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Proteases/Proteasome

Proteases/Proteasome

Protease and proteasome inhibitors are compounds that block the activity of proteases and the proteasome, which are involved in protein degradation and turnover. These inhibitors are vital for studying the regulation of protein homeostasis, cell cycle control, and apoptosis. Protease and proteasome inhibitors are also used in the treatment of diseases such as cancer, where abnormal protein degradation plays a role in disease progression. By inhibiting proteases or the proteasome, these compounds can induce cell death in cancer cells and are critical tools in both basic research and therapeutic development. At CymitQuimica, we provide a wide range of high-quality protease and proteasome inhibitors to support your research in biochemistry, cell biology, and drug development.

Subcategories of "Proteases/Proteasome"

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Found 1045 products of "Proteases/Proteasome"

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  • Sadopeptins B


    <p>Sadopeptins B, a natural product isolated from Streptomyces sp., is a potent proteasome inhibitor [1].</p>
    Formula:C48H69N9O13S
    Color and Shape:Solid
    Molecular weight:1012.18
  • Peptide 74

    CAS:
    <p>Peptide 74 is a synthetic peptide. It also inhibits the activated form of this enzyme.</p>
    Formula:C62H107N23O20S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1558.79
  • FFAGLDD TFA


    <p>FFAGLDD TFA: MMP9 peptide for controlled DOX delivery to cytoplasm.</p>
    Formula:C39H50F3N7O14
    Purity:98%
    Color and Shape:Solid
    Molecular weight:897.85
  • Monodes(N-carboxymethyl)valine Daclatasvir

    CAS:
    <p>Monodes(N-carboxymethyl)valine Daclatasvir, or Daclatasvir Impurity A, degrades Daclatasvir, a strong HCV NS5A inhibitor.</p>
    Formula:C33H39N7O3
    Color and Shape:Solid
    Molecular weight:581.71
  • Neutrophil elastase inhibitor 4


    <p>Neutrophil elastase inhibitor 4 (compound 4f) is a competitive inhibitor of human neutrophil elastase (HNE) with IC50 of 42.30 nM and Ki of 8.04 nM.</p>
    Formula:C20H21N3O5
    Color and Shape:Solid
    Molecular weight:383.4
  • BAY 1217224

    CAS:
    <p>BAY 1217224 is a neutral, non-prodrug Thrombin inhibitor with good oral pharmacokinetics.</p>
    Formula:C24H27ClFN3O5
    Color and Shape:Solid
    Molecular weight:491.94
  • Calpain Inhibitor-1

    CAS:
    <p>Calpain Inhibitor-1, a potent Calpain 1 blocker, has IC50 of 100 nM and Ki of 2.89 μM.</p>
    Formula:C19H17FN6O5S
    Color and Shape:Solid
    Molecular weight:460.44
  • TAPI1 acetate


    <p>TAPI1 acetate (TNF-α processing inhibitor-1) is a TACE (ADAM17) inhibitor that inhibits shedding of TNF-α cytokine receptors; MMP inhibitor .</p>
    Formula:C28H41N5O7
    Purity:98.82% - 99.94%
    Color and Shape:Solid
    Molecular weight:559.65
  • EP 171

    CAS:
    <p>EP 171 is a potent agonist of TP-receptors.</p>
    Formula:C23H29FO5
    Color and Shape:Solid
    Molecular weight:404.47
  • Histatin 5

    CAS:
    <p>Histatin 5, a human saliva peptide, blocks MMP-2 and MMP-9 at IC50s of 0.57/0.25 μM and kills fungi.</p>
    Formula:C133H195N51O33
    Purity:98%
    Color and Shape:Solid
    Molecular weight:3036.29
  • Aristololactam IIIa

    CAS:
    <p>Aristololactam IIIa inhibits superoxide and elastase generation; IC50: 0.12 μg/mL and 0.20 μg/mL.</p>
    Formula:C16H9NO4
    Color and Shape:Solid
    Molecular weight:279.25
  • NS5A-IN-4

