CymitQuimica logo
Proteases/Proteasome

Proteases/Proteasome

Protease and proteasome inhibitors are compounds that block the activity of proteases and the proteasome, which are involved in protein degradation and turnover. These inhibitors are vital for studying the regulation of protein homeostasis, cell cycle control, and apoptosis. Protease and proteasome inhibitors are also used in the treatment of diseases such as cancer, where abnormal protein degradation plays a role in disease progression. By inhibiting proteases or the proteasome, these compounds can induce cell death in cancer cells and are critical tools in both basic research and therapeutic development. At CymitQuimica, we provide a wide range of high-quality protease and proteasome inhibitors to support your research in biochemistry, cell biology, and drug development.

Subcategories of "Proteases/Proteasome"

Show 3 more subcategories

Found 1045 products of "Proteases/Proteasome"

Sort by

Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
products per page.
  • Bortezomib analog


    <p>Bortezomibanalog (Compound 13) is an analog of Bortezomib, functioning as an active control ligand for the 20S proteasome subunit β5.</p>
    Color and Shape:Odour Solid
  • PROTAC CG167


    <p>PROTAC CG167 is a potent and selective PROTAC degrader of CypA. It degrades CypA in a dose-dependent manner in Jurkat cells, with a DC50 of 123 nM. Additionally, PROTAC CG167 exhibits antiviral activity by inhibiting HIV-1 and HCV. (Pink: CypA Ligand; Black: Linker; Blue: E3LigaseLigand)</p>
    Formula:C65H79N13O11S
    Color and Shape:Solid
    Molecular weight:1250.47
  • Rivulariapeptolides 1185


    <p>Rivulariapeptolides 1185 inhibits serine proteases; IC50: chymotrypsin 13.17 nM, elastase 23.59 nM, proteinase K 55.26 nM.</p>
    Formula:C61H87N9O15
    Color and Shape:Solid
    Molecular weight:1186.39
  • Anticancer agent 114


    <p>Anticancer agent 114: oral dipeptide boronic acid, proteasome inhibitor, IC 50 = 2.2 nM, halts RPMI-8226 cell growth, for multiple myeloma research.</p>
    Formula:C28H33BF6N2O7
    Color and Shape:Solid
    Molecular weight:634.37
  • HIV-1 Rev (34-50)

    CAS:
    <p>HIV-1 Rev (34-50) (HIV-1 rev Protein (34-50)) is a 17 amino acid peptide with anti-HIV-1 activity.</p>
    Formula:C97H173N51O24
    Purity:99.91%
    Color and Shape:Solid
    Molecular weight:2437.74
  • FiVe1

    CAS:
    <p>FiVe1 is a vimentin-binding compound that disrupts mitosis in cancer cells, causing cell death, with an IC50 of 234 nM in FOXC2-HMLER.</p>
    Formula:C18H16Cl2N4
    Purity:99.67%
    Color and Shape:Solid
    Molecular weight:359.25
  • Sulodexide

    CAS:
    <p>Sulodexide is an orally administered combination of glycosaminoglycans, consisting of low molecular weight heparin (80%) and dermatan sulfate (20%). It demonstrates antithrombotic properties by interacting with antithrombin III (AT III) and heparin cofactor II (HC II), and by inhibiting thrombin formation. Additionally, sulodexide enhances profibrinolytic activity by releasing tissue plasminogen activator (tPA). It also offers endothelial protection, possesses anti-inflammatory effects, and alleviates chronic venous disease.</p>
    Color and Shape:Solid
  • BI-1230

    CAS:
    <p>BI-1230 is a potent inhibitor of HCV NS3 protease, exhibiting efficacy in the low nanomolar range, and notably suppresses viral replication.</p>
    Formula:C42H52N6O9S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:816.96
  • MMP-12 Inhibitor

    CAS:
    <p>MMP-12 Inhibitor is a selective inhibitor of MMP-12 with IC50s of 2, 160, 320, and 22.3 nM for human, mouse, rat, and sheep MMP-12.</p>
    Formula:C19H20N2O7S
    Purity:97.51% - 99.96%
    Color and Shape:Soild
    Molecular weight:420.44
  • DPP-4-IN-14


    <p>DPP-4-IN-14 (compound 30) is an inhibitor of DPP-4, with an IC50 value of 12.82 nM.</p>
    Formula:C33H27N7O3
    Color and Shape:Solid
    Molecular weight:569.613
  • Rivulariapeptolides 988


    <p>Rivulariapeptolides 988 inhibits serine proteases: chymotrypsin (IC50 = 95.46 nM), elastase (15.29 nM), proteinase K (85.50 nM).</p>
    Formula:C50H68N8O13
    Color and Shape:Solid
    Molecular weight:989.12
  • Sadopeptins A


    <p>Sadopeptins A, a natural product isolated from Streptomyces sp., is a potent proteasome inhibitor [1].</p>
    Formula:C49H71N9O13S
    Color and Shape:Solid
    Molecular weight:1026.21
  • Iso-VQA-ACC acetate


    <p>Iso-VQA-ACC acetate serves as a substrate for the constitutive proteasome.</p>
    Color and Shape:Odour Solid
  • 6,6′-Dihydroxythiobinupharidine

    CAS:
    <p>6,6′-Dihydroxythiobinupharidine, a cysteine proteases inhibitor, amplifies DNA cleavage facilitated by human topoisomerase IIα and IIβ by approximately 8-fold</p>
    Formula:C30H42N2O4S
    Color and Shape:Solid
    Molecular weight:526.73
  • Sofosbuvir impurity M

    CAS:
    <p>Sofosbuvir impurity M is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.</p>
    Formula:C22H30N3O10P
    Purity:98%
    Color and Shape:Solid
    Molecular weight:527.467
  • Paritaprevir dihydrate

    CAS:
    <p>Paritaprevir dihydrate: potent oral HCV NS3/4A inhibitor (EC50: 0.21-1 nM), SARS-CoV-3CL blocker (IC50: 1.31 μM), metabolized by CYP3A, boosted by Ritonavir.</p>
    Formula:C40H47N7O9S
    Color and Shape:Solid
    Molecular weight:801.91
  • Dutogliptin tartrate

    CAS:
    <p>Dutogliptin tartrate is an effective and selective oral dipeptide-peptide-4 (DPP4) inhibitor for the treatment of type 2 diabetes mellitus.</p>
    Formula:C14H26BN3O9
    Purity:98%
    Color and Shape:Solid
    Molecular weight:391.18
  • FFAGLDD


    <p>"FFAGLDD: MMP9 peptide for controlled DOX delivery inside cells."</p>
    Formula:C37H49N7O12
    Purity:98%
    Color and Shape:Solid
    Molecular weight:783.82
  • PROTAC 20S proteasome subunit β5 degrader 2


    <p>PROTAC 20S proteasome subunit β5 degrader 2 is a PROTAC degrader targeting the 20S proteasome subunit β5 (20Sproteasomesubunit β5), with a DC50 of 0.16 μM. It inhibits the proliferation of FaDu cancer cells, showcasing an IC50 of 0.23 μM. Additionally, PROTAC20Sproteasomesubunit β5 degrader 2 demonstrates antitumor activity in a mouse model.</p>
    Color and Shape:Odour Solid
  • Aristololactam IIIa

    CAS:
    <p>Aristololactam IIIa inhibits superoxide and elastase generation; IC50: 0.12 μg/mL and 0.20 μg/mL.</p>
    Formula:C16H9NO4
    Color and Shape:Solid
    Molecular weight:279.25