FXR
Farnesoid X Receptor (FXR) is a nuclear receptor that plays a key role in the regulation of bile acid homeostasis, lipid metabolism, and glucose regulation. FXR is a potential therapeutic target for treating liver diseases, metabolic disorders, and cardiovascular diseases. FXR inhibitors can modulate these pathways, offering insights into disease mechanisms and therapeutic strategies. At CymitQuimica, we provide a range of FXR inhibitors to support your research in hepatology, metabolism, and drug development.
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Chenodeoxycholic acid
CAS:474-25-9
Chenodeoxycholic acid (CDCA), a bile acid, usually conjugated with either glycine or taurine, acts as …
Formula:
C24H40O4
Purity:
99.72% - 99.97%
Color and Shape:
White - Almost White Solid Powder
Molecular weight:
392.57
Ref: TM-T0847
| 100mg | 59.00 € | ||
| 1mL*10mM (DMSO) | 55.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Ursodeoxycholic acid
CAS:128-13-2
Ursodeoxycholic acid (UDCA) can be used to dissolve gallstones and reduce cholesterol absorption.
Formula:
C24H40O4
Purity:
99.74% - ≥95%
Color and Shape:
White - Almost White Solid Powder
Molecular weight:
392.57
Ref: TM-T0700
| 1g | 54.00 € | ||
| 5g | 111.00 € | ||
| 1mL*10mM (DMSO) | 65.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
LY2562175
CAS:1103500-20-4
LY2562175 is an effective and selective FXR agonist (EC50: 193 nM).
Formula:
C28H27Cl2N3O4
Purity:
99.16% - 99.78%
Color and Shape:
Solid
Molecular weight:
540.44
Ref: TM-T15806
| 1mg | 103.00 € | ||
| 5mg | 225.00 € | ||
| 10mg | 364.00 € | ||
| 25mg | 730.00 € | ||
| 50mg | 1,154.00 € | ||
| 100mg | 1,547.00 € | ||
| 200mg | 2,091.00 € | ||
| 1mL*10mM (DMSO) | 266.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
ZLY28
ZLY28 is a novel, first-in-class compound with specific intestinal restriction and oral activity, serving as …
Formula:
C29H23Cl2NO4
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
520.4
Ref: TM-T78910
| 1mg | 335.00 € | ||
| 5mg | 1,413.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Tauro-β-muricholic acid sodium
CAS:145022-92-0
Tauro-β-muricholic Acid sodium is a endogenous metabolite, is a competitive and reversible antagonist of farnesoid …
Formula:
C26H44NNaO7S
Purity:
98%
Color and Shape:
Solid
Molecular weight:
537.69
Ref: TM-T13093
| 1mg | 321.00 € | ||
| 5mg | 1,006.00 € | ||
| 500µg | 171.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Osocimab
CAS:2056878-75-0
Osocimab (BAY 1213790) is a strong FXIa inhibitor, Ki 2.4 nM, EC50 0.2 nM, and …
Purity:
> 95% - > 95%
Color and Shape:
Liquid
Molecular weight:
144.46 kDa
Ref: TM-T77124
| 1mg | 230.00 € | ||
| 5mg | 601.00 € | ||
| 10mg | 916.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Tauro-β-muricholic acid
CAS:25696-60-0
Tauro-β-muricholic acid (TβMCA), a trihydroxylated bile acid, acts as a competitive and reversible FXR antagonist …
Formula:
C26H45NO7S
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
515.7
Ref: TM-T81030
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 10 Dec 2024
NR1H4 Protein, Human, Recombinant (His)
NR1H4 Protein, Human, Recombinant (His) is expressed in E.
Color and Shape:
Liquid
Molecular weight:
27.83 kDa (predicted)
Ref: TM-TMPY-06768
| 50µg | 589.00 € | ||
| 500µg | 3,716.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
NDB
CAS:1660153-08-1
NDB is a hFXRα antagonist that inhibits GW4064-stimulated FXR/RXR interactions in primary mouse hepatocytes.NDB is …
Formula:
C26H28Cl2N2O2
Purity:
98.94%
Color and Shape:
Solid
Molecular weight:
471.42
Ref: TM-T63042
| 1mg | 98.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
NR1H4 Protein, Mouse, Recombinant (His)
NR1H4 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. …
Color and Shape:
Liquid
Molecular weight:
27.80 kDa (predicted)
Ref: TM-TMPY-06756
| 50µg | 589.00 € | ||
| 500µg | 3,716.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Chenodeoxycholic Acid sodium salt
CAS:2646-38-0
Chenodeoxycholic Acid sodium salt (CDCA sodium salt) is a bile acid in humans that activates …
Formula:
C24H39NaO4
Purity:
99.72%
Color and Shape:
Liquid
Molecular weight:
414.55
Ref: TM-T65070
| 100mg | 40.00 € | ||
| 500mg | 60.00 € | ||
| 1mL*10mM (DMSO) | 45.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
T0901317
CAS:293754-55-9
T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of …
Formula:
C17H12F9NO3S
Purity:
98% - 99.58%
Color and Shape:
Solid
Molecular weight:
481.33
Ref: TM-T6690
| 5mg | 38.00 € | ||
| 10mg | 56.00 € | ||
| 25mg | 86.00 € | ||
| 50mg | 98.00 € | ||
| 100mg | 154.00 € | ||
| 200mg | 193.00 € | ||
| 1mL*10mM (DMSO) | 63.00 € |
Estimated delivery in United States, on Friday 13 Dec 2024
Vidofludimus
CAS:717824-30-1
Vidofludimus (SC12267) (4SC-101, SC12267) is a novel small molecule inhibitor of dihydroorotate dehydrogenase (DHODH).