    CAS:
    <p>NS5A-IN-4 (Compound 1.12) is a hepatitis C inhibitor effective against multiple genotypes, with IC50 values ranging from 1.2 to 2296 pM.</p>
    Formula:C47H48N8O6
    Color and Shape:Solid
    Molecular weight:820.93
  • Imitrodast

    CAS:
    <p>Imitrodast is a small molecule thromboxane A2 synthase (TXA2 synthase) inhibitor for the treatment of immune system disorders, respiratory disorders, and</p>
    Formula:C13H12N2O2S
    Purity:98.39%
    Color and Shape:Solid
    Molecular weight:260.31
  • AP-C2

    CAS:
    <p>AP-C2 is a potent small molecule guanosine 3',5'-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) inhibitor with a pIC50 of 5.2 for cGKII.</p>
    Formula:C18H16N4S
    Purity:99.87%
    Color and Shape:Soild
    Molecular weight:320.41
  • Sofosbuvir impurity A

    CAS:
    <p>Sofosbuvir impurity A is an diastereoisomer of Sofosbuvir. Sofosbuvir is anHCV RNA replication inhibitor ,with potent anti-hepatitis C virus activity.</p>
    Formula:C22H29FN3O9P
    Purity:98%
    Color and Shape:Solid
    Molecular weight:529.45
  • Sucunamostat

    CAS:
    <p>Sucunamostat is an L-aspartic acid enteropeptidase inhibitor.</p>
    Formula:C22H22N4O8
    Color and Shape:Solid
    Molecular weight:470.438
  • Plasma kallikrein-IN-1

    CAS:
    <p>Plasma kallikrein-IN-1 is a PKK inhibitor with an IC 50 value of 0.5 nM.</p>
    Formula:C23H25F2N7O
    Color and Shape:Solid
    Molecular weight:453.498
  • Sofosbuvir impurity J

    CAS:
    <p>Sofosbuvir impurity J is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.</p>
    Formula:C22H30FN4O8P
    Purity:98%
    Color and Shape:Solid
    Molecular weight:528.47
  • Acetyl-Calpastatin(184-210)(human)

    CAS:
    <p>Calpain inhibitor, Ki 0.2 nM for calpain I/II, doesn't affect papain/trypsin/cat L. Raises Aβ42, Aβ40 secretion &amp; Aβ42/Aβ40 ratio.</p>
    Formula:C142H230N36O44S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:3177.65
  • Berotralstat

    CAS:
    <p>Berotralstat (BCX7353) is an oral, low-toxicity, specific kallikrein inhibitor for hereditary angioedema research, blocking bradykinin release.</p>
    Formula:C30H26F4N6O
    Color and Shape:Solid
    Molecular weight:562.56
  • PF 00356231

    CAS:
    <p>PF 00356231 is a selectivity inhibitor MMP-12 and can be used in studies about the treatment of emphysema and chronic obstructive pulmonary disease (COPD).</p>
    Formula:C25H20N2O3S
    Purity:99.35%
    Color and Shape:Solid
    Molecular weight:428.5
  • Phaeosphaone D

    CAS:
    <p>Phaeosphaone D, a thiodiketopiperazine from Phaeosphaeria fuckelii fungus, inhibits mushroom tyrosinase (IC50 = 33.2 μM).</p>
    Formula:C20H27N3O3S2
    Color and Shape:Solid
    Molecular weight:421.58
  • CRA-2059 hydrochloride


    <p>CRA-2059 hydrochloride is a highly specific and selective tryptase inhibitor, with a Ki of 620 pM for recombinant human tryptase-β (rHTβ)[1][2].</p>
    Color and Shape:Solid
  • HIV-1 inhibitor-6 

    CAS:
    <p>HIV-1 inhibitor-6 (3-Pyridinecarboxamide, 1,4-dihydro-1-methyl-N-(5-nitro-1,2-benzisothiazol-3-yl)-4-oxo-) is a potent HIV-1 pre-mRNA selective splicing</p>
    Formula:C14H10N4O4S
    Purity:99.33%
    Color and Shape:Solid
    Molecular weight:330.32
  • Nostosin G


