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Proteases/Proteasome

Proteases/Proteasome

Protease and proteasome inhibitors are compounds that block the activity of proteases and the proteasome, which are involved in protein degradation and turnover. These inhibitors are vital for studying the regulation of protein homeostasis, cell cycle control, and apoptosis. Protease and proteasome inhibitors are also used in the treatment of diseases such as cancer, where abnormal protein degradation plays a role in disease progression. By inhibiting proteases or the proteasome, these compounds can induce cell death in cancer cells and are critical tools in both basic research and therapeutic development. At CymitQuimica, we provide a wide range of high-quality protease and proteasome inhibitors to support your research in biochemistry, cell biology, and drug development.

Subcategories of "Proteases/Proteasome"

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Found 1045 products of "Proteases/Proteasome"

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  • DPP-IV-IN-1

    CAS:
    <p>DPP-IV-IN-1 is an effective inhibitor of dipeptidyl peptidase IV (DPP-IV), a serine protease (IC50: 4.6 nM).</p>
    Formula:C11H18FN3O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:243.28
  • TNIK-IN-1

    CAS:
    <p>TNIK-IN-1 is an inhibitor of Traf2- and Nck-interacting kinase (TNIK).</p>
    Formula:C19H17N5O3S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:395.43
  • Kallikrein 5-IN-2

    CAS:
    <p>Kallikrein 5-IN-2 inhibits KLK5 (pIC50=7.1); may normalize skin shedding, lessen inflammation &amp; itching.</p>
    Formula:C23H22N6O
    Color and Shape:Solid
    Molecular weight:398.46
  • Diethyl pyimDC

    CAS:
    <p>Diethyl pyimDC is an inhibitor of human collagen prolyl 4-hydroxylase 1 (CP4H1).</p>
    Formula:C14H15N3O4
    Color and Shape:Solid
    Molecular weight:289.29
  • Aldumastat

    CAS:
    <p>Aldumastat (GLPG1972) is a highly potent, specific and orally active inhibitor of ADAMTS-5.Aldumastat is used for the study of osteoarthritis of the knee.</p>
    Formula:C20H24F2N4O3
    Purity:99.87%
    Color and Shape:Solid
    Molecular weight:406.43
  • ND-336

    CAS:
    <p>ND-336 selectively inhibits MMP-2, MMP-9, MMP-14, boosts diabetic wound healing, reduces inflammation, and promotes angiogenesis and skin repair.</p>
    Formula:C16H18ClNO3S2
    Color and Shape:Solid
    Molecular weight:371.9
  • Tyrosinase-IN-11

    CAS:
    <p>Tyrosinase-IN-11: potent inhibitor, IC50 - 50nM/64nM (L-tyrosinase/L-dopa), antioxidant, low toxicity, for hyperpigmentation study.</p>
    Formula:C15H14O5
    Color and Shape:Solid
    Molecular weight:274.27
  • MK-4882

    CAS:
    <p>MK-4882 is an effective inhibitor of HCV NS5A.</p>
    Formula:C42H50N8O7
    Purity:98%
    Color and Shape:Solid
    Molecular weight:778.9
  • YM-53601

    CAS:
    <p>YM-53601 is an SQS inhibitor that inhibits adipogenic biosynthesis and lipid secretion in rodents.YM-53601 is a cholesterol-lowering agent that inhibits FDFT1.</p>
    Formula:C21H22ClFN2O
    Purity:99.65%
    Color and Shape:Solid
    Molecular weight:372.86
  • Gosogliptin

    CAS:
    <p>Gosogliptin is a potent, orally active, highly selective, reversible and competitive inhibitor of DPP-4, increasing the level of intestinal GLP-1 and GIP.</p>
    Formula:C17H24F2N6O
    Purity:99.74%
    Color and Shape:Solid
    Molecular weight:366.41
  • (R)-ND-336

    CAS:
    <p>(R)-ND-336: potent, selective MMP-9 inhibitor (K i = 19 nM); inhibits MMP-2 (127 nM), MMP-14 (119 nM); studied for diabetic foot ulcers.</p>
    Formula:C16H18ClNO3S2
    Color and Shape:Solid
    Molecular weight:371.89
  • L-873724

    CAS:
    <p>L-873724: Selective, reversible cathepsin K inhibitor; IC50s—cat K: 0.2 nM, cat S: 178 nM, cat L: 264 nM, cat B: 5239 nM; inhibits bone resorption.</p>
    Formula:C23H26F3N3O3S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:481.53
  • JO146

    CAS:
    <p>JO146为针对沙眼衣原体高温需要蛋白A(CtHtrA)的蛋白酶抑制剂,其对CtHtrA和人中性粒细胞弹性蛋白酶(HNE)的IC50值分别为21.86 μM和1.15 μM,可应用于细菌感染的抑制。</p>
    Formula:C31H44N3O7P
    Color and Shape:Solid
    Molecular weight:601.67
  • Sortin1

