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Proteases/Proteasome

Proteases/Proteasome

Protease and proteasome inhibitors are compounds that block the activity of proteases and the proteasome, which are involved in protein degradation and turnover. These inhibitors are vital for studying the regulation of protein homeostasis, cell cycle control, and apoptosis. Protease and proteasome inhibitors are also used in the treatment of diseases such as cancer, where abnormal protein degradation plays a role in disease progression. By inhibiting proteases or the proteasome, these compounds can induce cell death in cancer cells and are critical tools in both basic research and therapeutic development. At CymitQuimica, we provide a wide range of high-quality protease and proteasome inhibitors to support your research in biochemistry, cell biology, and drug development.

Subcategories of "Proteases/Proteasome"

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Found 1045 products of "Proteases/Proteasome"

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  • Dup-714

    CAS:
    <p>Dup-714 is a thrombin inhibitor.</p>
    Formula:C21H33BN6O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:460.33
  • Feniralstat

    CAS:
    <p>Feniralstat (KVD-824) is a selective and potent kallikrein (kallikrein) inhibitor, useful in immune system diseases and cardiovascular disease research.</p>
    Formula:C26H25F2N5O4
    Purity:99.52%
    Color and Shape:Solid
    Molecular weight:509.51
  • M826


    <p>M826, a non-peptide, potent, selective, and reversible caspase-3 inhibitor, exhibits an IC50 of 0.005 μM and demonstrates strong anti-apoptotic activity in</p>
    Formula:C28H45N7O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:575.7
  • Cathepsin K inhibitor 2

    CAS:
    <p>Cathepsin K inhibitor 2 targets CTSK gene, may treat osteoporosis and osteoarthritis, detailed in patent WO2021147882A1.</p>
    Formula:C30H33F4N5O3
    Color and Shape:Solid
    Molecular weight:587.61
  • (2S,4R)-Teneligliptin

    CAS:
    <p>(2S,4R)-Teneligliptin is a selective inhibitor of dipeptidyl peptidase IV (DPP-4). It increases the concentration of active glucagon-like peptide-1 (GLP-1) in plasma, which in turn stimulates insulin secretion when blood glucose levels are elevated, thereby exhibiting hypoglycemic effects. (2S,4R)-Teneligliptin is a promising candidate for research in type 2 diabetes.</p>
    Formula:C22H30N6OS
    Color and Shape:Solid
    Molecular weight:426.578
  • Kallikrein-IN-1

    CAS:
    <p>Kallikrein-IN-1 (Formula A) is an inhibitor of the kinin-releasing enzyme Kallikrein.</p>
    Formula:C28H26FN5O4
    Color and Shape:Solid
    Molecular weight:515.54
  • TCL1

    CAS:
    <p>TCL1 acts as a selective non-covalent inhibitor targeting the Pru domain of the Rpn-13 subunit within the 19S regulatory particle (19S RP) of the proteasome, with an IC50 value around 26 μM. It disrupts the recognition and transport of ubiquitinated proteins by Rpn-13, thus inhibiting proteasomal degradation and affecting intracellular protein metabolism balance. TCL1 holds potential for research in hematologic malignancies.</p>
    Formula:C19H14BrClN4O2S
    Color and Shape:Solid
    Molecular weight:477.762
  • Cathepsin C-IN-5

    CAS:
    <p>Cathepsin C-IN-5 (SF38) is a potent, oral Cathepsin C blocker with an IC50 of 59.9 nM; less active against Cat L/S/B/K; has anti-inflammatory effects.</p>
    Formula:C21H17ClN6OS
    Color and Shape:Solid
    Molecular weight:436.92
  • GSK-2878175

    CAS:
    <p>GSK-2878175, a NS5B inhibitor, is used potentially for the treatment of HCV infection.</p>
    Formula:C27H23BClFN2O6S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:568.81
  • Piceid 6″-O-azelaic acid ester