    <p>Nostosin G, a linear peptide with Hpla, Hty, and argininal, inhibits trypsin effectively (IC50 = 0.1 μM).</p>
    Formula:C25H33N5O6
    Color and Shape:Solid
    Molecular weight:499.56
  • BPHA

    CAS:
    <p>BPHA is a selective oral inhibitor of MMP-2/9/14 (IC50: 12/16/17 nM), not affecting MMP-1/3/7, with anti-angiogenic and anti-tumor properties.</p>
    Formula:C21H20N2O4S
    Purity:99.44%
    Color and Shape:Solid
    Molecular weight:396.46
  • Enzyme-IN-1

    CAS:
    <p>Enzyme-IN-1(compound 1)为基于肽的N端亲核试剂(Ntn)水解酶抑制剂,特别针对20S蛋白酶体的糜胰蛋白酶样活性(CT-L)进行抑制,可能展现出抗炎特性。</p>
    Formula:C36H50N4O7
    Color and Shape:Solid
    Molecular weight:650.8
  • Sadopeptins A


    <p>Sadopeptins A, a natural product isolated from Streptomyces sp., is a potent proteasome inhibitor [1].</p>
    Formula:C49H71N9O13S
    Color and Shape:Solid
    Molecular weight:1026.21
  • JC-10

    CAS:
    <p>JC-10 is a potent inhibitor of metalloproteinases and is often used as a probe.</p>
    Formula:C25H29Cl2IN4
    Purity:95%
    Color and Shape:Solid
    Molecular weight:583.34
  • Ellipyrone A


    <p>Ellipyrone A: γ-pyrone macrocycle, inhibits DPP-4 (IC50=0.35mM), α-glucosidase (IC50=0.74mM), α-amylase (IC50=0.59mM).</p>
    Formula:C25H34O8
    Color and Shape:Solid
    Molecular weight:462.53
  • Leptosin D

    CAS:
    <p>Leptosin D, a thiodiketopiperazine alkaloid derived from mushrooms, effectively inhibits tyrosinase activity, demonstrating an inhibition concentration (IC50)</p>
    Formula:C25H24N4O3S2
    Color and Shape:Solid
    Molecular weight:492.61
  • Cys-TAT(47-57) acetate(583836-55-9 Free base)


    <p>Cys-TAT(47-57) acetate is derived from the HIV-1 transactivating protein. Cys-TAT(47-57) acetate is an arginine rich peptide that can penetrate cells.</p>
    Formula:C69H128N34O16S
    Purity:95.1100%
    Color and Shape:Solid
    Molecular weight:1722.04
  • CRA-2059 TFA


    <p>CRA-2059 is a highly specific and selective tryptase inhibitor, with a Ki of 620 pM for recombinant human tryptase-β (rHTβ)[1][2].</p>
    Color and Shape:Solid
  • CL 82198 hydrochloride

    CAS:
    <p>CL 82198 hydrochloride selectively inhibits MMP-13, not MMP-1/9/TACE, and blocks HP75 invasion and neurotoxicity in zebrafish.</p>
    Formula:C17H23ClN2O3
    Color and Shape:Solid
    Molecular weight:338.83
  • Nitidanin


    <p>Nitidanin is a useful organic compound for research related to life sciences and the catalog number is T125599.</p>
    Formula:C21H24O8
    Color and Shape:Solid
    Molecular weight:404.415
  • RJS308


    <p>RJS308 is a PROTAC degrader of cyclosporin A (cyclosporin A) with a DC50 of 284 nM. It exhibits antiviral activity by inhibiting the replication of HIV-1 and HCV. (Pink: ligand for target protein CypA ligand-2; Black: linker; Blue: ligand for E3 ligase VHL (S,R,S)-AHPC-Me)</p>
    Formula:C63H75N13O11S
    Color and Shape:Solid
    Molecular weight:1222.42
  • N-CBZ-Phe-Arg-AMC TFA


    <p>N-CBZ-Phe-Arg-AMC TFA (Z-FR-AMC TFA) is a fluorescent substrate for serine proteases. assess the activity of trypsin, plasmin, and cathepsin.</p>
    Formula:C35H37F3N6O8
    Purity:99.88%
    Color and Shape:Solid
    Molecular weight:726.7
  • RXP470