    CAS:
    <p>Sortin1, a chemical genetic-hit compound, specifically induces mislocalization of both soluble and membrane-associated vacuolar markers in plants and yeast.</p>
    Formula:C26H19NO6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:441.43
  • MDK7677

    CAS:
    <p>MDK7677 is a selective inhibitor of cathepsin B endopeptidase and exopeptidase activities.</p>
    Formula:C12H10N4O3
    Color and Shape:Solid
    Molecular weight:258.23
  • Furaprofen

    CAS:
    <p>Furaprofen is an HCV inhibitor with anti-inflammatory activity that inhibits carrageenan-induced paw edema in rats.</p>
    Formula:C17H14O3
    Purity:98.49% - 99.52%
    Color and Shape:Solid
    Molecular weight:266.29
  • Immunoproteasome inhibitor 1

    CAS:
    <p>Potent, reversible immunoproteasome inhibitor; Ki: β5c 1.18 μM, β1i 0.27 μM, β5i 1.91 μM; potential in treating cancer.</p>
    Formula:C20H26N2O4
    Color and Shape:Solid
    Molecular weight:358.43
  • GEMSA

    CAS:
    <p>GEMSA is a potent inhibitor of enkephalin convertase ( K i =8.8 nM) with analgesic effect[1].</p>
    Formula:C7H13N3O4S
    Color and Shape:Solid
    Molecular weight:235.26
  • Cysteine Protease inhibitor hydrochloride

    CAS:
    <p>Cysteine Protease inhibitor hydrochloride is a cysteine protease inhibitor.</p>
    Formula:C18H15ClN4O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:338.79
  • GSK2793660 HCl

    CAS:
    <p>GSK2793660 is a irreversible covalent α,β-unsaturated amide based DPP1 inhibitor.</p>
    Formula:C22H32ClN3O3
    Color and Shape:Solid
    Molecular weight:421.96
  • PMPA sodium

    CAS:
    <p>PMPA sodium is a potent and selective glutamate carboxypeptidase 2 (GCP II/N-acetylated a-linked dipeptidase/NAALADase) inhibitor.</p>
    Formula:C6H11Na4O7P
    Purity:98%
    Color and Shape:Solid
    Molecular weight:318.08
  • Nucleoside-Analog-1

    CAS:
    <p>Nucleoside-Analog-1 is a 4′-Azidocytidine analogue, used to against Hepatitis C virus replication.</p>
    Formula:C9H9N5O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:267.2
  • AK 275

    CAS:
    <p>AK 275 is a calpain inhibitor that prevents degradation of cytoskeletal and myelin proteins in spinal cord in vitro.</p>
    Formula:C20H31N3O4
    Color and Shape:Solid
    Molecular weight:377.48
  • AZD-9684

    CAS:
    <p>AZD-9684, a carboxypeptidase U inhibitor, is used potentially for the prevention of thrombosis.</p>
    Formula:C10H14N2O2S
    Color and Shape:Solid
    Molecular weight:226.3
  • CAA0225

    CAS:
    <p>CAA0225 is a selective inhibitor of cathepsin L. CAA0225 is a probe for autophagic proteolysis.</p>
    Formula:C28H29N3O5
    Color and Shape:Solid
    Molecular weight:487.55
  • ITX-4520

    CAS:
    <p>ITX-4520 novel highly potent, orally bioavailable inhibitor of hepatitis C virus (HCV) entry.</p>
    Formula:C24H23F2N3OS
    Color and Shape:Solid
    Molecular weight:439.52
  • WAY-151693

    CAS:
    <p>WAY-151693 is an inhibitor of human collagenase-3 (MMP-13).</p>
    Formula:C21H22ClN3O5S
    Color and Shape:Solid
    Molecular weight:463.93
  • L 722151

    CAS:
    <p>L 722151 is an FXIIIa inhibitor.</p>
    Formula:C8H9ClN2O5S3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:344.82
  • Epostatin

    CAS:
    <p>Epostatin is a new dipeptidyl peptidase II (DPP-II, EC 3.4.14.2) inhibitor.</p>
    Formula:C23H33N3O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:431.53
  • Chymase-IN-1

    CAS:
    <p>Chymase-IN-1 is a selective, orally active inhibitor of human mast cell chymase (IC50: 29 nM).</p>
    Formula:C20H15ClNO4PS
    Purity:99.17%
    Color and Shape:Solid
    Molecular weight:431.83
  • AL-9

    CAS:
    <p>AL-9 is a GT-1b and GT-2a replication inhibitor.</p>
    Formula:C23H22N4O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:402.45
  • ADAMTS-5-IN-2