Formula:
C20H18FNO4
Purity:
98.83% - 99.58%
Color and Shape:
Solid
Molecular weight:
355.36
Ref: TM-T2601
| 2mg | 58.00 € | ||
| 5mg | 83.00 € | ||
| 10mg | 121.00 € | ||
| 25mg | 215.00 € | ||
| 50mg | 343.00 € | ||
| 100mg | 485.00 € | ||
| 1mL*10mM (DMSO) | 67.00 € |
Estimated delivery in United States, on Friday 13 Dec 2024
Glyco-Obeticholic acid
CAS:863239-60-5
Glyco-Obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is an agonist of …
Formula:
C28H47NO5
Purity:
99.77% - 99.95%
Color and Shape:
Solid
Molecular weight:
477.68
Ref: TM-T11428
| 1mg | 167.00 € | ||
| 5mg | 417.00 € | ||
| 10mg | 612.00 € | ||
| 25mg | 917.00 € | ||
| 50mg | 1,291.00 € | ||
| 1mL*10mM (DMSO) | 469.00 € |
Estimated delivery in United States, on Friday 13 Dec 2024
Fexaramine
CAS:574013-66-4
Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity compared …
Formula:
C32H36N2O3
Purity:
98.87% - 99.61%
Color and Shape:
Solid
Molecular weight:
496.64
Ref: TM-T2015
| 2mg | 49.00 € | ||
| 5mg | 74.00 € | ||
| 10mg | 95.00 € | ||
| 25mg | 181.00 € | ||
| 50mg | 307.00 € | ||
| 100mg | 458.00 € | ||
| 1mL*10mM (DMSO) | 114.00 € |
Estimated delivery in United States, on Friday 13 Dec 2024
Forskolin
CAS:66575-29-9
Forskolin (Coleonol) is a natural product, an adenylate cyclase activator (EC50=0.5 μM).
Formula:
C22H34O7
Purity:
98.83% - 99.86%
Color and Shape:
Less Crystalline Solid Colorless Crystalline Solid
Molecular weight:
410.5
Ref: TM-T2939
| 5mg | 43.00 € | ||
| 10mg | 55.00 € | ||
| 25mg | 86.00 € | ||
| 50mg | 94.00 € | ||
| 100mg | 143.00 € | ||
| 200mg | 180.00 € | ||
| 500mg | 302.00 € | ||
| 1mL*10mM (DMSO) | 56.00 € |
Estimated delivery in United States, on Friday 13 Dec 2024
Cilofexor
CAS:1418274-28-8
Cilofexor inhibits binding of a synthetic peptide, Cilofexor is a farnesoid X receptor (FXR) agonist.
Formula:
C28H22Cl3N3O5
Purity:
99.32% - ≥95%
Color and Shape:
Solid
Molecular weight:
586.85
Ref: TM-T7436
| 1mg | 50.00 € | ||
| 2mg | 72.00 € | ||
| 5mg | 121.00 € | ||
| 10mg | 184.00 € | ||
| 25mg | 373.00 € | ||
| 50mg | 555.00 € | ||
| 100mg | 789.00 € | ||
| 500mg | 1,613.00 € | ||
| 1mL*10mM (DMSO) | 158.00 € |
Estimated delivery in United States, on Friday 13 Dec 2024
Vonafexor
CAS:1192171-69-9
Vonafexor (EYP001) is a farnesoid X receptor (FXR, NR1H4) agonist, with anti-HBV effects
Formula:
C19H15Cl3N2O5S
Purity:
98.74%
Color and Shape:
Solid
Molecular weight:
489.76
Ref: TM-T8471
| 2mg | 41.00 € | ||
| 5mg | 59.00 € | ||
| 10mg | 87.00 € | ||
| 25mg | 174.00 € | ||
| 100mg | 466.00 € | ||
| 1mL*10mM (DMSO) | 64.00 € |
Estimated delivery in United States, on Friday 13 Dec 2024
BAR502
CAS:1612191-86-2
BAR502 is a dual GPBAR1 and FXR agonist (IC50s: 0.4 μM and 2 μM).
Formula:
C25H44O3
Purity:
99.95%
Color and Shape:
Solid
Molecular weight:
392.62
Ref: TM-TQ0252
| 1mg | 68.00 € | ||
| 5mg | 177.00 € | ||
| 10mg | 269.00 € | ||
| 25mg | 430.00 € | ||
| 50mg | 598.00 € | ||
| 100mg | 813.00 € | ||
| 200mg | 1,089.00 € |
Estimated delivery in United States, on Friday 13 Dec 2024
Tauro-Obeticholic acid
CAS:863239-61-6
Tauro-Obeticholic acid is an active Obeticholic acid metabolite. Obeticholic acid is an orally bioavailable agonist …
Formula:
C28H49NO6S
Purity:
99.82% - 99.82%
Color and Shape:
Solid
Molecular weight:
527.76
Ref: TM-T13092
| 1mg | 115.00 € | ||
| 5mg | 270.00 € | ||
| 10mg | 405.00 € | ||
| 25mg | 675.00 € | ||
| 50mg | 917.00 € | ||
| 100mg | 1,287.00 € | ||
| 1mL*10mM (DMSO) | 348.00 € |
Estimated delivery in United States, on Friday 13 Dec 2024
