Proteases/Proteasome
Protease and proteasome inhibitors are compounds that block the activity of proteases and the proteasome, which are involved in protein degradation and turnover. These inhibitors are vital for studying the regulation of protein homeostasis, cell cycle control, and apoptosis. Protease and proteasome inhibitors are also used in the treatment of diseases such as cancer, where abnormal protein degradation plays a role in disease progression. By inhibiting proteases or the proteasome, these compounds can induce cell death in cancer cells and are critical tools in both basic research and therapeutic development. At CymitQuimica, we provide a wide range of high-quality protease and proteasome inhibitors to support your research in biochemistry, cell biology, and drug development.
Subcategories of "Proteases/Proteasome"
- Acetyl-CoA Carboxylase(38 products)
- Cysteine Protease(111 products)
- DPP-4(27 products)
- Glutaminase(46 products)
- HIV Protease(506 products)
- PAI-1(26 products)
- Protease Inhibitors(50 products)
- Protease-activated Receptor(55 products)
- Proteasome(86 products)
- Serine Protease(54 products)
- p97(15 products)
Show 3 more subcategories
Found 985 products of "Proteases/Proteasome"
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TNIK-IN-4
CAS:TNIK-IN-4: strong TNIK inhibitor, IC50 of 0.61 μM, suppresses HCT116 colorectal cancer cells.Formula:C20H16FN3O3Color and Shape:SolidMolecular weight:365.36Lodelaben
CAS:Lodelaben (Declaben, SC-39026) is a reversible, non-competitive,specific inhibitor of human neutrophil elastase (HNE) with high potency (IC50=0.5 μM).Formula:C25H41ClO3Purity:99.62% - >99.99%Color and Shape:SolidMolecular weight:425.04p-APMSF (hydrochloride)
CAS:p-APMSF irreversibly inhibits several serine proteases; Ki: 1.02-1.54 μM; selective over chymotrypsin and acetylcholinesterase.Formula:C8H10ClFN2O2SColor and Shape:SolidMolecular weight:252.69PF-06279794
CAS:PF-06279794 is a potent, selective and ATP-competitive TNIK inhibitor.Formula:C22H20N4OColor and Shape:SolidMolecular weight:356.42CP4d inhibitor
CAS:CP4d is a novel reversible tg2 transamidase site-specific inhibitorFormula:C18H13N5O5Color and Shape:SolidMolecular weight:379.33SA 152
CAS:SA 152 is an organophosphoric inhibitor.Formula:C19H12F12NO2PColor and Shape:SolidMolecular weight:545.26APC-366 HCl
CAS:APC-366 is a selective inhibitor of the mast cell tryptase that inhibits tryptase-induced histamine release from human tonsil and lung cells.Formula:C22H29ClN6O4Color and Shape:SolidMolecular weight:476.96ADAMTS-5-IN-3
CAS:ADAMTS-5-IN-3 is a potent inhibitor of ADAMTS-5 and ADAMTS-4, used in research on ADAMTS-5 or ADAMTS-4 mediated diseases.Formula:C20H23Cl2N3O3Color and Shape:SolidMolecular weight:424.32Ono 3307 Free Base
CAS:Ono 3307 Free Base is a new synthetic protease inhibitorFormula:C14H14N4O4SColor and Shape:SolidMolecular weight:334.35Odalasvir
CAS:Odalasvir is a novel NS5A inhibitor for the treatment of hepatitis C.Formula:C60H72N8O6Color and Shape:SolidMolecular weight:1001.26Pyrithione cadmium
CAS:Pyrithione cadmium suppresses tumor growth in vitro and in vivo through inhibition of proteasomal deubiquitinaseFormula:C10H8CdN2O2S2Color and Shape:SolidMolecular weight:364.73I 432
CAS:I 432 is a TMPRSS2 (transmembrane serine proteinase 2) inhibitor (Ki =0.9 nM).Formula:C33H35Cl2F6N5O7SColor and Shape:SolidMolecular weight:830.62AGG-523
CAS:AGG-523, an aggrecanase inhibitor, may slow cartilage wear after joint injury by reducing ARG-aggrecan in rats.Formula:C28H29FN2O4Color and Shape:SolidMolecular weight:476.54ABT-518
CAS:ABT-518 is an inhibitor of matrix metalloproteinases, which are associated with tumor growth and development of metastasis.Formula:C21H22F3NO8SColor and Shape:SolidMolecular weight:505.46ACH-806