    CAS:
    <p>ADAMTS-5-IN-2 is a potent inhibitor of ADAMTS-5, exhibiting an IC50 of 0.71 µM, and holds potential for osteoarthritis research.</p>
    Formula:C17H15N3OS
    Color and Shape:Solid
    Molecular weight:309.39
  • GSK-2793660

    CAS:
    <p>GSK-2793660, an oral, irreversible CTSC inhibitor, aids bronchiectasis research.</p>
    Formula:C20H27N3O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:357.45
  • Safironil

    CAS:
    <p>Safironil, a novel antifibrotic, competitively inhibits collagen synthesis and modulates fibrosis, impacting type I/III collagen levels.</p>
    Formula:C15H23N3O4
    Purity:99.83%
    Color and Shape:Solid
    Molecular weight:309.36
  • RID-F

    CAS:
    <p>RID-F is an inhibitor of the nonpeptidic proteasome.</p>
    Formula:C38H50N2O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:566.82
  • SP-Chymostatin B

    CAS:
    <p>SP-Chymostatin B inhibits proteases like chymotrypsin and papain; less effective on human elastase; works at 100-200 μg/ml.</p>
    Formula:C30H41N7O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:595.69
  • TNK2-IN-1

    CAS:
    <p>TNK2-IN-1 is a TNK2 inhibitor (IC50: 224 nM) that can be used in cancer research.</p>
    Formula:C23H24N6O2
    Color and Shape:Solid
    Molecular weight:416.48
  • BC-05

    CAS:
    <p>BC-05, an orally active inhibitor targeting CD13 and the proteasome, displays potent inhibition with IC50 values of 0.13 μM against human CD13 and 1.39 μM for</p>
    Formula:C21H29BN2O9
    Purity:98%
    Color and Shape:Solid
    Molecular weight:464.27
  • A-933548

    CAS:
    <p>A-933548: potent calpain inhibitor, selective vs. cathepsins, stable, effective in cell assays.</p>
    Formula:C25H21N5O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:439.47
  • Antiviral agent 30

    CAS:
    <p>Antiviral Agent 30 (Example 118) is an active compound against HCV and RSV with an inhibitory concentration (IC 50) of greater than 25μM [1].</p>
    Formula:C21H32N2O3S
    Color and Shape:Solid
    Molecular weight:392.56
  • K 579

    CAS:
    <p>K 579 is a dipeptidyl peptidase IV inhibitor.</p>
    Formula:C17H24N6O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:328.41
  • Tyrosinase-IN-7

    CAS:
    <p>Tyrosinase-IN-7 is a small-molecule tyrosinase inhibitor (IC50 1.57 μM) that suppresses melanin activity and cell growth with low cytotoxicity.</p>
    Formula:C15H10O5
    Purity:99%
    Color and Shape:Solid
    Molecular weight:270.24
  • PTIQ

    CAS:
    <p>MMP-3 expression inhibitor</p>
    Formula:C13H17NO3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:235.28
  • MDL 27399

    CAS:
    <p>MDL 27399 suppresses human neutrophil cathepsin G.</p>
    Formula:C26H36N4O8
    Color and Shape:Solid
    Molecular weight:532.59
  • AM 4299 B

    CAS:
    <p>AM 4299 B is a novel inhibitor of a thiol protease.</p>
    Formula:C16H27N3O7
    Purity:98%
    Color and Shape:Solid
    Molecular weight:373.4
  • BAY-678 racemate

    CAS:
    <p>BAY-678 racemate: orally active, selective cell-permeable HNE inhibitor with IC50 of 20 nM.</p>
    Formula:C20H15F3N4O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:400.35
  • HCV-IN-34

    CAS:
    <p>HCV-IN-35, an oral HCV blocker, has an EC50 of 0.010 μM and a CC50 of 7.5 μM, indicating strong antiviral effects.</p>
    Formula:C31H36ClN5
    Color and Shape:Solid
    Molecular weight:514.1
  • ABT-770

    CAS:
    <p>ABT-770: an orally potent and selective MMP inhibitor, shown to reduce tumor growth in animal models.</p>
    Formula:C22H22F3N3O6
    Color and Shape:Solid
    Molecular weight:481.42
  • Calpain Inhibitor XI

    CAS:
    <p>Calpain Inhibitor XI, a reversible covalent inhibitor of calpain-1, is utilized in the research of neurodegenerative disorders.</p>
    Formula:C26H40N4O6
    Color and Shape:Solid
    Molecular weight:504.62
  • Azo-Resveratrol

    CAS:
    <p>Azo-Resveratrol is an analog of Resveratrol used as a potent tyrosinase inhibitor.</p>
    Formula:C12H10N2O3
    Color and Shape:Solid
    Molecular weight:230.22