    <p>Piceid 6″-O-azelaic acid ester exhibited strong intracellular tyrosinase inhibition and decolorization activity.</p>
    Formula:C24H36O10
    Color and Shape:Solid
    Molecular weight:484.54
  • ABT-072

    CAS:
    <p>ABT-072 is a nonnucleoside NS5B polymerase inhibitor and a candidate drug evaluated for treatment of hepatitis C virus.</p>
    Formula:C24H27N3O5S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:469.55
  • Cyclophilin inhibitor 1

    CAS:
    <p>Cyclophilin inhibitor 1: orally available, Kd 5 nM, potent against HCV, EC50 for HCV 2a is 98 nM.</p>
    Formula:C31H39N5O7
    Purity:98%
    Color and Shape:Solid
    Molecular weight:593.67
  • Ciluprevir

    CAS:
    <p>Ciluprevir is a selective HCV NS3 protease inhibitor, effective against non-genotype-1 HCV; less potent for genotypes 2/3.</p>
    Formula:C40H50N6O8S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:774.93
  • MK-8876

    CAS:
    <p>MK-8876 is an Inhibitor of HCV NS5B Site D.</p>
    Formula:C32H24F2N4O5S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:614.62
  • GW311616

    CAS:
    <p>GW-311616 is a long duration, orally bioavailable, and selective human neutrophil elastase (HNE) inhibitor (IC50: 22 nM; Ki: 0.31 nM).</p>
    Formula:C19H31N3O4S
    Color and Shape:Solid
    Molecular weight:397.53
  • MeO-Suc-Ala-Ala-Pro-Ala-CMK

    CAS:
    <p>MeO-Suc-Ala-Ala-Pro-Ala-CMK (MSACK) is an inhibitor of human neutrophil elastase (HNE) with an IC50 of 20.3 μM. It effectively inhibits the hydrolysis of substrates like lung tissue elastin by HNE and is applicable in studies related to conditions such as chronic obstructive pulmonary disease (COPD).</p>
    Formula:C20H31ClN4O7
    Color and Shape:Solid
    Molecular weight:474.936
  • RIPK1-IN-26

    CAS:
    <p>RIPK1-IN-26 is a potent inhibitor of Receptor-Interacting Serine/Threonine Kinase 1 (RIPK1), exhibiting anti-necrotic properties in cells. This compound demonstrates good metabolic stability and binding specificity in mice. RIPK1-IN-26 holds potential for development as a PET imaging probe and in the research of neurodegenerative diseases.</p>
    Formula:C15H20FNO2
    Color and Shape:Solid
    Molecular weight:265.32
  • Freselestat

    CAS:
    <p>Freselestat (ONO-6818) inhibits neutrophil elastase, reduces interleukin 8, C5B-9, and inflammation in cardiopulmonary bypass.</p>
    Formula:C23H28N6O4
    Color and Shape:Solid
    Molecular weight:452.51
  • TMPRSS6-IN-1 TFA


    <p>TMPRSS6-IN-1 (TFA) is a potent inhibitor of TMPRSS6 (Matriptase-2), a member of the TTSP family (a type of transmembrane serine protease). TMPRSS6 is a type II TTSP, and genetically reduced levels of TMPRSS6 have been shown to improve symptoms of hemochromatosis and β-thalassemia in mice.</p>
    Formula:C35H41F3N8O6S2
    Color and Shape:Solid
    Molecular weight:790.875
  • JBJ-08-178-01

    CAS:
    <p>JBJ-08-178-01, a mutant-selective tyrosine kinase inhibitor, targets (HER2) human epidermal growth factor receptor 2 and exhibits antitumoral activity. This compound not only diminishes HER2's kinase activity and protein levels through the induction of proteasomal degradation of the receptor but also shows promise in non-small-cell lung cancer research.</p>
    Formula:C31H30N8O3
    Color and Shape:Solid
    Molecular weight:562.62