in macrophages [1].</p>
    Formula:C16H14F3N3O3
    Color and Shape:Solid
    Molecular weight:353.3

    Ref: TM-T84683

  • Crobenetine hydrochloride
    Targetmol
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    Crobenetine hydrochloride

    CAS:
    <p>Crobenetine hydrochloride, a sodium channel antagonist, is used potentially for the treatment of stroke.</p>
    Formula:C25H34ClNO2
    Color and Shape:Solid
    Molecular weight:416

    Ref: TM-T27086

  • Nalanthalide
    Targetmol
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    Nalanthalide

    CAS:
    <p>Nalanthalide, serving as a voltage-gated potassium channel Kv1.3 blocker (IC50 = 3.9 µM) with potential immunosuppressive properties, is applicable in the research of inflammatory immune diseases including neuroinflammation [1] [2].</p>
    Formula:C30H44O5
    Color and Shape:Solid
    Molecular weight:484.67

    Ref: TM-T85043

  • COR659
    Targetmol
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    COR659

    CAS:
    <p>COR659: suppresses alcohol/chocolate intake in rats; enhances GABAB receptor, blocks CB1 receptor.</p>
    Formula:C16H16ClNO3S
    Purity:99.75%
    Color and Shape:Solid
    Molecular weight:337.82

    Ref: TM-T36520

  • Ebio1
    Targetmol
    + Info

    Ebio1

    CAS:
    <p>Ebio1, a selective activator of the voltage-gated potassium channel KCNQ2, enhances channel conductance by promoting the formation of an expanded gate at a saturation voltage of +50 mV, leading to increased channel activity [1].</p>
    Formula:C19H14FNO
    Color and Shape:Solid
    Molecular weight:291.32

    Ref: TM-T84693

  • GSK 2833503A
    Targetmol
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    GSK 2833503A

    CAS:
    <p>GSK 2833503A: potent TRPC6/3 antagonist; IC50: 3-16/21-100 nM; &gt;63x selective; inhibits cardiac hypertrophy signaling.</p>
    Formula:C18H21ClFN3OS
    Color and Shape:Solid
    Molecular weight:381.9

    Ref: TM-T41232

  • 6-Iodoamiloride
    Targetmol
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    6-Iodoamiloride

    CAS:
    <p>6-Iodoamiloride is a potent inhibitor of acid-sensing ion channel 1 (ASIC1), exhibiting an IC50 value of 88 nM.</p>
    Formula:C6H8IN7O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:321.08

    Ref: TM-T79246

  • PU-48
    Targetmol
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    PU-48

    CAS:
    <p>PU-48 is a potent inhibitor of urea transporters A (UT-A) with an IC50 value of 0.32 μM, exhibiting a significant diuretic effect in mouse models without</p>
    Formula:C14H12N2O3S
    Color and Shape:Solid
    Molecular weight:288.32

    Ref: TM-T78201

  • URAT1 inhibitor 8
    Targetmol
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    URAT1 inhibitor 8

    CAS:
    <p>URAT1 Inhibitor 8 (example 247) serves as a highly potent inhibitor of URAT1, demonstrating an IC50 value of 0.001 μM.</p>
    Formula:C19H13ClFN3O4S
    Color and Shape:Solid
    Molecular weight:433.84

    Ref: TM-T78195

  • NaV1.7 Blocker-801
    Targetmol
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    NaV1.7 Blocker-801

    CAS:
    <p>NaV1.7 Blocker-801 is a potent NaV1.7 blocker.</p>
    Formula:C20H15ClF2N6O3S2
    Color and Shape:Solid
    Molecular weight:524.95

    Ref: TM-T28132

  • MCT1-IN-2
    Targetmol
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    MCT1-IN-2

    CAS:
    <p>SR13800 is a monocarboxylate transporter 1 (MCT1) inhibitor with cell-permeable.</p>
    Formula:C25H29N3O2S
    Color and Shape:Solid
    Molecular weight:435.58

    Ref: TM-T26221

  • mGAT3/4-IN-2
    Targetmol
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    mGAT3/4-IN-2

    CAS:
    <p>mGAT3/4-IN-2 are potent inhibitors of mGAT3/mGAT4 with their pIC50 values of 5.44 and 5.25, respectively.</p>
    Formula:C26H32ClN3OS2
    Color and Shape:Solid
    Molecular weight:502.13

    Ref: TM-T63408

  • GDC-6599
    Targetmol
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    GDC-6599

    CAS:
    <p>GDC-6599 (Example 8) is an orally active inhibitor of the TRPA1 channel, potentially useful for researching TRPA1-mediated conditions, including pain [1].</p>
    Formula:C20H19ClN6O3
    Color and Shape:Solid
    Molecular weight:426.86

    Ref: TM-T79875

  • M084 hydrochloride
    Targetmol
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    M084 hydrochloride

    CAS:
    <p>M084 hydrochloride, a TRPC4/5 channel blocker, exhibits IC50 values of 10.3 μM and 8.2 μM, respectively. This compound is noted for its antidepressant and anxiolytic effects [1] [2].</p>
    Formula:C11H16ClN3
    Color and Shape:Solid
    Molecular weight:225.72

    Ref: TM-T84900

  • MONIRO-1
    Targetmol
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    MONIRO-1

    CAS:
    <p>MONIRO-1 blocks T/N-type Ca²⁺ channels: hCav2.2 (IC50: 34μM), hCav3.1 (3.3μM), hCav3.2 (1.7μM), hCav3.3 (7.2μM).</p>
    Formula:C23H24ClFN4O3
    Color and Shape:Solid
    Molecular weight:458.92

    Ref: TM-T62876

  • NMDA receptor modulator 6
    Targetmol
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    NMDA receptor modulator 6

    CAS:
    <p>NMDA receptor regulator 6 (Compound 183) is an effective NMDA receptor regulator and has research value in neurological disorders.</p>
    Formula:C20H17FN2O4S
    Color and Shape:Solid
    Molecular weight:400.42

    Ref: TM-T61924

  • Clobutinol hydrochloride
    Targetmol
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    Clobutinol hydrochloride

    CAS:
    <p>Clobutinol hydrochloride, an antitussive agent, influences heart rate and blood pressure, and is utilized in cough-related research [1] [2] [3].</p>
    Formula:C14H23Cl2NO
    Purity:98%
    Color and Shape:Solid
    Molecular weight:292.25

    Ref: TM-T78523

  • CFTR corrector 12
    Targetmol
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    CFTR corrector 12

    CAS:
    <p>CFTR corrector 12 is a CFTR corrector that rescues all mutant proteins except M760R ABCA3 and can be used to study cystic fibrosis.</p>
    Formula:C19H21ClN4O2S2
    Purity:99.47%
    Color and Shape:Solid
    Molecular weight:436.98

    Ref: TM-T79578