CAS:ACH-806 is an NS4A antagonist. It can inhibit Hepatitis C Virus (HCV) replication with an EC50 of 14 nM.Formula:C19H20F3N3O2SPurity:98%Color and Shape:SolidMolecular weight:411.44AZD-1236
CAS:AZD1236 is a selective inhibitor for human MMP-9/MMP-12, less effective in rodents, and reduces lung injury and inflammation.Formula:C15H19ClN4O5SColor and Shape:SolidMolecular weight:402.85Butabindide
CAS:Butabindide (UCL-1397) selectively inhibits TPP II, protecting CCK-8, with Ki of 10 μM (TPP I) and 7 nM (TPP II).Formula:C17H25N3O2Color and Shape:SolidMolecular weight:303.4GM 1489
CAS:GM 1489 is an MMP inhibitor, effective against MMP-1, -2, -3, -8, -9, reduces cancer cell invasion, and prevents ear thickening in mice.Formula:C27H33N3O4Color and Shape:SolidMolecular weight:463.57GSK2793660 free base
CAS:GSK-2793660, a cathepsin C inhibitor, may treat cystic fibrosis and related lung conditions.Formula:C22H31N3O3Color and Shape:SolidMolecular weight:385.5THDP-17
CAS:THDP-17 is a inhibitor of glutaminase. THDP-17 shows a partial uncompetitive inhibition in vitro.Formula:C12H16N2SPurity:98%Color and Shape:SolidMolecular weight:220.33Garvagliptin
CAS:Garvagliptin has antidiabetic activity.Formula:C18H23F2N3O3SPurity:98%Color and Shape:SolidMolecular weight:399.46Cysteine protease inhibitor-2
CAS:Cysteine protease inhibitor from US20070032499A1; halts DCT116 at 6.5μM, PC3 at 4.4μM.Formula:C13H5N5OPurity:98%Color and Shape:SolidMolecular weight:247.21TPO agonist 1
CAS:TPO agonist 1, Thrombopoietin (TPO) mimetic, promotes platelet/megakaryocyte production, for thrombocytopenia research.Formula:C25H22N8O2Purity:98%Color and Shape:SolidMolecular weight:466.49ZD8321
CAS:ZD8321 is an effective inhibitor of human Neutrophil elastase (Ki: 13±1.7 nM).Formula:C18H28F3N3O5Purity:98%Color and Shape:SolidMolecular weight:423.43Proteasome-IN-1
CAS:Proteasome-IN-1 is an inhibitor of proteasome.Formula:C42H35N5O3Purity:98%Color and Shape:SolidMolecular weight:657.76AZD6564
CAS:AZD6564 is a fibrinolysis inhibitor which acts via interference of a protein-protein interaction.Formula:C13H22N2O2Color and Shape:SolidMolecular weight:238.33TAPI-1
CAS:TAPI1 (TAPI) , an ADAM17/TACE inhibitor, inhibits shedding of cytokine receptors.Formula:C26H37N5O5Purity:≥95%Color and Shape:SolidMolecular weight:499.6GS-9256
CAS:GS-9256 is a selective inhibitor of the HCV NS3 protease, exhibiting favorable pharmacokinetic properties and antiviral activity [1].Formula:C46H56ClF2N6O8PSPurity:98%Color and Shape:SolidMolecular weight:957.46Z-LLF-CHO
CAS:Z-LLF-CHO (Z-Leu-Leu-Phe-CHO) effectively inhibits the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex with a Ki value of 460 nM.Formula:C29H39N3O5Purity:98%Color and Shape:SolidMolecular weight:509.64MMP13-IN-4
CAS:MMP13-IN-4 (compound 13) is a potent, selective MMP-13 inhibitor with an IC50 of 14.6 μM, implicated in the pathology of osteoarthritis (OA) [1].Formula:C21H17BrN4O5Purity:98%Color and Shape:SolidMolecular weight:485.29ND-322 HCl
CAS:ND-322 HCl (ND 322 Hydrochloride) is a selective inhibitor of MT1-MMP and MMP2 and reduces in vitro melanoma cell growth, migration and invasion.Formula:C15H16ClNO3S2Purity:99.49%Color and Shape:SolidMolecular weight:357.88Ref: TM-T28145
1mg152.00€5mg334.00€10mg492.00€25mg780.00€50mg1,044.00€100mg1,414.00€1mL*10mM (DMSO)349.00€PF-00356231 hydrochloride
CAS:PF-00356231 hydrochloride is an inhibitor of matrix metalloproteinase MMP-12 with IC50 of 1.4 μM.Formula:C25H21ClN2O3SPurity:98.39%Color and Shape:SolidMolecular weight:464.96ZM223 hydrochloride (2031177-48-5 free base)
ZM223 hydrochloride is an orally active, potent non-covalent inhibitor of NEDD8 activating enzyme (NAE), and with excellent anticancer activity.Formula:C23H18ClF3N4O2S2Purity:98%Color and Shape:SolidMolecular weight:538.99Flovagatran