    CAS:
    <p>RXP470 is a potent and selective MMP-12 inhibitor (Ki 0.24 nM).</p>
    Formula:C35H35BrClN4O10P
    Color and Shape:Solid
    Molecular weight:818
  • L 659286

    CAS:
    <p>L 659286 is one kind of cephalosporin derivative.</p>
    Formula:C17H21N5O7S2
    Color and Shape:Solid
    Molecular weight:471.51
  • α 1(I) Collagen (614-639), human

    CAS:
    <p>This is a peptide inhibitor of collagen fibrillar matrix assembly.</p>
    Formula:C134H189N37O39
    Purity:98%
    Color and Shape:Solid
    Molecular weight:2942.16
  • Linagliptin Methyldimer

    CAS:
    <p>Linagliptin Methyldimer is a potent dipeptidyl peptidase IV inhibitor, IC50=6 pM.</p>
    Formula:C50H56N16O4
    Purity:97.23%
    Color and Shape:Solid
    Molecular weight:945.08
  • Alisporivir

    CAS:
    <p>Alisporivir (Debio-025) is a cyclophilin A inhibitor that disrupts the interaction between CypA and NS5A. HCV activity in vivo and in vitro.</p>
    Formula:C63H113N11O12
    Purity:99.95%
    Color and Shape:Solid
    Molecular weight:1216.64
  • Ecallantide TFA


    <p>Ecallantide (DX-88) TFA, a specific recombinant plasma kallikrein inhibitor, directly inhibits bradykinin production and is indicated for the prevention of</p>
    Color and Shape:Odour Solid
  • Obtusifolin-2-O-glucoside

    CAS:
    <p>Obtusifolin-2-O-glucoside (compound 7), a tyrosinase inhibitor with an IC50 value of 9.2 μM, can be isolated from cassia seed [1].</p>
    Formula:C22H22O10
    Color and Shape:Solid
    Molecular weight:446.4
  • DPP8/9-IN-1


    <p>DPP8/9-IN-1 (Compound 16) is a selective covalent inhibitor of dipeptidyl peptidase 8 and 9 (DPP8/9), with IC50 values of 14 nM and 298 nM, respectively. It irreversibly binds to the active site serine (such as S730 in DPP9) through a phosphate ester warhead, blocking substrate binding and inhibiting DPP8/9-mediated protein processing. DPP8/9-IN-1 holds potential for research in cancer and inflammatory diseases.</p>
    Color and Shape:Odour Solid
  • Recombinant Proteinase K


    <p>Recombinant Proteinase K: serine protease, cleaves carboxy-terminus peptides, digests proteins, purifies nucleic acids.</p>
    Color and Shape:Solid
  • Rivulariapeptolides 1155


    <p>Rivulariapeptolides 1155 inhibits chymotrypsin (41.84 nM), elastase (4.94 nM), and proteinase K (56.54 nM).</p>
    Formula:C59H81N9O15
    Color and Shape:Solid
    Molecular weight:1156.33
  • Ac-DEMEEC-OH

    CAS:
    <p>Ac-DEMEEC-OH is a competitive inhibitor of the HCV NS3 protease with a Ki of 0.6 µM.</p>
    Formula:C29H44N6O16S2
    Color and Shape:Solid
    Molecular weight:796.82
  • Relacatib

    CAS:
    <p>Relacatib (SB-462795) is a potent cathepsins K, L, V inhibitor with high affinity (Ki: 41-68 pM) and reduces bone resorption effectively.</p>
    Formula:C27H32N4O6S
    Color and Shape:Solid
    Molecular weight:540.64
  • Tyrosinase-IN-32


    <p>Tyrosinase-IN-32 (compound 11), a hydroxamate-based alkaloid extracted from black pepper (Piper nigrum L.), functions as an inhibitor of mushroom tyrosinase. In addition to its inhibitory properties, it exhibits antioxidant activity.</p>
    Formula:C15H19NO3
    Color and Shape:Solid
    Molecular weight:261.32