CAS:Flovagatran (TGN 255) is a potent, and selective inhibitor of thrombin and parenteral direct factor II.Flovagatran is used to study venous thromboembolism.Formula:C27H36BN3O7Purity:99.56%Color and Shape:SolidMolecular weight:525.4RO-9187
CAS:RO-9187 is an effective HCV virus replication inhibitor(IC50: 171 nM).Formula:C9H12N6O5Purity:98%Color and Shape:SolidMolecular weight:284.232-MPPA
CAS:2-MPPA (GPI-5693) is a GCP II inhibitor and NAALADase inhibitor, used in research on neurodegenerative diseases.Formula:C8H14O4SPurity:99.81%Color and Shape:SolidMolecular weight:206.26Ref: TM-T22497
1mg50.00€5mg99.00€10mg160.00€25mg358.00€50mg620.00€100mg1,108.00€200mg1,504.00€1mL*10mM (DMSO)109.00€Cofrogliptin
CAS:Cofrogliptin (HSK7653) is a DPP-4 inhibitor with hypoglycemic effects, which can be used to study type 2 diabetes (T2D).Formula:C18H19F5N4O3SColor and Shape:SolidMolecular weight:466.43Gosogliptin
CAS:Gosogliptin is a potent, orally active, highly selective, reversible and competitive inhibitor of DPP-4, increasing the level of intestinal GLP-1 and GIP.Formula:C17H24F2N6OPurity:99.74%Color and Shape:SolidMolecular weight:366.41Efegatran sulfate
CAS:Efegatran sulfate (LY294468 sulfate) is a potent thrombin inhibitor used in the treatment of thrombotic disorders.Formula:C21H34N6O7SPurity:≥98% - ≥98%Color and Shape:SolidMolecular weight:514.6ZD-0892
CAS:ZD-0892: potent, selective neutrophil elastase inhibitor; Ki 6.7 nM (human), 200 nM (porcine).Formula:C24H32F3N3O5Purity:95% - 99.53%Color and Shape:SolidMolecular weight:499.52Calpain Inhibitor XII
CAS:Calpain Inhibitor XII (Z-L-Nva-CONH-CH2-2-Py) is a calpain I inhibitor that inhibits calpain II and cathepsin B.
Formula:C26H34N4O5Color and Shape:SolidMolecular weight:482.57MMP2-IN-2
CAS:MMP2-IN-2 is an MMP-2 inhibitor that inhibits MMP-13, MMP-9, and MMP-8, and can be used in the study of cancer and immune diseases.Formula:C13H8N4O4Purity:98.09%Color and Shape:SolidMolecular weight:284.2320S Proteasome activator 1
CAS:20S Proteasome activator 1: IC50—0.3 μM (trypsin), 0.7 μM (chymotrypsin), 1.8 μM (caspase); reduces alpha-synuclein A53T, aids neurodegenerative studies.Formula:C27H19ClF2N2OSPurity:99.82%Color and Shape:SolidMolecular weight:492.97TG-2-IN-1
CAS:TG-2-IN-1 (Compound D003) is a transglutaminase-2 ( TGM-2 ) inhibitor. TG-2-IN-1 can be used in myopia research[1].Formula:C8H13ClN2OSPurity:98.43%Color and Shape:SolidMolecular weight:220.72MK-8325
CAS:MK-8325 is a potent and orally available HCV NS5A inhibitor with replicative activity against a wide range of genotypes.MK-8325 has demonstrated bioavailabilityFormula:C43H54Cl2F2N8O6SiPurity:99.61%Color and Shape:SolidMolecular weight:915.93Tyrosinase-IN-2
CAS:Tyrosinase-IN-2, a potent tyrosinase inhibitor, may help in skin lightening and food preservation research.Formula:C8H8N4O2SPurity:99.78%Color and Shape:SolidMolecular weight:224.24Ref: TM-T60278
5mg48.00€10mg71.00€25mg135.00€50mg212.00€100mg340.00€200mg467.00€1mL*10mM (DMSO)49.00€UPGL00004
CAS:UPGL00004: potent GAC inhibitor, IC50=29 nM, Kd=27 nM, suppresses triple-negative breast cancer cell growth.Formula:C25H26N8O2S2Purity:97.93%Color and Shape:SolidMolecular weight:534.66(2RS)-FPMPA
CAS:(2RS)-FPMPA（FPMPA） has antiviral activity with an IC50 value of 1.85 μM measured in human MT12 cells infected with SHIV (DH4R).Formula:C9H13FN5O4PPurity:99.9% - >99.99%Color and Shape:SolidMolecular weight:305.2TG2-IN-3h
CAS:TG2-IN-3h is a highly selective, potent, cell-permeable fluorescent irreversible tissue transglutaminase (tg2) inhibitorFormula:C21H26N4O4SPurity:99.34% - 99.76%Color and Shape:SolidMolecular weight:430.52P32/98 hemifumarate
CAS:P32/98 hemifumarate is a DPP4 inhibitor with hypoglycemic properties and is used in the study of type 2 diabetes.Formula:C22H40N4O6S2Purity:99.46%Color and Shape:SolidMolecular weight:520.71
